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| Number | Title | Issue Date |
| 8148128 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine hydrolases have one or more amino acid residues in a subsite replaced with ... | 04/03/2012 |
| 8076297 | Pharmaceutical composition containing polypeptide fragments of serralysins The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding ... | 12/13/2011 |
| 7906310 | Proteases The invention relates to a novel class of serine proteases of peptidase family S2A or S1E that are stable in the presence of copper (Cu2+) and/or inhibited by copper only to a limited extent. Structural features of potential relevance for this effect are ... | 03/15/2011 |
| 7892808 | Protease variants The invention relates to a novel 3D structure determined for a Nocardiopsis protease, as well as to variants of parent protease homologous to Nocardiopsis proteases, preferably of improved thermostability and/or with an altered temperature activity pro... | 02/22/2011 |
| RE41461 | Purification, composition and specificity of Heparinase I, II, and III from Flavobacterium heparinum A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activi... | 07/27/2010 |
| RE41328 | Purification of Heparinase I, II and III from Flavobacterium heparinum A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the co... | 05/11/2010 |
| 7485447 | Proteases and methods for producing them A secreted proteolytic polypeptide comprising at least three non-polar or uncharged polar amino acids within the last four amino acids of the C-terminus of the polypeptide, encoding polynucleotides, expression vectors comprising the polynucleotides, host cell compri... | 02/03/2009 |
| 7410638 | Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals The present invention relates to isolated nucleic acid molecules encoding an autoinducer inactivation protein, wherein the encoded protein comprises an amino acid sequence selected from the group consisting of 104HXHXDH109˜60aa˜H169 | 08/12/2008 |
| 7407789 | Recombinant staphylokinase derivatives and the preparation and applications thereof The present invention relates to the biotechnology field, more particularly, to novel recombinant staphylokinase (RGD/KGD-Sak) derivatives and the preparation the thereof. The derivatives, have a low polymerizing ability, low immunogenicity and a bifunctionality of ... | 08/05/2008 |
| 7354745 | Method for producing L-β-lysine Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds. Although enantiomerically pure β-amino acids, such as L-β-lysine, can be produced by standard chemical synthesis, this traditional approach is time consu... | 04/08/2008 |
| 7335486 | Method for universal enzymatic production of bioactive peptides The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any... | 02/26/2008 |
| 7332320 | Protease producing an altered immunogenic response and methods of making and using the same The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants... | 02/19/2008 |
| 7326531 | Proteases from gram-positive organisms The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for Bacillus MP. The present invention also provides host cells havin... | 02/05/2008 |
| 7320887 | Alkaline protease variants The invention relates to novel alkaline protease variants. These variants have, when enumerating the alkaline protease from Bacillus lentus, variations in amino acid position 61, positions 199 and/or 211 and, optionally, at least one modification that contrib... | 01/22/2008 |
| 7314744 | Hyperthermostable protease gene There are provided hyperthermostable proteases having an amino acid sequences represented by SEQ ID Nos. 1, 3 and 5 of the Sequence Listing or functional equivalents thereof and hyperthermostable protease genes encoding those hyperthermostable protease. There is als... | 01/01/2008 |
| 7306937 | Multiply-substituted protease variants Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or re-combinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding t... | 12/11/2007 |
| 7297332 | Protease, a gene therefor and the use thereof The present invention relates to a protease, and more specifically to a protease derived from Aranicola proteolyticus, a gene coding for said enzyme, a gene expression system for said protease, a process for purifying the protease, and the uses of said protea... | 11/20/2007 |
| 7297528 | Alkaline protease An alkaline protease having the following properties; a gene encoding the same; a microorganism producing the same; and washing compositions containing the same; (i) acting over a broad pH value range of 4 to 13 and achieving, at pH 6 to 12, 80% or more the activity... | 11/20/2007 |
| 7291407 | Ceramic material having ceramic matrix composite backing and method of manufacturing An article comprising a ceramic material having a ceramic matrix composite backing adapted for use in a gas turbine engine is provided. The article comprises a structural ceramic material having a hot side facing toward a high temperature environment and a cold side... | 11/06/2007 |
| 7288388 | Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having th... | 10/30/2007 |
| 7288401 | Protease variants and compositions The present invention relates to enzymes produced by mutating the genes for a number of subtilases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in any detergent in comparison to their wild type paren... | 10/30/2007 |
| 7288389 | Peptide-forming enzyme gene DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a dipeptide includes producing a dipeptide from a carboxy component and an ami... | 10/30/2007 |
| 7262271 | Synthetic peptide constructs for the diagnosis and treatment of periodontitis associated with The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease. ... | 08/28/2007 |
| 7250281 | Subtilisin variants Novel carbonyl hydrolase variants derived from the DNA sequences of naturally-occurring or recombinant non-human carbonyl hydrolases are disclosed. The variant carbonyl hydrolases, in general, are obtained by in vitro modification of a precursor DNA sequence encodin... | 07/31/2007 |
| 7241575 | Proteases from gram-positive organisms The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for Bacillus (MP). The present invention also provides host cells hav... | 07/10/2007 |
| 7232670 | Targeting proteins to cells expressing mannose receptors via expression in insect cells The present invention is based on the discovery that proteins produced in insect cell cultures are glycosylated in a unique manner that causes them to be selectively imported by cells that express mannose receptors on their membranes, particularly macrophages. Prote... | 06/19/2007 |
| 7229810 | Polymer conjugates of proteinases Methods are provided for the stabilization of proteinases by the covalent attachment of or admixture with water-soluble polymers. The resultant stabilized proteinases have increased stability under the harsh conditions used in industrial genomics, which permits thei... | 06/12/2007 |
| 7229554 | Purification process comprising microfiltration at elevated temperatures Process for microfiltration at elevated temperature. ... | 06/12/2007 |
| 7220564 | Carbonyl reductase, gene thereof and method of using the same The present invention provides a novel polypeptide efficiently forming (R)-N-benzyl-3-pyrrolidinol, a polynucleotide coding for said polypeptide, and use of the same. The present invention relates to a polypeptide having the following physical and chemical pr... | 05/22/2007 |
| 7220566 | Subtilisin variants New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also... | 05/22/2007 |
| 7217554 | Proteases and variants thereof The present invention relates to isolated proteases of the RP-II type and variants of RP-II proteases exhibiting improved properties in comparison to the parent RP-II protease, DNA constructs and vectors coding for the expression of said proteases and variants, host... | 05/15/2007 |
| 7211424 | Mammalian Subtilisin/kexin isozyme SKI-1: a proprotein convertase with a unique cleavage specificity Using RT-PCR and degenerate oligonucleotides derived from the active site residues of subtilisin-kexin-like serine proteinases, we have identified a highly conserved and phylogenetically ancestral human, rat and mouse type-I membrane-bound proteinase called subtilis... | 05/01/2007 |
| 7208458 | Surfactant composition comprising fatty alcohol alkoxylates and amorphous silica Surfactant compounds are claimed which consists essentially of a) fatty alcohol alkoxylates, b) amorphous silica, c) a carrier material and optionally d) an assistant. ... | 04/24/2007 |
| 7208310 | Proteases The present invention relates to proteases of high specific activity homologous to proteases derived from Nocardiopsis, and the production thereof by the wild-type, and in recombinant host cells including transgenic plants and non-human transgenic animals. Th... | 04/24/2007 |
| 7202202 | Consumable detergent composition for use in a lipophilic fluid The present invention relates to a surfactant system and a consumable detergent composition comprising the same. ... | 04/10/2007 |
| 7192730 | Thermostable proteolytic enzymes and uses thereof in peptide and protein synthesis The subject invention pertains to new thermostable enzymes and the use of these enzymes both in proteolysis as well as protein and polypeptide synthesis. The subject invention further concerns polynucleotide sequences which encode the enzymes of the subject inventio... | 03/20/2007 |
| 7192757 | Subtilase variants The present invention relates to subtilase variants having a reduced tendency towards inhibition by substances present in eggs, such as trypsin inhibitor type IV-0. In particular, the variants comprise at least one additional amino acid residue between positions 42â... | 03/20/2007 |
| 7189555 | Proteases from gram-positive organisms The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for Bacillus (MP). The present invention also provides host cells hav... | 03/13/2007 |
| 7189553 | Modified subtilisins and detergent, compositions containing same The present invention relates to enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in comparison to their wild type parent enzym... | 03/13/2007 |
| 7157416 | Stabilization of enzymes Enzyme-containing formulations having improved stability and enzymatic activity in liquid medium, comprising one or more protease enzymes produced from any Bacillus bacteria, at least about 5% alkali metal halide salt, and at least about 50% polyol. Also disc... | 01/02/2007 |
