Quotables
"That the automobile has practically reached the limit of its development is suggested by the fact that during the past year no improvements of a radical nature have been introduced."
Scientific American ; Jan. 2 edition, 1909
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 5856111 | Methods for identifying modulators of insulin receptor phosphorylation The present invention relates to cell lines useful for the screening and identification of compounds that by modulating phosphotyrosine phosphatase activity, modulate insulin receptor type tyrosine kinase mediated signal transduction. Genetically engineer... | 01/05/1999 |
| 5853974 | Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates Methods and compositions for enhancing the chemiluminescence from a stable 1,2-dioxetane triggered to produce a chemiluminescence are disclosed. Indirect, competitive nucleic acid hybridization assay formats are also described that employ these methods an... | 12/29/1998 |
| 5851786 | Product and process to regulate actin polymerization The present invention relates to methods useful for identifying compounds capable of specifically regulating actin polymerization, stress fiber formation or focal adhesion assembly by regulating G and/or G activity ... | 12/22/1998 |
| 5849495 | Chemiluminescent energy transfer assays A chemiluminescent assays for the determination of the presence or amount of a biopolymer in bound assays using 1,2-dioxetanes in connection with AttoPhos™ as chemiluminescent substrates for enzyme-labeled targets or probes is provided. Further disclose... | 12/15/1998 |
| 5846753 | Chemiluminescence-based method for rapid and sensitive in-situ detection of organophosphorus compounds and metal ions A method of detecting the presence of a substance being monitored in a medium, selected from the group of substances including organophosphorus compounds and the metal ions Zn, Be and Bi, including the steps of: providing a 1,2-dioxetane phenyl phosphate ... | 12/08/1998 |
| 5840505 | Method for inhibiting adenylosuccinate synthetase activity in methylthioadenosine phosphorylase deficient cells An in vivo method for depleting mammalian cells of adenosine 5'-monophosphate (AMP) useful in the treatment of certain cancers is provided. According to the method, a population of cells is obtained from a host and assayed for loss of methylthioadenosine ... | 11/24/1998 |
| 5830666 | Method of detecting nucleic acids or the like A method of detecting nucleic acids, proteins, or protein nucleic acid complexes. The method includes binding an enzyme, such as phosphatase, to a specimen of the nucleic acid, protein, or protein nucleic acid complex. The enzyme is then reacted with a fl... | 11/03/1998 |
| 5831065 | Kits for DNA sequencing by stepwise ligation and cleavage The invention provides a method of nucleic acid sequence analysis based on repeated cycles of ligation to and cleavage of probes at the terminus of a target polynucleotide. At each such cycle one or more terminal nucleotides are identified and one or more... | 11/03/1998 |
| 5830742 | TNF- converting enzyme A metalloprotease that converts TNF- from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified proteas... | 11/03/1998 |
| 5831102 | Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes Enzymatically cleavable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically cleavable labile substituent thereof is intentionally clea... | 11/03/1998 |
| 5827645 | Homocysteine assay The invention relates to a method for assaying homocysteine in a sample such as blood, plasma, or urine, which comprises the steps of contacting the sample with a homocysteine converting enzyme and at least one substrate for the enzyme other than homocyst... | 10/27/1998 |
| 5821061 | Method and reagent for detecting a ligand in a sample A novel alkaline phosphatase and a method for the production of the alkaline phosphatase are described. A method for detecting a ligand in a sample and a method for analyzing the sequence of nucleic acid in a sample using the alkaline phosphatase are also... | 10/13/1998 |
| 5821075 | Nucleotide sequences for novel protein tyrosine phosphatases The invention relates to the cloning of two novel protein tyrosine phosphatases. Nucleic acid sequences encoding these phosphatases (PTPL1 and GLM-2) as well as anti-sense sequences are also provided. The recombinantly produced PTPL1 and GLM-2 proteins al... | 10/13/1998 |
| 5817454 | Portable apparatus and method for detection of methylxanthine chemical species A portable apparatus for detecting the presence of at least one methylxanthine chemical species such as caffeine or theophylline in a beverage comprises a first portion comprising an effective concentration of phosphodiesterase enzyme, a second portion co... | 10/06/1998 |
| 5801006 | Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites Kits and methods for measuring enzyme activities and metabolites using NADH and NADPH analogs are disclosed. The analogs have extended stability in aqueous solutions and can used as replacements for NADH or NADPH cofactors in analytical procedures. Prefer... | 09/01/1998 |
| 5801000 | Detection and isolation of receptors Disclosed is a method of isolating a ligand from a sample, the method including: providing a hybrid molecule including the receptor for the ligand covalently bonded to the first member of a specific binding pair; contacting sample with the hybrid molecule... | 09/01/1998 |
| 5801007 | Methods for calibrating chemical assays Methods for internally and externally photostandardizing chemical assays, e.g. an ATP-bioluminescence assay. A pre-determined amount of a photosensitive derivative of the analyte of interest is used in the assay protocol which releases a known amount of t... | 09/01/1998 |
| 5795713 | Methods for identifying inducers and inhibitors of programmed cell death Methods for identifying inducers and inhibitors of programmed cell death in a cell-free system are described. The methods exploit the finding that programmed cell death is accompanied by shutdown of cellular protein synthesis and by phosphorylation of eIF... | 08/18/1998 |
| 5789186 | Marker for cerebral apoplexy A sample is treated with a phosphoglyceric acid mutase (PGAM) inhibitor (polythionic acid (salt) such as potassium tetrathionate) to inactivate the M-type isozyme activity and the B-type PGAM is quantified by determining PGAM isozymes by a rate assay. The... | 08/04/1998 |
| 5783410 | Bacteria identification method and apparatus The present invention discloses a bacteria-coding identification method,bacteria biochemical properties identifying papers which detect the biological properties using this method, and apparatus or means useful for identifying the genus and species of bac... | 07/21/1998 |
| 5773237 | Method for determining tyrosine kinase activity The subject invention provides for nucleotide sequences encoding polypeptide p62 and derivatives thereof. Another aspect of the subject invention also provides for methods of purifying p62 and derivatives thereof from cells naturally producing p62 and fro... | 06/30/1998 |
| 5773226 | Recombinant calf intestinal alkaline phosphatase The invention relates to isolated nucleic acids encoding recombinant calf intestinal alkaline phosphatase. Expression vectors and host cells transformed or transfected with such vectors are also provided. The invention further provides multifunctional pol... | 06/30/1998 |
| 5770391 | Reagents and methods for use in bioluminescence The subject invention pertains to a combination of enzyme activities comprising an ATP-degrading enzyme and one or more enzymes capable of degrading substances, other than ATP, that are substrates for the light-emitting reaction of firefly luciferase. The... | 06/23/1998 |
| 5763158 | Detection of multiple antigens or antibodies A method for simultaneously testing a sample for the presence of multiple rget antigens or antibodies in the sample, which comprises presenting the sample to a plurality of different binding sites, wherein at least two of the sites are binding sites for d... | 06/09/1998 |
| 5763198 | Screening assays for compounds The invention is directed to rapid and quantitative assay systems for screening test compounds for their ability to modulate tyrosine kinase or phosphatase activities involved in signal transduction by determining the tyrosine phosphorylation state of a p... | 06/09/1998 |
| 5756303 | Culture medium and a microbiological test method employing the same The present invention provides a culture medium for microbiological tests prepared by treating medium components containing adenosine triphosphate (ATP) with an acidic phosphatase as well as a microbiological test method characterized by using said cultur... | 05/26/1998 |
| 5753436 | Chemiluminescent energy transfer assays A chemiluminescent assays for the determination of the presence or amount of a biopolymer in bound assays using 1,2-dioxetanes in connection with AttoPhos™ as chemiluminescent substrates for enzyme-labeled targets or probes is provided. Further disclose... | 05/19/1998 |
| 5753443 | Crystallized formulation for staining DNA, its preparation and kit A process is disclosed for making a crystallized formulation for staining nuclear DNA to be used in flow cytometery. The crystallized DNA staining formulation and a kit containing the crystallized DNA staining formulation are provided. The staining formul... | 05/19/1998 |
| 5750358 | Quantitative clotting assay for activated factor VII An assay for activated factor VII (factor VIIa) has been developed using truncated tissue factor (tTF), a soluble mutant form of tissue factor (TF) that retains the cofactor function of TF toward factor VIIa. Unlike full-length TF, however, tTF appears no... | 05/12/1998 |
| 5741654 | Immunoassay for the detection of human autoantibodies An assay and test kit of the determination of LKM-1 autoantibodies in test samples suspected of containing anti-LKM-1 autoantibodies. The method uses a solid phase which preferably is a microparticle. The method is standardized and can be performed in aut... | 04/21/1998 |
| 5731158 | Catalyzed reporter deposition The present invention concerns a method to catalyze reporter deposition to improve detection or quantitation of an analyte in a sample by amplifying the detector signal which comprises reacting an analyte dependent enzyme activation system with a conjugat... | 03/24/1998 |
| 5716786 | VNTR probes and methods of using thereof According to the process of the invention, sets of restriction fragments from the DNA of an individual are prepared, these restriction fragments being separated by size. Probes are prepared by enzymatic hydrolysis of DNA from a genome bank of the species ... | 02/10/1998 |
| 5707559 | Chemiluminescent 1,2-dioxetane compounds Novel light producing 1,2-dioxetanes are described of the formula ##STR1## wherein ArOX is an aryl ring substituted with an X oxy group and A are passive organic groups which allow the 1,2-dioxetane to produce light when triggered by removing X. X is... | 01/13/1998 |
| 5695950 | Method of screening for antimitotic compounds using the cdc25 tyrosine phosphatase A method of identifying compounds or molecules which alter (enhance or inhibit) stimulation of kinase activity of pre-MPF and, thus, alter (enhance or inhibit) activation of MPF and entry into mitosis. The present method thus makes it possible to identify... | 12/09/1997 |
| 5674716 | DNA sequencing A method for sequencing a strand of DNA, including the steps of: providing the strand of DNA; annealing the strand with a primer able to hybridize to the strand to give an annealed mixture; incubating the mixture with a deoxyribonucleoside triphosphate, a... | 10/07/1997 |
| 5670346 | Modifying nucleotide analogues Fluorescently labelled dideoxynucleoside triphosphates are widely used as chain-terminators in Sanger dideoxy sequencing operations. But these unincorporated dye-terminators migrate in an electrophoresis gel and obscure the desired sequence ladder. This i... | 09/23/1997 |
| 5656448 | Dipstick immunoassay device The invention pertains to dipstick immunoassay devices. The device comprises a base member and a single, combined sample contact zone and test zone, wherein the test zone incorporates the use of symbols to detect analytes in a sample of biological fluid. ... | 08/12/1997 |
| 5654152 | Method of measuring enzyme activity by using a column having an immobilized substrate Enzyme activity is measured promptly with a high accuracy by introducing an enzyme, the activity of which is to be measured, into a column comprising a hollow tube packed with a filler comprising a support and a substrate that can be recognized by the enz... | 08/05/1997 |
| 5631127 | Enzymatic assay for homocysteine and a kit therefor The invention relates to a method for assaying homocysteine in a sample such as blood, plasma or urine, which comprises the steps of contacting the sample with a homocysteine converting enzyme and at least one substrate for the enzyme other than homocyste... | 05/20/1997 |
| 5618736 | Method for using synthesized kaolinite as carrier for bioreactor, a composite body composed substantially of synthesized kaolinite as carrier and enzyme carried on synthesized kaolinite, and bioreactor system using such a composite body A process using hydrothermally synthesized porous kaolinite as a carrier for use in a bioreactor. A carrier-biocatalyst composite body for use in a bioreactor, includes the synthesized kaolinite as a carrier and a biocatalyst fixed onto the synthesized ka... | 04/08/1997 |
