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...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!

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Class 435/283.1 - APPARATUS


Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Apparatus.
No. of patents: 913
Last issue date: 05/08/2012


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NumberTitleIssue Date
7838280Device for squeezing of biological mass of cultures
A device for wringing a biological mass of cultures has a substantially vertical container having a bottom provided with a discharge opening, a rotor means located under the discharge opening and including at least two rotors which are rotatable toward one another t...
11/23/2010
7799554Lateral flow devices
An analytical test for an analyte comprises (a) a base, having a reaction area and a visualization area, (b) a capture species, on the base in the visualization area, comprising nucleic acid, and (c) analysis chemistry reagents, on the base in the reaction area. The...
09/21/2010
7799553Microfabricated integrated DNA analysis system
Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cyc...
09/21/2010
7785863Digital optical chemistry micromirror imager
An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redir...
08/31/2010
7785862Thin film coated microwell arrays
The invention relates to a thin film coated array and the process of fabricating and using the array including methods of etching, depositing a thin film coating, preparing and using the thin film coated array. ...
08/31/2010
7759111Cell encapsulation microfluidic device
Devices and methods for the encapsulation of cells on microfluidic platforms are disclosed. The microfluidic device generally includes a plurality of functional regions to shear, focus, and encapsulate a desired cell or group of cells into a droplet. The microfluidi...
07/20/2010
7759112Apparatus, system, and method for purifying nucleic acids
Methods and devices for isolating nucleic acids from a mixture containing such nucleic acids and extraneous matter are provided. In one embodiment, the method of the invention comprises passing the mixture through a glass frit under conditions effective to separate ...
07/20/2010
7754472Device and method for detecting analytes by visualization and separation of agglutination
The invention relates to a device for detecting one or several analytes in a sample, characterized in that it comprises one or more reaction chambers and/or one or more reagent application channels, and one or more capillary systems and one or more negative vessels....
07/13/2010
7745203Base sequence detection apparatus and base sequence automatic analyzing apparatus
A base sequence detection apparatus is provided with a channel formed on a base sequence detection chip. Working electrodes are formed along the channel and include a probe immobilized thereon, counter electrodes are formed on the inner surface of the channel and, r...
06/29/2010
7741102Analyte detection and apparatus therefor
The present invention relates to sensitive SE(R)RS based methods for detecting analytes such as explosives and drugs, which may be present in a sample at extremely low levels. The methods may be generally carried out in situ employing novel chemistry which is compat...
06/22/2010
7736888Stage and platform for building a biochip and biochip
A biochip, a platform which composes the biochip, and a stage which composes the platform. The biochip is for detecting analytes in a test sample. The platform comprises a stage. The stage of the invention includes a carrier. ...
06/15/2010
7732190Modified two-component gelation systems, methods of use and methods of manufacture
Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer ...
06/08/2010
7709243Biochip and biomolecular detection system using the same
The present invention is related to a biochip and a biomolecular detection system using the same. In particular, the biomolecular detection system is capable of detecting biological molecules (biomolecules) such as DNA or protein at a high speed. The biochip compris...
05/04/2010
7704726Active programmable matrix devices
A system for performing molecular biological diagnosis, analysis and multistep and multiplex reactions utilizes a selfaddressable, selfassembling microelectronic system for actively carrying out controlled reactions in microscopic formats. The device includes a powe...
04/27/2010
7682816Thin film coated microwell arrays and methods of using same
This invention relates to microwell array compositions which are coated with one or more thin film coatings. The invention includes the process of fabricating and using thin film coated microwell arrays. ...
03/23/2010
7678562Addressable nanopores and micropores including methods for making and using same
Featured are devices and systems embodying one or more electrically-addressable-solid-state nanopores useful for sensing and/or characterizing single macromolecules as well as sequencing DNA or RNA. In one aspect of the present invention, there is featured a linear ...
03/16/2010
7670831Conductive carbon nanotubes dotted with metal and method for fabricating a biosensor using the same
Conductive carbon nanotubes (CNTs) obtained by dotting carboxylated CNTs with metal nanocrystals by chemical functional groups, are described, as well as a method for fabricating a pattern or film of the conductive CNTs which involves repeatedly depositing conductiv...
03/02/2010
7670832System for fluorescence monitoring
The present invention is directed to devices for performing PCR and monitoring the reaction of a sample comprising a nucleic acid and a fluorescent dye. Illustrative devices comprise a heat exchange component for heating and cooling the sample, a control device for ...
03/02/2010
7648833Container for germ layer formation and method of forming germ layer
The invention relates to a vessel for embryoid formation used for forming embryoid bodies from ES cells easily without complicated technique, and to a method for forming embryoid bodies easily and efficiently using the vessel. The method includes the steps of (A) pr...
01/19/2010
7635585Micro valve apparatus using micro bead and method for controlling the same
A micro (thin film type) valve apparatus for controlling fluid flow and its rate using a microbead and a method for controlling the apparatus are provided. The microbead is moved by the magnetic forge generated by upper and lower electromagnets disposed on the top a...
12/22/2009
7625746Method of denaturing and fragmenting DNA or RNA using ultrasound
A method and apparatus are provided for processing a DNA or RNA sample within a sample processing module. The method includes the steps of providing a sample well within the sample processing module that contains the DNA or RNA sample, coupling ultrasonic energy fro...
12/01/2009
7618806Methods and apparatus for mass spectral analysis of peptides and proteins
Apparatus, device, and methods for fragmenting high molecular weight molecular ions, such as peptides or proteins, by treating the ions with predetermined wavelengths of light are described. Vacuum ultraviolet radiation as a source of predetermined wavelengths of la...
11/17/2009
7615368Microarrays of polypeptides
Microarrays of polypeptides on a solid support are provided. The microarray compositions find use in the multiplexed detection and quantitation of ligands, e.g. antigens or antibodies, in a miniaturized format. The substrate is used for detecting binding of ligands ...
11/10/2009
7560267Apparatus and methods for on-chip monitoring of cellular reactions
This invention relates to apparatus and methods for on-chip monitoring of cellular reactions, and in particular to such an apparatus and method that enables soft-docking of cells by using a dam wall that is parallel to the direction of fluid flow. The invention furt...
07/14/2009
7560268Process for manufacturing biochip, probe solution, and biochip
The present invention provides a process for manufacturing a biochip having high density probe regions and being resistant to contamination caused by organic materials or the like. For achieving the object, the process for manufacturing a biochip of the present inve...
07/14/2009
7557070Multiplexed cell analysis system
Systems including apparatus, methods, compositions, and kits for multiplexed analysis of biological systems using nonpositional and/or positional arrays of coded carriers. ...
07/07/2009
7488595Method and apparatus for amplification of nucleic acid sequences using immobilized DNA polymerase
The present invention generally relates to methods and apparatuses for amplifying nucleic acid sequences using immobilized DNA polymerase. More particularly, it relates to methods and apparatuses useful for amplifying target nucleic acid sequences by forming a plura...
02/10/2009
7482152Methods and devices for microencapsulation of cells
Devices for the microencapsulation of cells include a first chamber for containing a cell-solution suspension. A plate covers one end of the first chamber. The plate has a plurality of apertures. A second chamber is provided for receiving encapsulated cells. The sec...
01/27/2009
7465578Nucleic acid sequencing by Raman monitoring of uptake of precursors during molecular replication
The methods, compositions and apparatus disclosed herein are of use for nucleic acid sequence determination. The methods involve isolation of one or more nucleic acid template molecules and polymerization of a nascent complementary strand of nucleic acid, using a DN...
12/16/2008
7449326System for simple nucleic acid analysis
A system for simple nucleic acid analysis is described in which the amplification space contains at least a part of the binding space. An additional improvement is achieved by the design of the binding or/and amplification space which is optionally surrounded by a h...
11/11/2008
7449327System and method for dispensing dehydrated culture media powder
An improved system and method for dispensing dehydrated culture media (DCM) powder into containers for preparation as a culture media. The manual and automated systems and methods operate to dispense DCM powder, as well as liquid, into vessels or media preparation i...
11/11/2008
7442499Substrates comprising polynucleotide microarrays
A method of determining the relative amounts of individual polynucleotides in a complex mixture of different-sequence polynucleotides is disclosed. The polynucleotides, after fluorescent labeling, are contacted under hybridization conditions with an array of differe...
10/28/2008
7442502Biochip
When the genetic analysis is performed by using a DNA microarray, the inspection accuracy is improved. A sample solution is supplied onto a base plate to prepare the DNA microarray comprising a large number of spots based on the sample solution arranged on the base ...
10/28/2008
7438856Microfluidic devices and methods
Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in...
10/21/2008
7439055Biomolecular detection device
A device for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least o...
10/21/2008
7435587Apparatus for growing cells under variable hydrostatic pressures
This invention provides an apparatus for growing cells under static or dynamic physiological pressure which contains a cell culture cassette having a cassette frame; two side walls secured to each side of the cassette frame to form a cell growing chamber, and at lea...
10/14/2008
7432112Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o...
10/07/2008
7432113Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o...
10/07/2008
7427513Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o...
09/23/2008
7427497In vitro metabolic engineering on microscale devices
Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a means for sequentially directing a starting material and each ensuing reac...
09/23/2008
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