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| Number | Title | Issue Date |
| 6423526 | Human serine protease Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic... | 07/23/2002 |
| 6423507 | Human osteoclast-derived cathepsin Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses an... | 07/23/2002 |
| 6420534 | Alzheimer's disease secretase, APP substrates therefor, and uses thereof The present invention provides the enzyme and enzymatic procedures for cleaving the ଲ secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a mo... | 07/16/2002 |
| 6420157 | Zymogen activation system We describe the DNA sequences encoding an expression vector system that will permit, through limited proteolysis, the activation of expressed zymogen precursor of (S1) serine proteases in a highly controlled and reproducible fashion. The processed express... | 07/16/2002 |
| 6413737 | Ecarin prothrombin protease and methods New forms of ecarin, a procoagulant protein from Echis carinatus venom, are described, as are polynucleotides encoding the new proteins, methods for production of the new proteins, and methods for activation of prothrombin using the new proteins. The new ... | 07/02/2002 |
| 6413760 | Highly purified mocarhagin cobra venom protease polynucleotides endcoding same and related proteases and therapeutic uses thereof Highly purified mocarhagin, a cobra venom protease, is disclosed. Pharmaceutical compositions and therapeutic uses of the highly purified protease are also provided. Polynucleotides encoding such protease and related proteases are also disclosed.... | 07/02/2002 |
| 6410704 | Methods and compositions for the preparation and use of a herpes protease The present invention relates to the identification and purification of a herpes protease and a nucleic acid segment coding for two proteins. The first protein is the herpes protease which is able to cleave itself and also cleave the second protein. This ... | 06/25/2002 |
| 6410272 | Production of thrombin inhibitors A method for the production and secretion of proteins with hirudin activity in an eukaryotic host organism is provided. There are also provided hybrid vectors comprising a DNA sequence encoding a signal peptide upstream of and in reading frame with the st... | 06/25/2002 |
| 6406901 | TNF-a converting enzyme A metalloprotease that converts TNF- from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified proteas... | 06/18/2002 |
| 6406877 | TNF- converting enzyme A metalloprotease that converts TNF- from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified proteas... | 06/18/2002 |
| 6399371 | Human matrix metalloprotease gene, proteins encoded therefrom and methods of using same The present invention provides novel complementary DNA (cDNA) sequences encoding human matrix metalloprotease proteins (MMP-ABT). The present invention also provides recombinant DNA molecules encoding human matrix metalloprotease polypeptides and processe... | 06/04/2002 |
| 6399350 | KUZ, a novel family of metalloproteases Members of a novel family of polypeptides, the KUZ family, are metalloproteases involved in neuronal partitioning and neuronal development. The invention provides KUZ poylpeptides, antibodies that bind the KUZ polypeptides, KUZ encoding nucleic acids, met... | 06/04/2002 |
| 6399349 | Human aminopeptidase P gene Disclosed are the human aminopeptidase P cDNA and genomic DNA. Also disclosed is the human aminopeptidase P protein and antibodies reactive with human aminopeptidase P. These molecules, and derivatives of these molecules, are useful for assay for detectin... | 06/04/2002 |
| 6399348 | DNA sequences for matrix metalloproteases, their production and use DNA sequences for human matrix metalloproteases are disclosed, as well as homologous DNA sequences homologous and derived therefrom. Also disclosed are the proteins and protein variants coded by these DNA sequences, there expression, preparation and use. ... | 06/04/2002 |
| 6391853 | Human tissue inhibitor of metalloproteinase-4 A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of d... | 05/21/2002 |
| 6391610 | Nucleic acids encoding zinc metalloproteases Isolated mammalian proteins having disintegrin-like and metalloprotease domains with thrombospondin type I motifs, i.e., ADAMTS proteins, are provided. The proteins are ADAMTS-5, ADAMTS-6, ADAMTS-7, ADAMTS-8, ADAMTS-9 and ADAMTS-10, collectively referred ... | 05/21/2002 |
| 6391300 | Method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal circulation This invention provides a method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal blood circulation which comprises contacting the extracorporeal circulating blood with a Factor IXa compound in an amount effective to inhib... | 05/21/2002 |
| 6387682 | Human osteoclast-derived cathepsin Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses an... | 05/14/2002 |
| 6383793 | Human osteoclast-derived cathepsin Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses an... | 05/07/2002 |
| 6372213 | Method of treating sickle cell disease or thalassemia The present invention provides a method of treatment of sickle cell disease (SCD) or thalassemia with protein C. The claimed invention provides a needed therapy for potentially serious and debilitating disorders while avoiding complications such as bleedi... | 04/16/2002 |
| 6346245 | Procedure for extraction and use of hatching fluid from Atlantic salmon A procedure is described for obtaining valuable endoproteases (or zonases) from hatchery-produced Atlantic salmon eggs. Synchronized hatching by for instance elevated temperature, is followed by filtration through cheese cloth. The filtrate (hatching flui... | 02/12/2002 |
| 6344353 | Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, met... | 02/05/2002 |
| 6344352 | Isolated human metalloprotease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, met... | 02/05/2002 |
| 6331427 | Protease homologs The invention relates to polynucleotides encoding newly identified protease homologs belonging to the superfamily of G-protein-coupled proteases. The invention also relates to the proteases. The invention further relates to methods using the protease poly... | 12/18/2001 |
| 6326162 | Assays and peptide substrate for determining aggrecan degrading metallo protease activity This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the pres... | 12/04/2001 |
| 6319704 | KUZ, a novel family of metalloproteases Members of a novel family of polypeptides, the KUZ family, are metalloproteases involved in neuronal partitioning and neuronal development. The invention provides KUZ poylpeptides, antibodies that bind the KUZ polypeptides, KUZ encoding nucleic acids, met... | 11/20/2001 |
| 6319681 | Mammalian TNF- convertases The present invention provides isolated human and bovine TNF- convertases, nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. Th... | 11/20/2001 |
| 6313268 | Secretases related to Alzheimer's dementia This invention is directed to a novel ଲ-secretase that produces the Aଲ peptide found in Alzheimer's Disease. One ଲ-secretase is a protein having a molecular weight of about 61, 81 or 88 kDa that cleaves an amyloid precursor protein (APP)... | 11/06/2001 |
| 6312937 | Metalloproteinases The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as... | 11/06/2001 |
| 6303754 | Recombinant procvf Recombinant proCVF exhibits substantially the same activity as CVF and is useful for lowering complement activity... | 10/16/2001 |
| 6303361 | Human glandular kallikrein-1 (hK2) A new form of human glandular kallikrein-1 (hK2) found from cloning a prepro-hK2 cDNA from a human protrate cancer tissue cDNA library. The new form differs in sequence from the prior art form in that Arg226 is substituted by Trp. A baculovirus... | 10/16/2001 |
| 6294363 | Rapid method of proteasome purification using proteins having sequence homology to ubiquitin Disclosed are methods for rapidly and efficiently purifying proteasomes using fusion proteins having homology to ubiquitin using amino acid sequences adhered to a solid support.... | 09/25/2001 |
| 6294169 | Interleukin-1 beta converting enzyme like apoptotic protease-6 Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to vir... | 09/25/2001 |
| 6287858 | DeUBiquitinating enzymes that regulate cell growth The present invention relates to ubiquitin-specific thiol proteases or deubiquitinating enzymes, referred to as DUB (DeUBiquitinating) enzymes, of eukaryotic origin which are members of a superfamily of deubiquitinating enzymes and which comprise a new su... | 09/11/2001 |
| 6284475 | Assays for diagnosis of thrombophilic disease The present invention provides methods for diagnosing and/or monitoring thrombophilic disease in a patient that can result from the antiphospholipid antibody syndrome (aPL syndrome). The methods of the invention are premised on the inhibition of binding o... | 09/04/2001 |
| 6284247 | Human tissue plasminogen activators Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular env... | 09/04/2001 |
| 6280994 | Zace 1: a human metalloenzyme Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the production of the potent vasopressor angiotensin II from angiotens... | 08/28/2001 |
| 6277618 | Recombinant blood-coagulation proteases The invention relates to a non-glycosylated protein with enzymatic and serin protease activity, the zymogenous form thereof comprising the following domains of a protease of the factor IX family: (a) a catalytic domain, N-terminal bonded with (b) a zymoge... | 08/21/2001 |
| 6277590 | Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells Compositions and methods are provided for endopeptidases and their production, and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides. These compositions and methods utilize recombinant PACE 4 and 4.1, mamma... | 08/21/2001 |
| 6274366 | Enzymatically-active recombinant human ଲ-tryptase and method of making same Disclosed is a method of expressing enzymatically-active, recombinant human ଲ-tryptase in a yeast host cell, expression constructs which drive the production of enzymatically-active tryptase in transformed yeast, and genetically-engineered yeast con... | 08/14/2001 |
