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| Number | Title | Issue Date |
| 8183024 | Compositions and methods comprising a subtilisin variant The present invention provides a subtilisin variant that is particularly well suited to cleaning applications. In particular, the present invention provides a Bacillus sp. subtilisin variant and cleaning compositions comprising this variant. ... | 05/22/2012 |
| 8119385 | Nucleic acids and proteins and methods for making and using them The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and... | 02/21/2012 |
| 8067221 | Von Willebrand factor (vWF)-cleaving protease This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partia... | 11/29/2011 |
| 8053222 | Protein expression system involving mutated severe respiratory syndrome-associated coronavirus 3C-like protease A mutated severe acute respiratory syndrome-associated coronavirus 3C-like protease and use thereof for cleaving a protein that includes a cleavage site recognizable by the mutated protease to yield a polypeptide fragment of interest. ... | 11/08/2011 |
| 8003362 | Methods and constructs for high yield expression of clostripain The invention provides methods and nucleic acid constructs to express clostripain. The source of the coding region for recombinantly expressed clostripain is Clostridium histolyticum. ... | 08/23/2011 |
| 7993899 | Method for the purification of chymosin We describe a method for purifying chymosin comprising providing an aqueous liquid sample containing chymosin and a separation medium comprising a base matrix and a plurality of firmly attached ligands that are capable of binding to chymosin, contacting the matrix w... | 08/09/2011 |
| 7985570 | Alkaline proteases and detergents and cleaners comprising these alkaline proteases The present application relates to two novel proteases (SEQ ID NO: 4 and 7) which are similar to one another. The DNA of the two proteases, was obtained from soil samples, and C-terminally deleted, producing proteolytically active fragments thereof (SEQ ID NO: 5 and... | 07/26/2011 |
| 7985569 | Cellulomonas 69B4 serine protease variants The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA enco... | 07/26/2011 |
| 7977081 | Recombinant carboxypeptidase B A nucleic acid coding for pro-carboxypeptidase B (Pro-CPB), comprising three segments A, B and C, wherein at least one of the segments has one of the sequences according to SEQ ID No. 1, 2 or 3. ... | 07/12/2011 |
| 7960162 | Protein having prolyl oligopeptidase activity, nucleic acid encoding same and method for producing and using same Proteins isolated from Coprinus clastophyllus having prolyl oligopeptidase activity, nucleic acids encoding the protein and methods for producing and using the protein, wherein SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:9 and SEQ ID NO:10 must be contained therein t... | 06/14/2011 |
| 7910348 | Polypeptides of sp. having glutamic peptidase activity Disclosed are isolated polypeptides of Alicyclobacillus sp. having glutamic peptidase activity. ... | 03/22/2011 |
| 7888092 | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon Provided herein is are polypeptides that include the protease domain of a type II transmembrane serine protease (MTSP) as a single chain. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP are provided. Also provided ... | 02/15/2011 |
| 7879588 | Protein-proteophore complexes The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition ... | 02/01/2011 |
| 7776577 | Ubiquitin protease The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NA... | 08/17/2010 |
| 7759103 | Extracellular serine protease The present invention provides a DNA encoding a human Tumor Antigen Derived Gene-14 (TADG-14) protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which en... | 07/20/2010 |
| 7741094 | Protein having prolyl oligopeptidase activity, and composition containing the same A protein of amino acid sequence SEQ ID NO:6 isolated from Coprinus clastophyllus. The protein is stable at 30 to 37 degrees centigrade and has an optimal prolyl oligopeptidase activity at about 45 degree centigrade and at about pH 7. The present invention al... | 06/22/2010 |
| 7704718 | Method of reducing the viscosity of mucus Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933 and other E. coli that binds to and cleaves C1-esterase inhibitor, and antibodies specific for the polypeptide. Also disclosed are methods employing the polypeptide for diagnosi... | 04/27/2010 |
| 7700341 | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon Provided herein is are polypeptides that include the protease domain of a type II transmembrane serine protease (MTSP) as a single chain. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP are provided. Also provided ... | 04/20/2010 |
| 7695948 | Antibodies that bind TNF-α converting enzyme A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for ... | 04/13/2010 |
| 7691618 | Alkaline proteases and detergents and cleaners comprising these alkaline proteases The present application relates to two novel alkaline proteases (SEQ ID NO. 4 and 7) which are similar to one another, whose DNA was obtained from soil samples, and which were C-terminally deleted. The present application also provides proteolytically active fragmen... | 04/06/2010 |
| 7642079 | Proteases, nucleic acids encoding them and methods for making and using them The invention is directed to polypeptides having protease activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of diagnostic, therapeu... | 01/05/2010 |
| 7618801 | Streptomyces protease Certain aspects of this disclosure relate to an isolated protease, and cleaning compositions containing the same. In some embodiments, the protease may comprise an amino acid sequence that is at least 80% identical to the wild type Streptomyces 1AG3 protease.... | 11/17/2009 |
| 7604975 | Glycosylated LPXTGases and uses thereof An endopeptidase is described which shows specificity for cleavage of a LPXTG (SEQ ID NO: 1) motif found in the cell membranes of gram positive bacteria, having an apparent molecular weight of 14,000 daltons, having a pH optimum of about 7.5 to 10, being salt sensit... | 10/20/2009 |
| 7482147 | Ubiquitin protease The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NA... | 01/27/2009 |
| 7468267 | Fungal proteins and nucleic acids encoding same Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or ... | 12/23/2008 |
| 7435420 | Dipeptidyl peptidase IV inhibitors for the treatment of anxiety The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression, insomnia, schizophrenia, epilepsy, spasm and chronic pain. Administra... | 10/14/2008 |
| 7427498 | Composition, methods and reagents for the synthesis of a soluble form of human PHEX This invention relates to a soluble form of PHEX, PHEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate-regulating gene with homologies to endopeptidases on the X chromosome. To produce a soluble form of PHEX, the transm... | 09/23/2008 |
| 7410775 | Method for making recombinant peptides or proteins using soluble endoproteases The present invention relates to the expression and secretion in Saccharomyces cerevisiae of readily purifiable soluble variants of the Kex1 endopeptidase of Kluyveromyces lactis and the purification and use thereof for the in vitro processing of recom... | 08/12/2008 |
| 7407789 | Recombinant staphylokinase derivatives and the preparation and applications thereof The present invention relates to the biotechnology field, more particularly, to novel recombinant staphylokinase (RGD/KGD-Sak) derivatives and the preparation the thereof. The derivatives, have a low polymerizing ability, low immunogenicity and a bifunctionality of ... | 08/05/2008 |
| 7407653 | Treatment of IgA1 deposition diseases The present invention discloses the use of bacterial IgA1 proteases to treat IgA1 deposition in tissue and organs. Bacterial IgA1 proteases specifically cleave IgA1 molecules and thus provide a means to specifically cleave and remove IgA1 depositions. Accordingly, t... | 08/05/2008 |
| 7402309 | Phage-associated lytic enzymes for treatment of and related conditions The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The disclosure further relates to methods and compositions for... | 07/22/2008 |
| 7393528 | Biological pesticide Methods for exterminating pests using compositions comprising at least one protease enzyme. A detergent component may also be utilized in such compositions. ... | 07/01/2008 |
| 7393659 | Analytical method for the determination of infant formula protein digestibility in vitro A method for in vitro determination of the digestibility of proteins in a nutritional product. The method utilized gastric and intestinal enzymes that are standardized for in vitro digestion process that mimics the in vivo digestive process. Further, specificity in ... | 07/01/2008 |
| 7378511 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP prote... | 05/27/2008 |
| 7378512 | Production of proteins by autoproteolytic cleavage The present invention relates to a process for the production of a heterologous polypeptide with homogeneous N-terminus in a bacterial host cell, wherein the heterologous polypeptide is autoproteolytically cleaved from an expressed fusion protein which comprises a p... | 05/27/2008 |
| 7375187 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP prote... | 05/20/2008 |
| 7371839 | Alkaline proteases The present invention relates to alkaline proteases having high specific activity and strong oxidant resistance. The present invention also relates to alkaline proteases having excellent detergency that are to be added to a detergent. ... | 05/13/2008 |
| 7368273 | Alkaline protease An alkaline protease wherein an amino acid residue at (a) position 65, (b) position 101, (c) position 163, (d) position 17-0, (e) position 171, (f) position 273, (g) position 320, (h) position 359 or (i) position 387 of SEQ. ID NO: 2 or at a position corresponding t... | 05/06/2008 |
| 7368536 | Alzheimer's disease secretase, APP substrates therefor, and uses therefor The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP prote... | 05/06/2008 |
| 7368272 | Expression of proteolytic enzymes in koji mold in the presence of carbon sources The present invention refers to a koji mold capable of expressing proteolytic enzymes in the presence of a carbon source in at least the same amount as in the absence thereof. In particular, the present invention pertains to a mutation in the creA gene as a tool to ... | 05/06/2008 |
