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| Number | Title | Issue Date |
| 7833778 | Continuous single vessel butanol synthesis by fermentation The present invention describes a method for producing butanol by fermentation of carbohydrates using mixed populations of acidogenic-phase cells and solventogenic-phase cells of Clostridium in a solitary vessel. The present system as described does not requi... | 11/16/2010 |
| 7732187 | Recombinant attenuated organisms and vaccine The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfrin... | 06/08/2010 |
| 7432090 | Blocking sporulation by inhibiting SpoIIE We have shown that the control of solventogenesis and sporulation can be genetically uncoupled in C. acetobutylicum. In strain 824(pASspo), the absence of SpoIIE causes sporulation to be blocked at stage II. The cell remains in a vegetative state, and this al... | 10/07/2008 |
| 7431935 | Proteins within the type E botulinum neurotoxin complex The invention features a polypeptide complex synthesized by bacteria of the genus Clostridia that contains the serotype E botulinum neurotoxin and five neurotoxin associated polypeptides having molecular weights of about 118, 80, 65, 40, and 18 kDa. re... | 10/07/2008 |
| 7425338 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 09/16/2008 |
| 7416879 | consortium for the production of materials with enhanced hydrogen content An isolated microbial consortium is described that includes a first microbial consortium having Thermacetogenium phaeum to metabolize a complex hydrocarbon substrate into metabolic products comprising an acetate compound. The consortium also includes a second... | 08/26/2008 |
| 7413742 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivativ... | 08/19/2008 |
| 7374769 | Method for treating a trigeminal neuralgia by peripheral administration of a neurotoxin Methods for treating a trigeminal neuralgia by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 05/20/2008 |
| 7361358 | Treatment of a facial pain by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 04/22/2008 |
| 7354740 | Animal product free system and process for purifying a toxin Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium. ... | 04/08/2008 |
| 7332567 | Fret protease assays for clostridial toxins The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor ... | 02/19/2008 |
| 7309592 | Ethanol production from biological wastes The invention provides methods, apparatuses, and kits for producing ethanol and other alcohols. The methods involve fermenting organic material in a fermentation mixture to a biogas comprising methane; converting at least a portion of the biogas to synthesis gas com... | 12/18/2007 |
| 7294339 | Method for treating allodynia by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 11/13/2007 |
| 7291344 | Method for treating phantom pain by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 11/06/2007 |
| 7288259 | Treatment of holocrine gland dysfunction with clostridia neurotoxins Methods of using clostridial toxins and other biological agents to control holocrine gland dysfunction in humans is provided. In preferred embodiments the methods provide beneficial effects in humans. ... | 10/30/2007 |
| 7288260 | Method for treating pain by peripheral administration of a neuroptoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 10/30/2007 |
| 7276245 | Method for treating hyperalgesia by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 10/02/2007 |
| 7273734 | Process for producing a polyester A process for producing a polyester, the process comprising the steps of (1) fermenting a saccharide with a microorganism to obtain at least one substituted α-hydroxy acid represented by the formula: HO—CHR—COOH (wherein R represents a hydrocarbon group having ... | 09/25/2007 |
| 7270826 | Methods of using toxin for the treatment of hypervolemic lip deformity (lip ectropion) The present invention uses pharmaceutical preparations of Botulinum toxin to induce neurogenic atrophy to alter muscle volume and subsequently, facial contour. Reduction in lip volume is accomplished using the disclosed methods thereby producing a favorable e... | 09/18/2007 |
| 7255865 | Methods of administering botulinum toxin Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The methods comprise the step of administering a Clostridium neuroto... | 08/14/2007 |
| 7255866 | Botulinum toxin therapy for fibromyalgia Methods for treating fibromyalgia by administering a therapeutically effective amount of a botulinum toxin to a patient with fibromyalgia. ... | 08/14/2007 |
| 7211262 | Burn pain treatment by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 05/01/2007 |
| 7189541 | Botulinum toxin production method Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-p... | 03/13/2007 |
| 7179635 | Peptides for use in culture media The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cel... | 02/20/2007 |
| 7176017 | Triphasic bioreactor and process for gas effluent treatment A triphasic bioreactor for physico-chemically treating a gas is disclosed. The triphasic bioreactor comprises a reaction chamber with a liquid and biocatalysts in suspension in the liquid, for catalyzing a reaction between the gas and the liquid to obtain a treated ... | 02/13/2007 |
| 7172763 | Post-operative pain treatment by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 02/06/2007 |
| 7160699 | Media for clostridium bacterium and processes for obtaining a clostridial toxin Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceu... | 01/09/2007 |
| 7148041 | Animal product free media and processes for obtaining a toxin Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-p... | 12/12/2006 |
| 7094588 | Variant EGIII-like cellulase compositions The present invention relates to novel variant EGIII or EGIII-like cellulases that have improved stability. The variant cellulases have performance sensitive residues replaced to a residue having modified stability. ... | 08/22/2006 |
| RE39175 | Microbial process for the preparation of acetic acid as well as solvent for its extraction from the fermentation broth A modified water-immiscible solvent useful in the extraction of acetic acid from aqueous streams is a substantially pure mixture of isomers of highly branched di-alkyl amines. This solvent is substantially devoid of mono-alkyl amines and alcohols. Solvent mixtures f... | 07/11/2006 |
| 7067300 | Process for the biological production of 1,3-propanediol with high titer The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanedio... | 06/27/2006 |
| 7052702 | Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby reduce or preferably prevent the transmission of afferent pain signal... | 05/30/2006 |
| 6984513 | Anaerobe targeted enzyme-mediated prodrug therapy Recombinant anaerobic bacterial compositions that under anaerobic conditions present in a solid tumor and produce an enzyme capable of catalyzing the conversion of a prodrug to its cytotoxic product in situ are described. Methods of treating tumors using the composi... | 01/10/2006 |
| 6977080 | Intrapericardial botulinum toxin treatment for bradycardia Methods for treating cardiac muscle disorders, such as cardiac arrhythmias, by administration of a neurotoxin to cardiac muscle are disclosed. Bradycardia can be alleviated for several months by a single intrapericardial or intracardiac injection or infusion of a bo... | 12/20/2005 |
| 6960465 | Increased cell resistance to toxic organic substances Recombinant microorganisms and related methods of use to enhance tolerance to toxic substances. In particular, such microorganisms and methods can be used to increase solvent production. ... | 11/01/2005 |
| 6927059 | Compositions and methods for identifying agents which regulate autolytic processes in bacteria A nucleic acid sequence which regulates the autolytic activity of bacteria is provided. Methods for identifying and using agents which interact with the gene to inhibit bacterial growth and infectivity also are provided. ... | 08/09/2005 |
| 6887698 | Glucuronyl C5-epimerase, DNA encoding the same and uses thereof The invention is directed to a novel purified mouse C5-epimerase, fragments thereof, nucleic acids encoding the same and the recombinant production thereof. The invention is also directed to fragments of such epimerase, especially N-terminal fragments that are usefu... | 05/03/2005 |
| 6869610 | Pain treatment by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 03/22/2005 |
| 6753170 | Microbial process for the preparation of acetic acid, as well as solvent for its extraction from the fermentation broth A modified water-immiscible solvent useful in the extraction of acetic acid from aqueous streams is a substantially pure mixture of isomers of highly branched di-alkyl amines. Solvent mixtures formed of such a modified solvent with a desired co-solvent, preferably a... | 06/22/2004 |
| 6713444 | Buforin I as a specific inhibitor and therapeutic agent for botulinum toxin B and tetanus neurotoxins The compounds of the invention are generally described by the formula: X1X2B3X4B5X*6X7X8 B9X10B11X1... | 03/30/2004 |
