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Patent No. 5970981

Mouthguard made at least partially from an edible candy

A mouthguard includes a U-shaped upper bite plate which removably fits over upper teeth of a person, with the entire upper bite plate being made from a soft, deformable and edible gummi candy.

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Class 435/252.3 - Transformants (e.g., recombinant DNA or vector or foreign or exogenous gene containing, fused bacteria, etc.)


Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter wherein the genotype of the microorganism
No. of patents: 9608
Last issue date: 05/22/2012


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NumberTitleIssue Date
7943363Methods and compositions for improving the production of products in microorganisms
Methods and compositions are provided for improving the production of products, such as fuel products like ethanol, in microorganisms. In particular, methods and compositions are described for improving ethanol production utilizing genes identified in Clostridium...
05/17/2011
7935510Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-ba...
05/03/2011
7915026Host cells for production of isoprenoid compounds
Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl...
03/29/2011
7901924Increased bacterial CoA and acetyl-CoA pools
Methods of increasing the cellular pool of A-CoA and thus driving the metabolic pathways in the direction of A-CoA containing metabolites by overexpressing rate limiting enzymes in A-CoA synthesis. Methods of increasing intracellular levels of CoA and A-CoA through ...
03/08/2011
7892810Corynephage integrase-based site-specific insertion vector system
The present invention provides a system for site-specific directed gene insertion of desired genes or foreign DNA into cellular genomes. The system includes novel vectors for integrating DNA into the genome of different hosts. Methods of using the vectors and transf...
02/22/2011
7888101Host cells comprising alpha 1,2 mannosidase and culture methods thereof
Improved host cells and culture methods involving overexpression of MAN1C1 activity to improve protein production are provided. ...
02/15/2011
7888102Cell line for producing coronaviruses
The invention relates to the production of coronaviruses. In particular, the invention relates to methods for producing SARS-CoV by using cells expressing a functional SARS-CoV receptor. ...
02/15/2011
7888100Isolated nucleic acid molecules which encode immunogenic portions of NY-ESO-1 protein
The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts. ...
02/15/2011
7867749Nematode phosphoethanolamine N-methyltransferase-like sequences
Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and po...
01/11/2011
7858358Rapid growing microorganisms for biotechnology applications
The present invention provides novel rapidly growing microorganisms and methods for their use in cloning or subcloning nucleic acid molecules. The rapid growing microorganisms of the present invention form colonies more rapidly than microorganisms typically used in ...
12/28/2010
7855064Antibiotic resistance free vaccines and methods for constructing and using same
The present invention provides Listeria strains that express a heterologous antigen and a metabolic enzyme, and methods of generating same. ...
12/21/2010
7846710Cell comprising an intein for the production of a cyclic peptide
Methods of producing cyclic peptides and splicing intermediates of peptides in a looped conformation are disclosed. The methods utilize the trans-splicing ability of split inteins to catalyze cyclization of peptides from a precursor peptide having a target peptide i...
12/07/2010
7842493Cell lines having enhanced cell longevity and protein expression
It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for protein production. The inventors have discovered that the expression ...
11/30/2010
7842492Compositions of and methods of using sulfatases from flavobacterium heparinum
This invention is related, in part, to sulfatase enzymes and methods of their use. ...
11/30/2010
7838278Compositions and methods for manipulating carbon flux in cells
Nucleotide and protein sequences that encode enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods of manipulating carbon flux in a cell also ...
11/23/2010
7833775Modified free-living microbes, vaccine compositions and methods of use thereof
Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modif...
11/16/2010
7807442PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding bi...
10/05/2010
7807441Methods for therapeutic vaccination
A method is disclosed for inducing cell-mediated immunity against cellular antigens. More specifically, the invention provides for a method for inducing cytotoxic T-lymphocyte immunity against weak antigens, notably self-proteins. The method entails that antigen pre...
10/05/2010
7803603Nematode ATP synthase subunit E polypeptide
Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like n...
09/28/2010
7803602Method for overexpression of zwitterionic polysaccharides
The present invention is directed to methods for producing and selecting new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant stra...
09/28/2010
7803601Production and secretion of glucose in photosynthetic prokaryotes (cyanobacteria)
The present invention includes compositions and methods for making and using an isolated cyanobacterium that includes a portion of an exogenous bacterial cellulose operon sufficient to express bacterial cellulose, whereby the cyanobacterium produces extracellular gl...
09/28/2010
7795001Midecamycin biosynthesis genes
The present invention provides an isolated polypeptide comprising a nucleotide sequence encoding a protein which is involved in midecamycin biosynthesis, wherein the protein contains an amino acid sequence selected from SEQ ID NOs: 2 to 10, 13, 14, 16, 19, 20, 22 to...
09/14/2010
7785859Methods for displaying (poly)peptides/proteins on bacteriophage particles via disulfide bonds
The present invention relates to methods for displaying (poly)peptides/proteins on the surface of bacteriophage particles by attaching the (poly)peptide/proteins via disulfide bonds. ...
08/31/2010
7785860Method for producing L-histidine using bacteria which has an enhanced gene produced
A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the AICAR transformylase-IMP cyclohydrolase encoded by the purH gene. ...
08/31/2010
7785861Hyperphotosynthetic organisms
The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for ...
08/31/2010
7771981Heparin/heparosan synthase from and methods of making and using same
The presently claimed and disclosed invention relates, in general, to dual action heparin synthases and, more particularly, to dual action heparin synthases obtained from Pasteurella multocida. The presently claimed and disclosed invention also relates to hep...
08/10/2010
7763452Purification of HER-2 variants
The present invention provides for a novel method for purification of EGFR family proteins obtained from cultures of insect cells. The process comprises subsequent steps of a) diafiltration and exchange of culture medium with buffer, b) immobilized metal affinity ch...
07/27/2010
7759107Thermostable nucleic acid polymerase from
A purified thermostable enzyme is derived form the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant, retains approximately 90% of its activity after incubation for two hours at 95° C. in the presence of stabilizi...
07/20/2010
7759106Construction of live attenuated vaccine strains that express CFA/I antigens (CfaB and CfaE) and the B subunit of heat-labile enterotoxin (LTB) from enterotoxigenic
With the goal of creating a combination vaccine against Shigella and other diarrheal pathogens we have constructed a prototype vaccine strain of Shigella flexneri 2a (SC608) that can serve as a vector for the expression and delivery of heterologous ant...
07/20/2010
7754466Method for producing dipeptides
The present invention provides a method of producing a dipeptide from starting materials that are available at low costs through a route industrially advantageous and simple. Dipeptides are produced from amino acid esters and amino acids by using a culture of a micr...
07/13/2010
7754467Surface expression of biologically active proteins in bacteria
Methods and compositions for targeting heterologous polypeptides to bacterial cell walls are provided. ...
07/13/2010
7754468Lipolytic enzyme ELIP
The present invention provides a novel nucleic acid sequence, designated ELIP, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding a...
07/13/2010
7745198Method of producing macrolide compound
The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula ...
06/29/2010
7741100Method for highly expressing recombinant glucose dehydrogenase derived from filamentous fungi
The present invention provides a method for highly expressing a recombinant FAD-GDH protein derived from filamentous fungi, protein obtained by the method, and a regent for measuring glucose using the protein. According to the invention, the FAD-GDH can be highly ex...
06/22/2010
7736882Host cells for production of isoprenoid compounds
Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl...
06/15/2010
7736881Antibacterial and herbicidal compounds and system for screening the same
A transgenic bacterial host cell that can be used as a screen for novel antibiotics and herbicides is provided. The genome of the transgenic bacterial host cell comprises disruptions in a first endogenous gene in the MEP pathway) and a transgene that functionally re...
06/15/2010
7732185Plasmid having response to dioxins, transgenic cell for measuring dioxins, dioxins sensing method and biosensor using the same
A plasmid comprising a gene, which is reactive with dioxins and/or polycyclic aromatic hydrocarbons to thereby be activated (hereinafter referred to as DRE gene), and a secretory marker protein expressing gene disposed understream of the DRE gene. Further, there is ...
06/08/2010
7732186Recombinant methods and materials for producing epothilone and epothilone derivatives
Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemothera...
06/08/2010
7723096Agonist peptides of carcinoembryonic antigen (CEA) and nucleic acid sequences encoding the agonist peptides
A nucleic acid molecule encoding an amino acid sequence consisting of an agonist of a MHC class I binding native sequence of CEA having an amino acid substitution and enhanced immunogenicity compared to the native sequence is described. A vector comprising the nucle...
05/25/2010
7718414Microorganism of genus haboring genes associated with L-carnitine biosynthesis and method of producing L-carnitine using the microorganism
Provided is a microorganism that belongs to Enterobacteriacae and a method of producing L-carnitine using the same. The microorganism includes polynucleotide encoding activity of S-adenosylmethionine-6-N-iysine methyltransferase from Neurospora crassa, polynucleotid...
05/18/2010
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