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| Number | Title | Issue Date |
| 7745200 | Formaldehyde dehydrogenase genes from methylotrophic yeasts The present invention provides formaldehyde dehydrogenase genes (FLD) from methylotrophic yeasts. The FLD structural genes confer resistance to formaldehyde and are therefore useful as a selectable marker in methylotrophic yeasts. The FLD promoter sequences are stro... | 06/29/2010 |
| 7501275 | Yeast transformation system Disclosed are methods for obtaining expression of polypeptides in organisms employing alternative codon systems, and polynucleotides for use therein. ... | 03/10/2009 |
| 7435168 | Compositions and methods for manipulating carbon flux in cells Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods ... | 10/14/2008 |
| 7429469 | Enzyme gene participating in the synthesis of polyester and process for producing polyester using the same This invention relates to a method of producing polyesters resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) and having biodegradability and good physical properties using yeasts as hosts. By constructing at least one enzyme gene i... | 09/30/2008 |
| 7422873 | Mutant carotenoid ketolase CrtW carotenoid ketolases are provided useful for the production of astaxanthin. The ketolases genes of the present invention exhibit improved ketolase activity when converting cyclic hydroxylated carotenoid intermediates into astaxanthin. Recombinant expression of ... | 09/09/2008 |
| 7393671 | Mutant carotenoid ketolases CrtW carotenoid ketolases are provided that are useful for the production of astaxanthin and other cyclic ketocarotenoids. The mutant ketolase genes of the present invention encode polypeptides characterized by an improvement in astaxanthin synthesis activity when c... | 07/01/2008 |
| 7393667 | Stereoselective reduction process for the preparation of pyrrolotriazine compounds The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib: ... | 07/01/2008 |
| 7368274 | Expression of recombinant proteinase K from in yeast The invention concerns a method for the expression of a gene coding for a soluble proteinase K in yeast e.g. in Pichia pastoris with subsequent secretion into the culture medium. In addition a method for purifying the heterologously expressed and secreted pro... | 05/06/2008 |
| 7335501 | Phytases and methods for producing these phytases The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel phytases derived from fungi of the Penicillium genus, in particular ... | 02/26/2008 |
| 7312063 | Overexpression of phytase genes in yeast systems The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a h... | 12/25/2007 |
| 7303903 | Production of weakly active or inactive mutants of alkaline phosphatase and their expression in yeast The invention concerns a method for the recombinant production or expression of eukaryotic alkaline phosphatase mutants in yeast cells wherein the specifically introduced mutations result in a reduction of the specific AP activity by at least a factor 1:100. The inv... | 12/04/2007 |
| 7294493 | Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitriles to th... | 11/13/2007 |
| 7291493 | Microbially expressed xylanases and their use as feed additives and other uses The present invention relates to codon-optimized xylanase coding sequences and the expression of xylanases in microbes and yeast. The invention further relates to using multiple copies of the xylanase expression construct for high levels of protein expression. The i... | 11/06/2007 |
| 7259007 | Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins The present invention relates to the elimination of mannosylphosphorylation on the glycans of glycoproteins in the yeast genus Pichia. The elimination of mannosylphosphorylated glycoproteins results from the disruption of the PNO1 gene and the newly isolated ... | 08/21/2007 |
| 7256034 | Inhibitor of cell proliferation and methods of use thereof An chimerical polypeptide that arrests proliferating cells in mitosis is provided. In general the polypeptide has an N-terminal transit peptide, such as HIV-1 Tat, and a C-terminal cell-cycle effector, such as a G2/M cyclin or a cytostatic factor. A polynucleotide u... | 08/14/2007 |
| 7252933 | Protein glycosylation modification in methylotrophic yeast The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced ... | 08/07/2007 |
| 7250502 | Formaldehyde dehydrogenase genes from methylotrophic yeasts The present invention provides formaldehyde dehydrogenase genes (FLD) from methylotrophic yeasts. The FLD structural genes confer resistance to formaldehyde and are therefore useful as a selectable marker in methylotrophic yeasts. The FLD promoter sequences are stro... | 07/31/2007 |
| 7244833 | Recombinant human albumin fusion proteins with long-lasting biological effects Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide h... | 07/17/2007 |
| 7241730 | Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides Heparin-binding regions of several proteins, such as neural cell adhesion molecule, fibronectin, laminin, midkine, and anti-thrombin III have been shown to promote neurite extension on two-dimensional surfaces. The effect of heparin-binding peptides on neurite exten... | 07/10/2007 |
| 7202072 | Production of weakly active or inactive mutants of alkaline phosphatase and their expression in yeast The invention concerns a method for the recombinant production or expression of eukaryotic alkaline phosphatase mutants in yeast cells wherein the specifically introduced mutations result in a reduction of the specific AP activity by at least a factor 1:100. The inv... | 04/10/2007 |
| 7198921 | Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia and provide a means of controlling the same. The present invention also int... | 04/03/2007 |
| 7135323 | Microbially expressed thermotolerant phytase for animal feed The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a thermotolerant phytase. ... | 11/14/2006 |
| 7091031 | Carotenoid hydroxylase enzymes A novel CrtZ carotenoid hydroxylase, isolated from Brevundimonas vesicularis DC263, is provided that is useful for the production of hydroxylated carotenoids. Additionally, a previously identified hypothetical protein from Novosphingobium aromaticivorans | 08/15/2006 |
| 7091032 | Expression of a human insulin precursor in Methylotrophic recombinant yeast strain producing human insulin precursor, the strain comprising, in its genome, a copy of a first DNA construction and a second DNA construction, wherein the constructions are capably of directing the expression and secretion of huma... | 08/15/2006 |
| 7070970 | Elongase genes and uses thereof The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. Two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, e... | 07/04/2006 |
| 7070952 | Genes encoding carotenoid compounds Genes have been isolated from Pectobacterium cypripedii encoding geranylgeranyl pyrophosphate (GGPP) synthase (CrtE), phytoene synthase (CrtB), phytoene desaturase (Crtl), lycopene cyclase (CrtY), β-carotene hydroxylase (CrtZ), and zeaxanthin glucosyl transf... | 07/04/2006 |
| 7067300 | Process for the biological production of 1,3-propanediol with high titer The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanedio... | 06/27/2006 |
| 7060810 | Regulation of human eosinophil serine protease 1-like enzyme A human eosinophil serine protease 1-like enzyme, cDNA, and reagents that regulate the enzyme can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, asthma, COPD, airway allergy, and osteoporosis. ... | 06/13/2006 |
| 7052879 | Recombinant lipases The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, ... | 05/30/2006 |
| 7037680 | Recombinant light chains of neurotoxins and light chain fusion proteins for use in research and clinical therapy Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cle... | 05/02/2006 |
| 7026150 | Overexpression of phytase genes in yeast systems The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a h... | 04/11/2006 |
| 7018829 | Metabolically engineered microbial cell with an altered metabolite production A recombinant microbial cell comprises at least one increased expressible enzyme activity controlling anabolic metabolism of ammonia as a nutrient source, the increased enzyme activity being an NADH-dependent activity catalysing the reaction ... | 03/28/2006 |
| 6998260 | Recombinant proteolytic tryptases, active site mutants thereof, and methods of making same Disclosed is a method of expressing enzymatically-active, recombinant proteolytic tryptase in a eukaryotic host cell, expression constructs which drive the production of enzymatically-active tryptase in transformed hosts, and genetically-engineered eukaryotic host c... | 02/14/2006 |
| 6962795 | Neutrophil inhibitors Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such com... | 11/08/2005 |
| 6929928 | Genes encoding carotenoid compounds A unique carotenogenic biosynthetic gene cluster has been isolated from Panteoa agglomerans strain DC404, wherein the genetic organization of the cluster is crtE-idi-crtY-crtI-crtB-crtZ. The genes contained within this cluster encode geranylgeranyl pyrophosph... | 08/16/2005 |
| 6924366 | Recombinant hexose oxidase, a method of producing same and use of such enzyme A method of producing hexose oxidase by recombinant DNA technology, recombinant hexose oxidase and the use of such enzyme, in particular in the manufacturing of food products such as doughs and dairy products, animal feed, pharmaceuticals, cosmetics, dental care pro... | 08/02/2005 |
| 6913916 | Elongase genes and uses thereof The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In p... | 07/05/2005 |
| 6908992 | Methanotrophic carbon metabolism pathway genes and enzymes Genes have been isolated from a Methylomonas sp encoding enzymes in the carbon flux pathway. The genes encode a 2-keto-3-deoxy-6-phosphogluconate (KDPGA) and a fructose bisphosphate aldolase (FFBPA), as well as numerous other genes. The genes will be useful i... | 06/21/2005 |
| 6893849 | Fermentation process for production of xylitol from Pichia sp The present invention deals with an improved fermentation process for the production of xylitol from Pichia sp. and the said process is submerged fermentation for the production of xylitol using cotton seed flour as cheap organic nitrogen source and the main ... | 05/17/2005 |
| 6841370 | Site-directed mutagenesis of Escherichia coli phytase The present invention relates to an isolated mutant acid phosphatase/phytase with improved enzymatic properties. The mutant acid phosphatase/phytase composition is particularly useful in animal feed compositions. ... | 01/11/2005 |
