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| Number | Title | Issue Date |
| 8163533 | Methods and compositions for combinatorial-based production of multivalent recombinant antigens The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of... | 04/24/2012 |
| 8153415 | Reduced by-product accumulation for improved production of isobutanol The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may furth... | 04/10/2012 |
| 8133715 | Reduced by-product accumulation for improved production of isobutanol The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may furth... | 03/13/2012 |
| 8097448 | Genetically modified yeast of the species and closely relates species, and fermentation processes using same Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer condit... | 01/17/2012 |
| 8062879 | URA5 gene and methods for stable genetic integration in yeast A novel gene encoding P. pastoris orotate-phosphoribosyl transferase (URA5) is disclosed. Methods for producing and selecting yeast strains capable of stable genetic integration of heterologous sequences into the host genome are also provided. ... | 11/22/2011 |
| 8058053 | Modification of protein glycosylation in methylotrophic yeast The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable o... | 11/15/2011 |
| 7977084 | Primary alcohol producing organisms The invention provides a non-naturally occurring microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-n... | 07/12/2011 |
| 7935513 | Combinatorial DNA library for producing modified -glycans in lower eukaryotes The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammal... | 05/03/2011 |
| 7858360 | Use of fungal mutants for expression of antibodies The disclosure relates to a filamentous fungal cell in which an endogenous alkaline protease activity, an endogenous neutral metalloprotease activity, an endogenous serine protease activity, and an endogenous kexin maturase activity have been completely or partially... | 12/28/2010 |
| 7776581 | Method of producing an aspartic protease in a recombinant host organism A polypeptide comprising an aspartic protease such as chymosin which is modified so as to comprise at least one —N—X-T-glycosylation site and a method for producing such a polypeptide. ... | 08/17/2010 |
| 7736886 | Recombination systems and methods for eliminating nucleic acid sequences from the genome of eukaryotic organisms The invention relates to recombination systems and methods for eliminating nucleic acid sequences from the chromosomal DNA of eukaryotic organisms, and to transgenic organisms—preferably plants—which comprise these systems or were generated using these methods. | 06/15/2010 |
| 7695950 | Δ5 desaturase and its use in making polyunsaturated fatty acids The present invention relates to a Δ5 desaturase, which has the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucl... | 04/13/2010 |
| 7678560 | Δ 5 desaturase and its use in making polyunsaturated fatty acids The present invention relates to a Δ5 desaturase, which has the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucl... | 03/16/2010 |
| 7670828 | Screening method for genes of brewing yeast Provided herein are a method for selecting a gene participating in the desired brewing character and compiling a database of the whole genome sequence of industrial yeast; identifying a gene participating in a brewing characteristic from the database; functional ana... | 03/02/2010 |
| 7507573 | Modification of protein glycosylation in methylotrophic yeast The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable o... | 03/24/2009 |
| 7432246 | Sir2 products and activities A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of S... | 10/07/2008 |
| 7431927 | TNFα-neutralizing antibodies The invention provides monoclonal antibodies that neutralize TNFα activity. The monoclonal antibodies may be rabbit monoclonal antibodies or monoclonal antibodies having CDR regions derived from those rabbit monoclonal antibodies. In certain embodiments, the monocl... | 10/07/2008 |
| 7432102 | Transformants producing substance pf1022 derivatives, methods for producing the same, and novel biosynthesis genes An objective of the present invention is to provide a method for producing substance PF1022 derivatives, in particular PF1022-220 and PF1022-260, by a direct fermentation method, and a transformant to be used for this method. According to the present invention, ther... | 10/07/2008 |
| 7432079 | Plant virus coat fusion proteins with GDF8 epitopes and vaccines thereof The invention provides a fusion protein comprising a plant virus coat protein and a GDF8 peptide domain, or antigenic fragment of the GDF8 peptide domain. Plant virus vectors expressing the fusion protein and methods of using these vectors are also provided. ... | 10/07/2008 |
| 7429484 | Nucleic acid molecules encoding osteogenic proteins Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homo... | 09/30/2008 |
| 7429476 | Acid fungal proteases The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and ... | 09/30/2008 |
| 7427492 | Polynucleotides encoding human tumor necrosis factor receptor-like2 The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, ... | 09/23/2008 |
| 7427484 | Global regulator of secondary metabolite biosynthesis and methods of use The invention provides polypeptides and nucleic acids which identify and encode LaeA, a regulator of fungal secondary metabolite production which exhibits global control over secondary metabolite biosynthetic gene clusters. The invention further provides expression ... | 09/23/2008 |
| 7425450 | Regulatable growth of filamentous fungi The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemica... | 09/16/2008 |
| 7422873 | Mutant carotenoid ketolase CrtW carotenoid ketolases are provided useful for the production of astaxanthin. The ketolases genes of the present invention exhibit improved ketolase activity when converting cyclic hydroxylated carotenoid intermediates into astaxanthin. Recombinant expression of ... | 09/09/2008 |
| 7420038 | Compositions for controlling hair growth FP-1 is a protein that is specifically expressed in the follicular papilla of the hair follicle. The nucleic acid and amino acid sequences of FP-1, as well as antibodies that specifically bind FP-1 are provided. In addition, methods of isolating follicular papilla c... | 09/02/2008 |
| 7419824 | BASB006 polypeptides from and immunogenic compositions thereof The invention provides BASB006 polypeptides and polynucleotides encoding BASB006 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 09/02/2008 |
| 7416881 | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that th... | 08/26/2008 |
| 7416849 | HBM variants that modulate bone mass and lipid levels The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The i... | 08/26/2008 |
| 7416874 | Recombinant bacterial phytases and uses thereof A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digesti... | 08/26/2008 |
| 7413879 | glucoamylase and homologs thereof The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for ... | 08/19/2008 |
| 7413882 | Methods for degrading or converting plant cell wall polysaccharides The present invention relates to methods for converting plant cell wall polysaccharides into one or more products, comprising: treating the plant cell wall polysaccharides with an effective amount of a spent whole fermentation broth of a recombinant microorganism, w... | 08/19/2008 |
| 7413887 | glucoamylase and homologs thereof The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for ... | 08/19/2008 |
| 7410790 | Method for producing γ-glutamylcysteine The yeast which has γ-glutamylcysteine-producing ability and is auxotrophic for pantothenic acid is proliferated in a medium containing a sufficient amount of pantothenic acid, and then it is cultured in a medium containing a limited amount of pantothenic acid to i... | 08/12/2008 |
| 7407788 | BGL7 beta-glucosidase and nucleic acids encoding the same The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant ... | 08/05/2008 |
| 7407795 | Method for growing on a substrate and novel method for hybridizing different strains of Two different strains of Cordyceps sinensis are placed at two different locations in a medium containing purified rattle snake venom and the two strains are allowed to grow until they meet in a boundary zone where a hybrid strain is formed due to exchange of ... | 08/05/2008 |
| 7407677 | Enzymes having alpha amylase activity and methods of use thereof The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided. The alpha amylases have increased activity and stability at acidic, neutral ... | 08/05/2008 |
| 7399465 | Pharmaceutical compositions for treating arthritis and inflammatory disease The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifyin... | 07/15/2008 |
| 7399627 | Transformation system in the field of filamentous fungal hosts A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner.... | 07/15/2008 |
| 7399848 | Polynucleotides encoding growth differentiation factor-8 Disclosed are polynucleotides encoding growth differentiation factor-8 (GDF-8) useful for increasing the muscle mass in chickens. ... | 07/15/2008 |
