...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7838280 | Device for squeezing of biological mass of cultures A device for wringing a biological mass of cultures has a substantially vertical container having a bottom provided with a discharge opening, a rotor means located under the discharge opening and including at least two rotors which are rotatable toward one another t... | 11/23/2010 |
| 7799554 | Lateral flow devices An analytical test for an analyte comprises (a) a base, having a reaction area and a visualization area, (b) a capture species, on the base in the visualization area, comprising nucleic acid, and (c) analysis chemistry reagents, on the base in the reaction area. The... | 09/21/2010 |
| 7799553 | Microfabricated integrated DNA analysis system Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cyc... | 09/21/2010 |
| 7785863 | Digital optical chemistry micromirror imager An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redir... | 08/31/2010 |
| 7785862 | Thin film coated microwell arrays The invention relates to a thin film coated array and the process of fabricating and using the array including methods of etching, depositing a thin film coating, preparing and using the thin film coated array. ... | 08/31/2010 |
| 7759111 | Cell encapsulation microfluidic device Devices and methods for the encapsulation of cells on microfluidic platforms are disclosed. The microfluidic device generally includes a plurality of functional regions to shear, focus, and encapsulate a desired cell or group of cells into a droplet. The microfluidi... | 07/20/2010 |
| 7759112 | Apparatus, system, and method for purifying nucleic acids Methods and devices for isolating nucleic acids from a mixture containing such nucleic acids and extraneous matter are provided. In one embodiment, the method of the invention comprises passing the mixture through a glass frit under conditions effective to separate ... | 07/20/2010 |
| 7754472 | Device and method for detecting analytes by visualization and separation of agglutination The invention relates to a device for detecting one or several analytes in a sample, characterized in that it comprises one or more reaction chambers and/or one or more reagent application channels, and one or more capillary systems and one or more negative vessels.... | 07/13/2010 |
| 7745203 | Base sequence detection apparatus and base sequence automatic analyzing apparatus A base sequence detection apparatus is provided with a channel formed on a base sequence detection chip. Working electrodes are formed along the channel and include a probe immobilized thereon, counter electrodes are formed on the inner surface of the channel and, r... | 06/29/2010 |
| 7741102 | Analyte detection and apparatus therefor The present invention relates to sensitive SE(R)RS based methods for detecting analytes such as explosives and drugs, which may be present in a sample at extremely low levels. The methods may be generally carried out in situ employing novel chemistry which is compat... | 06/22/2010 |
| 7736888 | Stage and platform for building a biochip and biochip A biochip, a platform which composes the biochip, and a stage which composes the platform. The biochip is for detecting analytes in a test sample. The platform comprises a stage. The stage of the invention includes a carrier. ... | 06/15/2010 |
| 7732190 | Modified two-component gelation systems, methods of use and methods of manufacture Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer ... | 06/08/2010 |
| 7709243 | Biochip and biomolecular detection system using the same The present invention is related to a biochip and a biomolecular detection system using the same. In particular, the biomolecular detection system is capable of detecting biological molecules (biomolecules) such as DNA or protein at a high speed. The biochip compris... | 05/04/2010 |
| 7704726 | Active programmable matrix devices A system for performing molecular biological diagnosis, analysis and multistep and multiplex reactions utilizes a selfaddressable, selfassembling microelectronic system for actively carrying out controlled reactions in microscopic formats. The device includes a powe... | 04/27/2010 |
| 7682816 | Thin film coated microwell arrays and methods of using same This invention relates to microwell array compositions which are coated with one or more thin film coatings. The invention includes the process of fabricating and using thin film coated microwell arrays. ... | 03/23/2010 |
| 7678562 | Addressable nanopores and micropores including methods for making and using same Featured are devices and systems embodying one or more electrically-addressable-solid-state nanopores useful for sensing and/or characterizing single macromolecules as well as sequencing DNA or RNA. In one aspect of the present invention, there is featured a linear ... | 03/16/2010 |
| 7670831 | Conductive carbon nanotubes dotted with metal and method for fabricating a biosensor using the same Conductive carbon nanotubes (CNTs) obtained by dotting carboxylated CNTs with metal nanocrystals by chemical functional groups, are described, as well as a method for fabricating a pattern or film of the conductive CNTs which involves repeatedly depositing conductiv... | 03/02/2010 |
| 7670832 | System for fluorescence monitoring The present invention is directed to devices for performing PCR and monitoring the reaction of a sample comprising a nucleic acid and a fluorescent dye. Illustrative devices comprise a heat exchange component for heating and cooling the sample, a control device for ... | 03/02/2010 |
| 7648833 | Container for germ layer formation and method of forming germ layer The invention relates to a vessel for embryoid formation used for forming embryoid bodies from ES cells easily without complicated technique, and to a method for forming embryoid bodies easily and efficiently using the vessel. The method includes the steps of (A) pr... | 01/19/2010 |
| 7635585 | Micro valve apparatus using micro bead and method for controlling the same A micro (thin film type) valve apparatus for controlling fluid flow and its rate using a microbead and a method for controlling the apparatus are provided. The microbead is moved by the magnetic forge generated by upper and lower electromagnets disposed on the top a... | 12/22/2009 |
| 7625746 | Method of denaturing and fragmenting DNA or RNA using ultrasound A method and apparatus are provided for processing a DNA or RNA sample within a sample processing module. The method includes the steps of providing a sample well within the sample processing module that contains the DNA or RNA sample, coupling ultrasonic energy fro... | 12/01/2009 |
| 7618806 | Methods and apparatus for mass spectral analysis of peptides and proteins Apparatus, device, and methods for fragmenting high molecular weight molecular ions, such as peptides or proteins, by treating the ions with predetermined wavelengths of light are described. Vacuum ultraviolet radiation as a source of predetermined wavelengths of la... | 11/17/2009 |
| 7615368 | Microarrays of polypeptides Microarrays of polypeptides on a solid support are provided. The microarray compositions find use in the multiplexed detection and quantitation of ligands, e.g. antigens or antibodies, in a miniaturized format. The substrate is used for detecting binding of ligands ... | 11/10/2009 |
| 7560267 | Apparatus and methods for on-chip monitoring of cellular reactions This invention relates to apparatus and methods for on-chip monitoring of cellular reactions, and in particular to such an apparatus and method that enables soft-docking of cells by using a dam wall that is parallel to the direction of fluid flow. The invention furt... | 07/14/2009 |
| 7560268 | Process for manufacturing biochip, probe solution, and biochip The present invention provides a process for manufacturing a biochip having high density probe regions and being resistant to contamination caused by organic materials or the like. For achieving the object, the process for manufacturing a biochip of the present inve... | 07/14/2009 |
| 7557070 | Multiplexed cell analysis system Systems including apparatus, methods, compositions, and kits for multiplexed analysis of biological systems using nonpositional and/or positional arrays of coded carriers. ... | 07/07/2009 |
| 7488595 | Method and apparatus for amplification of nucleic acid sequences using immobilized DNA polymerase The present invention generally relates to methods and apparatuses for amplifying nucleic acid sequences using immobilized DNA polymerase. More particularly, it relates to methods and apparatuses useful for amplifying target nucleic acid sequences by forming a plura... | 02/10/2009 |
| 7482152 | Methods and devices for microencapsulation of cells Devices for the microencapsulation of cells include a first chamber for containing a cell-solution suspension. A plate covers one end of the first chamber. The plate has a plurality of apertures. A second chamber is provided for receiving encapsulated cells. The sec... | 01/27/2009 |
| 7465578 | Nucleic acid sequencing by Raman monitoring of uptake of precursors during molecular replication The methods, compositions and apparatus disclosed herein are of use for nucleic acid sequence determination. The methods involve isolation of one or more nucleic acid template molecules and polymerization of a nascent complementary strand of nucleic acid, using a DN... | 12/16/2008 |
| 7449326 | System for simple nucleic acid analysis A system for simple nucleic acid analysis is described in which the amplification space contains at least a part of the binding space. An additional improvement is achieved by the design of the binding or/and amplification space which is optionally surrounded by a h... | 11/11/2008 |
| 7449327 | System and method for dispensing dehydrated culture media powder An improved system and method for dispensing dehydrated culture media (DCM) powder into containers for preparation as a culture media. The manual and automated systems and methods operate to dispense DCM powder, as well as liquid, into vessels or media preparation i... | 11/11/2008 |
| 7442499 | Substrates comprising polynucleotide microarrays A method of determining the relative amounts of individual polynucleotides in a complex mixture of different-sequence polynucleotides is disclosed. The polynucleotides, after fluorescent labeling, are contacted under hybridization conditions with an array of differe... | 10/28/2008 |
| 7442502 | Biochip When the genetic analysis is performed by using a DNA microarray, the inspection accuracy is improved. A sample solution is supplied onto a base plate to prepare the DNA microarray comprising a large number of spots based on the sample solution arranged on the base ... | 10/28/2008 |
| 7438856 | Microfluidic devices and methods Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in... | 10/21/2008 |
| 7439055 | Biomolecular detection device A device for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least o... | 10/21/2008 |
| 7435587 | Apparatus for growing cells under variable hydrostatic pressures This invention provides an apparatus for growing cells under static or dynamic physiological pressure which contains a cell culture cassette having a cassette frame; two side walls secured to each side of the cassette frame to form a cell growing chamber, and at lea... | 10/14/2008 |
| 7432112 | Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o... | 10/07/2008 |
| 7432113 | Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o... | 10/07/2008 |
| 7427513 | Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o... | 09/23/2008 |
| 7427497 | In vitro metabolic engineering on microscale devices Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a means for sequentially directing a starting material and each ensuing reac... | 09/23/2008 |