Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 8088613 | Nitrilases, nucleic acids encoding them and methods for making and using them The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. ... | 01/03/2012 |
| 8076116 | Nucleic acids encoding class II human histone deacetylases, and uses related thereto The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors. ... | 12/13/2011 |
| 7993901 | Nitrilases and methods for making and using them The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. ... | 08/09/2011 |
| 7985572 | Modified nitrilases and their use in methods for the production of carboxylic acids The present Invention relates to new nitrilases with modified Substrate acceptance, the method to obtain them and the use of the aforesaid nitrilases. Said nitrilases are encoded by a polypeptide sequence, which at a Position corresponding to Position 296 in wild-ty... | 07/26/2011 |
| 7981655 | Modified cytosine deaminases The document provides modified cytosine deaminases with increased solubility and high levels of DNA cytosine deaminase activity. ... | 07/19/2011 |
| 7955832 | Composition useful for protein fragment complementation assays (PCA) using fragments of /TEM-1 β-lactamase The present invention describes an assay method comprising: (A) generating (1) at least a first fragment of a reporter molecule linked to a first interacting domain and at least a second fragment of a reporter molecule linked to a second interacting domain, or (2) n... | 06/07/2011 |
| 7867748 | Immobilized microbial nitrilase for production of glycolic acid The present invention is directed to a process for improving the specific activity of a dehydrated enzyme catalyst having nitrilase activity for hydrolysis of glycolonitrile to glycolic acid upon rehydration. In particular, a process is provided comprising pretreati... | 01/11/2011 |
| 7816116 | Modified creatinine amide hydrolase having improved affinity for substrate, and reagent composition for determination of creatinine To overcome disadvantages of a known creatinine amide hydrolase, and provide a creatinine amide hydrolase having improved affinity for creatinine or having a decreased Km value for creatinine, and also provide a reagent composition for use in the determination of cr... | 10/19/2010 |
| 7811804 | Nitrilases, nucleic acids encoding them and methods for making and using them The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. ... | 10/12/2010 |
| 7655450 | Polypeptide having amidase activity and gene thereof It is an object of the present invention to provide a novel amidase that is useful for production of an optically active amino acid, and in particular, a D-amino acid, and a production method thereof. The present invention relates to a novel D-amidase isolate... | 02/02/2010 |
| 7608445 | Nitrilases, nucleic acids encoding them and methods for making and using them The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. ... | 10/27/2009 |
| 7569378 | Protein-deamidating enzyme, microorganism producing the same, gene encoding the same, production process therefor, and use thereof A method for the production of an enzyme, which comprises culturing in a medium a strain that belongs to a bacterium classified into Cytophagales or Actinomycetes, or a new bacterium Chryseobacterium sp. No. 9670 belonging to the genus Chryseobacterium... | 08/04/2009 |
| 7556955 | Nucleic acids encoding cytosine deaminase A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme. ... | 07/07/2009 |
| 7521216 | Nitrilases and methods for making and using them The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. ... | 04/21/2009 |
| 7501273 | Peptidylarginine deiminase 6 A nucleotide acid sequence is provided encoding a peptidylargine deiminase 6. The gene is found to be expressed in gonads only and may be used as target for male and female contraception. Its encoded protein can be used to screen for small molecular weight modulator... | 03/10/2009 |
| 7462477 | Protein-deamidating enzyme, microorganism producing the same, gene encoding the same, production process therefor, and use thereof A method for the production of an enzyme, which comprises culturing in a medium a strain that belongs to a bacterium classified into Cytophagales or Actinomycetes, or a new bacterium Chryseobacterium sp. No. 9670 belonging to the genus Chryse... | 12/09/2008 |
| 7445923 | Crystallization and structure of a plant peptide deformylase This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide. ... | 11/04/2008 |
| 7432086 | L-amino acid amide asymmetric hydrolase and DNA encoding the same A recombinant microorganism is produced by introducing a DNA encoding an enzyme which hydrolyzes an amido bond of L-amino acid amide, especially L-2-alkylcysteine amide, and L-amino acid is produced by using cells or cell processed product of the obtained microorgan... | 10/07/2008 |
| 7419815 | Inhibitors of plant peptide deformylase for use as broad-spectrum herbicides and methods for identifying the same The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides. ... | 09/02/2008 |
| 7387893 | Vectors, cells and processes for pyrimidine deoxyribonucleosides production Novel DNA constructs and host cells comprising the same are disclosed. DNA constructs comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for ribonucleotide reductase and thioredoxin or a uridine kinase gene and/or a dCTP deaminase gene. In... | 06/17/2008 |
| 7361507 | Method for modulating nitrilase selectivity, nitrilases obtained by said method and use thereof The invention concerns a modified nitrilase with modulated selectivity, characterized in that it comprises in position 162 an amino acid residue different from the original amino acid residue. ... | 04/22/2008 |
| 7358071 | Production of 3-hydroxycarboxylic acid using nitrilase mutants This invention relates to nitrilase mutants having improved nitrilase activity for converting 3-hydroxynitriles to 3-hydroxycarboxylic acids. More specifically, the Acidovorax facilis 72W (ATCC 55746) nitrilase gene was mutated using error-prone PCR and site-... | 04/15/2008 |
| 7356023 | System and method for facilitating packetized calls between managed networks A system and method for facilitating packetized calls between managed networks are disclosed. In one embodiment of a system incorporating teachings of the present disclosure, a mediation server may be associated with and maintain an information store holding a first... | 04/08/2008 |
| 7348173 | Fatty-acid amide hydrolase The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of cis-9,10-octadecenoamide by FAAH leads to the formation of oleic acid, a... | 03/25/2008 |
| 7323167 | Method of treatment with modified arginine deiminase The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis. ... | 01/29/2008 |
| 7314621 | Cytidine deaminase Antibodies that specifically bind to AID (Activation-Induced cytidine Deaminase) proteins, compositions comprising said antibodies, and cells producing said antibodies, are described. The AID proteins are structurally related to APOBEC-1,l an RNA editing enzyme, and... | 01/01/2008 |
| 7288402 | Rhodococcus nitrile hydratase The invention relates to a Rhodococcus polynucleotide cluster which contains nucleotide sequences which encode polypeptides having the activity of a nitrile hydratase, of an auxiliary protein P15K which activates this enzyme and of a cobalt transporter, to tr... | 10/30/2007 |
| 7285410 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids A method has been developed to prepare (E)- and (Z)-2-methyl-2-butenoic acids (2M2BA) from a mixture of (E,Z)-2-methyl-2-butenenitriles (2M2BN) by the regioselective hydrolysis of (E)-2M2BN to (E)-2-methyl-2-butenoic acid (2M2BA) using enzyme catalysts having either... | 10/23/2007 |
| 7282356 | D-aminoacylase mutants The present invention provides mutant D-aminoacylases and use thereof. The mutant D-aminoacylases are hard to be inhibited by the substrate and, comprise the amino acid sequences of the D-aminoacylase derived from Alcaligenes denitrificans subsp. xylosoxyd... | 10/16/2007 |
| 7264956 | Compounds and methods for inhibiting axillary malodour Enzymes mediating in the release of compounds characteristic of human malodour and in particular axillary malodour, and compounds that inhibit said enzymes having the general formula (I) ... | 09/04/2007 |
| 7264800 | Method and composition for inhibiting cancer cell growth Improvements in methods of treating cancer with weakly basic anti-cancer compounds are provided. In one aspect, the invention provides an improvement in a method of treating cancer cells whose extracellular environment contains 1–8 mM urea, by exposing the cells t... | 09/04/2007 |
| 7247435 | Enzymatic fluorometric assay for cAMP and adenylate cyclase The present invention relates to a method for quickly determining cAMP content or an adenylate cyclase activity in a biological sample containing non-cyclic adenine nucleotides without the use of radioactive agents. Particularly, the present invention provide... | 07/24/2007 |
| 7241602 | Nucleic acid sequences encoding enantioselective amidases The invention relates to nucleic acid sequence encoding enantioselective amides with an amino acid sequence of SEQ ID NO: 2. The invention also relates to a process for fermentation, comprising a batch and a feed phase, of a microorganism in a fermentation medium, w... | 07/10/2007 |
| 7229812 | Modified sarcosine oxidase, process for producing the same and reagent composition using the same A protein having been modified by addition, deletion, insertion or substitution of at least one amino acid in an amino acid sequence constituting a protein having a sarcosine oxidase activity and still having the sarcosine oxidase activity, characterized by having a... | 06/12/2007 |
| 7220562 | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids A method has been developed to prepare (E)- and (Z)-2-methyl-2-butenoic acids (2M2BA) from a mixture of (E,Z)-2-methyl-2-butenenitriles (2M2BN) by the regioselective hydrolysis of (E)-2M2BN to (E)-2-methyl-2-butenoic acid (2M2BA) using enzyme catalysts having either... | 05/22/2007 |
| 7211250 | Method and composition for inhibiting cancer cell growth A pharmaceutical composition and method for use in inhibiting growth of cancer cells in a mammalian subject are disclosed. The composition includes a urease enzyme, and associated therewith, a chemical entity effective to enhance the delivery of the enzyme to cancer... | 05/01/2007 |
| 7205140 | Nucleotide sequence for creatinine deiminase and method of use The present invention relates to the discovery of novel genes encoding a polypeptide having creatinine deiminase activity and methods of use. Also disclosed is a kit using the novel sequences for determining the concentration of creatinine in a sample. ... | 04/17/2007 |
| 7198926 | Preparation of ()- and ()-2-methyl-2-butenoic acids A method has been developed to prepare (E)- and (Z)-2-methyl-2-butenoic acids (2M2BA) from a mixture of (E,Z)-2-methyl-2-butenenitriles (2M2BN) by the regioselective hydrolysis of (E)-2M2BN to (E)-2-methyl-2-butenoic acid (2M2BA) using enzyme catalysts having either... | 04/03/2007 |
| 7186540 | Thermostable glutaminase and thermostable glutaminase gene A completely novel glutaminase is provided: (a) a protein consisting of an amino acid sequence represented by SEQ ID NO: 2, or (b) a protein consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substituti... | 03/06/2007 |
| 7169596 | Adenosine deaminase homolog This invention provides a novel isolated polynucleotide sequence, called ADARP1 (adenosine deaminase related protein 1), that displays significant homology to the adenosine deaminase (ADA) gene. Also provided is the amino acid sequence of the ADARP1 polypeptide enco... | 01/30/2007 |
