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| Number | Title | Issue Date |
| 6652849 | Anaerobe targeted enzyme mediated prodrug therapy A genetically-engineered anaerobic organism is provided which, under anaerobic conditions present in a solid tumor, produces an enzyme capable of catalyzing the conversion of a prodrug to its highly cytotoxic product in situ and methods of treating tumors... | 11/25/2003 |
| 6623775 | Treating or preventing illness growth of Clostridium difficile The present invention relates to the discovery that hop extract is useful as an antibacterial agent against the dangerous pathogens Clostridium botulinum, Clostridium difficile, and Helicobacter pylori at levels below that at which a flavor from the acids... | 09/23/2003 |
| 6620611 | Solid-chemical composition for sustained release of organic substrates and complex inorganic phosphates for bioremediation A slow-release solid chemical composition for environmental bioremediation is provided. The composition comprises a source of soluble organic substrates which include sugars, soluble organic polymers and mixtures of them in an amount of 7% to 90%, insolub... | 09/16/2003 |
| 6573241 | Therapeutic agent for the suppression of snoring noises In a method of manufacturing a therapeutic agent to be administered intramuscularly for suppressing snoring noises a high-purity Clostridium toxin BoNT/A or TeNT or at least one of a high-purity Clostridium toxin BoNT/B, BoNT/C1, BoNT/D, BoNT/E, BoNT/F an... | 06/03/2003 |
| 6558926 | Method for production of tetanus toxin using media substantially free of animal products The present invention provides a system for the growth of C. tetani and production of Tetanus Toxin for use in formulating Tetanus Toxoid preparations. The system includes growth media that contain significantly reduced levels of meat or dairy by-products... | 05/06/2003 |
| 6528498 | Selection and/or enhancement of resident microorganisms in the gastrointestinal tract Improved method of enhancing a population of one or more target micoorganisms in the gastrointestinal tract of an animal, the improvement comprising providing to the animal a selected modified or unmodified resistant starch or mixtures thereof, such that ... | 03/04/2003 |
| 6491905 | Recombinant bacterial cells for delivery of PNP to tumor cells The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in co... | 12/10/2002 |
| 6465435 | Treatment of C. difficile toxin B associated conditions This invention relates to prevention and/or treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD), pseudomembranous colitis (PMC) and other conditions associated with C. difficile infection, using oligosac... | 10/15/2002 |
| 6464986 | Method for treating pain by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.... | 10/15/2002 |
| 6416754 | Anaerobe targeted enzyme-mediated prodrug therapy A genetically-engineered anaerobic organism is provided which, under anaerobic conditions present in a solid tumor, produces an enzyme capable of catalyzing the conversion of a prodrug to its highly cytotoxic product in situ and methods of treating tumors... | 07/09/2002 |
| 6406895 | Process for the production of 1,3-propanediol by fermentation The present invention relates to a process for the production of 1,3-propanediol by the fermentation of a 1,3-propanediol-producing microorganism in a fermentation medium containing glucose, characterized in that the fermentation is carried out without me... | 06/18/2002 |
| 6368819 | Microbial process for the preparation of acetic acid as well as solvent for its extraction from the fermentation broth A modified water-immiscible solvent useful in the extraction of acetic acid from aqueous streams is a substantially pure mixture of isomers of highly branched di-alkyl amines. This solvent is substantially devoid of mono-alkyl amines and alcohols. Solvent... | 04/09/2002 |
| 6358717 | Method of producing butanol using a mutant strain of Clostridium beijerinckii The present invention relates to a method of producing high levels of butanol using a fermentation process that employs a mutant strain of Clostridium beijerinckii.... | 03/19/2002 |
| 6251461 | Antimicrobial activity of hops extract against Clostridium botulinum, Clostridium difficile and Helicobacter pylori The present invention relates to the discovery that hop extract is useful as an antibacterial agent against the dangerous pathogens Clostridium botulinum, Clostridium difficile, and Helicobacter pylori at levels below that at which a flavor from the acids... | 06/26/2001 |
| 6136577 | Biological production of ethanol from waste gases with Clostridium ljungdahlii A method and apparatus for converting waste gases from industrial processes such as oil refining, carbon black, coke, ammonia, and methanol production, into useful products is disclosed. The method includes introducing the waste gases into a bioreactor wh... | 10/24/2000 |
| 6087092 | Compositions and methods for animal husbandry and for treating gastrointestinal disorders Compositions containing hemicelluloses in combination with polyphenols, methods of preparing the compositions, and methods of treating humans or animals with the composition are provided. Also provided is a method for increasing growth rate, improving fee... | 07/11/2000 |
| 6069000 | Enzyme with pectin esterase activity The present invention relates to an enzyme with pectin esterase activity, a DNA construct encoding the enzyme with pectin esterase activity, a method of producing the enzyme, an enzyme composition comprising said enzyme with pectin esterase activity, and ... | 05/30/2000 |
| 6025170 | Process for the biotechnological production of δ-decalactone and δ-dodecalactone The invention describes a process for the preparation of δ-decalactone or δ-dodecalactone by the hydrogenation of 2-decen-5-olide and 2-dodecen-5-olide, or a derivative therof, by a bacteria capable of effecting said hydrogenation, preferably by a bacte... | 02/15/2000 |
| 5965699 | Assay for the proteolytic activity of serotype a from clostridium botulinum A label-based assay is described, through modifications of substrate strure and derivatization of serum albumin, which can be used to determine type A proteolytic activity without separation of products.... | 10/12/1999 |
| 5908758 | Microorganisms A novel category of microorganisms has been identified from its ribosomal DNA (rDNA) sequence. That sequence, P36, is characteristic of this category of microorganisms, here termed metathermophiles. Methods for isolating samples of metathermophiles using ... | 06/01/1999 |
| 5874238 | Mutant protein and methods and materials for making and using it The invention provides a mutant protein which has the same amino acid sequence as an unmutated C-reactive protein (CRP) subunit or an unmutated preCRP, except that at least one amino acid of the unmutated CRP subunit or unmutated preCRP has been deleted, ... | 02/23/1999 |
| 5874079 | Method for killing gram positive bacteria with isolated type II phospholipase A2 Disclosed herein are methods for killing Gram-positive bacterial infections in animals comprising exposing the bacteria to Gram-positive bactericidal-effective amounts of Type II phospholipase A2. The Type II phospholipase A2 can be isolated from mammalia... | 02/23/1999 |
| 5852196 | 12,13,17-trihydroxy-9(z)-octadeoenoic acid and derivatives and microbial isolate for production of the acid A novel compound, 12,13,17-trihydroxy-9(Z)-octadecenoic acid (THOA) was produced from linoleic acid by microbial transformation at 25% yield. The newly isolated microbial strain catalyzing this transformation was identified as Clavibacter sp. ALA2 (Access... | 12/22/1998 |
| 5830716 | Increased amounts of substances by modifying a microorganism to increase production of NADPH from NADH A method of producing a target substance by microbial fermentation, where the natural ability of the microorganism to produce NADPH from NADH is increased. The present method is useful for producing a wide variety of materials, such as amino acids, antibi... | 11/03/1998 |
| 5821092 | Production of 1,3-propanediol from glycerol by recombinant bacteria expressing recombinant diol dehydratase A process is provided for the bioconversion of glycerol to 1,3-propanediol in which genes from a bacteria known to possess a diol dehydratase enzyme for 1,2-propanediol degradation are cloned into a bacterial host and the host is grown in the presence of ... | 10/13/1998 |
| 5733741 | Thermocellulolytic bacteria and their uses Thermus aquaticus biovar. Nov. SK542 (FERM BP-3382) is an absolute aerobic bacteria. It grows at temperature limit of 40°-82° C. in a normal concentration medium, but its best growth is achieved at 72°-76° C. It produces protein decomposing enzymes ... | 03/31/1998 |
| 5648264 | Thermocellulolytic bacteria and their uses Clostridium thermocellum biovar. nov. SK522 (FERM BP-345 g) is a thermophilic cellulose decomposing bacteria, capable of solubilizing lignin and fermenting cellulose excellently. Although its temperature limit for growth is 40°-80° C., it grows best at ... | 07/15/1997 |
| 5593886 | Clostridium stain which produces acetic acid from waste gases A method and apparatus for converting waste gases from industrial processes such as oil refining, carbon black, coke, ammonia, and methanol production, into useful products. The method includes introducing the waste gases into a bioreactor where they are ... | 01/14/1997 |
| 5354688 | Anaerobic microbial remobilization of coprecipitated metals A process is provided for solubilizing coprecipitated metals. Metals in wastestreams are concentrated by treatment with an iron oxide coprecipitating agent. The coprecipitated metals are solubilized by contacting the coprecipitate with a bacterial culture... | 10/11/1994 |
| 5350692 | Microorganisms useful for hydrogen gas production The present invention relates to a process for preparing hydrogen gas on an industrial scale by culturing the microorganism Clostridium beijerinckii Ferm BP-3592 or the anaerobic asporogenic bacterium strain Ferm BP-3593 in a medium containing glucose and... | 09/27/1994 |
| 5350685 | Process for preparing hydrogen gas using microorganism The present invention relates to a process for preparing hydrogen gas on an industrial scale by culturing the microorganism Clostridium beijerinckii Ferm BP-3592 or the anaerobic asporogenic bacterium strain Ferm BP-3593 in a medium containing glucose and... | 09/27/1994 |
| 5332503 | Process for purifying collagenase A process for purifying crude collagenase is disclosed. The collagenase purification process includes providing a stabilized crude collagenase solution containing collagenase, pigment, toxins, bacterial materials, and proteolytic enzyme impurities includi... | 07/26/1994 |
| 5254465 | Process for manufacture of alkaline earth acetates A process for the manufacture of alkaline earth salts of acetic acid. Biomass is fermented under appropriate conditions to produce acetic acid, which is extracted from the fermentation broth with the aid of a basic liquid ion exchanger dissolved in an org... | 10/19/1993 |
| 5252481 | Mutant of bacterium Clostridium histolyticum, a process for the obtaining thereof, and its use in the production of clostripain-free collagenase A mutant of bacterium Clostridium histolyticum, designated Clostridum histolyticum K26 clo 88 of the following characteristics: the lack of a motility system which is a fundamental characteristic of the parenteral strain; and, the inability to biosynthesi... | 10/12/1993 |
| 5192673 | Mutant strain of C. acetobutylicum and process for making butanol A biologically pure asporogenic mutant of Clostridium acetobutylicum is produced by growing sporogenic C. acetobutylicum ATCC 4259 and treating the parent strain with ethane methane sulfonate. The mutant which as been designated C. acetobutylicum ATCC 550... | 03/09/1993 |
| 5173429 | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism A newly discovered microorganism was isolated in a biologically pure culture and designated Clostridium ljungdahlii, having the identifying characteristics of ATCC No. 49587. Cultured in an aqueous nutrient medium under anaerobic conditions, this microorg... | 12/22/1992 |
| 5158887 | Process for massive conversion of clostridia in synchronized cells of elongated length or refractile endospores A method is disclosed for producing specially prepared bacteria of the genus Clostridium for producing solvents, enzymes, antibiotics, toxic proteins, or spores. Cell elongation to a critical length of at least about 3x is induced in an economical, abunda... | 10/27/1992 |
| 5143845 | Mixture of saccarifying lactic acid producing and butyric acid producing bacteria A mixture of three kinds of bacteria is disclosed which is useful for humans and animals. The symbiotic mixture contains as effective ingredients lactic acid producing bacteria, saccarificating bacteria, and butyric acid producing bacteria which are usefu... | 09/01/1992 |
| 5068188 | Process for manufacture of alkaline earth acetates A process for the manufacture of alkaline earth salts of acetic acid. Biomass is fermented under appropriate conditions to produce acetic acid, which is extracted from the fermentation broth with the aid of a basic liquid ion exchanger dissolved in an org... | 11/26/1991 |
| 5047152 | Microbial stabilization and mass reduction of wastes containing radionuclides and toxic metals A process is provided to treat wastes containing radionuclides and toxic metals with Clostridium sp. BFGl to release a large fraction of the waste solids into solutin and convert the radionuclides and toxic metals to a more concentrated and stable form wi... | 09/10/1991 |