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| Number | Title | Issue Date |
| 7323328 | Obligately symbiotic thermophile SC-1 producing thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase The present invention relates to a novel obligately symbiotic thermophile Symbiobacterium toebii SC-1 (Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1. The pre... | 01/29/2008 |
| 7291493 | Microbially expressed xylanases and their use as feed additives and other uses The present invention relates to codon-optimized xylanase coding sequences and the expression of xylanases in microbes and yeast. The invention further relates to using multiple copies of the xylanase expression construct for high levels of protein expression. The i... | 11/06/2007 |
| 7285406 | Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitrites to th... | 10/23/2007 |
| 7267944 | Methods and compositions for combinatorial-based discovery of new multimeric molecules The present invention provides methods and compositions for producing and screening combinatorial libraries of multimeric proteins. The present invention relies on the use of filamentous fungal heterokaryons that are produced using two or more parent strains into wh... | 09/11/2007 |
| 7241607 | Microorganism producing fructosyl transferase and method for producing fructooligosaccharides and neofructooligosaccharides using the same The present invention relates to a novel microorganism and a method for producing fructooligosaccharides and neofructooligosaccharides. More particularly, the present invention relates to Penicillium citrinum KCTC 10225BP of soil origin which produces fructos... | 07/10/2007 |
| 7115725 | Multi-mutant diphtheria toxin vaccines Disclosed is DNA encoding diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines. ... | 10/03/2006 |
| 7070970 | Elongase genes and uses thereof The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. Two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, e... | 07/04/2006 |
| 6939704 | Enhanced expression of proteins in genetically modified fungi The present invention relates to increasing the production of a protein of interest from a fugal host. The invention discloses nucleotide sequences comprising, a regulatory region in operative association with xylanase secretion sequence and a gene of interest. The ... | 09/06/2005 |
| 6936449 | Regulatable growth of filamentous fungi The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemica... | 08/30/2005 |
| 6913916 | Elongase genes and uses thereof The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In p... | 07/05/2005 |
| 6869773 | Process for the manufacture of carotenoids and biologically useful materials thereof A process is provided for producing a carotenoid, which process includes cultivating a recombinant organism having a gene for one or more active oxygen species-quenching factor(s) that is substantially disrupted with a disruption cassette specific to the gene, and r... | 03/22/2005 |
| 6794180 | Morphological mutants of filamentous fungi The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more ex... | 09/21/2004 |
| 6677145 | Elongase genes and uses thereof The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., "elongases") and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acid... | 01/13/2004 |
| 6608189 | Fluorescent protein sensors for measuring the pH of a biological sample Disclosed are fluorescent protein sensors for measuring the pH of a sample, nucleic acids encoding them, and methods of use. The preferred fluorescent protein sensors are variants of the green fluorescent protein (GFP) from Aequorea victoria. Also disclos... | 08/19/2003 |
| 6531306 | Polynucleotides encoding mammalian DNA-dependent ATPase A polypeptides Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglyc... | 03/11/2003 |
| 6436643 | Process for site-directed integration of multiple copies of a gene in a mould A process for site-directed integration of multiple copies of a gene in a mould is provided, which comprises transforming a mould cell containing in its chromosomal DNA a restriction site for a rare-cutting endonuclease, e.g., I-Scel, preferably introduce... | 08/20/2002 |
| 6432672 | Gene conversion as a tool for the construction of recombinant industrial filamentous fungi The present invention relates to filamentous fungi that comprise in their genomes at least two substantially homologous DNA domains which are suitable for integration of one or more copies of a recombinant DNA molecule and wherein at least two of these DN... | 08/13/2002 |
| 6379928 | Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fung... | 04/30/2002 |
| 6358708 | Candida albicans SRB-7 Disclosed herein is a purified isolated nucleic acid encoding Candida Albicans SRB-7 (CaSRB-7) and an isolated polypeptide encoded by said nucleic acid. Also disclosed herein are vectors comprising the nucleic acid sequences, cells comprising the vectors,... | 03/19/2002 |
| 6316217 | Activin receptor-like kinases, proteins having serine threonine kinase domains and polynucleotides encoding same A new receptor family has been identified, of activin-like kinases. Novel proteins have activin/TGF-ଲ-type I receptor functionality, and have consequential diagnostic/therapeutic utility. They may have a serine/threonine kinase domain, a DFKSRN or D... | 11/13/2001 |
| 6315988 | Process for preparing protein-bound melanin and/or peptide bound melanin, and products thereof A process is provided for preparing protein- and/or peptide-bound melanin, which is soluble in an aqueous solution at pH 2 to 11 and temp 0° C. to 50° C., by the steps of reacting dihydroxyphenylalanine or tyrosine with an oxidant enzyme in the presence... | 11/13/2001 |
| 6268140 | Combinatorial metabolic libraries The present invention provides methods and compositions for producing and screening combinatorial metabolic libraries of multimeric proteins. The present invention relies on the use of filamentous fingal heterokaryons that are produced using two or more p... | 07/31/2001 |
| 6265204 | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi The invention includes novel fusion nucleic acids encoding fusion polypeptides which when expressed in a filamentous fungus result in the expression of fusion polypeptides. The fusion nucleic acids comprise four nucleic acids which encode a fusion polypep... | 07/24/2001 |
| 6255115 | Agrobacterium mediated transformation of moulds, in particular those belonging to the genus Aspergillus The invention relates to Agrobacterium mediated transformation of moulds comprising species of the fungal sub-divisions Ascomycotina, Basidiomycotina, Deuteromycotina, Mastigomycotina, and Zygomycotina. Examples demonstrate the transformation of Aspergillus aw... | 07/03/2001 |
| 6232112 | Reagents and methods for diversification of DNA The present invention provides methods and compositions for diversification of heterologous DNA sequences in vivo. The present invention employs a recombination hotspot functionally coupled to the heterologous DNA. The process of recombination generates n... | 05/15/2001 |
| 6180361 | Recombinant DNA expression vectors and DNA compounds that encode deacetoxycephalosporin C synthetase and deacetylcephalosporin C synthetase The present invention provides DNA compounds that encode the expandase/hydroxylase enzyme of Cephalosporium acremonium. The compounds can be used to construct recombinant DNA expression vectors for a variety of host cells, including E. coli, Penicillium, ... | 01/30/2001 |
| 6171817 | Heterologous polypeptides expressed in filamentous fungi, process for making same, and vectors for making same Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fung... | 01/09/2001 |
| 6153398 | Method to identify specific inhibitors of IMP dehydrogenase This invention relates to methods to identify specific inhibitors of the purine nucleotide synthesis enzyme, IMP dehydrogenase (IMPDH). IMPDH is an essential enzyme found in all free-living organisms from humans to bacteria and is an important therapeutic... | 11/28/2000 |
| 6130063 | DNA sequences, vectors, and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi The invention includes novel fusion DNA sequences encoding fusion polypeptides which when expressed in a filamentous fungus result in the expression of fusion polypeptides which when secreted result in increased levels of secretion of the desired polypept... | 10/10/2000 |
| 6103490 | Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fung... | 08/15/2000 |
| 6022725 | Cloning and amplification of the ଲ-glucosidase gene of Trichoderma reesei A process for expressing extracellular ଲ-glucosidase in a filamentous fungus by expressing a fungal DNA sequence encoding enhanced, deleted or altered ଲ-glucosidase in a recombinant host microorganism is disclosed. Recombinant fungal cellulase... | 02/08/2000 |
| 5997913 | Method enhancing flavor and aroma in foods by overexpression of ଲ-glucosidase A process for expressing extracellular ଲ-glucosidase in a filamentous fungus by expressing a fungal DNA sequence encoding enhanced, deleted or altered ଲ-glucosidase in a recombinant host microorganism is disclosed. Recombinant fungal cellulase... | 12/07/1999 |
| 5976828 | Identification of essential survival genes A method for identifying a strain having a conditional lethal mutation which is essential for survival when strain is incubated under restrictive growth conditions, and methods of identifying gene products and gene functions thereof.... | 11/02/1999 |
| 5958727 | Methods for modifying the production of a polypeptide The present invention relates to methods for modifying the production of a polypeptide, comprising: (a) introducing a nucleic acid construct into a cell, wherein the cell comprises a DNA sequence encoding a polypeptide, under conditions in which the nucle... | 09/28/1999 |
| 5958747 | Aspergillus oryzae 5-aminolevulinic acid synthases and nucleic acids encoding same The present invention relates to Aspergillus oryzae 5-aminolevulinic acid synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the 5-aminolevulinic acid synthases as well as nucleic acid constructs, vectors, and recombi... | 09/28/1999 |
| 5939306 | Osmosensing histidine kinases The present invention relates to histidine kinases, including osmosensing fungal histidine kinases. In particular, the present invention provides amino acid and nucleic acid sequences of fungal histidine kinases from organisms such as Candida (e.g., C. al... | 08/17/1999 |
| 5891669 | Methods for producing polypeptides in respiratory-deficient cells The present invention relates to methods of producing a polypeptide, comprising: (a) introducing into a respiratory-defective mutant of a cell (i) one or more first nucleic acid sequences which complement the respiratory defect and (ii) a second nucleic a... | 04/06/1999 |
| 5854056 | Fungal cell wall production and utilization as a raw resource for textiles The present invention reveals a product from fungi and a method for making the product. The method involves producing spores from a filamentous fungus, producing mycelia from the spores, growing the mycelia into a flat sheet, and recovering the fungus pro... | 12/29/1998 |
| 5834191 | Production of heterologous peptides The invention relates to a method and recombinant means for engineering the production of heterologous peptides in filamentous fungus. The invention involves the genetic manipulation of the glucoamylase gene in order to provide a restriction site in same ... | 11/10/1998 |
| 5821102 | Nucleic acids encoding polyeptides having absidia lipase activity The present invention relates to isolated nucleic acid sequences encoding polypeptides having Absidia lipase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods ... | 10/13/1998 |
