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| Number | Title | Issue Date |
| 8383388 | Modified coagulation factor IX polypeptides and use thereof for treatment Provided are modified factor IX (FIX) polypeptides and methods of generating modified FIX polypeptides. Also provided are pharmaceutical compositions, including compositions formulation for oral administration, that contain the modified FIX polypeptides, and methods... | 02/26/2013 |
| 8309341 | 2-mercaptocyclopentanecarboxylic acid compounds, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group of formula COR4, or R1 represents a group of formula (A): ... | 11/13/2012 |
| 8273714 | genes and proteins and variants, and therapeutic compositions and methods of utilizing the same The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and ... | 09/25/2012 |
| 8273536 | Marks as modifers of the PTEN pathway and methods of use Human MARK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that modulate the activity of MARK ... | 09/25/2012 |
| 7985571 | Isolated genomic polynucleotide fragments from chromosome 17 that encode human carboxypeptidase D The invention is directed to isolated genomic polynucleotide fragments that encode human carboxypeptidase D, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invent... | 07/26/2011 |
| 7888094 | Dipeptidyl peptidases Peptides including HisGlyTrpSerTyrGlyGlyPheLeu; LeuAspGluAsnValHisPhePhe; GluArgHisSerIleArg and PheValIleGlnGluGluPhe which show peptidase ability and have substrate specificity for at least one of the compounds H-Ala-Pro-pNA, H-Gly-Pro-pNA and H-Arg-Pro-pNA are di... | 02/15/2011 |
| 7824897 | Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein concentrations. The present invention further discloses methods for generating c... | 11/02/2010 |
| 7811803 | Methods and compositions for rapid purification of proteasomes and methods of use of components thereof Disclosed are methods for rapidly and efficiently purifying proteasomes using fusion proteins having homology to ubiquitin. Also disclosed are methods for assessing aberrant cell growth utilizing fusion proteins have homology to ubiquitin and a signal producing moie... | 10/12/2010 |
| 7785857 | Protein C variant This invention relates to a novel form of protein C or activated protein C. More specifically, the invention is directed to a variant of protein C that is activated at a higher rate than wild-type or other variants and produces an activated protein C with reduced an... | 08/31/2010 |
| 7754463 | Inhibitors of USP1 Deubiquitinating Enzyme Complex The invention provides compositions and methods used to inhibit USP1 deubiquitinase activity and to identify new inhibitors of USP1 deubiquitinase. The inhibitors can be used to treat or prevent cancer, bone marrow failure, and damage to cells or DNA resulting from ... | 07/13/2010 |
| 7745192 | Prothrombin activating protein The invention relates to snake venom protease polypeptides and nucleic acid sequences encoding same. This invention also relates to methods of making and using the snake venom proteases, e.g., to promote haemostasis and prevent blood loss such as during surgery or f... | 06/29/2010 |
| 7741096 | Crystal structure of hepatocyte growth factor activator complexed with Kunitz domain inhibitor The present disclosure provides crystals of and structural coordinates of Hepatocyte growth factor activator with and without bound pseudo-substrate or inhibitor. In a specific embodiment, a crystal structure of activated HGFA complexed with a Kunitz domain inhibito... | 06/22/2010 |
| 7622292 | Regulation of human transmembrane serine protease Reagents that regulate human transmembrane serine protease activity and reagents that bind to human transmembrane serine protease gene products can be used to regulate extracellular matrix degradation. Such regulation is particularly useful for treating COPD, metast... | 11/24/2009 |
| 7595183 | Cathepsins L-like cysteine protease derived from northern shrimp () The object of the present invention is to find and produce cathepsin L having high activity under neutral to alkaline conditions and at a low temperature range. The present inventors succeeded in discovering novel cathepsin L having activity even at a low temperatur... | 09/29/2009 |
| 7588927 | Composition and methods relating to SENP1—a sentrin-specific protease The invention relates to a novel protease, called SENP1, which is active against sentrin-modified proteins in vivo. The invention more specifically relates to the genomic and amino acid sequences for SENP1, compositions related to and based on these sequences, and m... | 09/15/2009 |
| 7572619 | Recombinant blood clotting factors The present invention relates to an improved method for the production of recombinant human blood clotting factors, in particular of factor VIII and factor IX. An immortalized human cell line can be used to stably express viral transcription activator proteins and c... | 08/11/2009 |
| 7482148 | Recombinant calf-chymosin and a process for producing the same The present invention relates to a recombinant calf-Chymosin protein as set forth in SEQ ID No. 1; a recombinant calf-Chymosin gene as set forth in SEQ ID No. 2 encoding the protein comprising amino acid sequence of SEQ ID NO.1; an E. coli comprising the reco... | 01/27/2009 |
| 7473544 | Alkaline protease The present invention provides an alkaline protease exhibiting high detergency and productivity, which is obtained by further enhancing the detergency of an alkaline protease effective against complex dirt and enhancing the specific activity. ... | 01/06/2009 |
| 7456007 | β-secretase enzyme compositions and methods Disclosed is an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that p... | 11/25/2008 |
| 7452708 | Human PRSS11-like S2 serine protease and uses thereof A novel human cDNA, termed PRSS11-L, was isolated which encodes a polypeptide that belongs to the S2/HtrA serine protease family. The PRSS11-L mRNA is widely expressed in several tissues throughout the body by multi-tissue Northern blotting. The full-length PRSS11-L... | 11/18/2008 |
| 7427478 | Beta-secretase enzyme compositions and methods Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recomb... | 09/23/2008 |
| 7416869 | Enzyme delivery systems, application in water based products Aqueous enzyme delivery systems as well as aqueous cosmetics and personal care products were provided which comprise at least one stabile enzyme and a polyglycerol containing at least 15 carbons. In addition, stabile non-aqueous enzyme delivery systems which are dis... | 08/26/2008 |
| 7410774 | Compounds modulating sister chromatid separation and method for identifying same Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity. Inhibitors of separin activity are useful in cancer therapy, to prevent ... | 08/12/2008 |
| 7407933 | Drug containing angiotensin convertase The medicine containing angiotensin-converting enzyme or its peptidase-inactivated mutants that specifically releasing GPI-anchored proteins from the cell surface, for preventing or curing diseases, such as prion-related diseases, inflammatory diseases, bacterial in... | 08/05/2008 |
| 7399466 | Method and compositions for promoting osteogenesis The object of the present invention is to increase PHEX activity to improve the osteogenic process in a mammal where this process has been diminished due to pathology or a condition that require osteogenesis. Osteocalcin is an endogenous inhibitor of the PHEX activi... | 07/15/2008 |
| 7399465 | Pharmaceutical compositions for treating arthritis and inflammatory disease The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifyin... | 07/15/2008 |
| 7378511 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP prote... | 05/27/2008 |
| 7374923 | Polypeptide A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the scre... | 05/20/2008 |
| 7374933 | Human metalloprotease and polynucleotides encoding the same Novel human polynucleotide and polypeptide sequences are disclosed that can be used in thereapeutic, diagnostic, and pharmacogenomic applications. ... | 05/20/2008 |
| 7368536 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP prote... | 05/06/2008 |
| 7364892 | Microbial trypsin mutants having chymotrypsin activity and nucleic acids encoding same The present invention relates to microbial trypsin variants having chymotrypsin-like activity, comprising: (a) a one or more substitutions corresponding to positions 144, 193, 198, 201, 218, 223, 227, 228, 229, 230, and 231 of amino acids 25 to 248 of SEQ ID NO: 2, ... | 04/29/2008 |
| 7358084 | Enhanced secretion of a polypeptide by a microorganism Described herein are methods for the enhanced production of secreted proteins. The secretion of a protein of interest having a substantially non-polar carboxy tail is enhanced by the placement of charged amino acid residues at the carboxy terminus either by adding t... | 04/15/2008 |
| 7358273 | Inhibitors of caspases The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1β converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and... | 04/15/2008 |
| 7351813 | Liver-specific gene expression cassettes, and methods of use In one aspect, the present invention provides nucleic acid expression cassettes that are predominantly expressed in the mammalian liver. The present invention also provides vectors comprising a nucleic acid expression cassette that is predominantly expressed in the ... | 04/01/2008 |
| 7342093 | Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins Disclosed herein are compounds that inhibit Hsp90 interactions with IAP proteins, such as Survivin, XIAP, cIAP1, or cIAP2, and methods for identifying and using such compounds. ... | 03/11/2008 |
| 7335504 | Engineered enzymes and uses thereof The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.... | 02/26/2008 |
| 7335758 | Catalytic domain of ADAM33 and methods of use thereof The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of g... | 02/26/2008 |
| 7329529 | Ubiqutin proteases The invention provides isolated nucleic acids molecules that encode novel ubiquitin protease polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the ubiquitin protease nucleic acid molecules of the in... | 02/12/2008 |
| 7329737 | Antibodies that bind hK-1 The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides. ... | 02/12/2008 |
| 7319016 | Crystallization of cathepsin S Provided are crystals relating to Cathepsin S and its various uses. ... | 01/15/2008 |
