Class 435/232 - Lyase (4. )

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter wherein the enzyme catalyzes the nonhydrolytic
No. of patents: 558
Last issue date: 05/29/2012

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Number	Title	Issue Date
8187856	Recombinant halohydrin dehalogenase polypeptides The present disclosure provides engineered halohydrin dehalogenase (HHDH) polypeptides having improved enzyme properties as compared to the wild-type HHDH enzyme HheC and other reference engineered HHDH polypeptides. Also provided are polynucleotides encoding the en...	05/29/2012
8173410	Isoprene synthase variants for improved microbial production of isoprene The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene product...	05/08/2012
8119387	Polypeptides of strain sp. P203 A new strain Bacillus sp. P203 (Bacillus plakortiensis) is disclosed. Isolated mature functional polypeptide which is obtainable from the bacterium strain Bacillus sp. P203 deposited under accession number DSM 17419 are disclosed. ...	02/21/2012
RE43166	Gene encoding chondroitinase ABC and uses therefor Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABE protein produced in a host cell transformed with a nucleic acid vector directing the expression of a nucleotide sequence coding for chondroitinase ABE protein described. Ch...	02/07/2012
8101395	Halohydrin dehalogenases and related polynucleotides The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid ...	01/24/2012
8067222	Pectate lyases, nucleic acids encoding them and methods for making and using them The invention is directed to polypeptides having pectate lyase (pectinase) activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as pectate lyases t...	11/29/2011
8062877	Pectate lyases with increased thermostability and/or enzymatic activity Using site-directed mutagenesis to mutate the Xanthomonas campestris pectate lyase gene, variants of Xanthomonas campestris pectate lyase with improved thermostability and/or enzymatic activity have been expressed in Escherichia coli, and then i...	11/22/2011
7888095	Methods of generating protein variants with altered function The present invention provides methods of designing and generating polypeptide variants that have altered function compared to a parent polypeptide. The present invention further provides a computer program product for carrying out the design of a variant polypeptid...	02/15/2011
7858355	Dimeric glycerol dehydratases The invention concerns a method for preparing 1,3-propanediol from a carbon-containing substance, said method comprising a step which consists in culturing a recombinant micro-organism not producing coenzyme B12 in the absence of coenzyme B12 or one of its precursor...	12/28/2010
7824898	Halohydrin dehalogenases and related polynucleotides The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid ...	11/02/2010
7790432	Alanine 2,3-aminomutases and related polynucleotides The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the pres...	09/07/2010
7790431	Methods and materials for the production of shikimic acid Novel enzymes and novel enzymatic pathways for the pyruvate-based synthesis of shikimate or at least one intermediate thereto or derivative thereof, nucleic acids encoding the enzymes, cells transformed therewith, and kits containing said enzymes, cells, or nucleic ...	09/07/2010
7790433	Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The inventio...	09/07/2010
7674611	Modified ethylenediamine-N, N′-disuccinate: ethylenediamine lyase The present invention provides a modified ethylenediamine-N,N′-disuccinate:ethylenediamine lyase. The present invention also provides a protein that comprises the amino acid sequence represented by SEQ ID NO: 1; or a protein that comprises an amino acid sequence d...	03/09/2010
7670822	Aldolase and production process of 4-hydroxy-L-isoleucine A novel aldolase is described. 4-hydroxy-3-methyl-2-keto-pentanoic acid, which is useful as an intermediate in the synthesis of 4-hydroxy-L-isoleucine, may be synthesized from acetaldehyde and α-ketobutyric acid using a novel aldolase, which is derived from the gen...	03/02/2010
7645605	Heat-resistant nitrile hydratase The present invention provides: a protein having an improved nitrile hydratase activity, whereby heat resistance has been improved when compared with a wild-type nitrile hydratase activity, wherein the amino acid sequence of a nitrile hydratase is modified; a gene D...	01/12/2010
7625738	Nucleic acid molecules encoding a ferrochelatase enzyme or fragment thereof The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, nucleic acid sequences from maize and soybean associated with the tetrapyrrole pathway. The invention enco...	12/01/2009
7611882	Detergent compositions comprising pectate lyases Detergent composition comprising a surfactant and a pectate lyase (EC 4.2.2.2) enzyme en-coded by a DNA sequence endogeneous to a strain of Bacillus subtilis or a stabilized variant thereof provides superior cleaning and stain removal. ...	11/03/2009
7604976	Sequence-determined DNA fragments encoding glutamine amidotransferase proteins The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR ...	10/20/2009
7601529	Pectate lyase variants The present invention relates to pectate lyase variants exhibiting alterations relative to a parent enzyme exhibiting pectate lyase activity as its major enzymatic activity; to a method of producing such enzymes; and to methods for using such enzymes in the textile,...	10/13/2009
7595184	Nitrile hydratase variant The amino acid sequence of a mutant which is obtained by introducing a novel mutation into a Pseudonocardia thermophila JCM3095-derived nitrile hydratase consisting of two types of heterogeneous subunits, and the base sequence of the gene are provided. The ni...	09/29/2009
7588928	Halohydrin dehalogenases and related polynucleotides The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid ...	09/15/2009
7560263	Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The inventio...	07/14/2009
7556956	Enzymes for the preparation of amides A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process. ...	07/07/2009
7553653	Variants and chemically-modified variants of phenylalanine ammonia-lyase The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More par...	06/30/2009
7541172	Transgenic amorpha-4, 11-diene synthesis The present invention relates to an isolated DNA sequence encoding a polypeptide having the biological activity of amorpha-4,11-diene synthase. This DNA sequence can be used for the transformation of bacteria, yeasts and plants for the production of amorpha-4,11-die...	06/02/2009
7541171	Halohydrin dehalogenases and related polynucleotides The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid ...	06/02/2009
7537923	Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The inventio...	05/26/2009
7534595	Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof The present invention is directed to phenylalanine ammonia-lyase (PAL) produced by prokaryotes, wherein such prokaryotic PAL wherein the PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The i...	05/19/2009
7531341	Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof The present invention is directed to phenylalanine ammonia lyase (PAL) produced by prokaryotes, wherein such prokaryotic PAL wherein the PAL variant has a greater phenylalanine-converting activity as compared to a wild-type PAL. The invention thus provides compositi...	05/12/2009
7521217	Carbonic anhydrase having increased stability under high temperature conditions The present invention relates to polynucleotide and polypeptide sequences of carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic anhydrase. ...	04/21/2009
7510861	Gluconate dehydratase A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-...	03/31/2009
7507570	Recombinant chondroitinase ABC I and uses thereof The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purp...	03/24/2009
7462478	Polynucleotide encoding 2-hydroxyisoflavanone dehydratase and application of the same 2-Hydroxyisoflavanone dehydratase substantially having the amino acid sequence represented by SEQ ID NO: 1 is isolated from licorice. Further, a polynucleotide encoding 2-hydroxyisoflavanone dehydratase of the SEQ ID NO: 2 is obtained. Furthermore, the amino acid se...	12/09/2008
7435572	Methods and compositions for DNA manipulation Methods and compositions are provided for generating a single-stranded extension on a polynucleotide molecule, the single-stranded extension having a desired length and sequence composition. Methods for forming single-stranded extensions include: the use of a casset...	10/14/2008
7432100	Variant aldolase and processes for producing an optically active IHOG and an optically active monatin using the same The present invention relates to variant aldolase enzymes that are modified so as to produce IHOG (4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid: IHOG), a process for producing an optically active IHOG using the same, and a process for producing an optically act...	10/07/2008
7429476	Acid fungal proteases The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and ...	09/30/2008
7429375	Proteoglycan degrading mutants for the treatment of CNS The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous sy...	09/30/2008
7414119	Aldolases, nucleic acids encoding them and methods for making and using them The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R-(R,R)]-2-(4-f...	08/19/2008
7413735	Pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis The present invention relates to a pharmaceutical composition for inhibiting angiogenesis which comprises arginine deiminase as an active ingredient, where the arginine deiminase, obtained from Mycoplasma arginini or prepared by a genetic recombination techni...	08/19/2008

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Class 435/232 - Lyase (4. )