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| Number | Title | Issue Date |
| 8227236 | Engineered microorganisms with enhanced fermentation activity Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms. ... | 07/24/2012 |
| 8187859 | Modulating urea degradation in wine yeast The invention provides yeast strains transformed to reduce nitrogen catabolite repression of a gene encoding a urea degrading enzymatic activity expressed by the yeast strain under fermenting conditions. Strains of Saccharomyces cerevisiae are for example pro... | 05/29/2012 |
| 8183030 | Use of cell surface displays in yeast cell catalyst supports Methods and compositions for providing novel catalyst supports are included herein. In one embodiment, included herein are yeast cell supports including one or more receptor proteins uniformly displayed on the surface of a yeast cell having the species Saccharomy... | 05/22/2012 |
| 8137954 | Erythropoietin compositions Methods and materials are provided for the production of compositions of erythropoietin protein, wherein said compositions comprise a pre-selected N-linked glycosylation pattern as the predominant N-glycoform. ... | 03/20/2012 |
| 8129171 | Arabinose- and xylose-fermenting strains A S. cerevisiae strain expressing both arabinose and xylose utilization pathways, and in particular to a S. cerevisiae strain fermenting both arabinose and xylose to ethanol, and more particularly a S. cerevisiae strain with overexpression or up... | 03/06/2012 |
| 8093037 | Engineered microorganisms with enhanced fermentation activity Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms. ... | 01/10/2012 |
| 7901928 | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, the genes encoding phophatidylcholine-diacylglycerol acyltransferase (PDAT) a... | 03/08/2011 |
| 7879592 | Modified yeasts and uses thereof, in particular for producing steroid derivatives The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More particularly, the invention describes strains having a reduced 20αHSD type activ... | 02/01/2011 |
| 7670829 | Yeast strains autonomously producing steroids The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains. ... | 03/02/2010 |
| 7531348 | Recombinant yeast for lignocellulose raw materials The present invention relates to a method for obtaining a recombinant yeast of Saccharomyces cerevisiae, which ferments lignocellulose raw materials to ethanol, including introducing DNA into a yeast so as to cause the yeast to have introduced genes encoding ... | 05/12/2009 |
| 7524669 | Transgenic and method for bioremediation An isolated and purified transgenic Saccharomyces cerevisiae yeast cell comprising a disrupted ACR3 gene and an isolated DNA sequence comprising a promoter operably linked to a nucleic acid molecule encoding yeast cadmium factor resistance protein Ycf1p, is p... | 04/28/2009 |
| 7521223 | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, the genes encoding phophatidylcholine-diacylglycerol acyltransferase (PDAT) a... | 04/21/2009 |
| 7507574 | Recombinant expressing chimeric glucose transporters The present invention provides a modified Saccharomyces yeast which produces significantly lower levels of ethanol than wild-type yeast under aerobic conditions and saccharide concentrations of 2% glucose, and which exhibits a growth rate of at least 30% of t... | 03/24/2009 |
| 7435168 | Compositions and methods for manipulating carbon flux in cells Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods ... | 10/14/2008 |
| 7429469 | Enzyme gene participating in the synthesis of polyester and process for producing polyester using the same This invention relates to a method of producing polyesters resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) and having biodegradability and good physical properties using yeasts as hosts. By constructing at least one enzyme gene i... | 09/30/2008 |
| 7422873 | Mutant carotenoid ketolase CrtW carotenoid ketolases are provided useful for the production of astaxanthin. The ketolases genes of the present invention exhibit improved ketolase activity when converting cyclic hydroxylated carotenoid intermediates into astaxanthin. Recombinant expression of ... | 09/09/2008 |
| 7410790 | Method for producing γ-glutamylcysteine The yeast which has γ-glutamylcysteine-producing ability and is auxotrophic for pantothenic acid is proliferated in a medium containing a sufficient amount of pantothenic acid, and then it is cultured in a medium containing a limited amount of pantothenic acid to i... | 08/12/2008 |
| 7405068 | Pyruvate producing yeast strain Disclosed herein are glucose tolerant C2 carbon source-independent (GCSI) yeast strains having no detectable amount of pyruvate decarboxylase activity, wherein wild type yeast strains for the glucose tolerant C2 carbon source-independent yeast ... | 07/29/2008 |
| 7393671 | Mutant carotenoid ketolases CrtW carotenoid ketolases are provided that are useful for the production of astaxanthin and other cyclic ketocarotenoids. The mutant ketolase genes of the present invention encode polypeptides characterized by an improvement in astaxanthin synthesis activity when c... | 07/01/2008 |
| 7393669 | Metabolically engineered micro-organisms having improved galactose uptake A recombinant prototrophic micro-organism such as a yeast is provided which over-expresses the activity of an enzyme catalysing the conversion of glucose-1 phosphate to glucose-6 phosphate in the galactose uptake and metabolism pathway. Suitably the increased enzyme... | 07/01/2008 |
| 7381551 | mutant The present invention relates to a method for improved ethanol production from xylose utilizing strain of Saccharomyces cerevisiae comprising genes for overexpression of xylose reductase, xylitol dehydrogenase and xylulokinase, wherein in addition to said gen... | 06/03/2008 |
| 7355038 | Phase isolation process for biomacromolecule components The present invention relates to a phase isolation process for biomacromolecule components, after pretreating the substance to be isolated: 1) adding sufficient amount of buffer (one of the compound selected from ammonium sulfate, cesium chloride, sodium sulfate, an... | 04/08/2008 |
| 7351564 | SQS gene The present invention relates to a gene useful in a process to increase the microbial production of carotenoids. The carotenoids astaxanthin is distributed in a wide variety of organisms such as animals, algae and microorganisms. It has a strong antioxidation proper... | 04/01/2008 |
| 7335501 | Phytases and methods for producing these phytases The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel phytases derived from fungi of the Penicillium genus, in particular ... | 02/26/2008 |
| 7326550 | Yeast strains for the production of lactic acid Yeast strains transformed with at least one copy of a gene coding for lactic dehydrogenase (LDH) and further modified for the production of lactic acid with high yield and productivities, are described. ... | 02/05/2008 |
| 7312063 | Overexpression of phytase genes in yeast systems The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a h... | 12/25/2007 |
| 7309599 | Aerobic fermentation method A method and apparatus for effectively aerating large-scale cultures of microorganisms is disclosed. ... | 12/18/2007 |
| 7294493 | Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitriles to th... | 11/13/2007 |
| 7291493 | Microbially expressed xylanases and their use as feed additives and other uses The present invention relates to codon-optimized xylanase coding sequences and the expression of xylanases in microbes and yeast. The invention further relates to using multiple copies of the xylanase expression construct for high levels of protein expression. The i... | 11/06/2007 |
| 7288395 | ACC gene The present invention relates to a gene useful in a process to increase the microbial production of carotenoids. The carotenoids astaxanthin is distributed in a wide variety of organisms such as animals, algae and microorganisms. It has a strong antioxidation proper... | 10/30/2007 |
| 7285403 | Xylose-fermenting recombinant yeast strains Disclosed are xylose-fermenting recombinant yeast strains expressing xylose reductase, xylitol dehydrogenase, and xylulokinase and having reduced expression of PHO13 or a PHO13 ortholog, as well as methods of fermenting xylose to obtain ethanol using the recombinant... | 10/23/2007 |
| 7273747 | Cell having amplified signal transduction pathway responses and uses therefor The invention provides recombinant cells that have been engineered such that ligand stimulation of a receptor expressed by the cells leads to amplified signal transduction responses. In one embodiment, the receptor-expressing cells have been engineered to carry a he... | 09/25/2007 |
| 7253001 | Metabolic engineering for improved xylose utilisation of The present invention relates to a method for preparing an ethanol producing, xylose utilizing strain of Saccharomyces cerevisiae comprising genes for overexpression of xylose reductase, xylitol dehydrogenase and xylulokinase, wherein in addition to said gene... | 08/07/2007 |
| 7250263 | Methods and compositions for identifying receptor effectors The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screeni... | 07/31/2007 |
| 7244833 | Recombinant human albumin fusion proteins with long-lasting biological effects Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide h... | 07/17/2007 |
| 7238514 | Diterpene-producing unicellular organism The present invention is directed to a unicellular organism system, such as a yeast, for producing geranylgeranyl pyrophosphate and a diterpene in vivo. The yeast cell preferably comprises an inducible nucleic acid sequence encoding geranylgeranyl pyrophosphate synt... | 07/03/2007 |
| 7235715 | Virus-resistant transgenic plants expressing L3 Disclosed are transgenic plants containing an exogenous nucleic acid encoding an L3 protein. The plant exhibits increased resistance to viruses and/or fungi that infect plants. The L3 proteins include wild-type proteins, spontaneously occurring mutants and non-natur... | 06/26/2007 |
| 7223550 | Biosensor for defecting chemical agents A biosensor for the identification of olfactants, including chemical and biological agents, prefumery, explosives and pharmaceuticals. The biosensors comprise robust eukaryotic cells, such as yeast, into which at least one exogenous olfactory signaling pathway has b... | 05/29/2007 |
| 7223533 | Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The ... | 05/29/2007 |
| 7220556 | Preparation of factor XIIIa by gene manipulation The cDNA which codes for factor XIIIa has been isolated using a cDNA bank from human placenta and probes constructed on the basis of the amino acid sequence of factor XIIIa peptide fragments. It is possible with this cDNA not only to obtain factor XIIIa by gene mani... | 05/22/2007 |
