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| Number | Title | Issue Date |
| 7029911 | AFC1 and RCE1: isoprenylated CAAX processing enzymes Two genes which encode polypeptides that mediate post-prenylation processing steps in CAAX polypeptides such as Ras are provided. The two genes (AFC1 and RCE1) encode polypeptides that mediate the removal of the AAX tripeptide from the CAAX polypeptide following pre... | 04/18/2006 |
| 6921664 | Telomerase The present invention is directed to expression vectors comprising a polynucleotide that encodes a human telomerase reverse transcriptase (hTRT) protein, variant, or fragment. The present invention is also directed to host cells that comprise expression vectors comp... | 07/26/2005 |
| 6897049 | Proteins producing an altered immunogenic response and methods of making and using the same The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization... | 05/24/2005 |
| 6863918 | Infant formula with improved protein content An improved infant formula resulting in reduced constipation, abdominal discomfort and gastrointestinal problems, comprises at least one protein component having a phosphorus content of less than 0.75 g P/100 g protein, and at least one lipid component that can be e... | 03/08/2005 |
| 6846656 | Process for producing N-acetylneuraminic acid The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process comprises: allowing (i) a culture of a microorganism having N-acetylneuraminic... | 01/25/2005 |
| 6791008 | Use of a class of enzymes and their encoding genes to increase the oil content in transgenic organisms The present invention relates to the use of a novel enzyme and its encoding gene for transformation. More specifically, the invention relates to the use of a gene encoding an enzyme with acyl-CoA:diacylglycerol acyltransferase activity. This gene expressed alone in ... | 09/14/2004 |
| 6770469 | Protein-deamidating enzyme, gene encoding the same, production process therefor, and use thereof A novel enzyme which has an activity to release side chain carboxyl groups and ammonia from a protein by acting upon side chain amido groups in the protein. This invention relates to a method for the production of an enzyme, which comprises culturing in a medium a s... | 08/03/2004 |
| 6653109 | Method of producing derivatives of lactosamine Disclosed is a method of producing a compound with 댡-4 linkage which contains the lactosamine structure involving reacting at least one donor substance GalଲOR where R is an organic group, and at least one acceptor substance which is a glucopy... | 11/25/2003 |
| 6596525 | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins The present invention relates to a novel improved protein mutant which produces low allergenic response in humans compared to the parent of that mutant. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recog... | 07/22/2003 |
| 6316251 | Gene, group of genes, and novel ଲ-gluclosidase An object of the present invention is to provide novel genes and gene group involved in cellulose synthesis of microorganisms. The present invention relates to a gene group encoding cellulase, cellulose synthase complex, ଲ-glucosidase and the like, and t... | 11/13/2001 |
| 6171828 | Method for culturing microorganisms having a methanol metabolic pathway The present invention discloses a method for culturing microorganisms having a methanol metabolic pathway in which an expression unit is introduced that comprises a target gene linked downstream from a promoter that can be induced by methanol; wherein, du... | 01/09/2001 |
| 6121025 | Process for producing optically active 3-quinuclidinol derivatives The present invention relates to a process for producing optically active 3-quinuclidinol or derivatives, wherein a racemic 3-quinuclidinol ester represented by the general formula (I): ##STR1## wherein R represents a straight-chain or branched alkyl... | 09/19/2000 |
| 6037145 | Process for production of protein A process for the production of a desired polypeptide comprising the steps of: (1) transforming host cells with an expression vector comprising a gene coding for a fusion protein comprising a desired polypeptide and a protective polypeptide; (2) culturing... | 03/14/2000 |
| 5998190 | Enzyme with protease activity An isolated and purified enzyme exhibiting protease activity at a pH of 4-7 which exhibits protease activity in 5% hydrogen peroxide and which is encoded by a DNA sequence which hybridizes to a DNA sequence depicted in SEQ ID NO. 1 or 2.... | 12/07/1999 |
| 5985627 | Modified carboxypeptidase A method for transamidating a peptide substrate having a P1 amino acid residue with a positively charged side chain. According to the invention, carboxypeptidase Y is modified to substitute at least one amino acid having a negatively charged si... | 11/16/1999 |
| 5891669 | Methods for producing polypeptides in respiratory-deficient cells The present invention relates to methods of producing a polypeptide, comprising: (a) introducing into a respiratory-defective mutant of a cell (i) one or more first nucleic acid sequences which complement the respiratory defect and (ii) a second nucleic a... | 04/06/1999 |
| 5888757 | Cell wall assay Disclosed are methods that can be used to (1) measure the level of polysaccharide in a sample; (2) measure the ability of a compound to degrade a polysaccharide; (3) measure the ability of a compound to modulate polysaccharide synthesis; and (4) identify ... | 03/30/1999 |
| 5885821 | Process for production of secretory Kex2 derivatives Kex2 protease derivatives obtained by transforming methanol-assimilating with expression vectors containing DNA coding for any amino acid sequence which is an amino acid sequence of Kex2 protease wherein the N-terminus is the Met at position 1 and the C-t... | 03/23/1999 |
| 5868868 | Peg-modified proteases and methods of use in contact lens cleaning The invention discloses PEG-modified proteases, compositions containing these modified enzymes, and methods for using them to clean contact lenses. The methods of the present invention are also directed to the simultaneous cleaning and disinfecting of con... | 02/09/1999 |
| 5854050 | Enzyme with protease activity A DNA construct comprising a DNA sequence encoding an enzyme exhibiting protease activity, which DNA sequence comprises the DNA sequence shown in SEQ ID No. 1 or 2 or an analog of any of these sequences being at least 80% homologous to the DNA sequence sh... | 12/29/1998 |
| 5843753 | Metalloprotease having increased activity The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA construct... | 12/01/1998 |
| 5807729 | Metalloprotease having increased activity The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA construct... | 09/15/1998 |
| 5736512 | Serine protease variants having peptide ligase activity The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity. The invention also includes novel ligation substrates whic... | 04/07/1998 |
| 5691295 | Detergent compositions A laundry detergent for washing fabrics composed of proteinogenic fibers is comprised of at least one surfactant and a proteolytically active amount of a protease having a keratinase/caseinase activity ratio of less than about 0.80.... | 11/25/1997 |
| 5691162 | Metalloprotease having increased activity The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA construct... | 11/25/1997 |
| 5677272 | Bleaching compositions comprising protease enzymes The invention herein provides bleaching compositions comprising a protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor... | 10/14/1997 |
| 5627043 | Yeast strains used to identify inhibitors of dibasic amino acid processing endoproteases The present invention relates to novel yeast strains which produce a heterologous precursor protein having a dibasic amino acid processing site which can be processed into at least one cleavage protein by a dibasic amino acid processing endoprotease. Such... | 05/06/1997 |
| 5561051 | Screen for inhibitors of chitinase The present invention is directed to a method for screening samples for the identification of agents exhibiting potential fungicidal and insecticidal activity for a wide variety of agricultural, medical and pharmaceutical uses. The method utilizes cells t... | 10/01/1996 |
| 5541112 | Genes which influence pichia proteolytic activity, and uses therefor The isolation and characterization of genes involved in proteolytic processing in species of the genus Pichia is described. The availability of such genes has enabled the generation of strains of Pichia which are deficient in proteolytic activity, which s... | 07/30/1996 |
| 5527483 | Nonaqueous gelled automatic dishwashing composition containing enzymes Nonaqueous gelled automatic dishwashing compositions containing a mixture of a protease enzyme and an amylase enzyme have been found to be very useful in the removal of protein and carbohydrate soils from dishware at operating temperatures of 100° F. to ... | 06/18/1996 |
| 5521093 | Yeast vector coding for heterologous gene fusions linked via KEX2 cleavage site and coding for truncated KEX2 genes The present invention relates to an improved system for producing mature heterologous proteins, and especially hirudin, by means of yeasts comprising an expression vector containing a sequence coding for the heterologous protein. This improvement is chara... | 05/28/1996 |
| 5468416 | Detergent enzymes This inventions is in the field of detergent enzymes. More specifically, the invention relates to the use of proteases from fungi of the genus Verticillium for detergent purposes.... | 11/21/1995 |
| 5429765 | Detergent and method for producing the same A high density, enzyme-containing powder detergent composition including a combination of alkaline proteases for improved cleaning characteristics and a combination of different density sodium carbonates for improved dispensing characteristics.... | 07/04/1995 |
| 5425942 | Polyfunctinal protease The present invention provides a human polyfuctional protease chracterized in that the protease has unique enzymological and physicochemical properties:... | 06/20/1995 |
| 5413914 | Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases The present invention relates to a novel method to identify compounds that inhibit proteolytic cleavage by dibasic amino acid processing endoproteases that includes contacting a yeast strain with a putative inhibitory compound under conditions in which, i... | 05/09/1995 |
| 5391490 | Ubiquitin-specific protease A ubiquitin-specific protease which cleaves ubiquitin from any protein or peptide to which ubiquitin is joined and the gene encoding the protease are disclosed. The protease specifically cleaves the peptide bond in a fusion of ubiquitin to a protein or pe... | 02/21/1995 |
| 5306637 | Method for recovery of intracellular material by disruption of microbial cells with carbon dioxide under pressure This invention is a method to rupture microbial cells in order to recover intracellular material in the cells comprising: a) treating the cells with carbon dioxide under pressure sufficient to enter the cells for time sufficient to allow enough carbon dioxide ... | 04/26/1994 |
| 5262322 | Host transformed with yeast gene and ubiquitin/polypeptide fusions A ubiquitin hydrolase is provided having a purity of at least 70% homogeneity based on the weight of the total protein in the composition. Also provided are DNA sequences encoding ubiquitin hydrolases, as well as expression systems for their recombinant p... | 11/16/1993 |
| 5254470 | Alkaline protease, alkaline protease gene, recombinant DNA, DNA fragment for the expression of gene, and process for the production of alkaline protease Alkaline protease which has leucine or isoleucine in the place of valine at the amino acid number 40 of wild type alkaline protease, a gene encoding the amino acid sequence of alkaline protease which has the substitution as described above, a recombinant ... | 10/19/1993 |
| 5234830 | DNA encoding a KEX2 endoprotease without a C-terminal hydrophobic region A KEX2 endoprotease produced by a recombinant DNA technique, a KEX2 endoprotease shortened at the C-terminal of a native enzyme and still containing a C-terminal hydrophobic region, a soluble KEX2 endoprotease without a C-terminal hydrophobic region; DNA'... | 08/10/1993 |
