Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 8178341 | Electrostatic particle exposure system and method of exposing a target material to small particles A system for exposing a target material to small particles. The system includes an exposure chamber that receives the target material. A stream of charged particles is directed via an inlet into the exposure chamber toward the target material. One or more electrodes... | 05/15/2012 |
| 8173416 | Circuit arrangement for injecting nucleic acids and other biologically active molecules into the nucleus of higher eucaryotic cells using electrical current The invention relates to a novel circuit arrangement for electrotransfection or electrofusion, which enables the transportation of DNA and/or other biologically active molecules to the nucleus of higher eukaryotic cells or the fusion of cells, independent of cell di... | 05/08/2012 |
| 8105818 | Ready-to-use electroporation cuvette including frozen electrocompetent cells A ready-to-use electroporation cuvette is provided that includes a cuvette, first and second electrodes positioned within the cuvette and electroporation competent cells frozen in a suspension solution within the cuvette, wherein the electroporation cuvette is confi... | 01/31/2012 |
| 8101401 | Container and device for generating electric fields in different chambers The invention concerns a container 1 with chambers 2 which each comprise at least one pair of electrodes including a first 4 and a second electrode 5 for the application of electric voltage for generating an electric field within one cham... | 01/24/2012 |
| 8008063 | Individual-cell electroporation using area-focused electric fields Electroporation is performed on a population of cells, liposomes, vesicles, or other membrane-encased structures with uniform results regardless of size variations within the population, by drawing the membrane-encased structures into micron-sized openings that cont... | 08/30/2011 |
| 8003372 | Device for performing cell assays A device for performing cell assays has at least one assay site. The site comprises a pair of stimulating electrodes and a cell confinement cavity for confining at least one cell in an extracellular fluid medium. The cell confinement cavity and the stimulating elect... | 08/23/2011 |
| 7960167 | Nanostructured surface for microparticle analysis and manipulation The present invention provides an apparatus, comprising a first mechanical structure having a first rigid surface, an area of the first rigid surface having a nanostructured surface. The apparatus also includes a second mechanical structure having a second rigid sur... | 06/14/2011 |
| 7943367 | High-throughput electroporation chamber with functional lid for risk reduction A chamber that includes electrical contacts and a protective lid with a manually operated release is designed to receive a multi-well electroporation plate and to allow high-throughput electroporation on the well contents with minimal risk of electrical shock to the... | 05/17/2011 |
| 7923238 | Multi-channel electroporation system Systems, methods and apparatus provide flexible and efficient high throughput electroporation systems. An electrical pulse may be transmitted to any number of channels of a multi-channel sample plate. Drivers can provide the selection of which channels to transmit t... | 04/12/2011 |
| 7901929 | High voltage nanosecond pulse generator using fast recovery diodes for cell electro-manipulation A pulse generator circuit may include a diode configured to operate as an opening switch, a tank circuit in series with the diode having an admittance that is switchable from a first value to a second value that is different from the first value, and a switching sys... | 03/08/2011 |
| 7901930 | High voltage nanosecond pulse generator using fast recovery diodes for cell electro-manipulation A pulse generator circuit may include a diode configured to operate as an opening switch, a tank circuit in series with the diode having an admittance that is switchable from a first value to a second value that is different from the first value, and a switching sys... | 03/08/2011 |
| 7799555 | Apparatus for high-throughput electroporation An electroporator for high-throughput electroporation is constructed with a well plate in which each well has internal electrodes that extend beyond the opening of the well to form contact areas, either as horizontal platforms extending laterally from the well rims ... | 09/21/2010 |
| 7771984 | Methods and devices related to a regulated flow electroporation chamber The electroporation chamber and its related devices combine the features of an electroporation chamber that acts as a manifold for regulation of sample flow with those of a flow electroporation device to form a regulated flow electroporation device. The invention fu... | 08/10/2010 |
| 7767433 | High voltage nanosecond pulse generator using fast recovery diodes for cell electro-manipulation A pulse generator circuit may include a diode configured to operate as an opening switch, a tank circuit in series with the diode having an admittance that is switchable from a first value to a second value that is different from the first value, and a switching sys... | 08/03/2010 |
| 7704727 | Device and method for processing biological material Disclosed is a device for processing biological material which at least comprises a chamber at least closable to the outside and having an inner space for receiving the biological material. The chamber comprises at least one electrode placed in contact with the inne... | 04/27/2010 |
| 7678564 | Container with at least one electrode The invention relates to a container 20, 30 for receiving an aqueous solution, which is formed at least partially by an outer limit 21 forming an inner chamber 22, 32 for receiving the solution, and which comprises at least one area which acts a... | 03/16/2010 |
| 7618807 | Apparatus for electrophoretic in situ tissue staining The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion ... | 11/17/2009 |
| 7608446 | Nanostructured surface for microparticle analysis and manipulation The present invention provides an apparatus, comprising a first mechanical structure having a first rigid surface, an area of the first rigid surface having a nanostructured surface. The apparatus also includes a second mechanical structure having a second rigid sur... | 10/27/2009 |
| 7572623 | Cell separation using electric fields The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One importa... | 08/11/2009 |
| 7560269 | Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, ... | 07/14/2009 |
| 7521224 | Microelectronic cell electroporation array The electroporation array is comprised of three technologies: microwire glass electrodes, microelectronic multiplexer stimulator chips and microfluidic flow chamber. Various substances, such as genes, gene silencing RNAi, gene inhibition agents or drugs, can be perf... | 04/21/2009 |
| 7501277 | Cell treatment chamber Chamber for treating cells contained in a suspension in the electrical field with a beaker made from electrically non-conductive material, into which an elongate core made from electrically non-conductive material is at least partially inserted axially through an op... | 03/10/2009 |
| 7501276 | Apparatus for intracellular manipulation of a biological cell A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane... | 03/10/2009 |
| 7470533 | Impedance based devices and methods for use in assays A device for detecting cells and/or molecules on an electrode surface is disclosed. The device detects cells and/or molecules through measurement of impedence changes resulting from the cells and/or molecules. A disclosed embodiment of the device includes a substrat... | 12/30/2008 |
| 7465579 | Device and method for introducing particle into cell and device and method for collecting particle from cell A device for introducing fine magnetic particles into a cell by applying an electric field to a reaction field where a sample solution containing cells and the fine magnetic particles are introduced, in order to form pores in the surface of the cell, and then applyi... | 12/16/2008 |
| 7456012 | Method and apparatus for spatially confined electroporation The invention provides hollow-tip-electrodes for spatially localized delivery of substances to one or more biological targets present in a population comprising target and non-target molecules, macromolecules, and/or cells. The invention also provides electrode plat... | 11/25/2008 |
| 7435578 | Device and methods for monitoring the status of at least one cell A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate... | 10/14/2008 |
| 7422891 | Label-free high-throughput optical technique for detecting biomolecular interactions Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ... | 09/09/2008 |
| 7419821 | Apparatus and methods for analyte measurement and immunoassay The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable ... | 09/02/2008 |
| 7410616 | Device for the controlled exposure of reservoir-based sensors Devices are provided for the controlled exposure of a sensor or sensor component. The device may include a substrate; at least one reservoir provided in the substrate; at least one sensor or sensor component located in the at least one reservoir; at least one reserv... | 08/12/2008 |
| 7407781 | Oocyte recording chamber An oocyte recording chamber for electrophysiological measurements. The recording chamber includes a base and a cover attached to the base. The cover and the base define a chamber having a size sufficient to accommodate an oocyte. The recording chamber includes a fir... | 08/05/2008 |
| 7396673 | Device for measuring extracellular potential A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding dr... | 07/08/2008 |
| 7393680 | Combined electroporation and microinjection method for the penetration of lipid bilayer membranes Disclosed is a method for penetration of lipid bilayer membranes in order to insert at the tip of a hollow needle-shaped object, such as a micropipet-, into a container formed of a lipid bilayer membrane, wherein said container is placed between said needle-shaped o... | 07/01/2008 |
| 7393681 | System and method for electroporating a sample A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the ... | 07/01/2008 |
| 7390650 | System and method for obtaining and maintaining high-resistance seals in patch clamp recordings The invention provides a system, system components, and a method for rapidly obtaining and stably maintaining a cell in optimal contact with the cell-contacting surface of a sensor in a cell-based biosensor. In one aspect, the system maximizes the seal between a who... | 06/24/2008 |
| 7384780 | Hybridization method and hybridization equipment The equipment of the present invention can implement high-speed hybridization with a simple construction and is configured as described below. The equipment comprises a biochip prepared by fixing biopolymers onto a plurality of sites on a substrate, positive ... | 06/10/2008 |
| 7371561 | In vitro, multiple electrode pair array and multiple treatment cell apparatus for use in electroporation A multiple electrode pair array apparatus is provided for use with a multiple well plate which has multiple wells distributed in a two-dimensional matrix array which has R rows and C columns. The multiple electrode pair array apparatus includes a non-conductive base... | 05/13/2008 |
| 7361500 | Apparatus and method for electrically contacting biological cells suspended in a liquid An apparatus for electrically contacting biological cells suspended in a liquid has a substrate having at least one opening and an electrode for electrically contacting a cell immobilized above the opening. A contact unit with a contact tip is arranged below said op... | 04/22/2008 |
| 7361478 | High-throughput screen for identifying selective persistent sodium channels channel blockers A method for identifying a selective persistent Na+ channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na+ current to a greater degree than a transient Na+ current. Aspects of the present method... | 04/22/2008 |
| 7358077 | Method and device for electroporation of biological cells Described are methods for electrical treatment of biological cells, in particular using electrical field pulses, involving the steps: arrangement of the cells (1) on apertures (2) of a solid planar carrier element (3) which divides a measuring c... | 04/15/2008 |
