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| Number | Title | Issue Date |
| 7432088 | Methods for the production of ansamitocins A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins. ... | 10/07/2008 |
| 7413728 | Immune modulator Use of an immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the genera Rhodococcus, Gordonia, Nocardia, Dietzia, Tsukamurella and Nocardioides, for use in the manufacture of a medicament for the ... | 08/19/2008 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7192750 | Mutant strain with increased maytansinoid production A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and... | 03/20/2007 |
| 6790954 | Mutant Actinosynnema pretiosum strain with increased maytansinoid production A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and... | 09/14/2004 |
| 6780629 | Subtilase enzymes The present invention relates to subtilase enzymes of the I-S1 and I-S2 sub-groups having an additional amino acid in the active site loop (c) region from positions 125 to 132. The variant subtilases of the present invention exhibit improved wash performance in a de... | 08/24/2004 |
| 6767533 | Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress A composition containing a peripheral benzodiazepine receptor ligand for topical use in the treatment of cutaneous stress. ... | 07/27/2004 |
| 6699695 | Rhodococcus microorganisms and process for producing amide compounds A nitrile compound having a complicated structure (e.g., 2-hydroxy-4-methylthiobutyronitrile) is converted into an amide compound with high production efficiency, by using a novel microorganism of which the gene 16S rRNA has a specific base sequence. As t... | 03/02/2004 |
| 6632935 | Genome DNA of bacterial symbiont of aphids The present invention provides a genomic DNA of Buchnera. That is, this invention provides genes derived from Buchnera sp., comprising DNA of the following (a) or (b); (a) a DNA selected from a group consisting of a DNA having a nucleotide sequence ra... | 10/14/2003 |
| 6485939 | Isolated human transporter cofactor proteins, nucleic acid molecules encoding human transporter cofactor proteins, and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter cofactor peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid mo... | 11/26/2002 |
| 6391614 | Auxiliary gene and protein of methicillin resistant bacteria and antagonists thereof The present invention is directed to the identification of mutant strains of methicillin resistant bacteria, in particular methicillin resistant Staphylococcus aureus, to identify the characteristics of such bacteria and develop drugs that can reverse, in... | 05/21/2002 |
| 6346396 | MurA The invention provides MurA polypeptides and polynucleotides encoding MurA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurA polypeptides to screen for antibacterial compounds.... | 02/12/2002 |
| 6291230 | Galk promoter The invention provides galK promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.... | 09/18/2001 |
| 6197570 | Norcardia sp. CKYS2 ((KCTC 0432BP) capable of desulfurizing fossil fuel containing organic sulfur compounds The present invention relates to Nocardia sp. CYKS2 (KCTC 0432 Br) capable of selective removal of organically bound sulfurs from carbonaceous fossil fuel such as petroleum and coal by cleaving bonds between carbon and sulfur atoms in the said sulfur-cont... | 03/06/2001 |
| 6197543 | Human vesicle membrane protein-like proteins The invention provides three human vesicle membrane protein-like proteins (VMP) and polynucleotides which identify and encode VMP. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provid... | 03/06/2001 |
| 6124130 | Microbial catalyst for desulfurization of fossil fuels Sulfur is removed from fossil fuels containing sulfur by incubation of the fuel with microbes isolated and purified from soil or water that selectively extract the sulfur without apparently utilizing the fuel as a carbon or energy source. Preferred biodes... | 09/26/2000 |
| 6117668 | Beauvericin detoxification compositions and methods The present invention provides a bacterial microorganism having the ability to degrade or detoxify beauvericin or derivatives or analogs of beauvericin. The present invention further provides a method for detoxification of plants pre- or post-harvest usin... | 09/12/2000 |
| 6043064 | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof An enzymatic hydroxylation process for the preparation of compounds useful as HMG-CoA reductase inhibitors and/or as intermediates in the preparation of HMG-CoA reductase inhibitors uses a microorganism or an enzyme derived from, or having the structure o... | 03/28/2000 |
| 6030834 | Human IKK-beta DNA constructs and cells A novel kinase has been identified which phosphorylates I.kappa.B. Reagents which inhibit this kinase can be used as therapeutic tools to inhibit inflammation. The kinase can also be used as a target for drug screening to identify anti-inflammatory compou... | 02/29/2000 |
| 6025185 | Fungus wherein the areA gene has been modified and an areA gene from Aspergillus oryzae A modified Aspergillus oryzae cell having an area gene which does not express a functional AreA activator, DNA sequences encoding the area gene, and method for using the cell of the invention for production of a heterologous polypeptide.... | 02/15/2000 |
| 6022703 | Expression of DNA sequences derived from nocardioform microorganisms A cloning vector contains a DNA sequence derived from a Nocardioform microorganism, and is capable of expressing the DNA sequence in a host microorganism. Recombinant cholesterol oxidase is produced by a host microbial cell transformed with a cloning vect... | 02/08/2000 |
| 6001575 | Therapeutic uses of grip and grip-related molecules This invention features GRIP and GRIP-related molecules relating to a gluatamate receiptor. In one aspect, the invention provides methods for detecting expression, drug screening, and treatment of disorders involving GRIP or GRIP 2 such a neuronal and fer... | 12/14/1999 |
| 5962304 | Zearalenone detoxification compositions and methods The present invention provides a bacterial microorganism of the Rhodococcus or Nocardia species having the ability to degrade zearalenone.... | 10/05/1999 |
| 5874079 | Method for killing gram positive bacteria with isolated type II phospholipase A2 Disclosed herein are methods for killing Gram-positive bacterial infections in animals comprising exposing the bacteria to Gram-positive bactericidal-effective amounts of Type II phospholipase A2. The Type II phospholipase A2 can be isolated from mammalia... | 02/23/1999 |
| 5854058 | Method of decomposing hard type rubber products The present invention relates to a method of decomposing hard type rubber products, which comprises treating hard type rubber products with a microorganism belonging to the genus Nocardia in the presence of soft type rubber products. According to the pres... | 12/29/1998 |
| 5846812 | Zearalenone detoxification compositions and methods The present invention provides a bacterial microorganism having the ability to degrade or detoxify zearalenone or derivatives or analogs of zearalenone. The present invention also provides a method for the isolation and utilization of a zearalenone-degrad... | 12/08/1998 |
| 5807697 | Biological tracer method The present invention is a biological tracer method for characterizing the movement of a material through a medium, comprising the steps of: introducing a biological tracer comprising a microorganism having ice nucleating activity into a medium; collectin... | 09/15/1998 |
| 5798255 | Beauvericin detoxification compositions and methods The present invention provides a bacterial microorganism having the ability to degrade or detoxify beauvericin or derivatives or analogs of beauvericin. The present invention further provides a method for detoxification of plants pre- or post-harvest usin... | 08/25/1998 |
| 5714364 | Phenylalanine dehydrogenase production A method for producing in culture phenylalanine dehydrogenase at yields of 50+ units of enzyme per litre of culture, one unit measured as the amount required to convert one micro-mole of phenylalanine to phenyl pyrovic acid at 25° C. and pH 10.8, in a gr... | 02/03/1998 |
| 5622706 | Cloning and sequencing of the gene which codes for a new pilinic subunit of bordella pertussis The cloning and sequencing of the gene which codes for a new pilinic subunit of Bordetella pertussis are described. The aminoacid sequence of the mature subunit, deduced from its necleotide sequence, is similar but not identical to that of the known pilin... | 04/22/1997 |
| 5523219 | Enzymatic hydrolysis method for the preparation of C-10 hydroxyl-bearing taxanes and enzymatic esterification method for the preparation of C-10 acyloxy-bearing An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one ... | 06/04/1996 |
| 5519164 | Expression of a multigene RNA having self-splicing activity Expression of a multigene RNA having self-splicing activity An RNA is expressed which can release two or more active genes by means of inserted ribozyme structures. The expression can be carried out in plants or other organisms.... | 05/21/1996 |
| 5516649 | Process for the production of 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione from ergosterol with mycobacterium A process for the production of 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione of the general formula ##STR1## wherein . . . . . symbolizes a single bond or a double bond, characterized in that ergosterol ##STR2## is fermented wit... | 05/14/1996 |
| 5516676 | Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom Compounds useful as intermediates in the preparation of taxanes such as taxol are prepared by contacting one or more C-13 acyloxy-bearing taxanes with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. In a preferred... | 05/14/1996 |
| 5487983 | Expression systems for making single-chain monellin analogs Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corr... | 01/30/1996 |
| 5451403 | A87689 compounds Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C1-6 -alkyl ether and C1-6 -alkanoyl ester derivatives and ... | 09/19/1995 |
| 5416019 | Rhodococcus microorganisms that produce phenylalanine dehydroganase The invention is directed to obtaining phenylalanine-dehydrogenase containing microorganisms by a special selection process comprising obtaining microorganisms, especially strains of Rhodococcus and the phenylalanine-dehydrogenase obtained in them. With t... | 05/16/1995 |
| 5350579 | A87689 compounds employed as a phospholipase A2 (PLA2) inhibitor to treat inflammatory diseases Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C1-6 -alkyl ether and C1-6 -alkanoyl ester derivatives and ... | 09/27/1994 |
| 5312748 | Protease Novel alkaline serine proteases produced by Nocardiopsis sp. strains, for example by aerobic cultivation of strain 10R (NRRL-18262) and Nocardiopsis dassonvillei strain M58-1 (NRRL 18133), the proteases being characterized by a pH optimum of about 8, and ... | 05/17/1994 |
| 5312738 | A82846 antibiotics New glycopeptide antibiotic A82846, comprising A82846A, A82846B and A82846C, is produced by Nocardia orientalis strains NRRL 18098, NRRL 18099 and NRRL 18100. The A82846 antibiotics have activity against Gram-positive bacteria comparable to that of vancom... | 05/17/1994 |
