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| Number | Title | Issue Date |
| 4273867 | Method and reagent for counteracting lipemic interference A method and reagent for counteracting lipemic interference in an assay of a lipid-containing sample, e.g. blood. The method includes the steps of: (a) mixing with the sample prior to or during said assay a high surface area, finely-divided adsorbent havi... | 06/16/1981 |
| 4267272 | Prostatic acid phosphatase immuno assay Prostatic acid phosphatase is immunologically unstable under typical laboratory conditions. Thus it is necessary to combine a stabilizing composition with samples taken for immunological assay of prostatic acid phosphatase content, and to similarly stabil... | 05/12/1981 |
| 4264727 | Assaying of digoxin by means of bioluminescence and inhibition of NA+ - + -ATPase A method is described for quantitative measurement of digoxin and other digitaloids in serum. The method is based on the inhibition of Na+, K+ --specific ATPase enzyme by digitaloids as a result of receptor binding principle and the ... | 04/28/1981 |
| 4250255 | Assay method for isoenzyme activity The activity of an isoenzyme in a sample is determined by assaying for the isoenzyme in the presence of a predetermined concentration of an ionic amphiphile having a hydrophilic and a hydrophobic portion that has a discriminating effect on the activity of... | 02/10/1981 |
| 4250254 | Stabilized liquid enzyme and coenzyme compositions Stabilized liquid enzyme and/or coenzyme compositions are prepared for use in biological diagnostic determinations. The compositions contain an enzyme and/or coenzyme, an organic solvent such as a polyol and an aqueous vehicle. The compositions may also c... | 02/10/1981 |
| 4243753 | Apparatus for enzyme detection An apparatus is disclosed for enzyme detection that is particularly well suited for high performance liquid chromatography. The apparatus is basically a flow-through enzyme detector that is capable of maintaining zero-order reaction kinetics with respect ... | 01/06/1981 |
| 4226935 | Enzymatic diagnostic composition Disclosed herein is a method for binding enzymes comprising reacting an amino acid and/or a protein with an excess of a urethane prepolymer, curing the resulting product and coupling an enzyme thereto by use of a carbodiimide. The product of the process i... | 10/07/1980 |
| 4206280 | Determination of acid phosphatase A method of improving the determination of acid phosphatase by adding a reagent which considerably increases the activity of the enzyme is disclosed. Also disclosed are reagent kits containing said reagent.... | 06/03/1980 |
| 4179334 | Hydrolysis of protein-bound triglycerides A novel process is described for hydrolyzing protein-bound triglycerides such as blood serum triglycerides comprising contacting sample containing protein-bound triglycerides with a compatible mixture of an enzyme preparation which demonstrates triglyceri... | 12/18/1979 |
| 4168203 | Quantitative analysis of neutral lipids and lecithin A reagent for quantitative analysis of neutral lipids in serum or internal organs comprising a lipase produced by the NRS-400 strain of Rhizopus and an aqueous solvent.... | 09/18/1979 |
| 4166766 | Method for quantitative assay of alkaline phosphatase isoenzymes in serum A method of assay for fast electrophoretic mobility alkaline phosphatase isoenzyme variant in serum comprising the steps of first separating the fast electrophoretic mobility alkaline phosphatase isoenzyme variant from the serum and from slower mobility i... | 09/04/1979 |
| 4162194 | Kinetic assay for acid phosphotase and composition therefore A kinetic assay is provided for determining the acid phosphatase in an aqueous solution by measuring the amount of of reduced coenzyme produced. The assay is based on the following coupled reactions:... | 07/24/1979 |
| 4132598 | Stabilized liquid phosphate containing diagnostic compositions and method of preparing same A stabilized liquid phosphate containing diagnostic composition and generally a phosphate containing substrate used in the determination of enzymes such as alkaline phosphatase and acid phosphatase. The composition actually includes a buffer composition c... | 01/02/1979 |
| 4129417 | Multisystem test means Multisystem test means, method of making same and method for determining a constituent in a sample under a plurality of reaction parameters. More particularly, a multisystem test means for the determination of a constituent in a liquid sample comprising a... | 12/12/1978 |
| 4123614 | Novel assay reagents The present invention relates to novel assay reagents, their composition, methods of preparation, and use in the detection and measurement of various biological systems and/or components, e.g. enzymes, antibodies, antigens, and periodate concentration. Th... | 10/31/1978 |
| 4082781 | Synthesis of 2-alkanoylamino-4-nitrophenyl phosphorylcholine-hydroxide A method for synthesizing a 2-alkanoylamino-4-nitrophenyl phosphorylcholine-hydroxide useful as a sphingomyelinase-specific chromogenic artificial substrate in the diagnostic testing for Niemann-Pick disease. The method comprises reacting 2-amino-4-nitrop... | 04/04/1978 |
| 4067963 | Substance acting to prevent and improve cerebral function disorder and process for preparing the same Substance acting to prevent and improve cerebral function disorder which is prepared by treating albumin with a fatty acid and hydrolizing the modified albumin is described.... | 01/10/1978 |
| 4059490 | Measurement of alkaline phosphatase levels in body fluids A method of measuring the alkaline phosphatase level in a body fluid such as serum or plasma comprising hydrolyzing excess monophosphate ester dissolved in a suitable buffer by action of alkaline phosphatase in a predetermined volume of the body fluid to ... | 11/22/1977 |
| 4059407 | Disposable chemical indicators A disposable indicator is disclosed which is useful for the measurement of ketones, proteins including albumin and uric acid in biological fluids. The instrument registers the concentration of substance in a given biological fluid with indicia which are d... | 11/22/1977 |
| 4046634 | Assay of isoenzymes by ion exchange chromatography A simple, rapid anion-exchange column chromatographic technique is used to determine the presence of fractions of proteins and enzymes in human serum by separating the fractions on the basis of their net electrical charges. Samples of serum of unaltered i... | 09/06/1977 |
| 4045290 | Diagnostic method and compounds for use therewith An assay for phosphatase enzymes in body fluids comprising contacting a sample of such body fluid with the substrate, Thymol Blue Monophosphate, which is chromogenic at the pH of the reaction mixture and determining activity of the enzyme by measuring the... | 08/30/1977 |
| 4040907 | Iodothyronine enzyme conjugates Polyiodothyronine conjugates to enzymes are provided which find use in the determination of polyiodothyronine compounds, particularly thyroxine, normally in physiological fluids, such as serum. The enzymes can provide substantial variation in activity whe... | 08/09/1977 |
| 4039385 | Cardiac glycoside enzyme conjugates Enzyme conjugates are prepared of cardiac glycosides and aglycones for use in homogeneous enzyme immunoassays. The conjugates retain a substantial degree of the original activity of the enzyme and upon binding of receptor to the steroid moiety, a substant... | 08/02/1977 |
| 4039388 | Diagnostic test for Niemann-Pick disease An artificial substrate consisting of a 2-alkanoylamino-4-nitrophenyl phosphorylcholine hydroxide is used for determining the sphingomyelinase activity in an extract of human cells or tissues by incubating the substrate together with the extract, whereby ... | 08/02/1977 |
| 4030995 | Alkaline phosphatase isoenzyme determination Alkaline phosphatase isoenzymes are separated electrophoretically in agarose gels, or cellulose acetate membranes, equilibrated in a solution containing a low ionic strength buffer and a non-ionic detergent, such as Triton X-100. The electrophoretically s... | 06/21/1977 |
| 4013513 | Ion exchange chromatographic isoenzyme separation and isolation A process of separating and isolating fractions containing isoenzymes from a sample of tissue extract or blood serum comprising ion-exchange column chromatographically separating the sample containing the isoenzymes into a first fraction containing the he... | 03/22/1977 |
| 4012285 | Analysis of isoenzyme patterns Isoenzyme patterns of an enzyme in biological fluids, extracts, and/or excretions are quantitatively determined by precipitating at least 90% of an isoenzyme antigen with a corresponding heterologous antiserum and comparing the remaining enzyme activity w... | 03/15/1977 |
| 3993451 | Test for a given constituent in a liquid The device, for use in analysis of a sample of liquid material applied thereto, comprises a plastic film support having adhered to one surface thereof a reagent-containing layer, said reagent reacting with a component of said sample to produce a color cha... | 11/23/1976 |
| 3975405 | Monophosphate salt of o-cresolphthalein O-cresolphthalein monophosphoric acid and salts thereof useful as substrates for alkaline phosphatase determinations are produced by reacting cresolphthalein with dibenzyl phosphite in the presence of carbon tetrachloride and an organic amine, hydrogenati... | 08/17/1976 |
| 3966898 | Method and reagent for determining immunologic materials A method of qualitatively or quantitatively indicating immunoglobulin whose Fab-portion is bound to or is caused to bind to an antigen or a hapten or indicating the antigen or hapten which is bound to or caused to bind to the Fab-portion of the immunoglob... | 06/29/1976 |
| 3950133 | Reagent formulations for assaying biological specimens and methods of preparing and using same A solid, water-soluble substantially anhydrous, storage-stable reagent formulation for use in conducting a clinical diagnostic test on a biological specimen is provided. The reagent formulation comprises a mixture containing a reagent capable of participa... | 04/13/1976 |
| 3932221 | Immunological isozyme determination method This invention relates to a process, to a diagnostic agent employed therein and to the use thereof, for the organ-specific and/or disease-specific diagnosis of the isozyme pattern of an enzyme occurring in multiple molecular configurations in a sample of ... | 01/13/1976 |
