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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8173409 | Acid fungal proteases The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and ... | 05/08/2012 |
| 7588926 | Proteases The invention relates to a novel class of serine proteases of peptidase family S2A or S1E that are stable in the presence of copper (Cu2+) and/or inhibited by copper only to a limited extent. Structural features of potential relevance for this effect are also disclo... | 09/15/2009 |
| 7404977 | Rennets The present invention describes an aspartic protease produced by a fungus from the class Eurotiomycetes, comprising the amino acid sequence of FDTGSSD or FDTGSSE. The present invention further provides a process for identifying new milk clotting enzymes comprising s... | 07/29/2008 |
| 7393667 | Stereoselective reduction process for the preparation of pyrrolotriazine compounds The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib: ... | 07/01/2008 |
| 7368272 | Expression of proteolytic enzymes in koji mold in the presence of carbon sources The present invention refers to a koji mold capable of expressing proteolytic enzymes in the presence of a carbon source in at least the same amount as in the absence thereof. In particular, the present invention pertains to a mutation in the creA gene as a tool to ... | 05/06/2008 |
| 7368274 | Expression of recombinant proteinase K from in yeast The invention concerns a method for the expression of a gene coding for a soluble proteinase K in yeast e.g. in Pichia pastoris with subsequent secretion into the culture medium. In addition a method for purifying the heterologously expressed and secreted pro... | 05/06/2008 |
| 7262287 | yapsin deficient mutant strain and process for the preparation of recombinant proteins using the same The present invention relates to a nucleic acid molecule comprising the HpYPS1 gene encoding H. polymorpha yapsin1, a polypeptide encoded by the nucleic acid molecule, a H. polymorpha mutant strain having reduced yapsin activity by mutation of the HpYP... | 08/28/2007 |
| 7252972 | Methods for secretory production of proteins The object of the present invention is to provide a method of producing a heterologous protein by making a coryneform bacterium to produce and efficiently extracellularly secrete (secreto-production) an industrially useful heterologous protein. According to the pres... | 08/07/2007 |
| 7202074 | Protein and nucleic acid sequence encoding a KRILL-derived cold adapted trypsin-like activity enzyme The present invention provides nucleic acid and corresponding amino acid sequences of two isoforms of cold adapted trypsin-like activity protein, insolated from antarctic marine origin, preferably from antarctic krill (Euphausia superba) that can be used in a... | 04/10/2007 |
| 7192754 | -origin ecdysteroid 22-oxidase and molt hormone inactivation system with the use of the same A material and a system are provided that efficiently inactivate a molting hormone by means of a protein having ecdysteroid 22-oxidase activity. ... | 03/20/2007 |
| 7186546 | Process for the preparation of alkaline protease The present invention relates to a process for the preparation of alkaline protease using a fungal culture of the order entomophthorales and to the use of the said protease in the pretanning processes of leather manufacture. ... | 03/06/2007 |
| 7169757 | Stabilizing cGMP in aqueous formulation A cGMP containing aqueous composition exhibiting a reduced off-flavor even after extended storage, comprising a hydrophobic resin; and an agent, that chemically blocks functional groups in cGMP. Methods of preparing and using the product are also provided. ... | 01/30/2007 |
| 7037673 | Dipeptide production method, L-amino acid amide hydrolase used therein, and production method of L-amino acid amide hydrolase A process for industrially advantageously producing a dipeptide via a convenient pathway starting with less expensive and easily available materials is provided. A dipeptide is produced from an L-amino acid amide and an L-amino acid by using a culture of a microbe c... | 05/02/2006 |
| 7018793 | Combinatorial screening of mixed populations of organisms Provided is a method of screening gene libraries derived from a mixed population of organisms for a bioactivity or biomolecule of interest. The mixed population of organisms can be a cultured population or an uncultured population from, for example, the environment.... | 03/28/2006 |
| 6960462 | Use of acid-stable subtilisin proteases in animal feed Acid-stable proteases of the subtilisin family, their use in animal feed, feed-additives and feed compositions containing such proteases, and methods for the treatment of vegetable proteins using such proteases. ... | 11/01/2005 |
| 6905868 | Proteases from gram-positive organisms The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for Bacillus MP. The present invention also provides host cells havin... | 06/14/2005 |
| 6897049 | Proteins producing an altered immunogenic response and methods of making and using the same The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization... | 05/24/2005 |
| 6846656 | Process for producing N-acetylneuraminic acid The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process comprises: allowing (i) a culture of a microorganism having N-acetylneuraminic... | 01/25/2005 |
| 6797273 | Neisseria meningitidis antigen The invention provides BASB053 polypeptides and polynucleotides encoding BASB053 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses. ... | 09/28/2004 |
| 6777219 | Process for the preparation of alkaline protease The present invention relates to a process for the preparation of alkaline protease using a fungal culture of the order entomophthorales and to the use of the said protease in the pretanning processes of leather manufacture. ... | 08/17/2004 |
| 6770469 | Protein-deamidating enzyme, gene encoding the same, production process therefor, and use thereof A novel enzyme which has an activity to release side chain carboxyl groups and ammonia from a protein by acting upon side chain amido groups in the protein. This invention relates to a method for the production of an enzyme, which comprises culturing in a medium a s... | 08/03/2004 |
| 6759228 | Alkaline protease An alkaline protease having the following properties; a gene encoding the same; a microorganism producing the same; and washing compositions containing the same; (i) acting over a broad pH value range of 4 to 13 and achieving, at pH 6 to 12, 80% or more the activity... | 07/06/2004 |
| 6596525 | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins The present invention relates to a novel improved protein mutant which produces low allergenic response in humans compared to the parent of that mutant. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recog... | 07/22/2003 |
| 6548745 | Italian rye grass and a method of introducing endophytic fungi into an italian rye grass To provide an Italian rye grass with excellent characteristics, and in particular, excellent insect resistance and disease resistance, an endophyte, which is a filamentous endophytic fungus living together with a wild plant occurring in nature, is isolate... | 04/15/2003 |
| 6475485 | Two novel human cathepsin proteins The present invention provides two novel human cathepsin proteins (HCPs) and polynucleotides encoding HCPs. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HCPs. The inventi... | 11/05/2002 |
| 6440413 | Medicament for optimizing mucosal viscosity and stimulating intestinal function The invention pertains to the field of biology, and more particularly, to therapeutic chemistry, and discloses pharmaceutical compositions containing, as an active ingredient, an enzyme or an enzyme complex containing said enzyme, obtained by cultivating ... | 08/27/2002 |
| 6379928 | Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fung... | 04/30/2002 |
| 6207437 | Crystalline protease and method for producing same A method for preparing a crystalline protease is provided which comprises preparing an aqueous solution containing the protease enzyme and adding to the aqueous solution sodium sulfate, allowing the crystallization to take place at a temperature between 1... | 03/27/2001 |
| 6187579 | Customized proteases The invention provides customized proteases (i.e., mutant enzymes), methods of making customized proteases, as well as methods of using customized proteases. The customized proteases of the invention are derived from the known proteases. Altered transacyl... | 02/13/2001 |
| 6171817 | Heterologous polypeptides expressed in filamentous fungi, process for making same, and vectors for making same Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fung... | 01/09/2001 |
| 6156557 | Alkaline protease from streptomyces sp. and method for preparing the same Disclosed is an alkaline protease having a specific activity of 214,000 (U/mg protein) when using casein as a substrate and 52,700 (U/mg protein) when using keratin as a substrate. The alkaline protease is produced by a strain belonging to alkalophilic ac... | 12/05/2000 |
| 6127142 | Microbially derived enzymes having enhanced milk clotting activity and method of producing same A method of producing a milk clotting enzyme including the steps of (a) fermenting a strain of Rhizomucor miehei or Aspergillus oryzae to form a fermentation product having a glycoslated Rhizomucor miehei aspartic protease and other proteins, and (b) subj... | 10/03/2000 |
| 6103511 | Lichenase and coding sequences The present invention provides a fungal lichenase, i.e., an endo-1,3-1,4-ଲ-D-glucanohydrolase, its coding sequence, recombinant DNA molecules comprising the lichenase coding sequences, recombinant host cells and methods for producing same. The prese... | 08/15/2000 |
| 6090607 | Enhanced expression of proteolytic enzymes in koji mold The present invention has for an object a koji mold which expresses at least 2 times more endo- and exo-peptidases than the wild type strain of Aspergillus oryzae CNCM I-1882, and especially at least 30 mU of endopeptidase activity, at least 30 mU of leuc... | 07/18/2000 |
| 6017762 | Cassette for the expression of an endothiapepsin precursor in Cryphonectria parasitica The present invention relates to a new cassette for the expression of an endothiapepsin precursor in Cryphonectria parasitica, to a strain of this species transformed with this cassette, to a process for preparing endothiapepsin using this strain and also... | 01/25/2000 |
| 5998190 | Enzyme with protease activity An isolated and purified enzyme exhibiting protease activity at a pH of 4-7 which exhibits protease activity in 5% hydrogen peroxide and which is encoded by a DNA sequence which hybridizes to a DNA sequence depicted in SEQ ID NO. 1 or 2.... | 12/07/1999 |
| 5985627 | Modified carboxypeptidase A method for transamidating a peptide substrate having a P1 amino acid residue with a positively charged side chain. According to the invention, carboxypeptidase Y is modified to substitute at least one amino acid having a negatively charged si... | 11/16/1999 |
| 5945329 | Customized proteases The invention provides customized proteases (i.e., mutant enzymes), methods of making customized proteases, as well as methods of using customized proteases. The customized proteases of the invention are derived from the known proteases. Altered transacyl... | 08/31/1999 |
| 5888757 | Cell wall assay Disclosed are methods that can be used to (1) measure the level of polysaccharide in a sample; (2) measure the ability of a compound to degrade a polysaccharide; (3) measure the ability of a compound to modulate polysaccharide synthesis; and (4) identify ... | 03/30/1999 |
| 5876945 | Methods for identifying herbicidal agents that inhibit D1 protease D1 protease has been isolated from the alga (Scenedesmjus obliquus), wheat, and Synechocystis PCC 6803 and the genes encoding these enzymes have been cloned and sequenced. Native or recombinantly produced enzyme has been used to develop assays to detect h... | 03/02/1999 |
