Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 6965433 | Optical biodiscs with reflective layers An optical biodisc has a substrate, a first reflective layer over the substrate, an opening in the first reflective layer for receiving an investigational feature, and a second reflective layer over the opening for reflecting light transmitted through the substrate.... | 11/15/2005 |
| 6962782 | Method for producing addressed ligands matrixes on a support A method for fabricating matrices of addressed ligands on a carrier. In the method, an element is used such as a reservoir filled with ligand and containing an electrode to deposit and electrochemically fix the ligand to the conductive carrier. The ligand may be an ... | 11/08/2005 |
| 6958216 | DNA-bridged carbon nanotube arrays A class of biological sensing devices that include a substrate comprising an array of carbon nanotubes (CNTs) to which are chemically attached biological molecules is disclosed. The attached biological molecules are capable of electrical conductivity that is respons... | 10/25/2005 |
| 6958221 | Cell flow apparatus and method for real-time measurements of patient cellular responses The present invention is directed to a method for determining the effect of each of a plurality of test agents on cells from a subject, and a method to profile patient cell responses to test agents. ... | 10/25/2005 |
| 6958214 | Polymorphic kinase anchor proteins and nucleic acids encoding the same Polymorphic A-kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herei... | 10/25/2005 |
| 6958245 | Array cytometry A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled elektrokinetic assembly of particles near surfaces relies on t... | 10/25/2005 |
| 6958131 | Optical sensor and optical process for the characterization of a chemical and/or bio-chemical substance The optical sensor contains an optical waveguide (1) with a substrate (104), waveguiding material (105), a cover medium (106) and a waveguide grating structure (101-103). By means of a light source (2), light can be emitted ... | 10/25/2005 |
| 6955878 | Apparatus for analyzing samples using linear probe array There is used at least one probe array obtained by arraying particles having various probes, respectively, fixed thereon (probe particles) in a definite order in a holder. A plurality of capillaries or grooves packed with various kinds, respectively, of probe partic... | 10/18/2005 |
| 6955788 | Apparatus and method for aligning microarray printing head An alignment apparatus and method are described for accurately and reliably depositing biological materials on a microscope slide or other substrate. A preferred implementation includes a first mounting assembly that enables rotation of deposit elements around a fir... | 10/18/2005 |
| 6955881 | Method and apparatus for producing biochips A method and apparatus for mass producing biochips quickly and easily, wherein a plurality of DNA molecules are amplified using a PCR (polymerase chain reaction) method and transcribing the amplified DNA molecule to other substrates by contact. ... | 10/18/2005 |
| 6953676 | Mesoscale polynucleotide amplification device and method Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide polymerization reaction. The devices comprise a substrate microfabricated to define a sample inlet port and a mesoscale flow system, which extends from the i... | 10/11/2005 |
| 6951632 | Microfluidic devices for introducing and dispensing fluids from microfluidic systems The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices. ... | 10/04/2005 |
| 6951713 | Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent p... | 10/04/2005 |
| 6949633 | Primers useful for sizing nucleic acids The present invention provides modified oligonucleotide primers designed to incorporate a cleavable moiety so that a 3′ portion of the primer (linked to an extension product) can be released from an upstream 5′ portion of the primer. Upon selective cleavage of t... | 09/27/2005 |
| 6942968 | Array compositions for improved signal detection The invention relates methods of improving signal detection from an array and methods for background subtraction in an array. The invention provides for novel array compositions including arrays with wells with different shapes, or surfaces coated with reflective or... | 09/13/2005 |
| 6942962 | Computer monitoring and control of fermentation It is desirable to enhance reproducibility and control of batch fermentation processes. Some examples of these processes include: alcoholic beverage manufacture, and acetone and pharmaceutical production. A cellular yield curve defines the relationship between subst... | 09/13/2005 |
| 6942971 | Apparatus for analysis of a nucleic acid amplification reaction An apparatus for determining a threshold value (e.g., a threshold cycle number or a time value) in a nucleic acid amplification reaction comprises a detection mechanism for measuring, at a plurality of different times during the amplification reaction, at least one ... | 09/13/2005 |
| 6933144 | Apparatus for growing cells A cell-culture apparatus forms an extra-capillary space between at least one hollow fiber and an enclosed chamber. Cells are placed in the extra-capillary space to grow. A media reservoir holds a cell-culture medium. The cell-culture medium is allowed to pass throug... | 08/23/2005 |
| 6933112 | Device for mass transport assisted optical assays An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the s... | 08/23/2005 |
| 6929731 | Parallel array of independent thermostats for column separations A thermostat array including an array of two or more capillary columns (10) or two or more channels in a microfabricated device is disclosed. A heat conductive material (12) surrounded each individual column or channel in array, each individual column ... | 08/16/2005 |
| 6926864 | Microfluidics apparatus and methods for use thereof A microfluidics device includes a plurality of interaction cells and fluid control means including i) means for providing to the interaction cells a preparation fluid, and ii) means for providing to the interaction cells a sample fluid, wherein each interaction cell... | 08/09/2005 |
| 6927029 | Surface with tethered polymeric species for binding biomolecules The invention provides a solid support for adsorbing a biomolecule. The support comprises a surface coating having a non-nucleotidic polymer tethered to a surface reactive site. The polymer comprises a backbone, terminus, and adsorbing moieties covalently attached t... | 08/09/2005 |
| 6923907 | Separation column devices and fabrication methods Pressure-driven microfluidic separation devices, such as may be used for performing high performance liquid chromatography, are provided. Multiple separation columns may be defined in a single device and packed with stationary phase material retained by porous frits... | 08/02/2005 |
| 6921636 | Method and apparatus for conducting an array of chemical reactions on a support surface The invention provides apparatus and methods for determining the nucleotide sequence of target nucleic acids using hybridization to arrays of oligonucleotides. The invention further provides apparatus and methods for identifying the amino acid sequence of peptides t... | 07/26/2005 |
| 6921642 | Protein expression profiling Disclosed are compositions and methods for detecting small quantities of analytes such as proteins and peptides. The method involves associating a primer with an analyte and subsequently using the primer to mediate rolling circle replication of a circular DNA molecu... | 07/26/2005 |
| 6919046 | Microfluidic analytical devices and methods Modular microfluidic systems includes a plurality of microfluidic modules, each capable of performing fluidic operations including, but not limited to, filtering, splitting, regulating pressure, mixing, metering, reacting, diverting, heating, cooling, and condensing... | 07/19/2005 |
| 6919181 | Methods for generating ligand arrays Methods of producing ligand arrays, e.g., polypeptide and nucleic acid arrays, as well as the arrays produced thereby, methods for use of the arrays and kits that include the same, are provided. In the subject methods, a substrate having a surface displaying carboxy... | 07/19/2005 |
| 6916621 | Methods for array-based comparitive binding assays The invention provides computer systems, computer program products and methods for in silico array-based methods for determining the relative amount of biological molecules (e.g., nucleic acid sequences) in two or more samples. The invention also provides novel arra... | 07/12/2005 |
| 6916620 | Random array of micro-spheres for the analysis of nucleic acid using enzyme digestion A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of nucleic acid probe modified micro-spheres immobilized in a coating containing a gelling agent or a precursor to ... | 07/12/2005 |
| 6911182 | Device for placement of effluent A device for placement of effluent comprises a substrate positioner, a deposition conduit, and a conduit positioner. The substrate positioner supports and positions a substrate on which effluent exiting from the deposition conduit is to be deposited. The conduit pos... | 06/28/2005 |
| 6911339 | Transparent polymer support for organic synthesis The invention provides polyol (allyl carbonate) polymer solid supports. The supports can be modified for attachment of a chemical moiety or ligand. A solid support comprising one or more ligands immobilized to a polyol (allyl carbonate) polymer solid support. The so... | 06/28/2005 |
| 6911181 | Self-dispensing storage device A system and method for dispensing a sample using a self-dispensing system including a sample storage device, a dispensing mechanism, and a driving mechanism for driving the dispensing mechanism. The dispensing mechanism is formed as part of and is in dispensing com... | 06/28/2005 |
| 6908766 | Device and method for capturing biological tissues A device and method for capturing a biological tissue, comprises cutting a minute biological cellular tissue using a contactless cutting apparatus, wherein, by inverting a biological tissue slide provided with a sample thereon, and after cutting a cellular tissue pr... | 06/21/2005 |
| 6909073 | Integrated device based upon semiconductor technology, in particular chemical microreactor An integrated device based upon semiconductor technology, in particular a chemical microreactor, including a semiconductor body having a high-temperature operating portion and a low temperature operating portion. The semiconductor body is provided with a thermal-ins... | 06/21/2005 |
| 6905843 | Preparation containing cell extracts for synthesizing cell-free protein and means for synthesizing cell-free protein Disclosed are a preparation containing cell extracts for cell-free protein synthesis, prepared by excluding from a living organism a system, participating to inhibiting of self protein synthesis reaction, an apparatus for cell-free protein synthesis reaction equippe... | 06/14/2005 |
| 6902705 | Device comprising a plurality of analysis sites on a support The subject of the invention is a device for chemical or biological analysis comprising a carrier (21) containing a plurality of analysis sites able to fix a chemical or biological reagent, in which the analysis sites are formed of microdishes (23) hol... | 06/07/2005 |
| 6899696 | Method of noninvasively obtaining intraductal fluid A method is disclosed for noninvasively obtaining intraductal fluid. The method includes the use of an intraductal fluid sampling device to contact the patient, provide compression, and deliver heat thereto according to predetermined cycle characteristics. The cycle... | 05/31/2005 |
| 6897026 | Array imaging method A method for imaging molecules contained in an array of discrete reaction sites on the surface of a solid support comprises: (i) imaging the array and detecting a first molecule located on the solid support at a known position with... | 05/24/2005 |
| 6893862 | Method for producing drum and paddle assembly for accelerated remediation This invention relates to a method of producing a drum and paddle assembly for the accelerated remediation of a contaminated material. The method comprises providing at least one paddle which is connectable to, and extendable outwardly from the periphery of, an elon... | 05/17/2005 |
| 6893824 | Gene detection system, gene detection device comprising same, detection method, and gene detecting chip A gene detection system for detecting a target gene upon hybridization with a probe comprising a probe-immobilizing support on which a probe is immobilized, and heating and cooling means disposed in contact with another location different from the surface of the pro... | 05/17/2005 |
