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| Number | Title | Issue Date |
| 8173414 | Sulfide perfusion apparatus An apparatus for establishing sulfide perfusion is described and includes a sulfide supply for introducing sulfide into fluid for perfusion, an apparatus for delivery of the perfusion fluid, a fluid chemistry monitor for monitoring the concentration of sulfide and o... | 05/08/2012 |
| 8163536 | Device for preparing an undifferentiated cell from a more committed cell A device for preparing an undifferentiated cell, the device comprises means for contacting a more committed cell with an agent that causes the more committed cell to retrodifferentiate into an undifferentiated cell. ... | 04/24/2012 |
| 8158407 | Systems and methods of coating a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft in a mammal Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an externa... | 04/17/2012 |
| 8097449 | Method and apparatus for transferring heat to or from an organ or tissue container An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods in... | 01/17/2012 |
| 8039246 | Systems and methods of promoting endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft in a mammal Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an externa... | 10/18/2011 |
| 8034608 | Systems and methods of promoting endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft in a mammal Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an externa... | 10/11/2011 |
| 7998725 | Method and apparatus for holding a plurality of tubes connectible to an organ or tissue container An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods fu... | 08/16/2011 |
| 7968329 | Method of conditioning a hybrid synthetic tubular structure to yield a functional human hybrid coronary bypass graft A method of yielding a functional human hybrid coronary bypass graft is provided. The method includes conditioning a hybrid synthetic tubular structure having stem cells and/or endothelial cells on at least one surface to yield the functional human hybrid coronary b... | 06/28/2011 |
| 7964387 | Method of conditioning a hybrid synthetic tubular structure to yield a functional human hybrid hemodialysis access graft A method of yielding a functional human hybrid hemodialysis access graft is provided. The method includes conditioning a hybrid synthetic tubular structure having stem cells and/or endothelial cells on at least one surface to yield the functional human hybrid hemodi... | 06/21/2011 |
| 7960166 | Microfabricated compositions and processes for engineering tissues containing multiple cell types The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment ... | 06/14/2011 |
| 7915028 | Tissue regeneration substrate, complex thereof with cells, and method for its production A tissue regeneration substrate comprising a film with a honeycomb structure composed primarily of a polymer compound and a phospholipid. A tissue regeneration complex comprising the tissue regeneration substrate and cells held in the tissue regeneration substrate. ... | 03/29/2011 |
| 7897377 | Cell- and tissue culture device The present invention relates to the field of cell and tissue culture. In particular, the invention provides a novel device for organotypic culture. The device comprises a medium conduit having one open end and one end closed by a porous membrane fused across it; an... | 03/01/2011 |
| 7851200 | Bioreactor for growing engineered tissue A bioreactor and a method for growing engineered tissue provide facing surfaces in a vessel for containing cell-culture media. The facing surfaces are equidistant and define a gap therebetween while providing substrates for cell tissue growth. By maintaining conditi... | 12/14/2010 |
| 7829325 | Drug testing with bio-artificial organ slices including for example those derived from liver A drug testing system using any number of bio-artificial organs, for example liver-slices based in a culture apparatus. The apparatus has a chamber with plasma and gas valves, animal organ slices being positioned securely in the chamber so as to maximize the surface... | 11/09/2010 |
| 7811808 | Portable preservation apparatus for a donor organ A portable preservation apparatus of the cold storage type for a donor organ, comprising a cooling box provided with an organ chamber for receiving a donor organ in preservative fluid and a lid, wherein, on the side which operatively faces the organ chamber, the lid... | 10/12/2010 |
| 7790437 | Organ transportation device An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relati... | 09/07/2010 |
| 7759113 | Fabrication of tissue lamina using microfabricated two-dimensional molds Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold o... | 07/20/2010 |
| 7691622 | Method and apparatus for transferring heat to or from an organ or tissue container An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods in... | 04/06/2010 |
| 7678563 | Method and apparatus for controlling air pressure in an organ or tissue container An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods in... | 03/16/2010 |
| 7662611 | Apparatus and method for in vitro storage of a cornea A fixture and method is provided for in vitro storage of a cornea. The fixture includes a platform having a corneal-sceral rim receiving surface, a clamp having a mating surface for the cornel-scleral rim and handles. A locking mechanism is provided to secure a dono... | 02/16/2010 |
| 7572622 | Heart preservation chamber A heart preservation chamber is disclosed which comprises a housing, an inclined trough support surface, and inlet and outlet fluid connections for the major heart blood vessels. ... | 08/11/2009 |
| 7547538 | High quality, continuous throughput, tissue processing A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt... | 06/16/2009 |
| RE40570 | Apparatuses and methods for treating biological tissue to mitigate calcification An apparatus for treating fixed biological tissue to inhibit calcification of the biological tissue following implantation thereof in a mammalian body. The apparatus includes a container for placing the biological tissue in contact with a treatment solution, structu... | 11/11/2008 |
| 7410792 | Instrumented bioreactor with material property measurement capability and process-based adjustment for conditioning tissue engineered medical products A microprocessor controlled and instrumented bioreactor for conditioning tissue engineered medical products. The microprocessor control providing measurement and control of the tissue displacement and subsequent determination of material and growth properties. The m... | 08/12/2008 |
| 7410474 | Methods and means for extracorporeal organ perfusion Apparatus and methods of operation of apparatus for the extracorporeal perfusion of organs are provided which support viability and function of an organ such as a liver, generally outside the body. Blood is supplied as described herein to an organ such as a liver un... | 08/12/2008 |
| 7384794 | Micro-devices and analytical procedures for investigation of biological systems Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the investigation of living systems. A number of interfaces to analytical instru... | 06/10/2008 |
| 7368279 | Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor This invention relates to a three dimensional bioengineered sphincter such as a bioengineered internal anal sphincter (IAS) and three-dimensional physiological models of smooth muscle cells. The invention also related to methods for generating a bioengineered sphinc... | 05/06/2008 |
| 7364905 | Apparatus and method for high throughput analysis of compound-membrane interactions An article and method for high throughput and a high content investigation of compound interactions with live tissue or its substitutes under controlled conditions during compound absorption and related processes. In some variations of the illustrative embodiment, t... | 04/29/2008 |
| 7353658 | Systems and methods for freezing, storing, transporting, and thawing biopharmacuetical material A system for freezing, thawing, transporting, and storing a biopharmaceutical material, which includes a container, a supporting structure, a temperature control unit, and a transportation cart. The container is adapted to receive the biopharmaceutical material ther... | 04/08/2008 |
| 7354764 | Method and device for culturing cells In a method for culturing cells (2), according to which cells (2) are introduced into a cell culture chamber in order to form a cellular layer, the chamber being configured inside a carrier structure (1). The shape and size of the carrier struct... | 04/08/2008 |
| 7348175 | Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively small volume of fluid nutrient. The microprocessor control providing... | 03/25/2008 |
| 7338461 | Modified organ support devices Methods and devices are provided that improve the function of organ support devices, and also provided are improved methods of treating conditions associated with hemodynamic instability. ... | 03/04/2008 |
| 7326564 | Flow system for medical device evaluation and production In some embodiments, a flow system includes a medical device mount, fluid and a conduit containing the fluid and medical device mount. The conduit is mounted on an assembly that moves the conduit along with the medical device mount to induce relative motion of the f... | 02/05/2008 |
| 7316922 | Method for preserving organs for transplant Methods and apparatus for preserving tissue such as harvested organs for transplant are described. A preferred method includes delivering to a harvested organ an effective amount of electromagnetic energy, the electromagnetic energy having a wavelength in the visibl... | 01/08/2008 |
| 7310545 | Method and device to form a sensor using isolated cardiomyocytes A method and device are described to form a sensor using a cardiomyocyte by advancing a catheter into the tissue of interest, cardiac in the preferred embodiment, and using the catheter to ablate a cone- or a dome-shaped region to form an electrically isolated secti... | 12/18/2007 |
| 7303729 | Apparatus and method for immunological labeling for thin tissue sections An apparatus and a method for immunological labeling of thin tissue sections are disclosed. The treatment fluid is applied in the form of liquid droplets onto at least one slide, the arrangement of liquid droplets corresponding to the arrangement of the thin tissue ... | 12/04/2007 |
| 7297500 | Use of Troponin I as a species marker protein for meat speciation in both raw and heat-processed products Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample. Furthermore, the antibodies can be used to determine the end point temperature o... | 11/20/2007 |
| 7287504 | Over-center actuator The disclosure allows a short runner valve or manifold tuning valve type manifold tuning device to retain sufficient force on the valve assembly in its closed state to eliminate any vibration or chatter from the system under normal engine operation. The disclosure a... | 10/30/2007 |
| 7276367 | Method of etching islands of cells in a grid pattern An apparatus and process for monitoring migratory cell proliferation with restricted migration on a substrate includes providing a substrate, coating the substrate with extracellular matrix, plating cells suspended in cell culture media on extracellular matrix, and ... | 10/02/2007 |
| 7232689 | Calibration procedure for investigating biological systems Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems. ... | 06/19/2007 |
