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| Number | Title | Issue Date |
| 7427484 | Global regulator of secondary metabolite biosynthesis and methods of use The invention provides polypeptides and nucleic acids which identify and encode LaeA, a regulator of fungal secondary metabolite production which exhibits global control over secondary metabolite biosynthetic gene clusters. The invention further provides expression ... | 09/23/2008 |
| 7425450 | Regulatable growth of filamentous fungi The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemica... | 09/16/2008 |
| 7422873 | Mutant carotenoid ketolase CrtW carotenoid ketolases are provided useful for the production of astaxanthin. The ketolases genes of the present invention exhibit improved ketolase activity when converting cyclic hydroxylated carotenoid intermediates into astaxanthin. Recombinant expression of ... | 09/09/2008 |
| 7404977 | Rennets The present invention describes an aspartic protease produced by a fungus from the class Eurotiomycetes, comprising the amino acid sequence of FDTGSSD or FDTGSSE. The present invention further provides a process for identifying new milk clotting enzymes comprising s... | 07/29/2008 |
| 7393671 | Mutant carotenoid ketolases CrtW carotenoid ketolases are provided that are useful for the production of astaxanthin and other cyclic ketocarotenoids. The mutant ketolase genes of the present invention encode polypeptides characterized by an improvement in astaxanthin synthesis activity when c... | 07/01/2008 |
| 7371546 | Glucoamylase variants The invention relates to a variant of a parental fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates. ... | 05/13/2008 |
| 7368272 | Expression of proteolytic enzymes in koji mold in the presence of carbon sources The present invention refers to a koji mold capable of expressing proteolytic enzymes in the presence of a carbon source in at least the same amount as in the absence thereof. In particular, the present invention pertains to a mutation in the creA gene as a tool to ... | 05/06/2008 |
| 7354752 | Acid-stable alpha amylases having granular starch hydrolyzing activity and enzyme compositions The present invention relates to an acid-stable alpha amylase (asAA) derived from a strain of Aspergillus kawachi, which has granular starch hydrolyzing (GSH) activity, the heterologous expression of the asAA having GSH activity in filamentous fungal host cel... | 04/08/2008 |
| 7348172 | Method and DNA constructs for increasing the production level of carbohydrate degrading enzymes in filamentous fungi The invention is related to a method and DNA constructs for obtaining in a filamentous fungus host a higher production level of a carbohydrate degrading (CD) enzyme, having in its original state a catalytic module (CAT) and a carbohydrate binding module (CBM) separa... | 03/25/2008 |
| 7341848 | Isomaltose synthase-knockout microorganism belonging eumycota It is intended to provide a host microorganism whereby the expression of a gene encoding a target protein can be effectively elevated in the case of transferring the gene. It is also intended to provide a transformant whereby a target protein can be produced at a hi... | 03/11/2008 |
| 7335733 | Tissue cement proteins from The present invention relates to tissue cement proteins produced by certain species of blood-feeding ectoparasites. These proteins and compositions comprising these proteins are particularly useful for the temporary or permanent bonding of animal tissues to each oth... | 02/26/2008 |
| 7335501 | Phytases and methods for producing these phytases The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel phytases derived from fungi of the Penicillium genus, in particular ... | 02/26/2008 |
| 7332319 | Heterologous alpha amylase expression in The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same. ... | 02/19/2008 |
| 7323327 | Genes encoding novel proteolytic enzymes The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein... | 01/29/2008 |
| 7312063 | Overexpression of phytase genes in yeast systems The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a h... | 12/25/2007 |
| 7309599 | Aerobic fermentation method A method and apparatus for effectively aerating large-scale cultures of microorganisms is disclosed. ... | 12/18/2007 |
| 7303877 | Methods for producing biological substances in enzyme-deficient mutants of The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent Aspergillus niger strain in a medium suitable for the production of the heterologous biological substance, wherein (i) ... | 12/04/2007 |
| 7303868 | Mutant bank The invention relates to a mutant bank of diploid micro-organisms which consists of a population of mutant cells in which at least one cell has a random mutation which disrupts the activity of at least one gene, wherein the micro-organism is inducible into haploid f... | 12/04/2007 |
| 7294493 | Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitriles to th... | 11/13/2007 |
| 7291493 | Microbially expressed xylanases and their use as feed additives and other uses The present invention relates to codon-optimized xylanase coding sequences and the expression of xylanases in microbes and yeast. The invention further relates to using multiple copies of the xylanase expression construct for high levels of protein expression. The i... | 11/06/2007 |
| 7285407 | Genes of cell wall-degrading enzymes derived from aspergillus, and method for the production the enzymes The purpose of the present invention is to isolate a gene encoding novel exo-, or endo-β-1,3-glucanase, to obtain a microorganism having an enhanced expression of said gene and to degrade β-1,3-glucan to its low molecular weight form by means of said enzymes. The ... | 10/23/2007 |
| 7262041 | Expression of granular starch hydrolyzing enzyme in The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity. ... | 08/28/2007 |
| 7252985 | Carotenoid ketolases Novel CrtW carotenoid ketolase are provided that are useful for the production of ketocarotenoids. The ketolases genes of the present invention exhibit low homology in comparison to other CrtW ketolases previously reported. Expression of the carotenoid ketolases in ... | 08/07/2007 |
| 7208303 | Bacterial nitric oxide synthases and uses thereof The present invention relates to isolated nucleic acid molecules encoding nitric oxide synthases. The isolated nucleic acid molecules and their encoded protein or polypeptides are useful in methods for attaching a nitrogen group to a target moiety of a compound and ... | 04/24/2007 |
| 7198938 | Morphological mutants of filamentous fungi The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more ex... | 04/03/2007 |
| 7163819 | Bacterial hemoglobin genes and their use to increase carotenoid production Genes encoding bacterial oxygen binding proteins are provided. Recombinant expression of at least one of the present bacterial hemoglobin genes increased the growth characteristics and/or carotenoid production levels in microbial host cells grown under microaerobic ... | 01/16/2007 |
| 7091031 | Carotenoid hydroxylase enzymes A novel CrtZ carotenoid hydroxylase, isolated from Brevundimonas vesicularis DC263, is provided that is useful for the production of hydroxylated carotenoids. Additionally, a previously identified hypothetical protein from Novosphingobium aromaticivorans | 08/15/2006 |
| 7087232 | Process for producing a culture of and product obtained thereby The present invention relates to the establishment of a cultivation condition that is suitable for the large-scale production of pharmacologically active filtrates from a culture of A. camphorata, in particular, by optimizing the agitation rate and/or pH valu... | 08/08/2006 |
| 7070970 | Elongase genes and uses thereof The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. Two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, e... | 07/04/2006 |
| 7067300 | Process for the biological production of 1,3-propanediol with high titer The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanedio... | 06/27/2006 |
| 7063976 | Process for preparing beta-fructofuranosidase enzyme and a process for producing fructooligosaccharides A process for preparing beta-fructofuranosidase enzyme and a process for producing fructooligosaccharides, in which the preparation of the enzyme is obtained by cultivating the fungus Aspergillus niger, either wild or mutated, in a preferably semi-solid cultu... | 06/20/2006 |
| 7057030 | gene encoding aldoxime dehydratase A gene has been isolated from a Rhodococcus sp. encoding an aldoxime dehydratase enzyme useful for the conversion of aldoxime substrates to nitrilases and other downstream intermediates. The gene has been cloned into a recombinant host and expressed. ... | 06/06/2006 |
| 7056707 | Bioactive compound and its isolation and method of treatment for lipoxygenase inhibition and as free radical scavenging agent The present invention relates to a novel compound having a molecular formula C13H15NO5 having molecular structure of Formula I and a process for the isolation of said compound. The present invention also relates to a method of inhibi... | 06/06/2006 |
| 7052869 | Consensus phytases A process for obtaining a consensus protein from a group of amino acid sequences of a defined protein family, proteins and polynucleotides so obtained, and compositions containing such proteins. ... | 05/30/2006 |
| 7053204 | Global regulator of secondary metabolite biosynthesis and methods of use The invention provides polypeptides and nucleic acids which identify and encode LaeA, a regulator of fungal secondary metabolite production which exhibits global control over secondary metabolite biosynthetic gene clusters. The invention further provides expression ... | 05/30/2006 |
| 7049125 | EGVIII endoglucanase and nucleic acids encoding the same The present invention provides a novel endoglucanase nucleic acid sequence, designated egl8, and the corresponding EGVIII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVIII, recombina... | 05/23/2006 |
| 7029888 | Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate The present invention relates to a modified enzyme of a non-heme iron (II) dependent family of oxygenases and oxidases which renders the enzyme dependent on bicarbonate for activity. In a preferred embodiment, the modification is an arginine, lysine, or other amino ... | 04/18/2006 |
| 7026460 | lovE variant regulator molecules The invention provides variant regulator proteins of secondary metabolite production and nucleic acids encoding said variant regulator proteins. In particular, the invention provides variant regulator molecules of the lovE protein. ... | 04/11/2006 |
| 7026150 | Overexpression of phytase genes in yeast systems The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a h... | 04/11/2006 |
| 7022508 | Saponin-digesting enzymes, genes thereof and soyasapogenol B mass production system The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce soyasapogenol B, a polynucleotide encoding such a protein, and a method of prod... | 04/04/2006 |
