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| Number | Title | Issue Date |
| 7670826 | Confluence regulated adhesion molecules useful in modulating vascular permeability The invention relates to new polypeptides in isolated form belonging to a subfamily of the human immunoglobulin superfamily, which polypeptide shows at least 70% sequence homology with the amino acid sequence of the murine Confluency Regulated Adhesion Molecules 1 o... | 03/02/2010 |
| 7670825 | Method for enhancing production of isoprenoid compounds The present invention provides methods of producing an isoprenoid or an isoprenoid precursor in a genetically modified host cell. The methods generally involve modulating the level of hydroxymethylglutaryl-CoA (HMG-CoA) in the cell, such that the level of HMG-CoA is... | 03/02/2010 |
| 7670823 | Compositions for use in recombinational cloning of nucleic acids The present invention relates generally to compositions and methods for use in recombinational cloning of nucleic acid molecules. In particular, the invention relates to nucleic acid molecules encoding one or more recombination sites or portions thereof, to nucleic ... | 03/02/2010 |
| 7670824 | Multicopy-integration of heterologous genes and expression in The integration of genes into methylobacterium, such as M. extorquens ATCC is disclosed, using a transposon system, preferably the mini-Tn7 transposon system, and under the control of a promoter, such as the strong methanol dehydrogenase promoter (PmxaF | 03/02/2010 |
| 7666655 | bacteria transformed with the yddG gene to enhance L-amino acid producing activity The present invention relates to a method for producing L-amino acid, such as L-phenylalanine and L-tryptophan, is provided using bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an ... | 02/23/2010 |
| 7659105 | Methods and compositions for butanol production A butanol producing cell and a method for the production of butanol are provided. Butanol producing cells comprising a butanol synthesis system or butanol export proteins may be used to enhance the production of butanol from a carbon substrate composition. ... | 02/09/2010 |
| 7655453 | Recombinant lipases The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, ... | 02/02/2010 |
| 7642082 | Methods for determining the presence of staphylococcal enterotoxin A gene in a sample The present invention relates to methods and assays for determining the presence of staphylococcal enterotoxin A in a sample through detection of a nucleic acid encoding staphylococcal enterotoxin A. ... | 01/05/2010 |
| 7642083 | Biocatalytic synthesis of quinic acid and conversion to hydroquinone by recombinant microbes A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided. ... | 01/05/2010 |
| 7629160 | Vectors and methods for enhanced cell longevity and protein expression It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for protein production. The inventors have discovered that the expression ... | 12/08/2009 |
| 7629161 | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism A process is provided for the bioconversion of a carbon substrate to 1,3-propanediol by a single organism utilizing microorganisms containing the genes encoding for an active glycerol or diol dehydratase enzyme by contacting these organisms with a carbon substrate u... | 12/08/2009 |
| 7625744 | Biologically based test system The invention is concerned with a biologically based test system for the detection of inorganic and organic pollutants in water samples. In particular, the present invention is concerned with the development of a strategy for the control of background expression of ... | 12/01/2009 |
| 7611884 | nucleic acid molecules The present invention relates to immunogenic Toxoplasma gondii proteins, to T. gondii nucleic acid molecules, including those that encode such proteins and to antibodies raised against such proteins. The present invention also includes methods to obtai... | 11/03/2009 |
| 7611883 | Plasmid maintenance The invention relates to a system for stable maintenance of a plasmid, to host cells for use in this system and to methods of using the system to obtain a plasmid useful in medical applications. In particular, the invention provides transformed host cell containing:... | 11/03/2009 |
| 7604980 | Protein expression system The present invention relates to proteomics, especially downstream processing of proteins. The present invention also relates to novel expression cassettes having unique cleavage sites for efficient removal of purification tags. The invention further provides expres... | 10/20/2009 |
| 7601531 | polynucleotides and uses thereof The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication pr... | 10/13/2009 |
| 7595185 | Cytotoxin-based biological containment Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and si... | 09/29/2009 |
| 7595186 | Cytotoxin-based biological containment Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including E. coli relBE locus and simila... | 09/29/2009 |
| 7588930 | Compositions and methods for enhancing the immunogenicity of antigens The present invention includes compositions, methods and kits for enhancing the immunogenicity of an antigen via fusion to a Listerial protein. The present invention further encompasses Listeria vaccine strains for enhancing the immunogenicity of an antigen. | 09/15/2009 |
| 7585658 | Staphylococcus aureus antigenic polypeptides and compositions The invention relates to a method for the identification of antigenic polypeptides expressed by pathogenic microbes; vaccines comprising such polypeptides; recombinant methods to manufacture such polypeptides; and therapeutic antibodies directed to such polypeptides... | 09/08/2009 |
| 7585659 | Carotene synthase gene and uses therefor Described herein is a novel three domain gene from Schizochytrium, denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is t... | 09/08/2009 |
| 7582465 | Beta secretase genes Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides. ... | 09/01/2009 |
| 7575913 | Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication p... | 08/18/2009 |
| 7569380 | Simultaneous anaerobic production of isoamyl acetate and succinic acid In vivo method of producing esters from acetyle coA, such as isoamyl acetate and succinate, has been developed by producing null mutants in pathways that use acetyl coA and by overexpressing products that use NADH and in order to maintain the proper redox balance be... | 08/04/2009 |
| 7569379 | Pentose-fermentative transformed zymobacter microorganisms This invention provides transformed microorganisms which can produce ethanol from pentose, by introducing pentose metabolizing enzymes into microorganisms belonging to genus Zymobacter which cannot utilize pentose. ... | 08/04/2009 |
| 7566563 | Compositions and methods for manipulating carbon flux in cells Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods ... | 07/28/2009 |
| 7563611 | Recombinant microorganism The present invention provides a recombinant microorganism obtained by transferring, into a host microorganism which is capable of producing protein or polypeptide with increased productivity and which was identified by the present inventors, a gene encoding a prote... | 07/21/2009 |
| 7563612 | Recombinant bifunctional protein of human lutropin receptor and human chorionic gonadotropin B-subunit and uses thereof The present invention relates to a chimeric nucleic acid molecule encoding a fusion protein having a human lutropin hormone-receptor domain and a human chorionic gonadotropin-β subunit domain, the isolated human lutropin hormone-receptor/human chorionic gonadotropi... | 07/21/2009 |
| 7560265 | Compositions for regulation of tumor necrosis factor-alpha The present invention relates to compositions relating a nucleic acid encoding an interleukin 18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In particular, the present invention provides vectors for express... | 07/14/2009 |
| 7556958 | Enzyme derived from thermophilic organisms that functions as a chromosomal replicase, and preparation and uses thereof A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus, and corresponds to Polymerase III in E. coli. The genes and the p... | 07/07/2009 |
| 7556959 | Polynucleotide encoding a polypeptide having a larvae growth inhibiting or insecticidal effect on Scarabaeidae insects Through screening using an antibody to a polypeptide that constitutes a parasporal body in sporangia of Bacillus popilliae and has a larvae growth inhibiting or insecticidal effect on a Scarabaeidae insect and through polymerase chain reaction, polynuc... | 07/07/2009 |
| 7544502 | Polynucleotide encoding polypeptide having larvae growth inhibiting or insecticidal effect on scarabaeidae insects Through screening using an antibody to a polypeptide that constitutes a parasporal body in sporangia of Bacillus popilliae and has a larvae growth inhibiting or insecticidal effect on a Scarabaeidae insect and through polymerase chain reaction, polynucleotide... | 06/09/2009 |
| 7541173 | Solvent tolerant microorganisms and methods of isolation Lactobacillus bacteria having enhanced tolerance to butanols have been isolated. The bacteria are useful for the fermentive production of butanol. New methods for the isolation of butanol tolerant Lactobacillus are also provided. ... | 06/02/2009 |
| 7531345 | Mutations for enhanced tyrosine production The present invention provides cells genetically engineered to express mutated chorismate mutase/prephenate dehydrogenase (CM/PDH), the nucleic acid coding for each mutated CM/PDH and similar nucleic acids and methods for utilizing cells expressing mutated CM/PDH to... | 05/12/2009 |
| 7527962 | Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylg... | 05/05/2009 |
| 7521222 | Farnesyl dibenzodiazepinone and processes for its production This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain... | 04/21/2009 |
| 7521221 | strain CYL1892 This disclosure presents embodiments of novel strains of Staphylococcus aureus that through genetic engineering produce type 5 capsular polysaccharide at greater levels than Staphylococcus aureus strain Reynolds. ... | 04/21/2009 |
| 7504250 | Process for the biological production of 1,3-propanediol with high titer The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanedio... | 03/17/2009 |
| 7498162 | Lactic acid bacteria capable of reducing an individual's tendency to develop allergic reactions The present invention pertains to novel strains of lactic acid bacteria that are capable to reduce an individual's tendency to mount allergic reactions. In particular, the present invention relates to the generation of lactic acid bacteria strains that express prote... | 03/03/2009 |
| 7494800 | N-acetylgalactosamine transferases and nucleic acids encoding the same An enzyme which transfers N-acetylgalactosamine to N-acetylglucosamine via a β1-4 linkage was isolated and the structure of its gene was explained. This led to the production of said enzyme or the like by genetic engineering techniques, the production of oligosacch... | 02/24/2009 |