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| Number | Title | Issue Date |
| 7410796 | Proteinase inhibitor, precursor thereof and genetic sequences encoding same The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or is complem... | 08/12/2008 |
| 7402561 | Compositions and methods for inhibiting abnormal cell growth In the US about ⅓ of college women show evidence of HPV infection. The clinical problem may be even larger in developing countries. There are currently no effective therapies for HPV infections, aside from therapeutic cone biopsies, which often are followed by rec... | 07/22/2008 |
| 7332160 | Medical device and method for tissue removal and repair The present invention relates to medical devices that are to be implanted or inserted into the body of a patient for the purpose of removing undesired body tissues. In one embodiment of the invention the medical device comprises a body tissue removal agent for remov... | 02/19/2008 |
| 7309596 | Isolated monomers of a type II serine proteinase inhibitor The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to isolated monomers of a type II serine proteinase inhibitor. ... | 12/18/2007 |
| 7291595 | Use of Alpha-1 antitrypsin for the preparation of medicaments for the treatment of fibromyalgia The invention is based on the use of alpha-1 antitrypsin for the preparation of medicaments for the treatment of fibromyalgia, comprising the preparation of therapeutic concentrates of alpha-1 antitrypsin, in any form of administration tolerated by humans, the alpha... | 11/06/2007 |
| 7235269 | Bowman-birk inhibitor concentrate product and process A Bowman Birk Inhibitor (BBI) concentrate including at least 50% soy protein by weight of dry matter; and a chymotrypsin inhibitor activity level of at least 200 milligrams of chymotrypsin inhibited per gram of dry matter of product. A method of making a BBI concent... | 06/26/2007 |
| 7232670 | Targeting proteins to cells expressing mannose receptors via expression in insect cells The present invention is based on the discovery that proteins produced in insect cell cultures are glycosylated in a unique manner that causes them to be selectively imported by cells that express mannose receptors on their membranes, particularly macrophages. Prote... | 06/19/2007 |
| 7223595 | Use of purified trypsin for production of a biomass of cells and viral propagation The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease mixture in a single affinity chromatography step and uses of the purified SGT. ... | 05/29/2007 |
| 7125702 | Process for the preparation of angiotensis converting enzyme (ACE) inhibitors and its use The invention is a process for the preparation of angiotensin converting enzyme (ACE) inhibitors and the use thereof. ... | 10/24/2006 |
| 7049484 | Commercial production of proteases in plants Production of proteases in plants is set forth, whereby heterologous DNA encoding the protease is introduced into the plant and expression of the protein achieved. By such methods, expression is achieved in plants wherein the plant cell is not damaged, the protein c... | 05/23/2006 |
| 6955916 | Proteinase inhibitor, precursor thereof and genetic sequences encoding same The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or is complem... | 10/18/2005 |
| 6946278 | Proteinase inhibitor, precursor thereof and genetic sequences encoding same The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or is complem... | 09/20/2005 |
| 6887498 | Method of making Bowman-Birk inhibitor product A method for preparing a Bowman-Birk inhibitor (BBI) product from soybeans is provided. The product produced in accordance with the method of the invention and compositions including the product are also provided. BBI product produced in accordance with the inventio... | 05/03/2005 |
| 6852834 | Fusion peptides isolatable by phase transition Genetically-encodable, environmentally-responsive fusion proteins comprising ELP peptides. Such fusion proteins exhibit unique physico-chemical and functional properties that can be modulated as a function of solution environment. The invention also provides methods... | 02/08/2005 |
| 6846663 | Regulation of target protein activity through modifier proteins The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain an... | 01/25/2005 |
| 6846656 | Process for producing N-acetylneuraminic acid The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process comprises: allowing (i) a culture of a microorganism having N-acetylneuraminic... | 01/25/2005 |
| 6830917 | Method of isolation and purification of trypsin from pronase protease and use thereof The present invention is directed to methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease in a single affinity chromatography step and uses of the purified SGT. ... | 12/14/2004 |
| 6806074 | Proteinase inhibitor, precursor thereof and genetic sequences encoding same The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or is complem... | 10/19/2004 |
| 6689836 | Process for the preparation of thermoprecipitating affinity polymers The present invention relates to a process for the preparation of thermoprecipitating affinity polymers useful in the enhanced recovery of enzymes. The process comprises polymerising a monomer comprising a spacer and a co-monomer with a polymerisation ini... | 02/10/2004 |
| 6649395 | Tyrosine-containing cyclophilin and related methods The present invention relates to the use of these cyclophilins, hereinafter referred to as `tyrosine-containing` cyclophilins, in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such com... | 11/18/2003 |
| 6645934 | Peptide with radio protective effect The invention makes available a peptide having a radioprotective effect that comprises a modified form and/or an optionally modified fragment of the Bowman-Birk protease inhibitor (BBI).... | 11/11/2003 |
| 6638503 | STREPTOMYCES MEGASPORUS SD5, PROCESS FOR THE ISOLATION THEREOF, NOVEL FIBRINOLYTIC ENZYME PREPARED THEREFROM, PROCESS FOR THE PRODUCTION OF SAID ENZYME AND METHOD OF TREATMENT OF THROMBOLYTIC DISORDERS USING SAID ENZYME The present invention relates to a novel microorganism Streptomyces megasporus SD5. The present invention also relates to a process for the isolation of said Streptomyces megasporus SD5. The invention also relates to a novel fibrinolytic enzyme actinokina... | 10/28/2003 |
| 6579849 | Antibiotic peptides from bovine milk A peptide having the amino acid sequence H2 N--X1 --R--X3 --X2 --COOH (formula I) wherein X1 is either zero or X1 and/or X2 are a residue representing at least five amino acid residues (s... | 06/17/2003 |
| 6569662 | Nucleic acids and polypeptides The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.... | 05/27/2003 |
| 6534283 | Method for treatment and prevention of physiological shock Shock is a life threatening complication in situations associated with trauma including burns, surgery, ischemia, sepsis, and other critical care applications. Shock is induced by pancreatic proteases when they are released into the small intestine when t... | 03/18/2003 |
| 6534281 | Immunoassay for measuring human C-peptide and kit therefor An immunoassay for selectively measuring human C-peptide as well as a kit therefor is disclosed. In the method, human C-peptide contained in a sample, a first anti-human C-peptide antibody, and a second anti-human C-peptide antibody which is immobilized o... | 03/18/2003 |
| 6451573 | Proteinase inhibitor, precursor thereof and genetic sequences encoding same The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or... | 09/17/2002 |
| 6448031 | Process for producing LH-RH derivatives This invention relates to a method for producing an LH-RH derivative, characterized in that a peptide fragment shown by general formula (1): pGlu-His-Trp-OR1 (where R1 denotes a lower alkyl) and a peptide fragment shown by general fo... | 09/10/2002 |
| 6440727 | Proteinase inhibitor, precursor thereof and genetic sequences encoding same The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or... | 08/27/2002 |
| 6420156 | Purified proteolytic enzyme and method of purification A purified protease preparation of chymotrypsin and porcine trypsin is prepared by adjusting the pH of a protease solution comprising chymotrypsin and porcine trypsin to a value of between 6 and 9, maintaining the solution at this pH and at 20-35° C. for... | 07/16/2002 |
| 6284247 | Human tissue plasminogen activators Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular env... | 09/04/2001 |
| 6261821 | Proteinase inhibitor, precursor thereof and genetic sequences encoding same The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or... | 07/17/2001 |
| 6239106 | Family of protease inhibitors, and other biologic active substances The invention relates to novel protease-inhibitors which are obtainable from leeches. It also relates to uses thereof, for instance as a medicament, thus pharmaceutical preparations are provided, as are derivatives, mutants, genes encoding, vectors compri... | 05/29/2001 |
| 6177268 | Method for stabilizing trypsin, method for increasing enzymatic activity of trypsin, and kit for measuring enzymatic activity of trypsin The present invention provides a method for stabilizing trypsin, in which enzyme reaction of trypsin can be generated in a two-solution system, degradation of trypsin and its substrate can be prevented, and enzymatic activity of trypsin is improved compar... | 01/23/2001 |
| 6171813 | Enzyme catalysis in organic solutions containing water A method is presented for catalyzing the conversion of substrate into product in an organic reaction solvent with an enzyme-surfactant ion pair. The enzyme-surfactant ion pair comprises the enzyme catalyzing the reaction and a surfactant capable of formin... | 01/09/2001 |
| 6103523 | Pluripotent rabbit cell lines and method of making The present invention relates to a rabbit embryonic stem (ES) cell line, comprising at least 70%, preferably 80 to 90% undifferentiated cells and obtainable by isolating the inner cell mass of 5.5 days postcoitus blastocysts and culturing them on feeder c... | 08/15/2000 |
| 6093397 | Amyloid precursor protein protease This invention describe a novel human amyloid precursor protein protease; nucleic acids encoding the protease; and methods employing the protease, as well as methods employing the nucleic acids encoding the protease.... | 07/25/2000 |
| 6090912 | Topologically segregated, encoded solid phase libraries comprising linkers having an enzymatically susceptible bond The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports. In particular, the invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain codin... | 07/18/2000 |
| 6043033 | Human prostate-associated protease The present invention provides a human prostate-associated protease (HUPAP) and polynucleotides which identify and encode HUPAP. The invention also provides expression vectors, host cells, antibodies, antagonists, and antisense molecules. The invention al... | 03/28/2000 |
| 6031087 | Proteinase inhibitor, precursor thereof and genetic sequences encoding same The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or... | 02/29/2000 |
