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| Number | Title | Issue Date |
| 4666837 | DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits DNA sequences and recombinant DNA molecules comprising at least a portion coding for all or part of subunits A and/or B of cholera toxin are prepared by enzymatic digestion of DNA of V. cholerae strains, isolating specific fragments and inserting them in ... | 05/19/1987 |
| 4659669 | Microbial expression of human influenza hemagglutinin proteins Disclosed herein are methods and means for microbially expressing human influenza hemagglutinin proteins, useful in the preparation of vaccines, by recombination of DNA gene sequences coding for hemagglutinin protein with microbially operable promoter-ope... | 04/21/1987 |
| 4657858 | Cloning vectors comprising a restriction site bank and the construction thereof Vectors are disclosed for cloning any foreign DNA in prokaryotic and eukaryotic organisms, which vectors comprise a restriction site bank containing a large number of unique restriction sites. The disclosed vectors permit the cloning of large DNA fragment... | 04/14/1987 |
| 4656136 | Method for producing L-aspartic acid A novel microorganism of the genus Serratia containing a hybrid plasmid prepared by integrating a plasmid with a deoxyribonucleic acid carrying the gene for aspartase which is obtained from a microorganism of the genus Serratia. An industrially advantageo... | 04/07/1987 |
| 4650765 | Biologically pure culture of Streptoverticillium stramineum sp. nov. This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208 and LL-BO1208ଲ produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum ... | 03/17/1987 |
| 4643975 | Novel cloning vectors for use in streptomyces, escherichia coli and related organisms The present invention discloses novel selectable recombinant DNA cloning vectors for use in Streptomyces, E. coli and related organisms. The invention further comprises transformants of the aforementioned vectors.... | 02/17/1987 |
| 4637980 | Externalization of products of bacteria A bacterial product is made by transforming a temperature sensitive lysogen with a DNA molecule which codes, directly or indirectly, for the product, culturing the transformant under permissive conditions and externalizing the product by raising the tempe... | 01/20/1987 |
| 4632830 | Oral vaccine for immunization against enteric disease A living, attenuated, oral vaccine system is described for the immunization gainst enteric disease. This oral vaccine is a genetic hybrid derivative of an attenuated galactose epimeraseless strain of S. typhi which carries at least one protective antigen o... | 12/30/1986 |
| 4626504 | DNA transfer vector for gram-negative bacteria Modified E. coli vectors are disclosed that are mobilizable to a wide range of gram-negative bacteria, but are not self-transmissible. The modified E. coli plasmids replicate only in bacterial strains of the E. coli group. Mobilizer strains of E. coli are... | 12/02/1986 |
| 4594323 | Hybrid DNA conferring osmotic tolerance Non-conjugative episomes characterized by having a mutated proBA region are provided for conferring osmotic tolerance on osmotically sensitive hosts. The mutated DNA sequence overproduces at least one enzyme in the biosynthetic pathway for an amino acid w... | 06/10/1986 |
| 4582800 | Novel vectors and method for controlling interferon expression Improved vectors and methods for regulating the expression in bacteria of a eucaryotic anti-viral protein, such as mature human immune interferon, the gene for which has been cloned onto a bacterial plasmid, is disclosed. The improved vectors incorporate ... | 04/15/1986 |
| 4581335 | Process for producing a cloned luciferase-synthesizing microorganism A process for producing a cloned luciferase-synthesizing microorganism, capable of the expression of bioluminescence, is disclosed. The process involves isolation and digestion of the genomic DNA of an appropriate bioluminescent microorganism, such as Vib... | 04/08/1986 |
| 4569908 | Multiclass hybrid interferons New multiclass hybrid interferon polypeptides, their corresponding encoding recombinant DNA molecules and transformed hosts which produce the new interferons are described. The amino acid sequences of these hybrids include at least two different subsequen... | 02/11/1986 |
| 4562155 | Hybrid viral plasmid and microorganisms containing same pML BK is a hybrid plasmid which is constructed of :pML which contains the entire nucleotide sequence of the plasmid pBR322 except for deletion of nucleotide sequences 1120-2490 bp and 0 to 375 bp, and BK which contains the entire nucleotide sequence of t... | 12/31/1985 |
| 4559302 | DNA for directing transcription and expression of structural genes The present invention relates to a novel transcriptional and translational activating sequence. The novel activating sequence can be either chemically synthesized or isolated on a 0.17 kb PstI-SacI restriction fragment from plasmid pKC203, a plasmid of E.... | 12/17/1985 |
| 4550081 | Non-reverting salmonella Salmonella typhimurium strain SL1479, ATCC No. 39183 and Salmonella dublin strain SL1438, ATCC No. 39184 are provided which are useful as live vaccines. The vaccines are prepared by introducing at least one modification in a gene involved in at least one,... | 10/29/1985 |
| 4540667 | Fluorescent siderophore genes DNA sequences encoding for plant growth promotant activity have been isolated and introduced into microorganisms. The modified organisms are able to confer plant growth promotant activity analogous to that of the DNA source host. Such modified hosts find ... | 09/10/1985 |
| 4535060 | Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthetase, production and use Enhanced resistance to glyphosate, an inhibitor of the aromatic amino acid biosynthesis pathway, is imparted to a glyphosate sensitive host. A mutated aroA gene is employed which expresses 5-enolpyruvyl-3-phosphoshikimate synthetase (EC: 2.5.1.19) (ES-3-P... | 08/13/1985 |
| 4530901 | Recombinant DNA molecules and their use in producing human interferon-like polypeptides Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying a biological or immunological activity of human interferon, the gene coding for these polypeptides and methods of making and using these molecules, hosts, gene... | 07/23/1985 |
| 4530904 | Method for conferring bacteriophage resistance to bacteria A novel method for protecting a bacterium from a naturally occurring bacteriophage and the cloning vectors and transformants for carrying out the aforementioned method are disclosed.... | 07/23/1985 |
| 4520106 | Tartrate catabolism gene DNA sequences which are capable of expressing a polypeptide with the ability to catabolize L-tartrate are incorporated into suitable vectors and used to transform both prokaryotic and eukaryotic hosts.... | 05/28/1985 |
| 4517294 | Human antithrombin III A DNA sequence encoding human antithrombin III, cloning vehicles and cells containing that DNA sequence.... | 05/14/1985 |
| 4514502 | Composite plasmid A composite plasmid which comprises (A) a drive-unit region derived from a plasmid a capable of propagating in a Coryneform glutamic acid-producing bacterium, and (B) a gene fragment derived from a plasmid b capable of propagating in Escherichia coli or B... | 04/30/1985 |
| 4513086 | Cloning vectors for use in streptomyces and related organisms The present invention discloses selectable recombinant DNA cloning vectors for use in Streptomyces and related organisms.... | 04/23/1985 |
| 4508826 | Bacteriophage DNA cloning vector TG1 and microorganisms containing TG1 Disclosed is the novel bacteriophage TG1, TG1 derivatives, and the corresponding genome or nucleic acid components of such bacteriophages and derivatives of such genome, which are useful as DNA cloning vectors into organisms, such as bacteria, for example... | 04/02/1985 |
| 4508823 | Gene splicing method and products produced therefrom An improved gene splicing and recombinant plasmid transformation method is described. The method includes mechanical fragmenting of chromosomal DNA followed by conventional digestion with a restriction enzyme and gene splicing into a vector to provide rec... | 04/02/1985 |
| 4503155 | Multifunctional, cloning vectors for use in Streptomyces, Bacillus, and E. coli The present invention discloses multifunctional recombinant DNA cloning vectors for use in Streptomyces, Bacillus, and E. coli. The invention further discloses transformants of the aforementioned vectors.... | 03/05/1985 |
| 4472502 | Malolactic gene DNA sequences which are capable of converting L-malate into L-lactate are incorporated into suitable vectors and used to transform both prokaryotic and eukaryotic hosts. The DNA sequences and vectors are particularly useful in conferring the ability to pe... | 09/18/1984 |
| 4416994 | Plasmid pEL7 and related cloning vectors for use in streptomyces and related organisms The present invention discloses selectable pairs of recombinant DNA cloning vectors for use in Streptomyces and related organisms.... | 11/22/1983 |
| 4399220 | Stabilizing lactobacilli A process for producing a stable culture of a microorganism of the genus Lactobacillus containing at least one extrachromosomal genetic element which, on the one hand, stimulates its ability to produce lactic acid from lactose and which, on the other hand... | 08/16/1983 |
| 4387162 | Hybrid plasmids and microorganisms containing them A hybrid plasmid comprising at least the DNA of a bacterial plasmid, all or part of the DNA of the 2μ plasmid of yeast and a segment of DNA including the gene URA3+ of yeast. These plasmids are useful as vectors of exogenous DNA in ... | 06/07/1983 |
| 4375514 | Preparation and use of recombinant plasmids containing genes for alkaline phosphatases PhoA mutant E. coli SB44, prepared by mutation of E. coli HB101 with an N-nitroso compound, can be used to identify and isolate recombinant plasmids into which a phoA gene has been incorporated. These plasmids can be used to transform bacteria which can b... | 03/01/1983 |
| 4374927 | Extrachromosomal regulation of expression Microbiological methods, compositions and transformants are used for production of organic products for controlling cellular properties. Extrachromosomal elements are used which are subject to external modulation for production of a control element. The c... | 02/22/1983 |
| 4337314 | Genetically attenuated bacterial vaccines with multiple mutations of the same phenotype A vaccine composition comprising a genetically attenuated bacterial strain which contains at least two mutations of the same phenotype which strain is rendered avirulent while retaining immunogenicity.... | 06/29/1982 |
| 4322499 | Adrenocorticotropin-lipotropin precursor gene A technique suitable for cloning a cDNA having a base sequence coding for the ACTH/LPH precursor is disclosed. The invention is exemplified by the cloning of a cDNA fragment comprising a base sequence coding for the endorphin region. The fragment, hereina... | 03/30/1982 |
