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| Number | Title | Issue Date |
| 6214611 | Process for the preparation of prostaglandin precursors A propargylic alcohol, enriched in the (R)-enantiomer, has the formula ##STR1## wherein R is C1-4 alkoxy, halogen, or C1-4 alkyl optionally substituted by OH or halogen. This is prepared by the steps of: (a) enantioselective (R)-esterific... | 04/10/2001 |
| 6214610 | Process for the preparation of optically active N-benzyl-3-pyrrolidinol The invention provides an efficient method of producing optically active N-benzyl-3-pyrrolidinol by an enzymatic reaction stereoselectively reducing N-benzyl-3-pyrrolidinone. The invention consists in a method of producing optically active N-benzyl-3-pyrr... | 04/10/2001 |
| 6214609 | Method and apparatus for preparation of chiral beta amino acids using penicilln G acylase A method for preparing a chiral beta amino acid or its corresponding esters which comprises contacting a racemic beta amino acid, an acyl donor and Penicillin G acylase enzyme under conditions appropriate to stereoselectively acylate one enantiomer of the... | 04/10/2001 |
| 6214608 | Resolution of racemates of primary and secondary heteroatom-substitued amines by enzyme-catalyzed acylation A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprises a) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carri... | 04/10/2001 |
| 6214604 | Biotechnical production process of piperazine R--carboxylic acids and piperazine S--carboxylic acid amide A biologically pure culture of microorganisms capable of converting RS--piperazinecarboxamides into the corresponding R--piperazinecarboxylic acid. R--piperazinecarboxamides is the only nitrogen source.... | 04/10/2001 |
| 6210956 | Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters with high enantiomeric purity and process for their preparation Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters of >90% enantiomeric excess (ee) and methods of preparing the monoesters are described. One method contacts a cis-1,3-cyclohexanedicarboxylic acid diester with a lipase under aqueous conditi... | 04/03/2001 |
| 6207444 | Enzymatic process of making alpha 1a adrenergic receptor antagonists using protease This invention relates to crystalline pharmaceutically acceptable salts of an alpha 1a adrenergic receptor antagonist, Compound A, which are useful in the treatment of benign prostatic hyperplasia. Pharmaceutical compositions employing the crystalline sal... | 03/27/2001 |
| 6207429 | Method for producing optically active cyclopropanecarboxylic acid The objective of the present invention is to provide a method which makes it possible to produce (1R)-trans-2,2-dimethyl-3-(substituted vinyl)cyclopropane-1-carboxylic acid which is useful as the acid component of a pyrethroid ester in an industrially adv... | 03/27/2001 |
| 6204050 | Producing diastereomers of 4-hydroxyproline using 4-hp epimerase from Serratia marcescens or Acinetobacter baumanni The present invention relates to two novel microorganisms, Acinetobacter baumanni WT-50/50-4A (ATCC 202144) and Serratia marcescens WT-L-4A1(RED) (ATCC 202145) characterized by 4-hydroxyproline epimerase activity. The compounds trans-4-hydroxy-L-proline (... | 03/20/2001 |
| 6201151 | Processes for preparing optically active (S)--aryl propionic acid or ester therof A process for preparing an optically active (S)--aryl propionic acid, by hydrolyzing a racemic thioester of -aryl propionic acid at various temperature in different aqueous organic solvents in the presence of an (S)-stereoselective lipase to... | 03/13/2001 |
| 6184008 | Production of optically active sphingoid compound An industrially advantageous production method of an optically active alcohol useful for cosmetics and medical supplies or production intermediates thereof using an esterase having an ability to selectively hydrolyze an optically active sphingoid compound... | 02/06/2001 |
| 6184005 | Enzymatic resolvation for obtaining a (-)-3,4-trans-diarylchroman The invention relates to a process for the preparation of (-)-3,4-trans-compounds involving an enzymatic hydrolysis. These compounds and their salts are useful in the treatment of bone loss, hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia, o... | 02/06/2001 |
| 6180394 | Method of carrying out a treatment in the presence of a centrifugal force and an apparatus therefor The invention relates to a method and an apparatus for carrying out a treatment in the presence of centrifugal force. The treatment may be a physical or a chemical treatment. For this purpose the first and second phase are brought into contact with each o... | 01/30/2001 |
| 6171832 | Process for the preparation cis-(1S,2R)-indanediol by direduction of 1,2-indanedione using trichosporon cutaneum A process for preparing cis-(1S,2R)-indanediol is disclosed. The process comprises (A) fermenting a culture medium containing a yeast strain selected from the group consisting of Trichosporon cutaneum MY 1506 (ATCC 74440) and mutants thereof and 1,2-indan... | 01/09/2001 |
| 6168935 | Preparation of optically active alcohol substituted with one or more halogen atoms An optically active alcohol substituted with one or more halogen atoms, such as optically active 4-halo-3-hydroxybutyrate esters, is efficiently synthesized by using a secondary alcohol dehydrogenase and an alcohol as a substrate accompanied by the renatu... | 01/02/2001 |
| 6165777 | Process for the resolution of cis 1,2-indane diols using Pseudomonas putida A process for resolution of a mixture of dihydroxydihydroindene enantiomers comprising treating the mixture of enantiomers with a Pseudomonas putida species microorganism. Resolved dihydroxydihydroindenes are valuable intermediates for the synthesis of bi... | 12/26/2000 |
| 6143554 | Process for producing optically active n-substituted azetidine-2 carboxylic acid compound There is provided a process for producing an optically active N-substituted azetidine-2-carboxylic acid compound represented by the formula (2): ##STR1## by contacting a corresponding N-substituted azetidine-2-carboxylic acid ester of formula (2) wit... | 11/07/2000 |
| 6136591 | Bioresolution of N-acylazetidine-2-carboxylic acids Process for obtaining an enantiomerically enriched N-acylazetidine-2-carboxylic acid, wherein a racemic N-acylazetidine-2-carboxylic acid ester is contacted with an enzyme that displays enantiospecificity to form enantiomerically enriched N-acylazeti... | 10/24/2000 |
| 6136573 | Process for producing alkali metal [S,S]-ethylenediamine-n,n'-disuccinates A process for producing an [S,S]-ethylenediamine-N,N'-disuccinic acid alkali metal salt which comprises reacting fumaric acid with ethylenediamine in an aqueous medium in the presence of an ion of at least one metal selected from the group consisting of a... | 10/24/2000 |
| 6133001 | Stereoselective microbial reduction for the preparation of 1-(4-fluorophenyl)-3(R)-[3(S)-Hydroxy-3-(4-fluorophenyl)propyl)]-4(S)-(4 -hydroxyphenyl)-2-azetidinone A process for the stereoselective microbial reduction of compound of formula II to compound of formula I ##STR1## comprising adding compound of formula II to a medium, medium and buffer, medium and solvent, or medium and a mixture of buffer and solve... | 10/17/2000 |
| 6133018 | Enzymatic synthesis of chiral amines using -2-amino propane as amine donor 2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase i... | 10/17/2000 |
| 6121025 | Process for producing optically active 3-quinuclidinol derivatives The present invention relates to a process for producing optically active 3-quinuclidinol or derivatives, wherein a racemic 3-quinuclidinol ester represented by the general formula (I): ##STR1## wherein R represents a straight-chain or branched alkyl... | 09/19/2000 |
| 6114582 | Processes for producing optically active 2-amino-1-phenylethanol derivatives An (R)-2-amino-1-phenylethanol derivative shown by the general formula (IIa) ##STR1## wherein R1 and R5 represent a hydrogen atom, etc.; R2, R3 and R4 independently represent a halogen atom, etc.... | 09/05/2000 |
| 6114163 | Process for obtaining active L--amino carboxylic acids from corresponding racemic d, L--amino carboxylic acids The disclosure relates to a process for obtaining optically active L--aminocarboxylic acids from the corresponding racemic D,L,-aminocarboxylic acids. The following steps are involved: (a) the D,L,-aminocarboxylic acids are acetylated... | 09/05/2000 |
| 6110729 | Enzymatic process for stereoselective preparation of a tertiary alcohol by hydrolysis of corresponding acid A stereoselective method for making compounds of Formula VIII ##STR1## wherein A and * are as defined in the specification. Enzymic processes and intermediates useful for preparing compound of Formula VIII are disclosed.... | 08/29/2000 |
| 6103517 | Process for the production of an optically active alcohol and a novel optically active alcohol A process for the production of R-configuration or S-configuration optically active alcohol having the formula (1), CH3 C*H(OH)(CH2)m OCn H2n+1 (1) wherein m is an integer of 3 to 5, n is an integer of 1 ... | 08/15/2000 |
| 6090616 | Microorganism, lactamase enzyme obtained therefrom, and their use A lactamase enzyme having good stability, capable of hydrolysing an enatiomer of the bicyclic lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one, to give (-) lactam and (+) amino acid, has been found in a strain of Comamonas acidivorans. The enzyme has been isola... | 07/18/2000 |
| 6063615 | Enzymatic acylation of amino acid esters using a carboxylic acid ester substituted with oxygen on the alpha carbon Disclosed is a process for preparing acylated amino esters and a process for preparing optically active amino esters from racemic amino esters with a carboxylic ester as acylating agent, whose acid component has a halogen, nitrogen, oxygen or sulfur atom ... | 05/16/2000 |
| 6060290 | Esterase and methods for the production of optically active chroman compounds Optically active chroman-3-acetic acids and optically active chroman-3-acetic acid esters can be obtained by treating a mixture of (3R)- and (3S)-chroman-3-acetic esters of formula (I) ##STR1## [wherein R1 is a straight or branched alkyl g... | 05/09/2000 |
| 6046042 | (S)-hydroxynitrilelyase from Hevea brasiliensis A purified (S)-hydroxy-nitrile-lyase is disclosed. Also disclosed is an amino acid sequence for (S)-hydroxy-nitrile-lyase and DNA sequence encoding the same.... | 04/04/2000 |
| 6037166 | Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics The invention relates to a process for preparing a substituted (6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine compound of the formula (+)-I ##STR1## wherein: R, R1, R2, R3 and R4 are i... | 03/14/2000 |
| 6027926 | Method of producing optically active 1,2,4-butanetriol Optically active 1,2,4-butanetriol of high optical purity can be produced economically and simply using a microorganism capable of increasing the content of (S)-1,2,4-butanetriol or (R)-1,2,4-butanetriol by acting on a mixture of enantiomers of 1,2,4-buta... | 02/22/2000 |
| 6020174 | Chemoenzymatic synthesis of the taxol C-13 side chain N-benzolyl- (2R,3S)-Phenylisoserine (2R,3S)- and (2S,3R)-enantiomers of trans-ଲ-phenylglycidic esters, prepared by lipase-mediated enantioselective transesterification, are used for the synthesis of the taxol C-13 side chain with good yield.... | 02/01/2000 |
| 6015698 | Method of producing D-amino acid and method of producing amine D-amino acid with high optical purity represented by formula (1-A) and/or formula (1-B), ##STR1## wherein R represents H or OH, ##STR2## wherein R1, R2 each represents H or OH, and amine represented by formula (2-A) an... | 01/18/2000 |
| 6001615 | Enzymatic reduction of ketone groups in 6-cyano-3,5-dihydroxy-hexanoic alkyl ester A compound of formula (III) ##STR1## is produced by selectively reducing a compound of formula (II) ##STR2## using a reductase possessing the properties of one produced by Beauveria, Candida, Kluyveromyces, Torulaspora or Pichia. or A compound o... | 12/14/1999 |
| 6001618 | Haloacetoacetate reductase, method for producing said enzyme, and method for producing alcohols using said enzyme A novel enzyme is provided. This enzyme is capable of reducing 4-haloacetoacetic acid esters to produce (S)-4-halo-3-hydroxybutyric acid esters with high optical purity. The enzyme was isolated from a microorganism belonging to the genus Kluyveromyces. Us... | 12/14/1999 |
| 5989900 | Process for preparing optically active allylic alcohol derivatives A process for preparing optically active allylic alcohol derivatives comprises reacting a racemic mixture of the following formula I ##STR1## wherein R is alkyl, alkenyl, or substituted or unsubstituted aryl or arylalkyl; with acetate or anhydride un... | 11/23/1999 |
| 5981239 | Synthesis of optically active phenylalanine analogs using Rhodotorula graminis A biocatalytic process to produce optically active phenylalanine analogs from arylacrylic acids is disclosed in which Rhodotorula graminis yeast containing phenylalanine ammonia-lyase introduces a molecule of ammonia stereoselectively onto the double bond... | 11/09/1999 |
| 5981267 | Enantioselection of amines using homocarbonates with hydrolase Racemic amines are enzymically converted by enantioselective carbamation to produce to chiral carbamates. Simple homocarbonates employed as substrates. The chiral carbamates may then be deprotected to yield the original amine in a chiral form. Alternative... | 11/09/1999 |
| 5977385 | Method for the preparation of (+)-calanolide A and analogues thereof A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to... | 11/02/1999 |
