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| Number | Title | Issue Date |
| 8183029 | Replicable expression vector for bacterial expression of a mammalian polypeptide Refractile particles containing a heterologous polypeptide as an insoluble aggregate are recovered from bacterial periplasm. The process involves culturing bacterial cells so as to express nucleic acid encoding phage lysozyme and nucleic acid encoding the heterologo... | 05/22/2012 |
| 8178339 | Reduced genome Reduced genome strains of E. coli MG1655 are described. In various embodiments, the strains have one or more of equal or improved growth rate, transformation efficiency, protein expression, DNA production, DNA yield and/or DNA quality compared to the parental... | 05/15/2012 |
| 8178338 | Inducible expression vectors and methods of use thereof The present invention provides nucleic acids that include a promoter that is inducible by a transcriptional activator protein; and a nucleotide sequence that encodes the transcriptional activator protein. The present invention provides expression vectors that provid... | 05/15/2012 |
| 8178340 | Human specific strains The present invention relates to human specific Escherichia coli strains. ... | 05/15/2012 |
| 8148137 | Mutant microorganism having improved production ability of branched amino acid and method for preparing branched amino acid using the same The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant microorganisms. More specifically, relates to mutant microorganisms having impro... | 04/03/2012 |
| 8012739 | Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA synthetase pairs This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are al... | 09/06/2011 |
| 8003368 | Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which enco... | 08/23/2011 |
| 8003367 | Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which enco... | 08/23/2011 |
| 7985575 | Single protein production in living cells facilitated by a messenger RNA interferase The present invention describes a single-protein production (SPP) system in living E. coli cells that exploits the unique properties of an mRNA interferase, for example, MazF, a bacterial toxin that is a single stranded RNA- and ACA-specific endoribonuclease,... | 07/26/2011 |
| 7935512 | Colicinogenic strain of Described herein is the isolation of colicin-producing strains of E. coli for use as probiotic treatments for the prevention of E. coli K88+ diarrhea. These strains of E. coli, designated as UM-17, and UM-19, express a filament and produce colic... | 05/03/2011 |
| 7935511 | Aerobic succinate production in bacteria Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid. ... | 05/03/2011 |
| 7927859 | High molar succinate yield bacteria by increasing the intracellular NADH availability The invention relates to increasing the yield of succinate in bacteria by increasing the intracellular availability of cofactors such as NADH. ... | 04/19/2011 |
| 7892811 | Controlled lysis of bacteria The present invention relates to the simple, gentle, and efficient extraction of biological material from Escherichia coli (E. coli). The use of E. coli in research laboratories depends on the ability to prepare lysates to isolate the desired pr... | 02/22/2011 |
| 7893032 | NgR variants and compositions thereof for suppressing axonal growth inhibition The invention provides compositions and methods for interfering with Nogo-receptor mediated signaling and mediating axonal growth. The invention also provides methods for treating central nervous system diseases, disorders or injuries. ... | 02/22/2011 |
| 7858359 | Method for tapping the immunological repertoire The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are ... | 12/28/2010 |
| 7855066 | Methods for making Apo-2 ligand using divalent metal ions Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided... | 12/21/2010 |
| 7833776 | Lipidating sequences and use thereof for producing lipidated proteins in Production in E. coli of a lipidated fusion protein containing a lipidating sequence derived from Ag473 and a target polypeptide. ... | 11/16/2010 |
| 7807444 | Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence... | 10/05/2010 |
| 7767431 | strains which over-produce L-threonine and processes for the production of L-threonine by fermentation The present invention relates to the fields of microbiology and microbial genetics. More specifically, the invention relates to novel bacteria strains and processes employing these strains for the fermentative production of amino acids such as threonine. ... | 08/03/2010 |
| 7749746 | Nucleic acid encoding 238P1B2 useful in detecting cancer A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a ... | 07/06/2010 |
| 7741101 | Escherichia strain capable of converting XMP to GMP and maintaining the inactivated state of gene(s) associated with GMP degradation and methods of using the same Provided are mutant strains derived from Escherichia sp. GPU1114 (Accession No. KCCM-10536), having cumulative inactivation of deoD, aphA, appA, and hprt genes, and methods of using the same. ... | 06/22/2010 |
| 7723097 | strains that over-produce L-threonine and processes for their production The invention relates to novel bacterial strains and constructs as well as methods for production of L-amino acids, including but not limited to L-threonine. Such novel bacterial strains may be characterized by, for instance, Escherichia coli strains in which... | 05/25/2010 |
| 7687253 | strains which over-produce L-threonine and processes for the production of L-threonine by fermentation The present invention relates to the fields of microbiology and microbial genetics. More specifically, the invention relates to novel bacteria strains and processes employing these strains for the fermentative production of amino acids such as threonine. ... | 03/30/2010 |
| 7662609 | host cells with modified PhoS/PstS periplasmic phosphate-binding proteins, and method of manufacturing recombinant fabs The present invention provides an Ecoli host cell expressing a recombinant antibody characterized in that the Ecoli host cell has been genetically modified in order to change at least one physical property of one or more Ecoli proteins which in ... | 02/16/2010 |
| 7629162 | Materials and methods for efficient lactic acid production The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a gr... | 12/08/2009 |
| 7618803 | Method for producing L-amino acid using bacteria belonging to the genus A method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine is provided using Escherichia bacteria wherein the L-amino acid productivity of the bacteria is enhanced by increasing the activity of proteins encoded by the b268... | 11/17/2009 |
| 7618804 | Method for producing L-amino acid using bacteria belonging to the genus There is provided a method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine using a bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of the bacterium is enhanced by enhancing the activiti... | 11/17/2009 |
| 7553655 | Bacterial host cell for the direct expression of peptides Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful co... | 06/30/2009 |
| 7541174 | Bacterial host cell for the direct expression of peptides Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful co... | 06/02/2009 |
| 7517679 | Recombinant watermelon () hydroperoxide lyase and uses thereof Recombinant watermelon (Citrullus lanatus)hydroperoxide lyase protein, DNA sequences encoding the protein, vectors containing the DNA sequences and hosts containing the vectors are provided, together with methods for recombinantly producing watermelon hydrope... | 04/14/2009 |
| 7494801 | Method of selecting strain which highly expresses exogenous genes, mutant strains selected by this method and process for producing enzymes and compounds using the same The invention relates to a selection method of an Escherichia coli mutant strain which expresses an exogenous gene at a high level, wherein stress resistance such as hydrogen peroxide decomposition activity is used as an index, the Escherichia coli mut... | 02/24/2009 |
| 7476531 | Method for producing L-amino acid using bacteria belonging to the genus There is provided a method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine using bacterium belonging to the genus Escherichia wherein L-amino acid productivity of the bacterium is enhanced by enhancing an activity of pro... | 01/13/2009 |
| 7468269 | Reagents for recombinogenic engineering and uses thereof The present invention features homologous recombination methods and systems. The methods and systems promote highly efficient homologous recombination in cells (e.g., in prokaryotic cells). The methods and systems are useful, for example, in pharmaceutical drug deve... | 12/23/2008 |
| 7452710 | Process for the biological production of 1,3-propanediol with high titer The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanedio... | 11/18/2008 |
| 7442787 | Polynucleotide The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE). The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or... | 10/28/2008 |
| 7435804 | Method for obtaining single chain antibodies to human interferon α2b A bacterial high-expression system which is applicable for simultaneous screening of large numbers of recombinant clones from combinatorial antibody libraries is disclosed. The method pertains to screening of single chain antibodies from libraries expressed in the p... | 10/14/2008 |
| 7435168 | Compositions and methods for manipulating carbon flux in cells Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods ... | 10/14/2008 |
| 7432095 | Formate dehydrogenase tolerant to halogen compounds and process for producing the same The invention provides a formate dehydrogenase having high specific activity, small Km values for formate and NAD, broad temperature and pH ranges of stability, broad temperature and pH ranges for action, and capable of regenerating a coenzyme with good efficiency i... | 10/07/2008 |
| 7432419 | Compositions and methods for the treatment of Pierce's disease Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a su... | 10/07/2008 |
| 7432091 | Highly efficient hydrogen production method using microorganism It is intended to obtain anaerobic microbial cells in an amount sufficient for hydrogen generation reaction, impart a hydrogen generation function to an aerobic microorganism within a short time and provide an industrial advantageous method of producing hydrogen. | 10/07/2008 |
