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| Number | Title | Issue Date |
| 8119597 | Non-neurotoxic plasminogen activating factors for treating of stroke The invention concerns the use and the production of non-neurotoxic plasminogen activating factors, derived, for example, from the common vampire Desmodus rotundus (DSPA), for therapeutic treatment of stroke in humans. The invention provides a novel therapeut... | 02/21/2012 |
| 8114656 | Thermostable neutral metalloproteases The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly pr... | 02/14/2012 |
| 8101394 | Recombinantly modified plasmin Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that n... | 01/24/2012 |
| 7993900 | Subtilases The present invention relates to novel JP170 like subtilases from wild-type bacteria, hybrids thereof and to methods of construction and production of these proteases. Further, the present invention relates to use of the claimed subtilases in detergents, such as a l... | 08/09/2011 |
| 7960163 | Matriptase, a serine protease and its applications The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directe... | 06/14/2011 |
| 7951572 | Construction of gold nanoparticle-based peptide chip, and assaying enzyme activity and inhibitor effect using secondary ion mass spectrometric analysis thereof Disclosed herein is a gold nanoparticle (AuNP)-based peptide chip prepared by forming a monolayer of AuNPs onto a self-assembled monolayer constructed on a solid support, and then immobilizing a peptide on the AuNPs. The AuNPs can effectively amplify the mass signal... | 05/31/2011 |
| 7867747 | Fibrinolytic metalloprotease and composition comprising the same The present invention relates to a novel protease, a polynucleotide encoding the protease, and a fibrinolytic agent comprising the same. The protease is obtained from a new gene source by using metagenomic library technology, and can replace the conventional fibrino... | 01/11/2011 |
| 7846706 | PCSK9 polypeptides The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention fu... | 12/07/2010 |
| 7829319 | Glutamic acid-modified classical swine fever virus autoproteases N The invention relates to a process for the recombinant production of a heterologous polypeptide of interest by cultivating a bacterial host cell transformed with an expression vector comprising a nucleic acid molecule encoding a fusion polypeptide wherein (a) the am... | 11/09/2010 |
| 7816114 | Methods of using crystals of beta amyloid cleaving enzyme (BACE) Methods of using monoclinic crystals of human beta-secretase (BACE) having unit cell dimensions of a, b, and c, wherein a is about 81±20 Å to about 101 Å, b is 103±20 Å, c is 100±20 Å, and α=γ=90°, and β is 105°±10° for crystals of symmetry P2... | 10/19/2010 |
| 7807435 | Method for the purification of alpha-1 proteinase inhibitor (a1PI) The present invention relates to a method for the purification of alpha-1 proteinase inhibitor (a1PI) from protein fractions. More specifically, the invention relates to an improved method for the purification of alpha-1 proteinase inhibitor (a1PI), wherein the yiel... | 10/05/2010 |
| 7776578 | Alkaline protease Provided in the present invention is an alkaline protease wherein an amino acid residue at (a) position 65, (b) position 101, (c) position 163, (d) position 170, (e) position 171, (f) position 273, (g) position 320, (h) position 359 or (i) position 387 of SEQ. ID NO... | 08/17/2010 |
| 7732183 | Method for refolding enzymes The invention provides methods for efficient recombinant expression, refolding, and purification of Beta-site APP cleaving enzyme (BACE) polypeptides. In various aspects, the method includes the steps of expressing a recombinant construct in bacteria, dissolving inc... | 06/08/2010 |
| 7727756 | Subtilases The present invention relates to methods for producing variants of a parent JP170 subtilase and of a parent BPN′ subtilase and to JP170 and BPN′ variants having altered properties as compared to the parent JP170/BPN′ subtilase. ... | 06/01/2010 |
| 7718413 | Glycosylation variants of BACE Human BACE polypeptides having modifications to the N-linked glycosylation sites including one or more of the following amino acid substitutions: S174I, N223A, N153Q and N354S. DNA sequences, vectors, and host cells for producing the polypeptides. Crystalline protei... | 05/18/2010 |
| 7670821 | Method for the purification of microbial protease The invention disclose a method for purifying microbial protease, comprising:(i) providing an aqueous liquid sample containing a microbial protease, and a separation medium comprising a base matrix and a plurality of attached ligands that are capable of binding to m... | 03/02/2010 |
| 7608444 | Use of acid stable protease in animal feed The present invention relates to acid-stable proteases of the subtilisin family, their use in animal feed, feed-additives and feed compositions containing such proteases, and methods for the treatment of vegetable proteins using such proteases. ... | 10/27/2009 |
| 7601528 | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, an... | 10/13/2009 |
| 7579180 | Beta secretase polypeptides Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides. ... | 08/25/2009 |
| 7572618 | Polynucleotides encoding novel PCSK9 variants The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention fu... | 08/11/2009 |
| 7550282 | Biological glue based on thrombin-conjugated nanoparticles Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated nanoparticles are suitable for use in the preparation of fibrin-based biolo... | 06/23/2009 |
| 7544500 | Process for the production of a reversibly inactive acidified plasmin composition Disclosed is both a process for producing a reversibly inactive acidified plasmin by activating plasminogen and a process for producing a purified plasminogen. The produced plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantia... | 06/09/2009 |
| 7524668 | Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof The present invention provides a crystal of human beta-secretase (BACE) having monoclinic space group symmetry C2, in a representative example, comprising a unit cell having dimensions of a, b, and c, wherein a is about 53 Å to about 103 Å, b is about 85 Å to ... | 04/28/2009 |
| 7485446 | Stable retrovirus and methods of use The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold increase in infectivity half-life as compared to wild-type retrovirus. U... | 02/03/2009 |
| 7476528 | Proteins producing an altered immunogenic response and methods of making and using the same The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less aller... | 01/13/2009 |
| 7462476 | Methods for large scale production of recombinant DNA-derived tPA or K2S molecules The invention belongs to the field of thrombolysis and of tissue plasminogen activator (tPA) derivative production in prokaryotic cells. The invention relates to methods for the production of a recombinant DNA-derived tPA, a variant thereof or a (Kringle 2 Serine) K... | 12/09/2008 |
| 7442537 | Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE activity. ... | 10/28/2008 |
| 7429476 | Acid fungal proteases The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and ... | 09/30/2008 |
| 7425326 | Use of collagenase to facilitate guide wire crossing in total arterial occlusions The use of a collagenase containing formulation for degrading collagen within an occlusive atherosclerotic plaque in a chronic fibrotic occlusion, chronically occluded animal tube or cavity. A medical-related apparatus is provided comprising a medical-related device... | 09/16/2008 |
| 7410796 | Proteinase inhibitor, precursor thereof and genetic sequences encoding same The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or is complem... | 08/12/2008 |
| 7410774 | Compounds modulating sister chromatid separation and method for identifying same Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity. Inhibitors of separin activity are useful in cancer therapy, to prevent ... | 08/12/2008 |
| 7407789 | Recombinant staphylokinase derivatives and the preparation and applications thereof The present invention relates to the biotechnology field, more particularly, to novel recombinant staphylokinase (RGD/KGD-Sak) derivatives and the preparation the thereof. The derivatives, have a low polymerizing ability, low immunogenicity and a bifunctionality of ... | 08/05/2008 |
| 7399465 | Pharmaceutical compositions for treating arthritis and inflammatory disease The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifyin... | 07/15/2008 |
| 7393659 | Analytical method for the determination of infant formula protein digestibility in vitro A method for in vitro determination of the digestibility of proteins in a nutritional product. The method utilized gastric and intestinal enzymes that are standardized for in vitro digestion process that mimics the in vivo digestive process. Further, specificity in ... | 07/01/2008 |
| 7384773 | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity. ... | 06/10/2008 |
| 7378511 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP prote... | 05/27/2008 |
| 7375187 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP prote... | 05/20/2008 |
| 7371839 | Alkaline proteases The present invention relates to alkaline proteases having high specific activity and strong oxidant resistance. The present invention also relates to alkaline proteases having excellent detergency that are to be added to a detergent. ... | 05/13/2008 |
| 7371553 | Chemically modified enzymes with multiple charged variants This invention provides modified enzymes comprising one or more amino acid residues replaced by cysteine residues, where the cysteine residues are modified by replacing the thiol hydrogen in the cysteine residues with a substituent group providing a thiol side chain... | 05/13/2008 |
| 7368272 | Expression of proteolytic enzymes in koji mold in the presence of carbon sources The present invention refers to a koji mold capable of expressing proteolytic enzymes in the presence of a carbon source in at least the same amount as in the absence thereof. In particular, the present invention pertains to a mutation in the creA gene as a tool to ... | 05/06/2008 |
