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...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
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| Number | Title | Issue Date |
| 6756217 | Glass composite materials containing alkoxosilane derivative having alterable charge, hydrophobic and hydrophilic groups A porous glass composite material is prepared comprising a gel containing water and a polymeric network containing at least one alkoxosilane derivative having a group of alterable charge, a hydrophobic group and a hydrophilic group. The alkoxosilane derivative is pr... | 06/29/2004 |
| 6753144 | Biochip When genetic analyses are performed using the DNA microarray of the present invention, the inspection accuracy is improved. A sample solution is supplied onto a base plate 10 to prepare the DNA microarray 20 which includes a large number of spots 80... | 06/22/2004 |
| 6752966 | Microfabrication methods and devices Microfabrication methods and devices in which microscale structural elements are provided in an intermediate polymer layer between two planar substrates. Preferred aspects utilize photoimagable or ablatable polymer layers as the intermediate polymer layer. ... | 06/22/2004 |
| 6748696 | Self-automated mushroom growing system A self-automated mushroom growing apparatus and method for providing a continuous water and air supply for growing mushrooms on a small-scale. The apparatus is an enclosed, terrarium-like Grow Space including a porous Wicking Medium substrate, and an Air Diffuser ro... | 06/15/2004 |
| 6750055 | Implantable artificial organ and physiological monitoring system An apparatus for regulating the concentration of insulin within the blood of a living organism, wherein said apparatus is comprised of an in vitro cell culture for producing insulin, an in vitro cell culture for producing glucagon, an in vitro cell culture for produ... | 06/15/2004 |
| 6750039 | Filtration apparatus and method for the separation of microscopic entities from a fluid This invention relates to a filtration apparatus and method for the separation of microscopic entities from a fluid (liquid or gas) and subsequent visual or imaging microscopic analysis of the entities separated thereon either directly or after treatment of the enti... | 06/15/2004 |
| 6750036 | System and method for monitoring cellular activity A system and method for monitoring cellular activity in a cellular specimen. According to one embodiment, a plurality of excitable markers are applied to the specimen. A multi-photon laser microscope is provided to excite a region of the specimen and cause fluoresce... | 06/15/2004 |
| 6750033 | Positive response biosensors and other sensors A sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme and a substrate for the first enzyme. The analyte inhibits the reaction of the substrate catalyzed by the first enzyme (in other words, the analyte inhibits... | 06/15/2004 |
| 6750023 | Porous inorganic substrate for high-density arrays A porous inorganic substrate and method of fabricating such substrate for attaching an array of biological or chemical molecules to be used in a high-density microarray device. The substantially planar substrate comprises a porous inorganic layer adhered to a flat, ... | 06/15/2004 |
| 6746840 | Micro array and analyzing method using the same A micro array, which comprises a stimulable phosphor sheet, and multiple kinds of biomolecules arrayed and fixed on the stimulable phosphor sheet, is prepared. A biomolecule labeled with an energy generating substance is brought into contact with the micro array and... | 06/08/2004 |
| 6743624 | Process for continuous purification and concentration of leukocytes from blood Process and apparatus for the continuous purification and concentration of leukocytes from blood, characterized in that said process comprises the following steps: (a) seperating plasma from the blood by filtration in order to achieve a filtered buffy coat fraction;... | 06/01/2004 |
| 6743581 | Multifunctional and multispectral biosensor devices and methods of use An integrated biosensor system for the simultaneously detection of a plurality of different types of targets includes at least one sampling platform, the sampling platform including a plurality of receptors for binding to the targets. The plurality of receptors incl... | 06/01/2004 |
| 6737265 | Microelectronic unit forming methods and materials Releasable leads having an elongated fixed portion extend over a surface defined by a dielectric material of a component or by a semiconductor body. A semiconductor element having a conductive structure connected to a set of contacts is also disclosed. A method of m... | 05/18/2004 |
| 6734000 | Nanoporous silicon support containing macropores for use as a bioreactor A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrient... | 05/11/2004 |
| 6733968 | Microarray, method for producing the same, and method for correcting inter-pin spotting amount error of the same The present invention has an objective of obtaining more accurate data of microarray experiments by correcting an inter-pin spotting amount error caused upon microarray production using a plurality of pins. Upon microarray production, samples are immobilized on a mi... | 05/11/2004 |
| 6730516 | Microfluidic devices and methods Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in... | 05/04/2004 |
| 6720143 | Genetic assay system A genetic analysis device particularly for determining the presence or absence of Single Nucleotide Polymorphisms (SNPs) within specific sequences of DNA. The device includes a housing, at least one glass slide member, and an elastomeric member with channels thereon... | 04/13/2004 |
| 6716629 | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of che... | 04/06/2004 |
| 6716619 | Stylet for use with tissue microarrayer and molds A stylet for use with an automatic tissue microarrayer is provided for arraying frozen tissue samples on a substrate. In one embodiment, the stylet comprises a stylet needle having a pushing surface for pushing either frozen tissue or embedding media out of a coring... | 04/06/2004 |
| 6716580 | Method for the automated generation of nucleic acid ligands The present invention includes a method and device for performing automated SELEX. The steps of the SELEX process are performed at one or more work stations on a work surface by a robotic manipulator controlled by a computer. The invention also includes methods and ... | 04/06/2004 |
| 6713297 | Apparatus for quantitative analysis of a nucleic acid amplification reaction An apparatus for determining a threshold value (e.g., a threshold cycle number or a time value) in a nucleic acid amplification reaction comprises a detection mechanism for measuring, at a plurality of different times during the amplification reaction, at least one ... | 03/30/2004 |
| 6712785 | Method of noninvasively obtaining intraductal fluid A method is disclosed for noninvasively obtaining intraductal fluid. The method includes the use of an intraductal fluid sampling device to contact the patient, provide compression, and deliver heat thereto according to predetermined cycle characteristics. The cycle... | 03/30/2004 |
| 6709855 | Methods for detection and use of differentially expressed genes in disease states The present invention relates to methods and compositions for the detection, diagnosis, prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and related disorders. The present invention also relates to compositions and methods... | 03/23/2004 |
| 6709816 | Identification of alleles A method for determining the genotype of one or more individuals at a polymorphic locus employs amplification of a region of DNA using primers containing tags and hybridization of the products to one or more probes on a solid support. The genotype or ratio of allele... | 03/23/2004 |
| 6703235 | Complex multicellular assemblies ex vivo Various embodiments of the present invention provide both apparatus and method for the patterning of cells onto non-adhesive substrates and the controlled regulation of cells through the use of photoactivated cellular morphogenic factors.... | 03/09/2004 |
| 6703216 | Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB) Methods, compositions and articles of manufacture for assaying a sample for a GHB source are provided. A sample suspected of containing a GHB source is contacted with a first oxidoreductase selective for GHB and an oxidized cofactor. In the presence of GH... | 03/09/2004 |
| 6703203 | Integrated microarray devices This invention relates generally to the field of microarray technology. In particular, the invention provides an integrated microarray device, which device comprises a substrate comprising a plurality of distinct microlocations and a plurality of microarr... | 03/09/2004 |
| 6699706 | Cell lysis method using a vortex mixer Cell lysis may be brought about by contacting a suspension of cells with a lysis reagent such as sodium hydroxide solution; subsequent treatment enables organic molecules such as plasmid DNA to be separated from other cell components. Intimate mixing of t... | 03/02/2004 |
| 6699711 | Device and method for selective exposure of a biological sample to sound waves A device and method are disclosed for selective exposure of a biological sample, preferably biological cell material, to sound waves. The device is provided with a receptacle for the sample, in which the biological sample is in a suspended form, and havin... | 03/02/2004 |
| 6699710 | Tumor tissue microarrays for rapid molecular profiling An array-based technology facilitates rapid correlated gene copy number and expression profiling of very large numbers of human tumors. Hundreds of cylindrical tissue biopsies (diameter 0.6 mm) from morphologically representative regions of individual tum... | 03/02/2004 |
| 6698134 | Method of cultivating fresh spirulina at home and device thereof The present invention discloses a method and an apparatus for cultivating and consuming fresh Spirulina at home. The method comprises species selection of Spirulina for cultivation at home, cultivation environment and apparatus conditions, cultivation and... | 03/02/2004 |
| 6696269 | Microbiological testing method and related apparatus with diffuse-white light emitting diodes An apparatus for use in carrying out a microbiological assay on samples in a petri plate has a support for holding the petri plate, a camera, and a plurality of diffuse-white-light emitting diodes. The camera optically detects microbe-growth inhibition zo... | 02/24/2004 |
| 6696287 | System for co-culturing bacteria and eukaryotic cells The present invention is directed to an apparatus that can be used for co-culturing bacteria and eukaryotic cells. The apparatus allows the bacteria to be grown under steady state conditions and then perfused over the eukaryotic cells. The invention also ... | 02/24/2004 |
| 6686184 | Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks Microfluidic systems and methods are provided for fabricating complex patterns of materials, such as proteins, inorganic materials or cells, on surfaces. Complex, discontinuous patterns on surfaces can be formed incorporating or depositing multiple materi... | 02/03/2004 |
| 6682899 | Apparatus and method for detecting and identifying infectious agents Solid phase methods for the identification of an analyte in a biological medium, such as a body fluid, using bioluminescence are provided. A chip designed for performing the method and detecting the bioluminescence is also provided. Methods employing biom... | 01/27/2004 |
| 6680177 | Low molecular weight heparin assay, system and reagent therefor A method, kit, system and reagent for measuring low molecular weight heparin in a whole blood sample is provided which involves the use of a Factor Xa activator, such as Russell's Viper Venom, as the coagulation assay initiator.... | 01/20/2004 |
| 6677132 | Device and method for monitoring and controlling biologically active fluids The present invention relates to a device and a method for determining the concentration of organisms in a fluid, where metabolite parameters are recorded by means of a data acquisition unit and subsequently converted.... | 01/13/2004 |
| 6673592 | Continuous cultivation of microorganisms in large open tanks in sunlight An open, continuous system for culturing Chaetoceros sp. microalgae includes a large outdoor container and full strength sunlight as a light source. The container is preferably a fiberglass tank having an open top, a diameter of approximately 18 inches, a... | 01/06/2004 |
| 6673593 | Integrated device for microfluid thermoregulation, and manufacturing process thereof The integrated device for microfluid thermoregulation comprises a semiconductor material body having a surface; a plurality of buried channels extending in the semiconductor material body at a distance from the surface of the semiconductor material body; ... | 01/06/2004 |
| 6673565 | Enzymatic polymeric sensors A sensor for detecting an analyte enzyme includes at least one substrate compound and at least one indicator compound selected to produce a measurable change of state as a result of the interaction of the substrate and at least one target or analyte enzym... | 01/06/2004 |
