Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 7429469 | Enzyme gene participating in the synthesis of polyester and process for producing polyester using the same This invention relates to a method of producing polyesters resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) and having biodegradability and good physical properties using yeasts as hosts. By constructing at least one enzyme gene i... | 09/30/2008 |
| 7427500 | Method for preparing xylitol with high yield using recycling microorganism Provided is a process for continuously producing xylitol in high yield and productivity using a vacuum microfiltration bioreactor containing a fermentation medium for a strain of the genus Candida, which includes: 5 300 g/l of xylose, 1 10 g/l of urea, 1 10 g... | 09/23/2008 |
| 7422873 | Mutant carotenoid ketolase CrtW carotenoid ketolases are provided useful for the production of astaxanthin. The ketolases genes of the present invention exhibit improved ketolase activity when converting cyclic hydroxylated carotenoid intermediates into astaxanthin. Recombinant expression of ... | 09/09/2008 |
| 7405063 | Biooxidation capabilities of sp A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates. ... | 07/29/2008 |
| 7393671 | Mutant carotenoid ketolases CrtW carotenoid ketolases are provided that are useful for the production of astaxanthin and other cyclic ketocarotenoids. The mutant ketolase genes of the present invention encode polypeptides characterized by an improvement in astaxanthin synthesis activity when c... | 07/01/2008 |
| 7320884 | Fermentation process A process for forming a color and odor stable polycarboxylic acid or polyhydroxy acid is provided. The process is carried out by fermenting a mixture containing a substrate which can be converted by fermentation into a polycarboxylic acid or a polyhydroxy acid, an o... | 01/22/2008 |
| 7297513 | Gene encoding glutathione synthetase from A gene encoding glutathione synthetase from Candida utilis is provided and food containing γ-glutamylcysteine cysteine or cystenylglycine is produced by cultivating Candida utilis modified by means of a gene encoding glutathione synthetase under a sui... | 11/20/2007 |
| 7267976 | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, the genes encoding phophatidylcholine-diacylglycerol acyltransferase (PDAT) a... | 09/11/2007 |
| 7262038 | Simplified eukaryotic nitrate reductase The invention provides modification to the polynucleotide coding sequence for Pichia angusta NAD (P)H: nitrate reductase [YNaR1; GenBank accession number Z49110], which has Enzyme Commission number 1.7.1.2 (formerly EC 1.6.6.2), yielding the polynucleotide co... | 08/28/2007 |
| 7256033 | Delta-8 desaturase and its use in making polyunsaturated fatty acids Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast. ... | 08/14/2007 |
| 7244833 | Recombinant human albumin fusion proteins with long-lasting biological effects Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide h... | 07/17/2007 |
| 7241613 | Identification of cell surface proteins and their uses The invention provides for novel polypeptides of Candida species found on the cell wall of the Candida organism. The invention further provides for methods of using these polypeptides, the genes encoding the polypeptides and fragments thereof for prepa... | 07/10/2007 |
| 7238482 | Production of polyunsaturated fatty acids in oleaginous yeasts The present invention relates to methods for the production of ω-3 and/or ω-6 fatty acids in oleaginous yeast. Thus, desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic a... | 07/03/2007 |
| 7217538 | : a gene, methods for making and using, and targeting it or its expression products for antifungal applications Disclosed and claimed is the CaESS1 gene, portions thereof such as primers or probes, expression products therefrom, and methods for using the gene, and expression products; for instance, for diagnostic, therapeutic or preventive compositions. ... | 05/15/2007 |
| 7214491 | Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts The present invention relates to a Δ12 fatty acid desaturase able to catalyze the conversion of oleic acid to linoleic acid (LA; 18:2). Nucleic acid sequences encoding the desaturase, nucleic acid sequences that hybridize thereto, DNA constructs comprising the desa... | 05/08/2007 |
| 7192762 | Mortierella alpina glycerol-3-phosphate o-acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms Glycerol-3-phosphate o-acyltransferase (GPAT) participates in the first step of oil biosynthesis and is expected to play a key role in altering the quantity of long-chain polyunsaturated fatty acids (PUFAs) produced in oils of oleaginous organisms. The present appli... | 03/20/2007 |
| 7163819 | Bacterial hemoglobin genes and their use to increase carotenoid production Genes encoding bacterial oxygen binding proteins are provided. Recombinant expression of at least one of the present bacterial hemoglobin genes increased the growth characteristics and/or carotenoid production levels in microbial host cells grown under microaerobic ... | 01/16/2007 |
| 7141410 | Methods and materials for the production of organic products in cells of species The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable increased production of organic products. More specifically, the invention r... | 11/28/2006 |
| 7129067 | Method for producing lactone This invention relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid, a hydroxy fatty acid derivative, and a hydrolysate of a hydroxy ... | 10/31/2006 |
| 7091031 | Carotenoid hydroxylase enzymes A novel CrtZ carotenoid hydroxylase, isolated from Brevundimonas vesicularis DC263, is provided that is useful for the production of hydroxylated carotenoids. Additionally, a previously identified hypothetical protein from Novosphingobium aromaticivorans | 08/15/2006 |
| 7070952 | Genes encoding carotenoid compounds Genes have been isolated from Pectobacterium cypripedii encoding geranylgeranyl pyrophosphate (GGPP) synthase (CrtE), phytoene synthase (CrtB), phytoene desaturase (Crtl), lycopene cyclase (CrtY), β-carotene hydroxylase (CrtZ), and zeaxanthin glucosyl transf... | 07/04/2006 |
| 7070970 | Elongase genes and uses thereof The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. Two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, e... | 07/04/2006 |
| 7063958 | Nucleic acids db, the receptor for leptin The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and char... | 06/20/2006 |
| 7001757 | Protein This invention relates to polynucleotides, polypeptides encoded by these polynucleotides, to the production of such polynucleotides and polypeptides, and to the uses of such polynucleotides and polypeptides. More specifically, the invention relates to the phosphomev... | 02/21/2006 |
| 6955890 | Method for the identification and treatment of pathogenic microorganisms infections by inhibiting one or more enzymes in an essential metabolic pathway A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the acti... | 10/18/2005 |
| 6946283 | Ginkgo biloba levopimaradiene synthase The present invention is directed to nucleic acid sequences of Ginkgo biloba diterpene synthases, particularly of a levopimaradiene synthase. More specifically, the invention is directed to a cell of a unicellular organism, such as Saccharomyces cerevisiae... | 09/20/2005 |
| 6929941 | Chimeric cell-targeting pathogenic organism and method of therapeutic use The invention chimeric organism comprises a chimeric surface integrin-like fusion protein in which the I domain has been replaced by an antibody fragment that binds a disease-associated antigen on a cell. Binding of the antibody fragment to the disease-associated an... | 08/16/2005 |
| 6913916 | Elongase genes and uses thereof The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In p... | 07/05/2005 |
| 6908992 | Methanotrophic carbon metabolism pathway genes and enzymes Genes have been isolated from a Methylomonas sp encoding enzymes in the carbon flux pathway. The genes encode a 2-keto-3-deoxy-6-phosphogluconate (KDPGA) and a fructose bisphosphate aldolase (FFBPA), as well as numerous other genes. The genes will be useful i... | 06/21/2005 |
| 6875855 | NUCLEIC ACID AND AMINO ACID SEQUENCES OF HEMOGLOBIN-RESPONSE GENES IN CANDIDA ALBICANS AND THE USE OF REAGENTS DERIVED FROM THESE SEQUENCES IN THE DIAGNOSIS OF DISSEMINATED CANDIDA ALBICANS INFECTION Three hemoglobin-response genes in the pathogenic yeast Candida albicans are disclosed. The expression of these genes is specifically induced when the organism is exposed to hemoglobin during disseminated infections. The invention relates to the nucleic acid ... | 04/05/2005 |
| 6841370 | Site-directed mutagenesis of Escherichia coli phytase The present invention relates to an isolated mutant acid phosphatase/phytase with improved enzymatic properties. The mutant acid phosphatase/phytase composition is particularly useful in animal feed compositions. ... | 01/11/2005 |
| 6828092 | In vivo assays for modulators of sterol biosynthesis A method for the identification of agents which modulate sterol biosynthesis which method comprises contacting a test compound with a host cell comprising a DNA sequence which controls expression of a yeast acetoacetyl CoA thiolase gene operably linked to a reporter... | 12/07/2004 |
| 6824996 | Production of ascorbic acid The present invention provides for the production of ASA from yeast capable of producing ASA from KLG. The present invention provides methods for the production of ASA as well as recombinant yeast capable of producing ASA from a carbon source. ... | 11/30/2004 |
| 6803225 | Protein glycosylation modification in Pichia pastoris The present invention provides genetically engineered strains of Pichia capable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present invention are capable of expressing either or both of an (α-1,2-mannos... | 10/12/2004 |
| 6803191 | Candida albicans two-component hybrid kinase gene, CaNik1, and use thereof A Candida albicans gene, CaNik1, is involved in phenotypic switching which is significant because of a direct correlation between the switching and the level of virulence of the organism. A method of screening for anti-fungal pharmaceutical candidates entails... | 10/12/2004 |
| 6783985 | Gene disruption methodologies for drug target discovery The present invention provides methods and compositions that enable the experimental determination as to whether any gene in the genome of a diploid pathogenic organism is essential, and whether it is required for virulence or pathogenicity. The methods involve the ... | 08/31/2004 |
| 6773911 | Apoptosis-inducing factor The present invention related generally novel mammalian apoptosis-inducing factors, polynucleotides encoding such factors and methods related thereto. ... | 08/10/2004 |
| 6723540 | Manufacture of xylitol using recombinant microbial hosts Novel methods for the synthesis of xylitol are described. ... | 04/20/2004 |
| 6720151 | Therapeutic agents that inhibit the tup1 pathway A gene previously identified in the context of controlling filamentous growth in C. albicans, TUP1, plays a central role in the regulation of phenotype switching in Candida cells. Accordingly, compounds and therapeutic protocols can be screened for an ability... | 04/13/2004 |
| 6706688 | Methods for regulating bud-hypha transitions and cAMP levels by the adenylate cyclase-associated protein gene, CAP1 The infection of a mammalian host by a microorganism can be prevented or treated through the disruption of the C. albicans homologue of adenylate cyclase-associated protein gene. These methods may be used in the identification, prevention or treatment of micr... | 03/16/2004 |
