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| Number | Title | Issue Date |
| 6114159 | DNA sequences for matrix metalloproteases, their production and use The invention relates to matrix metalloproteases and variants thereof and DNA sequences that encode these matrix metalloproteases. The invention further relates to obtaining the matrix metalloproteases from natural sources or by recombinant methods by exp... | 09/05/2000 |
| 6110701 | DNA encoding precursor of interleukin-1ଲ converting enzyme--related cysteine proteinase II (ICErel -II) A complementary DNA (cDNA) encoding full length form of ICErel -II is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICE | 08/29/2000 |
| 6103513 | Interleukin-1ଲ converting enzyme-related cysteine proteinase II (ICErel -II) A complementary DNA (cDNA) encoding full length form of ICErel -II is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICE | 08/15/2000 |
| 6103483 | Molecule involved in binding of sperm to egg surfaces and procedures for use of this molecule to enhance or decrease potential fertility A purified polypeptide which provides for initial binding of sperm to oocyte investments and has an active amino acid sequence of SEQ ID NO:12 (Cys-Gln-Ser-Leu-Gln-Glu-Tyr-Leu-Ala-Glu-Gln-Asn-Gln-Arg-Gln-Leu-Glu-Ser-A sn-Lys-Ile-Pro-Glu-Val-Asp-Leu-Ala-Arg... | 08/15/2000 |
| 6093397 | Amyloid precursor protein protease This invention describe a novel human amyloid precursor protein protease; nucleic acids encoding the protease; and methods employing the protease, as well as methods employing the nucleic acids encoding the protease.... | 07/25/2000 |
| 6087150 | Interleukin-1 ଲ converting enzyme like apoptosis protease-3 and 4 Disclose are human interleukin-1ଲ converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists agai... | 07/11/2000 |
| 6087160 | Programmed cell death genes and proteins This invention relates to genes involved in regulating programmed cell death, the proteins encoded by such genes and methods for controlling programmed cell death by regulating the activity of the cell death gene products.... | 07/11/2000 |
| 6083735 | Programmed cell death genes and proteins This invention relates to proteins encoded by the cell death genes that are involved in regulating programmed cell death. In particular, the invention describes the cell death protein Ich-1 (Caspase-2) and its alternative splicing products Ich-1L | 07/04/2000 |
| 6077694 | Method for over-expression and rapid purification of biosynthetic proteins The subject invention relates to a method of producing and purifying large quantities of a biosynthetic protein. The gene which codes for the protease is placed between the binding domain of a gene which codes for a binding protein and a gene coding for the ... | 06/20/2000 |
| 6068990 | Proteins, their production and use This invention relates to a novel calpain having a proteolytic activity, its partial peptide or a salt either of them, a DNA coding for the protein, a recombinant vector comprising the DNA, a transformant carrying the recombinant vector, a process for pro... | 05/30/2000 |
| 6066488 | Cathepsin C homolog The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP,... | 05/23/2000 |
| 6057119 | Crystal structure and mutants of interleukin-1ଲ converting enzyme Interleukin-1ଲ converting enzyme ("ICE") processes an inactive precursor to the pro-inflammatory cytokine, interleukin-1ଲ. The high-resolution structure of human ICE crystallized in complex with an inhibitor is determined by X-ray diffraction.... | 05/02/2000 |
| 6057121 | Method of catalyzing stereochemical reactions A method for increasing the rate of a chemical reaction involving conversion of at least one reactant to at least one product which comprises contacting the reactant with at least one appropriate monoclonal antibody to the reactant under suitable conditio... | 05/02/2000 |
| 6046031 | Metalloproteinases The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as ... | 04/04/2000 |
| 6043033 | Human prostate-associated protease The present invention provides a human prostate-associated protease (HUPAP) and polynucleotides which identify and encode HUPAP. The invention also provides expression vectors, host cells, antibodies, antagonists, and antisense molecules. The invention al... | 03/28/2000 |
| 6039944 | Modified Factor VII The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical compositions... | 03/21/2000 |
| 6033894 | Kaposi's Syndrome Herpesvirus protease and assembly protein compositions and methods Kaposi's Sarcoma Herpesvirus (KSHV) protease and assembly protein sequences are disclosed. Also disclosed are polynucleotides that encode the protease and assembly protein. The invention includes screening and detection methods, as well as KSHV protease i... | 03/07/2000 |
| 6030612 | Antimicrobial uses of multifunctional enzyme The invention relates to a multifunctional enzyme that can be derived from crustaceans or fish. The enzyme has at least one of a chymotrypsin, trypsin, elastase, collagenase and exo peptidase activity, and a molecular weight between about 20 kd and about ... | 02/29/2000 |
| 6020181 | Inhibition of thrombus formation by medical related apparatus comprising treating with fibrinolytic matrix metalloproteinase The invention provides a method of causing the degradation of fibrin(ogen) (i.e., fibrin, fibrinogen, and related substances) by means of a fibrinolytic matrix metalloproteinase, preferably an MMP-3 or MMP-7. The method of the invention can be performed i... | 02/01/2000 |
| 6017882 | Modified vitamin K-dependent polypeptides The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.... | 01/25/2000 |
| 6017747 | Nucleic acids encoding a collagenase An isolated sequence is provided that encodes crab serine collagenase I. The mature recombinant collagenase (SEQ. I.D. No:4) has a molecular weight of 23,500 and may be expressed in a variety of expression systems for production of readily isolated and re... | 01/25/2000 |
| 6013466 | TNF- converting enzyme A metalloprotease that converts TNF- from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified proteas... | 01/11/2000 |
| 6013503 | Human prohormone convertase 4 The present invention provides polynucleotide and polypeptide molecules for a novel human prohormone convertase 4. The polynucleotides encoding human prohormone convertase 4, are located on chromosome 19, and may, for example, be used to identify a region... | 01/11/2000 |
| 6010893 | Process for producing human matrilysin by means of recombinant DNA The present invention relates to a process for producing a human matrilysin characterized in that a human promatrilysin is expressed in E. coli and secreted into the periplasm thereof; the inclusion body is formed, the human promatrilysin is solubilized w... | 01/04/2000 |
| 6008199 | Methods for treating hypercoagulable states or acquired protein C deficiency A method of treatment for human patients with an acquired hypercoagulable state or acquired protein C deficiency associated with sepsis, purpura fulminans, meningococcal sepsis, bone marrow and other transplantations, severe burns, pregnancy, major surger... | 12/28/1999 |
| 6008019 | Plasminogen activator from saliva of the vampire bat The present invention relates to novel thrombolitic v-PA's which dissolve blood clots in the human body and thus are suitable for the treatment of cardial infarction, for example.... | 12/28/1999 |
| 6004794 | Human serine protease Isolated nucleic acids encoding a human serine protease PSP1, protein obtainable from the nucleic acids, recombinant host cells transformed with the nucleic acids, oligonucleotides and primer pairs specific for PSP1 polymorphisms and use of the protein an... | 12/21/1999 |
| 6001629 | Mitochondrial processing peptidase subunit The invention provides a human mitochondrial processing peptidase subunit (MPPS-1) and polynucleotides which identify and encode MPPS-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also p... | 12/14/1999 |
| 5997864 | Modified factor VII The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. The invention relates to no... | 12/07/1999 |
| 5989856 | Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins The invention is based on the finding that furin belongs to a family of endoproteolytically active enzymes and relates to a process for the in vitro cleavage of a protein by treating the protein in the presence of Ca2+ ions with furin or furin ... | 11/23/1999 |
| 5989890 | Compositions and methods for PACE 4 and 4.1 gene and polypeptides in cells Compositions and methods are provided for endopeptidases and their production, and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides. These compositions and methods utilize recombinant PACE 4 and 4.1, mamma... | 11/23/1999 |
| 5989542 | Capsular polysaccharides from enterococci The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In addition, the invention is directed to the antigens produced... | 11/23/1999 |
| 5986079 | Expression of pace in host cells and methods of use thereof Compositions and methods are provided for endopeptidase production and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides, including proteins requiring gamma-carboxylation for biological activity. These comp... | 11/16/1999 |
| 5985640 | Mch2, an apoptotic cysteine protease, and compositions for making and methods of using the same A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2, and an inactive isoform of it, Mch2ଲ, are disclosed. Isolated nucleic acid molecules that encode Mch2 and Mch2ଲ, respec... | 11/16/1999 |
| 5981256 | Recombinant stratum corneum chymotryptic enzyme (SCCE) The present invention relates to a polypeptide having the amino acid sequence SEQ ID NO:2 or an analogue or variant thereof having SCCE activity as defined in the present application, such as a polypeptide having a sub-sequence of the amino acid sequence ... | 11/09/1999 |
| 5976841 | Proteins having fibrinolytic and coagulation--inhibiting properties Proteins having fibrinolytic and coagulation-inhibiting properties which are linked at the N- and/or C-terminal end of the plasminogen-activating amino acid sequence to a thrombin- or factor Xa-inhibiting amino acid sequence. The proteins, which are produ... | 11/02/1999 |
| 5976530 | Peptide plasminogen activators Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, enhanced specific activity, reduced response to inhibiti... | 11/02/1999 |
| 5972636 | ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting The ATP-ubiquitin-dependent process has been shown to be responsible for the excessive protein degradation which occurs in conditions or disease states in which there is severe loss of body mass and negative nitrogen balance has been identified and key co... | 10/26/1999 |
| 5972680 | Glucose transporter vesicle aminopeptidase An aminopeptidase which is a component of GLUT4-containing vesicles in the natural state, and which cleaves insulin. The claimed protein has an apparent molecular weight of approximately 110 kD in its deglycosylated form and a predicted molecular weight o... | 10/26/1999 |
| 5968782 | Mast cell protease that cleaves fibrinogen Compositions containing a Trypson-like serine protease from mast cells ("tryptase-7") are provided. The compositions are useful for treating blood clot formation in vitro and in in vitro. Also provided is a novel bioengineering method to produce the trypt... | 10/19/1999 |
