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| Number | Title | Issue Date |
| 8105816 | Nucleic acid molecules encoding BANK1 splice variants The present invention relates to a new splice variant of BANK1, the use of SNPs in BANK1 for diagnostics and the use of antagonists to modulate BANK1 and/or the BANK1 pathway. ... | 01/31/2012 |
| 8101398 | Modified cellulases with increased thermostability, thermophilicity, and alkalophilicity A modified Family 6 cellulase enzyme comprising a proline residue at position 413 is provided. Genetic constructs and genetically modified microbes comprising DNA sequences encoding the modified Family 6 cellulase are also provided. Family 6 cellulases of the invent... | 01/24/2012 |
| 8097446 | strain CYL1892 This disclosure presents embodiments of novel strains of Staphylococcus aureus that through genetic engineering produce type 5 capsular polysaccharide at greater levels than Staphylococcus aureus strain Reynolds. ... | 01/17/2012 |
| 8084243 | Blocking sporulation by inhibiting SpoIIE We have shown that the control of solventogenesis and sporulation can be genetically uncoupled in C. acetobutylicum. In strain 824(pASspo), the absence of SpoIIE causes sporulation to be blocked at stage II. The cell remains in a vegetative state, and this al... | 12/27/2011 |
| 8080402 | Surface expression method of peptides P5 and Anal3 using the gene encoding poly-gamma-glutamate synthetase The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Anal3 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63, 65, 67, 69, 71, on the microbial surface, using a vector containing o... | 12/20/2011 |
| 8076120 | 3-hydroxypropionic acid and other organic compounds Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed. ... | 12/13/2011 |
| 8071355 | Polyhydroxyalkanoate production by coenzyme A-dependent aldehyde dehydrogenase pathways Organisms are provided containing genes encoding one or more enzymes, Coenzyme-A-dependent aldehyde dehydrogenase, acyl-CoA transferase, acyl-CoA synthetase, β-ketothiolase, acetoacetyl-CoA reductase and/or PHA synthase. In some cases one or more of these genes are... | 12/06/2011 |
| 8071356 | strains of reduced pathogenicity, method for their preparation and uses thereof The invention concerns novel Salmonella enterica attenuated strains, characterized in that they are inactivated at the level of the znuABC operon through mutation in at least one of the znuA, znuB, znuC genes of such operon, for uses in medical or veterinary ... | 12/06/2011 |
| 8067224 | Presenilin associated membrane protein (PAMP) and uses thereof Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment,... | 11/29/2011 |
| 8058052 | Isolated genomic polynucleotide fragments from chromosome 12 that encode human carboxypeptidse M The invention is directed to isolated genomic polynucleotide fragments that encode human carboxypeptidase M and human mouse double minute 2 homolog, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense olig... | 11/15/2011 |
| 8048666 | Ethanol production in microorganisms The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth me... | 11/01/2011 |
| 8043841 | Nucleic acid molecules encoding alanine 2,3-aminomutases Alanine 2,3-aminomutase sequences are disclosed, as are cells having alanine 2,3-aminomutase activity and methods of selecting for such cells. Methods for producing beta-alanine, pantothenate, 3-hydroxypropionic acid, as well as other organic compounds, are disclose... | 10/25/2011 |
| 8034603 | Nucleic acid molecule The invention relates to an isolated nucleic acid molecule encoding a polypeptide capable of producing a triterpenoid hydrocarbon. The invention also relates to the encoded polypeptide, a vector comprising the nucleic acid molecule, a recombinant non-human organism ... | 10/11/2011 |
| 8034602 | Method for producing L-arginine using Disclosed herein are a microorganism producing L-arginine and a method of producing L-arginine using the same. The microorganism is a mutant strain of the genus Corynebacterium, Corynebacterium glutamicum CJR0500. The method for L-arginine production comprise... | 10/11/2011 |
| 8034604 | High viscosity xanthan polymer preparations Increasing the molecular length of xanthan polymer makes a higher viscosity xanthan composition. Xanthan with higher specific viscosity characteristics provides more viscosity at equivalent concentration in food, industrial and oilfield applications. Methods for inc... | 10/11/2011 |
| 8030052 | Midecamycin hyper producing strain A midecamycin hyper producing strain having improved productivity of midecamycin which is a member of macrolide antibiotics, and a method for producing midecamycins using the strain are provided. The midecamycin producing actinomycetes comprises a midecamycin biosyn... | 10/04/2011 |
| 8030053 | Substitutional variants of hydroxynitrile lyase with high specific activity and methods of use An improved hydroxynitrile lyase characterized by having a mutation of substitution of at least one amino acid residue in the amino acid sequence of a wild-type hydroxynitrile lyase with another amino acid and by its hydroxynitrile lyase activity per transformant be... | 10/04/2011 |
| 7998722 | Zymomonas with improved xylose utilization Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and whe... | 08/16/2011 |
| 7989193 | Compositions and methods for producing gamma-carboxylated proteins The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reducta... | 08/02/2011 |
| 7989194 | PCB-degrading recombinant bacterium, product for the bioremediation and method of bioremediation A recombinant bacterium capable to completely degrade or mineralize pollutants such as polychlorobiphenyls (PCBs), which corresponds to Cupriavidus necator strain JMS34, deposited under the access number NRRL B-30817 a product for the bioremediation of enviro... | 08/02/2011 |
| 7981658 | Nucleic acid molecules, vectors, and host cells encoding fluorescent protein The present invention provides a fluorescent protein having an amino acid sequence of the green fluorescent protein, the yellow fluorescent protein or mutants thereof wherein the 46th phenylalanine residue is substituted with a leucine residue. According ... | 07/19/2011 |
| 7972833 | Isolated nucleic acid molecules which encode T cell inducible factors (TIFs), the proteins encoded, and uses thereof The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to t... | 07/05/2011 |
| 7972834 | Modified fluorescent proteins and methods for using same Embodiments of the present invention provide nucleic acid molecules encoding improved fluorescent mutants of the Katushka fluorescent protein, variants and derivatives thereof, as well as proteins and peptides encoded by these nucleic acids. Also of interest are pro... | 07/05/2011 |
| 7968325 | Methods for the biosynthesis of polyesters Coexpression of a polyhydroxyalkanoic acid synthase and a either a fatty acid:acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids, bacteria, materials, and methods for the preparation of polyesters are di... | 06/28/2011 |
| 7943361 | Mutants of and process thereof The present invention provides mutant Mycobacterium strains harboring a modified tyrosine phosphatase gene (mptpA or mptpB) wherein the mutant Mycobacterium strain is incapable of expressing the active tyrosine phosphatase. The invention provides a met... | 05/17/2011 |
| 7943363 | Methods and compositions for improving the production of products in microorganisms Methods and compositions are provided for improving the production of products, such as fuel products like ethanol, in microorganisms. In particular, methods and compositions are described for improving ethanol production utilizing genes identified in Clostridium... | 05/17/2011 |
| 7943362 | Biosynthesis of phloroglucinol and preparation of 1,3-dihydroxybenzene therefrom The present invention provides methods, enzymes, and cells for the biosynthetic production of phloroglucinol from malonyl-CoA, which is ultimately obtained from simple starting materials such as glucose; also provided are methods for preparing derivatives of biosynt... | 05/17/2011 |
| 7935510 | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-ba... | 05/03/2011 |
| 7915026 | Host cells for production of isoprenoid compounds Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl... | 03/29/2011 |
| 7901924 | Increased bacterial CoA and acetyl-CoA pools Methods of increasing the cellular pool of A-CoA and thus driving the metabolic pathways in the direction of A-CoA containing metabolites by overexpressing rate limiting enzymes in A-CoA synthesis. Methods of increasing intracellular levels of CoA and A-CoA through ... | 03/08/2011 |
| 7892810 | Corynephage integrase-based site-specific insertion vector system The present invention provides a system for site-specific directed gene insertion of desired genes or foreign DNA into cellular genomes. The system includes novel vectors for integrating DNA into the genome of different hosts. Methods of using the vectors and transf... | 02/22/2011 |
| 7888100 | Isolated nucleic acid molecules which encode immunogenic portions of NY-ESO-1 protein The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts. ... | 02/15/2011 |
| 7888102 | Cell line for producing coronaviruses The invention relates to the production of coronaviruses. In particular, the invention relates to methods for producing SARS-CoV by using cells expressing a functional SARS-CoV receptor. ... | 02/15/2011 |
| 7888101 | Host cells comprising alpha 1,2 mannosidase and culture methods thereof Improved host cells and culture methods involving overexpression of MAN1C1 activity to improve protein production are provided. ... | 02/15/2011 |
| 7867749 | Nematode phosphoethanolamine N-methyltransferase-like sequences Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and po... | 01/11/2011 |
| 7858358 | Rapid growing microorganisms for biotechnology applications The present invention provides novel rapidly growing microorganisms and methods for their use in cloning or subcloning nucleic acid molecules. The rapid growing microorganisms of the present invention form colonies more rapidly than microorganisms typically used in ... | 12/28/2010 |
| 7855064 | Antibiotic resistance free vaccines and methods for constructing and using same The present invention provides Listeria strains that express a heterologous antigen and a metabolic enzyme, and methods of generating same. ... | 12/21/2010 |
| 7846710 | Cell comprising an intein for the production of a cyclic peptide Methods of producing cyclic peptides and splicing intermediates of peptides in a looped conformation are disclosed. The methods utilize the trans-splicing ability of split inteins to catalyze cyclization of peptides from a precursor peptide having a target peptide i... | 12/07/2010 |
| 7842493 | Cell lines having enhanced cell longevity and protein expression It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for protein production. The inventors have discovered that the expression ... | 11/30/2010 |
| 7842492 | Compositions of and methods of using sulfatases from flavobacterium heparinum This invention is related, in part, to sulfatase enzymes and methods of their use. ... | 11/30/2010 |
