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| Number | Title | Issue Date |
| 7514253 | URA5 gene and methods for stable genetic integration in yeast A novel gene encoding P. pastoris orotate-phosphoribosyl transferase (URA5) is disclosed. Methods for producing and selecting yeast strains capable of stable genetic integration of heterologous sequences into the host genome are also provided. ... | 04/07/2009 |
| 7465577 | Methods for reducing or eliminating α-mannosidase resistant glycans for the production of glycoproteins The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on glycoproteins results from the disruption of the newly isolated P. pastor... | 12/16/2008 |
| 7279309 | Process for manufacture of Nematode-extracted Anticoagulant Protein (NAP) The present invention provides a process for manufacture of purified Nematode-extracted Anticoagulant Proteins (NAPs), wherein the NAP manufactured by the claimed process method is a NAP drug substance that can be formulated as a NAP drug product. The present invent... | 10/09/2007 |
| 7259007 | Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins The present invention relates to the elimination of mannosylphosphorylation on the glycans of glycoproteins in the yeast genus Pichia. The elimination of mannosylphosphorylated glycoproteins results from the disruption of the PNO1 gene and the newly isolated ... | 08/21/2007 |
| 7252985 | Carotenoid ketolases Novel CrtW carotenoid ketolase are provided that are useful for the production of ketocarotenoids. The ketolases genes of the present invention exhibit low homology in comparison to other CrtW ketolases previously reported. Expression of the carotenoid ketolases in ... | 08/07/2007 |
| 7229789 | Methods and compositions for extracting proteins from cells A process is disclosed for releasing proteins from cells and/or inactivating viruses. In the process, a host cell containing a protein of interest is contacted with a solution of an effective amount of a detergent. ... | 06/12/2007 |
| 7109005 | Process for the simultaneous production of xylitol and ethanol Effective processes are provided for the production of xylitol and ethanol and other products from solutions derived from lignocellulose-containing material in biomass. The solutions can be hydrolyzed or partially hydrolyzed before being fermented with microbes. The... | 09/19/2006 |
| 7078191 | Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation The present invention relates to novel compositions useful for elucidating the onset or progress of diseases such as Huntington's disease, that are associated with the formation of fibrils or protein aggregates. Further, the present invention relates to methods for ... | 07/18/2006 |
| 7067298 | Compositions and methods of using a synthetic Dnase I Compositions and method for making and using a synthetic bovine DNase I are disclosed. More particularly, the sbDNase I of the present invention is a versatile enzyme that cleaves DNA nonspecifically to release 5′-phosphorylated nucleotides. The sbDNase I molecule... | 06/27/2006 |
| 7029873 | Nucleic acids to PRO1387 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 04/18/2006 |
| 7009045 | Transformation systems for flavinogenic yeast This invention is directed to the transformation of the flavinogenic yeasts, Pichia guilliermondii and Candida famata, and mutants thereof, by electroporation (electrotransformation) and by spheroplast transformation. The invention is also directed to ... | 03/07/2006 |
| 6987005 | DNA encoding SNORF33 receptor This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 r... | 01/17/2006 |
| 6984726 | Recombinant major allergen of the pollen of (mugwort) The invention relates to DNA molecules which code for the allergen Art v 1 or isoforms thereof, the sequence of the allergen, a method for the production of an Art v 1 molecule, a vector and a transformed host cell. ... | 01/10/2006 |
| 6949359 | Human IL-1 epsilon DNA and polypeptides The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented pe... | 09/27/2005 |
| 6902912 | Process for producing glutathione There is disclosed a fermentation process for producing glutathione which comprises (a) the obtainment of a biomass pre-culture by pre-cultivating, in aerobic conditions, a strain of a glutathione producing yeast wherein the glutathione content per biomass unit is h... | 06/07/2005 |
| 6884602 | Expression of alkaline phosphatase in yeast This invention involves a process for selecting and producing eukaryotic alkaline phosphatase in yeast. Yeast cells are subjected to multiple transformations using a vector comprising a first resistance marker gene and the alkaline phosphatase gene. Those strains th... | 04/26/2005 |
| 6846657 | Process for the simultaneous production of xylitol and ethanol The invention relates to a process for the simultaneous production of xylitol and ethanol from a hydrolyzed lignocellulose-containing material starting. The starting material is fermented with a yeast strain, the ethanol produced is recovered, a chromatographic sepa... | 01/25/2005 |
| 6821752 | Methods and compositions for extracting proteins from cells The present invention relates to a process of releasing a protein, recombinant or otherwise, from a cell. The process of the present invention involves contacting a host cell containing a protein of interest with a solution comprising one or more detergents and one ... | 11/23/2004 |
| 6734164 | Process for the stabilization of proteins in complex mixtures during their storage in aqueous solvents The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of heterologous prot... | 05/11/2004 |
| 6730499 | Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1 The present invention provides formaldehyde dehydrogenase genes (FLD) from methylotrophic yeasts. The FLD structural genes confer resistance to formaldehyde and are therefore useful as a selectable marker in methylotrophic yeasts. The FLD promoter sequences are stro... | 05/04/2004 |
| 6699691 | Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast Polynucleotides that comprise regulatory regions of the yeast alcohol oxidase 1 promoter are provided. Isolated polynucleotides, recombinant polynucleotides, vectors, expression cassettes and transformed cells containing the regulatory regions are disclos... | 03/02/2004 |
| 6692735 | Variant of C6 ଲ-chemokine leukotactin-1(shLkn-1) with enhanced biological activity The present invention relates to a variant of Lkn-1(shLkn-1) with enhanced biological activity, which is a truncated form of Lkn-1, a process for preparing a recombinant shLkn-1 by employing expression vector therefor and pharmaceutical application of the... | 02/17/2004 |
| 6638735 | Plasmid for gene expression in pichia ciferrii and transformation method using the same Expression cassettes for transforming Pichia ciferrii and their use are disclosed. The present invention relates to expression cassettes containing Pichia ciferrii ribosomal DNA fragment, CYHr gene resistant to cycloheximide, and a desired gene... | 10/28/2003 |
| 6500425 | Inhibiting plant pathogens with an antagonistic microorganism(s) The present invention is drawn to biological control of plant pathogens (e.g. either preharvest or postharvest diseases) on agricultural commodities (such as fruits, vegetables, cereals, grains, nuts, seeds and silage) by use of at least one microorganism... | 12/31/2002 |
| 6498029 | Pentose fermentation of normally toxic lignocellulose prehydrolysate with strain of Pichia stipitis yeast using air Strains of the yeast Pichia stipitis NPw9 (ATCC PTA-3717) useful for the production of ethanol using oxygen for growth while fermenting normally toxic lignocellulosic prehydrolysates.... | 12/24/2002 |
| 6489147 | Gene for adenylate cyclase and its use A gene which contains the nucleotide sequence shown in SEQ ID NO:1 from nucleotide 671 to nucleotide 6295 or a nucleotide sequence which can be obtained therefrom by substitution, insertion or deletion of up to 30%, preferably up to 10%, particularly pref... | 12/03/2002 |
| 6423310 | Biological coating with a protective and curative effect for the control of postharvest decay Novel methods and compositions are provided for the biocontrol of plant diseases by use of a biological coating that confers both a protective and a curative effect for the control of postharvest decay. The coating includes chitosan salts, an antagonistic... | 07/23/2002 |
| 6342375 | Modified methylotrophic Pichia pastoris yeast which secretes human growth hormone In the present system an adequate expression system for the production and secretion of biologically active human growth hormone (HGH) in its natural form in which a methylotrophic yeast such as Pichia pastoris is used as host organism has been developed.... | 01/29/2002 |
| 6339061 | Process for the stabilization of proteins in complex mixtures during their storage in aqueous solvents The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of hetero... | 01/15/2002 |
| 6316245 | Mutant cells of Pichia The present invention relates to a fermentation process to have a high productivity with a novel mutant of Pichia sp., more specifically, for preparing erythritol under optimal fermentation conditions for maximum erythritol production by optimizing the en... | 11/13/2001 |
| 6204006 | Microbial strains producing sphingolipid bases Microbial strains capable of producing enhanced levels of sphingosine, dihydrosphingosine, phytosphingosine and/or derivatives thereof are disclosed. Additionally, there are disclosed methods based on mutagenesis, or other selection techniques, whereby su... | 03/20/2001 |
| 6204012 | Protein production process A method for producing a protein by culturing a cell capable of expressing the protein and which contains a methylotrophic yeast promoter for an enzyme of the methanol metabolic pathway controlling expression of the protein, in a fermentative batch proces... | 03/20/2001 |
| 6194169 | Enhanced expression of human platelet-derived growth factor in Pichia pastoris Enhanced yields of the platelet-derived growth factor (PDGF) B-chain are obtained using the Pichia pastoris yeast system. Yields of both wild-type and mutant human proteins are enhanced when the yeast is transformed with a vector containing the yeast mati... | 02/27/2001 |
| 6184018 | ଲ-glucosidase coding sequences and protein from orpinomyces PC-2 Provided is a novel ଲ-glucosidase from Orpinomyces sp. PC2, nucleotide sequences encoding the mature protein and the precursor protein, and methods for recombinant production of this ଲ-glucosidase.... | 02/06/2001 |
| 6171828 | Method for culturing microorganisms having a methanol metabolic pathway The present invention discloses a method for culturing microorganisms having a methanol metabolic pathway in which an expression unit is introduced that comprises a target gene linked downstream from a promoter that can be induced by methanol; wherein, du... | 01/09/2001 |
| 6121034 | Coniothyrium minitans xylanase gene Cxy1 The nucleotide sequence of a novel xylanase gene obtained from the soilborne fungus Coniothyrium minitans, and denoted cxy1, is provided. The amino acid sequence of the encoded xylanase enzyme, denoted Cxy1, is also provided.... | 09/19/2000 |
| 6107057 | Pichia secretory leader for protein expression Polynucleotides, vectors, and host cells comprising a polynucleotide having a fragment of a leader sequence and a second nucleotide sequence that encodes a polypeptide heterologous to the leader sequence, wherein the leader sequence fragment is sufficient... | 08/22/2000 |
| 6066469 | Cloning, expression, and uses of human lactoferrin Disclosed is human lactoferrin expressed using recombinant DNA, its method of production and purification.... | 05/23/2000 |
| 6051419 | Genes which influence pichia proteolytic activity, and uses therefor The isolation and characterization of genes involved in proteolytic processing in species of the genus Pichia is described. The availability of such genes has enabled the generation of strains of Pichia which are deficient in proteolytic activity, which s... | 04/18/2000 |
| 6037149 | DNA encoding human asthma associated factor 1 A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1. When this substitution occurs in both alleles in one indi... | 03/14/2000 |
