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| Number | Title | Issue Date |
| 8183025 | virus A Unique Solenopsis invicta viruse (SINV2) have been identified and its genome sequenced. Oligonucleotide primers have been developed using the isolated nucleic acid sequences of the SINV2. The virus is used as a biocontrol agent for control of fire ants.... | 05/22/2012 |
| 8168418 | Expression of HIV polypeptides and production of virus-like particles The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as... | 05/01/2012 |
| 8168419 | Prevention and remediation of petroleum reservoir souring and corrosion by treatment with virulent bacteriophage Petroleum reservoir souring, caused by microbially induced production of hydrogen sulfide and other sulfur compounds, and the attendant corrosion are remediated by isolating bacteriophage(s) specific for the problematic bacteria (target bacteria) and adding an effec... | 05/01/2012 |
| 8163530 | Nucleic acids encoding respiratory syncytial virus subgroup B strain 9320 The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids... | 04/24/2012 |
| 8148130 | T4 bacteriophage bound to a substrate T4 bacteriophages are bound to substrates such as liposomes using a binder. ... | 04/03/2012 |
| 8148131 | Bacteriophage and antibacterial composition comprising the same The present invention relates to a novel bacteriophage, more particularly, a bacteriophage that has a specific bactericidal activity against Fowl Typhoid causing Salmonella Gallinarum (SG) and Pullorum disease-causing Salmonella Pullorum (SP). Further,... | 04/03/2012 |
| 8148129 | Generation of potent dominant negative transcriptional inhibitors The present invention provides methods and compositions for regulating gene expression using transcription factors linked to proteins that localize to the transcriptional machinery. ... | 04/03/2012 |
| 8143213 | Effect of TULA on HIV A method of inhibiting a retrovirus production, the method includes administering a retrovirus inhibitor selected from at least one of a TULA protein, a fragment of TULA containing a UBA domain, a UBA domain of TULA, a peptide mimicking TULA, a peptide mimicking a f... | 03/27/2012 |
| 8137947 | Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by heat in the presence or absence of a small-molecule regulator The present invention relates to conditionally replicating viruses or pairs of viruses containing a gene switch that is activatable by transient heat or other proteotoxic stress in the presence or absence of a small molecule regulator. The gene switch controls the e... | 03/20/2012 |
| 8133712 | Inactivated chimeric vaccines and related methods of use Embodiments of the present invention provide an inactivated chimeric virus and immunogenic compositions for the treatment or prevention of infection with West Nile virus. Further, other embodiments of the present invention relate to methods of preventing and treatin... | 03/13/2012 |
| 8124398 | Recombinant flavivirus vaccines The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations. ... | 02/28/2012 |
| 8124397 | Inactivating pathogens with oxidizing agents for vaccine production The present disclosure provides methods for producing a vaccine composition containing a pathogen that is rendered noninfectious by exposure to hydrogen peroxide. The methods disclosed herein are suitable for the preparation of vaccines for a wide variety of pathoge... | 02/28/2012 |
| 8110390 | PRRS viruses, infectious clones, mutants thereof, and methods of use The present invention provides isolated infectious polynucleotides, such as infectious clones, having a nucleotide sequence with identity to PRRS viruses such as VR-2332, Lelystad, or others, and optionally further including a deletion in a region of ORF1 that encod... | 02/07/2012 |
| 8093033 | Multi plasmid system for the production of influenza virus Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invent... | 01/10/2012 |
| 8071352 | Bacteriophage having killing activity specific to The present invention relates to a novel bacteriophage, more precisely a novel bacteriophage having killing activity specific to Staphylococcus aureus which is the causing agent of infectious diseases in human and animals, a pharmaceutical composition for the... | 12/06/2011 |
| 8067179 | Immunoglobulin libraries Methods and compositions for the screening and isolation of ligand-binding polypeptides, such as antibodies. In some aspects, methods of the invention enable the isolation of intact soluble antibodies comprising a constant domain. Screening methods that employ genet... | 11/29/2011 |
| 8058048 | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric in... | 11/15/2011 |
| 8026092 | Replication competent hepatitis C virus and methods of use The present invention provides replication competent polynucleotides that include a coding sequence encoding a hepatitis C virus polyprotein having adaptive mutations. The invention also includes methods for malting replication competent polynucleotides, identifying... | 09/27/2011 |
| 8012735 | Infectious cDNA clone of the modified live virus vaccine strain of virus An isolated polynucleotide molecule includes a DNA sequence encoding an infectious RNA molecule encoding a modified live viral strain of an Equine arteritis virus, wherein the DNA sequence is SEQ ID NO:1 or a degenerate variant thereof. Also provided are transformed... | 09/06/2011 |
| 7985573 | Targeted drug-carrying bacteriophages The present invention relates to the field of drug delivery. More specifically, the invention relates to the preparation and use of a bacteriophage conjugated through a labile/non labile linker or directly to at least 1,000 therapeutic drug molecules such that the d... | 07/26/2011 |
| 7981656 | Pseudotyped retrovirus with modified ebola glycoprotein Pseudotyped retroviruses having viral glycoproteins with modified O glycosylation regions are provided. Also provided are methods for making the pseudotyped retroviruses of the present invention and for using the pseudotyped retroviruses for transduction of target c... | 07/19/2011 |
| 7955833 | Animal protein free media for cultivation of cells The present invention relates to animal protein free cell culture media comprising a combination of non-animal derived peptides derived from soy hydrolysate and yeast hydrolysate. The invention also provides an animal protein free culture process, wherein cells are ... | 06/07/2011 |
| 7951575 | Isolated phages and their use in food or pet food products The present invention relates to phage isolates having a strong lytic activity against pathogenic Enterobacteriaceae such as Escherichia coli and/or Salmonella strains and their use in various human or pet food products for the treatment or prevention ... | 05/31/2011 |
| 7951576 | Methods for preparing cells and viruses Methods for preparing cells and viruses such as poxviruses are provided herein. ... | 05/31/2011 |
| 7932074 | Multivalent human-bovine rotavirus vaccine The present invention provides vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human×bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are comb... | 04/26/2011 |
| 7919301 | Recovery of recombinant human parainfluenza virus type 2 (HPIV2) from CDNA and use of recombinant HPIV2 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric vector viruses, provided according to the invention are infectious and at... | 04/05/2011 |
| 7919302 | virus A Unique Solenopsis invicta viruse (SINV2) have been identified and its genome sequenced. Oligonucleotide primers have been developed using the isolated nucleic acid sequences of the SINV2. The virus is used as a biocontrol agent for control of fire ants.... | 04/05/2011 |
| 7910350 | Adaptor-directed helper systems The present invention provides adapter-directed display systems for expressing exogenous polypeptide within a host cell and/or displaying the exogenous polypeptide on the outer surface of a genetic package. This subject systems are particularly useful for displaying... | 03/22/2011 |
| 7906312 | Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by heat in the presence or absence of a small-molecule regulator The present invention relates to conditionally replicating viruses or pairs of viruses containing a gene switch that is activatable by transient heat or other proteotoxic stress in the presence or absence of a small molecule regulator. The gene switch controls the e... | 03/15/2011 |
| 7906311 | Cotton rat lung cells for virus culture A cotton rat cell line, uses of cotton rat cells for growing, propagating, or culturing organisms, pathogens or viruses, such as PRRSV, and uses of the resultant organisms, pathogens or viruses, are disclosed. ... | 03/15/2011 |
| 7901919 | Chimaeric phages The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat comprising a protein mixture. The protein mixture comprises a fusion protein ... | 03/08/2011 |
| 7892809 | Chimeric vectors The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as ... | 02/22/2011 |
| 7888096 | Liquid adenovirus formulations The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired ... | 02/15/2011 |
| 7888097 | Formulation for adenovirus storage The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired ... | 02/15/2011 |
| 7871807 | Method for producing the flu virus The invention relates to a method for producing flu virus according to which: a) immunizing a hen by administering a flu vaccine to the hen, b) triggering embryogenesis in one or more eggs of the immunized hen, | 01/18/2011 |
| 7858356 | Mutant paramyxovirus and method for production thereof The present invention provides a modified paramyxovirus containing a reduced amount of receptor-binding protein compared with the wild type; a method of preparing a modified paramyxovirus, comprising the following steps: (1) a step for introducing a nucleic acid tha... | 12/28/2010 |
| 7851195 | High-efficiency wild-type-free AAV helper functions The present invention provides methods and compositions for producing high titer, wild-type-free preparations of recombinant AAV (“rAAV”) virions. The compositions of the present invention include novel nucleic acids encoding AAV helper functions and AAV helper ... | 12/14/2010 |
| 7851194 | West Nile viruses with mutations in the 3′ terminal stem and loop secondary structure for use as live virus vaccines The invention provides West Nile (WN) viruses and chimeric WN viruses having one or more mutations in the 3′ terminal stem loop secondary structure (3′SL) that results in decreased neurovirulence, methods of making such WN viruses, and methods for using these WN... | 12/14/2010 |
| 7838277 | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins Chimpanzee serotype C68 proteins, peptides, and polypeptide are provided. Also provided are novel adenoviruses derived from these proteins, as well as compositions containing these proteins and methods of using same for immunization and therapy. Further, a rapid met... | 11/23/2010 |
| 7820426 | Bionanomaterials and their synthesis The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensi... | 10/26/2010 |
