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| Number | Title | Issue Date |
| 7195892 | Acylase gene The subject of the present invention is to provide a β-lactam acylase protein having high activity, a gene coding for said β-lactam acylase protein, a recombinant vector having said gene, a transformant containing said recombinant vector, and a method of producing... | 03/27/2007 |
| 7183094 | Bacterial mycothiol S-conjugate amidase family The present invention provides a family of bacterial acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. The invention amidases are characterized by a highly conserved 20 amino acid ... | 02/27/2007 |
| 7170084 | Strained silicon MOSFET having improved source/drain extension dopant diffusion resistance and method for its fabrication An n-type MOSFET (NMOS) is implemented on a substrate having an epitaxial layer of strained silicon formed on a layer of silicon germanium. The MOSFET includes first halo regions formed in the strained silicon layer that extent toward the channel region beyond the e... | 01/30/2007 |
| 7067324 | Photon reducing agents for fluorescence assays The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method fo... | 06/27/2006 |
| 7052833 | Absorptive hypercalciuria locus on human chromosome 1 Disclosed is a region on human chromosome 1 that provides a genetic basis for absorptive hypercalciuria. The genes, proteins, and other biological materials provided are envisioned for use in diagnostic and therapeutic methods related to absorptive hypercalciuria an... | 05/30/2006 |
| 6699690 | Molecular constructs with a carcinoembryonic antigen (CEA) transcriptional regulatory sequence Novel molecular chimaeras produced by recombinant DNA techniques are described. They comprise a target-tissue specific transcriptional regulatory sequence (TRS) linked and controlling the expression of a heterologous enzyme, for example Varicella Zoster V... | 03/02/2004 |
| 6576454 | Modified enzymes and their use for peptide synthesis The present invention relates to modified enzymes with one or more amino acid residues from an enzyme being replaced by cysteine residues, where at least some of the cysteine residues are modified by replacing thiol hydrogen in the cysteine residue with a... | 06/10/2003 |
| 6525190 | Amidase A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be us... | 02/25/2003 |
| 6500659 | Amidase A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be us... | 12/31/2002 |
| 6465204 | Amidase A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be us... | 10/15/2002 |
| 6429004 | Amidase A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be us... | 08/06/2002 |
| 6410259 | Process for the fermentative production of deacylated cephalosporins The present invention disclosures a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.... | 06/25/2002 |
| 6403356 | Mutant penicillin G acylases New mutant penicillin G acylases preferably from E. coli are provided, exhibiting altered enzymatic activity. These penicillin G acylases are obtained by expression of a gene encoding said penicillin G acylase having an amino acid sequence which differs a... | 06/11/2002 |
| 6395532 | Modified enzymes and their use for peptide synthesis The present invention relates to modified enzymes with one or more amino acid residues from an enzyme being replaced by cysteine residues, where at least some of the cysteine residues are modified by replacing thiol hydrogen in the cysteine residue with a... | 05/28/2002 |
| 6268216 | Reagents and methods for the screening of compounds useful in the treatment of neurological diseases This invention relates to the gene sequence of a novel transcription factor specific for central 5-HT (serotonergic) neurons. The sequence and products are useful in screening methods for identifying and testing agonists and antagonists of seronergic acti... | 07/31/2001 |
| 6221612 | Photon reducing agents for use in fluorescence assays The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides ... | 04/24/2001 |
| 6214563 | Photon reducing agents for reducing undesired light emission in assays The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides ... | 04/10/2001 |
| 6200762 | Photon reducing agents and compositions for fluorescence assays The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides ... | 03/13/2001 |
| 6136583 | AMIDASE A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be us... | 10/24/2000 |
| 6071713 | Bioprocesses for preparing 7-ACA and 7-ADAC A bioprocess for preparing adipoyl-7-ACA comprising the steps: (a) transforming cells of a strain of Penicillium chrysogenum which produces isopenicillin N with an expression vector containing DNA encoding an enzyme, having expandase activity capable of a... | 06/06/2000 |
| 6048708 | Process for preparation of ଲ-lactams at constantly high concentration of reactants An improvement for enzymatically syhnthesizing a ଲ-lactam compound is presented. The improvement comprises catalyzing the acylation of an amino ଲ-lactam with an acylating agent for at least 5 hours with an amidase or acylase, wherein the conce... | 04/11/2000 |
| 6017726 | Bioprocesses for preparing 7-ACA and 7-ADAC A process for making 7-aminodeacetyl-cephalosporanic acid (7-ADAC).... | 01/25/2000 |
| 6004796 | Amidase A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be us... | 12/21/1999 |
| 5935831 | Mutated ଲ-lactam acylase genes New mutant ଲ-lactam acylases are provided exhibiting altered substrate specificities. These ଲ-lactam acylases are obtained by expression of a gene encoding said ଲ-lactam acylase and having an amino acid sequence which differs at least in... | 08/10/1999 |
| 5928888 | Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities The invention provides for a methods and compositions for identifying proteins or compounds that directly or indirectly modulate a genomic polynucleotide and methods for identifying active genomic polynucleotides. Generally, the method comprises inserting... | 07/27/1999 |
| 5891703 | Mutated penicillin G acylase genes New mutant ଲ-lactam Penicillin G acylases are provided, exhibiting altered substrate specificities. These Penicillin G acylases are obtained by expression of a gene encoding for said Penicillin G acylase and having an amino acid sequence which diffe... | 04/06/1999 |
| 5877001 | Amidase A purified thermostable enzyme is derived from the archael bacterium Thermococcus GU5L5. The enzyme has a molecular weight of about 68.5 kilodaltons and has cellulase activity. The enzyme can be produced from native or recombinant host cells and can be us... | 03/02/1999 |
| 5801011 | Process for preparing cephalosporins with penicillin acylase without pH control The invention relates to an improved process for preparing cephalosporins by reaction compounds such as 7-amino-cephalosporanic acid, 7-amino-3-deacetoxy-cephalosporanic acid or their derivatives with derivatives of -amino acids in the presence of ... | 09/01/1998 |
| 5695978 | Penicillin G acylase, a gene encoding the same and a method for the production of this enzyme The invention provides a gene encoding penicillin G acylase, the enzyme encoded by said gene and a method for the production of said enzyme by incorporating said gene in a host and bringing the same to expression. The gene is preferably obtained from a st... | 12/09/1997 |
| 5629171 | Recombinant bioprocess for the preparation of 7-amino cephalosporanic acid (7-ACA) Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in... | 05/13/1997 |
| 5612210 | Process for producing 7ଲ-(4-carboxybutanamido)-cephalosporanic acid acylase ("GA") enzyme The present invention relates to a process for producing large amounts of 7ଲ-(4-carboxybutanamido)-cephalosporanic acid acylase ("GA") enzyme, which process consists in growing, under suitable culture conditions, a recombinant Escherichia coli K12 s... | 03/18/1997 |
| 5559005 | Bioprocess for preparing 7-ACA and 7-ADAC Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in... | 09/24/1996 |
| 5521068 | Process for 7-aminodesacetoxycephalosporanic acid The invention relates to an improved process for converting 6-acylaminopenicillanic acid (6-AAPA) to 6-aminopenicillanic acid (6-APA). The process employs a solution or suspension of penicillin acylase from which the product is separated after reaction by... | 05/28/1996 |
| 5516679 | Penicillin V amidohydrolase gene from Fusarium oxysporum Nucleic acids coding for penicillin V amidohydrolase (PVA) from Fusarium oxysporum. Also, expression vectors, host cells and a method for production of PVA.... | 05/14/1996 |
| 5500352 | Membrane filtration process for 6-aminopenicillanic acid The invention relates to an improved process for converting 6-acylaminopenicillanic acid (6-AAPA) to 6-aminopenicillanic acid (6-APA). The process employs a solution or suspension of penicillin acylase from which the product is separated after reaction by... | 03/19/1996 |
| 5457032 | Mutated ଲ-lactam acylase genes New mutant ଲ-lactam acylases are provided exhibiting altered substrate specificities. These ଲ-lactam acylases are obtained by expression of a gene encoding said ଲ-lactam acylase and having an amino acid sequence which differs at least in... | 10/10/1995 |
| 5352670 | Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides Disclosed are methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides. Specifically, in the disclosed methods, sialyltransferase is activated to transfer an analogue of sialic acid, employed as its CMP-nucleotide derivative, to ... | 10/04/1994 |
| 5318896 | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) An important intermediate for preparing cephalosporin antibiotics, 7-aminodesacetoxy cephalosporanic acid (7-ADCA), is prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in the presence of an adipate feedstock... | 06/07/1994 |
| 5268271 | Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase Synthesis of semi-synthetic monobactamic or ଲ-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a thermodynamically controlled strategy in monophase water/coso... | 12/07/1993 |
| 5194383 | Process for making L-aminoacylase A process for making L-aminoacylase includes a cultivation of microorganism selected from a specy of Alcaligenes, especially the Alcaligenes denitrificans DA 181, and a separation of a produced L-aminoacylase from the bacterial cells for obtaining the L-a... | 03/16/1993 |
