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| Number | Title | Issue Date |
| 8187865 | Nanowire sensor, sensor array, and method for making the same The present invention relates to a nanowire sensor and method for forming the same. More specifically, the nanowire sensor comprises at least one nanowire formed on a substrate, with a sensor receptor disposed on a surface of the nanowire, thereby forming a receptor... | 05/29/2012 |
| 8178344 | System and method for antigen structure-independent detection of antigens captured on antibody arrays The present invention provides a system and method for detecting antigens captured on an antibody array. The method comprises the following steps of providing the antibody array having at least two antibodies, contacting the antibody array with a sample containing a... | 05/15/2012 |
| 8178342 | In vivo flow cytometry system and method The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in vivo so as to excite t... | 05/15/2012 |
| 8178343 | Gene cluster diagnosis apparatus A diagnosis apparatus is provided. A gene chip having a target gene cluster is used with the apparatus. The target gene cluster comprises a plurality of target genes related to a cancer. Thus, a fast, accurate, sensitive and cheap WEnCA-Chipball platform is provided... | 05/15/2012 |
| 8173417 | Ruggedized apparatus for analysis of nucleic acid and proteins The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as ... | 05/08/2012 |
| 8173077 | Reusable PCR amplification system and method A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an... | 05/08/2012 |
| 8168424 | Differentiation and identification of analogous chemical and biological substances with biosensors A biosensor for detecting particular substances biosensor comprises a piezoelectric material, an input transducer supported by the piezoelectric material to receive an input signal and propagate a corresponding acoustic wave within the piezoelectric material and an ... | 05/01/2012 |
| 8158350 | Probe, probe set, probe-immobilized carrier, and genetic testing method A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 76 to 77 a... | 04/17/2012 |
| 8148140 | Target substance detecting element, target substance detecting apparatus, and target substance detecting method The present invention enables to classify and measure two or more kinds of target substances which have the same recognition site recognized by a specific capturing body. Specifically, by using a target substance detecting element for detecting two or more targets, ... | 04/03/2012 |
| 8148073 | Probe, probe set, probe-immobilized carrier, and genetic testing method A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 68 to 69 a... | 04/03/2012 |
| 8148076 | Gene expression profiling of EGFR positive cancer The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing ... | 04/03/2012 |
| 8133719 | Methods for making single molecule arrays Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly dis... | 03/13/2012 |
| 8133720 | Biosensor The invention provides a biosensor comprising a microbe-binding aptamer(s) in the substrate recognition element. It is possible to obtain a stabilized biosensor wherein the detection sensitivity for target microbe (target bacterium) is not impaired depending on the ... | 03/13/2012 |
| 8129176 | Integrated active flux microfluidic devices and methods The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting ... | 03/06/2012 |
| 8129175 | Point source diffusion cell activity assay apparatus Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in contact with a cell suspension media containing cells, diffusing the t... | 03/06/2012 |
| 8105820 | Assay chip, and uses of said assay chip to determine molecular structures and functions An assay chip for investigation the functionality of membrane proteins and their interactions with molecules includes a nanopore array having a plurality of nanopores in a suitable support layer deposited on the nanopore substrate and being a substantially planar su... | 01/31/2012 |
| 8105821 | Silane mixtures Silanation compositions containing a mixture of two or more silanation reagents, where at least one silanation reagent includes a functional group capable of supporting polymer synthesis and at least one silanation reagent includes no functional group capable of sup... | 01/31/2012 |
| 8101402 | Medical device for analyte monitoring and drug delivery The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and i... | 01/24/2012 |
| 8101403 | Method and device for rapid parallel microfluidic molecular affinity assays Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume fl... | 01/24/2012 |
| 8088616 | Heater unit for microfluidic diagnostic system The present technology provides for a heater substrate that contains networks of heater elements configured to controllably and selectively deliver heat to one or more PCR reaction chambers in a microfluidic substrate with which the heater substrate makes contact. I... | 01/03/2012 |
| 8088615 | Optical component for observing a nanometric sample, system comprising same, analysis method using same, and uses thereof The invention concerns an optical component for observing a sample, which includes a substrate and at least one complex index layer of predetermined thickness, designed to show a high intensity or color contrast for optical path variations, reliefs, nanometric thick... | 01/03/2012 |
| 8084203 | Methods for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population The invention relates to methods and reagents for the determination of telomere length in tissue sections by the single cell telomeric mapping technique based on a fluorescent in situ hybridization step using a telomere-specific probe and an interpolation step using... | 12/27/2011 |
| 8080381 | Infectious etiologic agent detection probe and probe set, carrier, and genetic screening method An infectious etiologic agent detection probe set which detects an infectious etiologic agent gene, includes a plurality of kinds of probes including oligonucleotide having base sequences selected from each of a plurality of groups selected from a first group includ... | 12/20/2011 |
| 8080409 | Sample processing device compression systems and methods Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during ope... | 12/20/2011 |
| 8080408 | Bioassay substrate and bioassay method A bioassay substrate and method thereof is provide. In the bioassay substrate, a sample solution is dripped onto a spot area to which a plurality of detection substances is fixed and an interaction between the detection substance and a target substance in the sample... | 12/20/2011 |
| 8076126 | Single column immunological test elements A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover str... | 12/13/2011 |
| 8076079 | Single molecule detection using molecular motors The present invention provides methods and compositions for highly sensitive nucleic acid detection, down to the single nucleic acid molecule level. In one aspect, the present invention provides methods for detecting a target nucleic acid comprising: (a) providing f... | 12/13/2011 |
| 8071363 | Chip for cell electrophysiological sensor, cell electrophysiological sensor using the same, and manufacturing method of chip for cell electrophysiological sensor A chip for a cell electrophysiological sensor has a substrate. The substrate has a through-hole formed from the upside to the downside, and the opening of the through-hole is formed in a curved surface curved from the upside and downside of the substrate toward the ... | 12/06/2011 |
| 8067226 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 11/29/2011 |
| 8067169 | Detection of macromolecular complexes on ultraflat surfaces with harmonic cantilevers Method and apparatus which uses harmonic cantilevers, such as used in atomic force microscopy, to detect variations in the attractive and repulsive forces on a solid surface as a result of macromolecular binding, for example, hybridization of a single stranded DNA m... | 11/29/2011 |
| 8062883 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality ... | 11/22/2011 |
| 8058055 | High resolution chromosomal mapping The present invention generally relates to spatial and structural genomic analysis compositions, which can be used for the mapping of chromosomes and structural analyses of chromosomal rearrangements, including the entire chromosome, as well as specific portions or ... | 11/15/2011 |
| 8053227 | Biosensor A biosensor provided herein includes a semiconductor laser device having an optical resonator with at least one reflective surface and a light output surface, and a surface plasmon resonance (SPR) unit disposed on the reflective surface of the optical resonator. The... | 11/08/2011 |
| 8053226 | Device and method for simultaneously identifying blood group antigens The invention relates to a device for simultaneously, qualitatively or quantitatively identifying a number of analytes in a liquid sample. The device comprises a membrane with: a charging zone for applying the liquid sample; at least two indicator zones, which can i... | 11/08/2011 |
| 8039249 | Compact disk based platform for separating and detecting immunomagnetic bead labeled cells Disclosed is a disk based platform for separating and detecting cells that are labeled with immunomagnetic beads. A disk-like carrier board forms therein at least one flow channel structure, which includes an inner reservoir for receiving a sample fluid, an outer re... | 10/18/2011 |
| 8039250 | Piezoelectric-based nanopore device for the active control of the motion of polymers through the same Apparatus, system, and methods are provided for utilizing piezoelectric material for controlling a polymer through a nanopore. A reservoir is formed filled with conductive fluid. A membrane is formed that separates the reservoir. A nanopore is formed through the mem... | 10/18/2011 |
| 8030060 | Gene signature for diagnosis and prognosis of breast cancer and ovarian cancer A first embodiment is a breast cancer prognosticator comprising a detection mechanism consisting a 15-gene signature. In addition there are embodiments comprised of 23-gene signatures and 28-gene signatures. The 28-gene signature may also be used for the prognosis o... | 10/04/2011 |
| 8026094 | Microarray synthesis instrument and method During the light illumination period of a monomer addition cycle in synthesizing an DNA microarray, undesirable reflections of illumination light from various interfaces that the illumination light passes through near the synthesis surface of the substrate may reduc... | 09/27/2011 |
| 8017381 | Composite electroporation plate with interchangeable well inserts Electroporation on a plurality of samples of membranous structures is performed in an electroporation well plate that includes a frame that can hold a plurality of well strips to form a two-dimensional array of wells, and a set of well strips, the set containing str... | 09/13/2011 |
| 8012743 | Detection of target analytes using particles and electrodes The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected... | 09/06/2011 |
