Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 8093014 | Kit for detecting and measuring element tagged kinases and phosphatases by inductively coupled plasma mass spectrometry Kits for the assay of enzymes involved in post-translational modifications are provided. The kits facilitate the execution of methods of assay that allow for convenient and accurate analysis using atomic mass spectrometry of post-translation modifications of substra... | 01/10/2012 |
| 8039229 | Identification of toxin-binding protein involved in resistance to 1 toxins, and related screening methods The subject invention relates in part to the surprising and unexpected discovery that insects that are resistant to Bacillus thuringiensis Cry toxins have measurably altered alkaline phosphatase (ALP) activity as compared to insects that are susceptible to Cr... | 10/18/2011 |
| 8008035 | Enhancement of vanadium-containing phosphatase inhibitors The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention ... | 08/30/2011 |
| 7939289 | Distinction method for the catch capacity of proteins A distinction method is provided to distinguish catch capacity where myosin, a protein that constitutes muscles, or filaments containing myosin bind to actin due to the contribution of twitchin that constitutes thick filaments along with myosin, while certain tensio... | 05/10/2011 |
| 7892777 | Methods for measuring whether a treatment affects RPTP-κ activity Methods are provided for ascertaining and measuring RPTP-κ activity in response to insults such as UV irradiation and with respect to administration of a treatment and/or composition. Attenuation of EGFR activity by RPTP-κ affects aspects of photoaging, including ... | 02/22/2011 |
| 7824880 | High sensitivity assay for detection of nucleoside diphosphate production The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bin... | 11/02/2010 |
| 7807400 | Methods for identifying chemical modulators of Ras superfamily GTPase activity The present invention provides a method of identifying a compound having the ability to modulate the guanine nucleotide exchange cycle of a Ras superfamily GTPase, comprising: a) contacting the compound with a guanine nucleotide exchange factor and a GTPase and obta... | 10/05/2010 |
| 7794965 | Method of identifying modulators of PP2A methylase The invention relates to methylated proteins that control protein phosphorylation, particularly phosphoesterases, such as PP2A. It relates to screening methods for determining agents that affect methylation of these proteins and thus also modulate the level of phosp... | 09/14/2010 |
| 7763441 | Modulators of gluconeogenesis The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed. ... | 07/27/2010 |
| 7745165 | Phosphatase associated with metastasis Among the genes identified, in a comparison of the global gene expression profile of metastatic colorectal cancer to that of primary cancers, benign colorectal tumors, and normal colorectal epithelium, the PRL-3 protein tyrosine phosphatase gene was of particular in... | 06/29/2010 |
| 7582442 | Methods and compositions for using aleveolar macrophage phospholipase A2 The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and t... | 09/01/2009 |
| 7494784 | Method of treating cell-migration conditions or diseases The present invention relates to methods of identifying agents which modulate the activity of PIPKIγ661. Methods of using such agents to prevent or treat a cell migration-mediated condition or disease in a subject are also provided. ... | 02/24/2009 |
| 7465556 | Method of immunoassay tartrate resistant acid phosphatase 5b and kit to be used therein Specific and accurate immunoassay of tartrate resistant acid phosphatase 5b (TRACP 5b) in a specimen may be carried out by bonding TRACP 5b in the specimen to an antibody, subjecting the TRACP 5b bonded to the antibody to enzyme reaction with a 2-halo-4-nitrophenylp... | 12/16/2008 |
| 7449304 | Method for enhancing the efficiency of an enzymatic process for removal of contaminating nucleotides This invention relates to methods for enhancing the efficiency of biological processes that involve successive enzymatic reactions. More specifically, the invention relates to methods for enhancing the efficiency of an enzymatic purification process by increasing th... | 11/11/2008 |
| 7442398 | Phytase produced from The present invention relates to phytase enzyme, a gene encoding the enzyme, and a Citrobacter sp. producing the enzyme. Particularly, the present invention relates to the phytase enzyme produced from Citrobacter sp. having (a) molecular weight of 47 k... | 10/28/2008 |
| 7435572 | Methods and compositions for DNA manipulation Methods and compositions are provided for generating a single-stranded extension on a polynucleotide molecule, the single-stranded extension having a desired length and sequence composition. Methods for forming single-stranded extensions include: the use of a casset... | 10/14/2008 |
| 7432070 | Homogenous assay for enzymatic activity An assay is disclosed for measuring activity of enzymes, such as kinases, phosphatases, and proteases. Measurements of enzymatic activity are accomplished in a homogenous assay format utilizing a fluorescence quenching technique employing paramagnetic metal ions. | 10/07/2008 |
| 7427485 | Method for classification of anti-psychotic drugs The present invention provides a method for identifying an agent to be tested for an ability to treat a psychotic disorder in a patient in need of such treatment. The invention provides a method for screening candidate drugs for anti-psychotic drug activity, prefera... | 09/23/2008 |
| 7422845 | Detection of NO by using guanylyl cyclase and cGMP production as a readout system The present invention relates to a method for determining NO enzymatically and its use for the identification of substances which can modulate a nitric oxide synthase activity. ... | 09/09/2008 |
| 7416703 | Polymer based lanthanide luminescent sensors for the detection of organophosphorus compounds A device for measuring and detecting the organophosphonis compounds, such as a pesticides or a nerve agents is provided. The devices function by selectively binding an organophosphorous compound to a luminescent functionality-imprinted copolymer. The copolymers poss... | 08/26/2008 |
| 7416856 | High sensitivity assay for detection of nucleoside diphosphate production The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bin... | 08/26/2008 |
| 7407783 | Fructosylamine oxidase The present invention provides a fructosylamine oxidase which is obtainable by culturing Fusarium proliferatum, and purifying two types of fructosylamine oxidase (FAO) with different substrate specificities from the culture, and which is useful in the measure... | 08/05/2008 |
| 7402406 | Methods of evaluating phosphatase inhibitors The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using these genes, and/or proteins encoded by these genes. Furthermore, these ... | 07/22/2008 |
| 7396658 | Methods for screening HIF like ouabain-resistant Na—K-ATPase agents The present invention relates to rapid, quantitative, specific, high through-put methods for screening test substances for their ability to inhibit activity of an ouabain-resistant Na+—K+-ATPase involved in a variety of biological processes s... | 07/08/2008 |
| 7384751 | Methods of diagnosing muscle damage A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage, and evaluating the sample for the presence or absence of a myofilamen... | 06/10/2008 |
| 7384761 | Methods of identifying an agent capable of interfering with Rad9 dephosphorylation The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells polypeptides of the present invention fused to heterologous polypep... | 06/10/2008 |
| 7378254 | Compositions and assays utilizing ADP or phosphate for detecting protein modulators Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high th... | 05/27/2008 |
| 7374900 | Fluorescent substrates for detecting organophosphatase enzyme activity Disclosed are compounds of the formula (I): wherein R3, R4, R5, R9, and R10 are selected from the group consisting of H and groups or atoms other than H, and R6 and R8 are halo or hydrogen;... | 05/20/2008 |
| 7374899 | Sucrose-6-phosphate phosphatase as target for herbicides The present invention relates to the use of a polypeptide with the biological activity of a sucrose-6-phosphate phosphatase which, if not present, brings about growth retardation symptoms and chlorotic leaves and which is encoded by the nucleic acid sequences SEQ ID... | 05/20/2008 |
| 7371537 | Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment o... | 05/13/2008 |
| 7364843 | Method of identifying target cell using target cell-specific virus Provided is a method of identifying a target cell using a virus. The method includes infecting the target cell with the virus by contacting the virus to the target cell and culturing the target cell to propagate the virus; adding a chromogenic substrate to the resul... | 04/29/2008 |
| 7364856 | PknB kinase and pstP phosphatase and methods of identifying inhibitory substances The present invention relates to a pknB kinase and a pstP phosphatase as well as their use for identifying antibacterial substances. ... | 04/29/2008 |
| 7358052 | Catalytic amplification of multiplexed assay signals Methods, compositions, kits, and a system are disclosed for detecting one or more analytes in a sample. A mixture comprising the (i) sample, (ii) a first binding reagent comprising a cleavage-inducing moiety and a first binding agent specific for an analyte, and (ii... | 04/15/2008 |
| 7353830 | TRAP-coated bone grafts and prostheses A composition or device suitable for orthopedic or dental implantation to bone, characterized by tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum. ... | 04/08/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7348159 | Methods for determining phosphoryltransferase activity using adenosine 5'-triphosphate (ATP)-gamma-S This invention relates to screening assay methods that can be applied to broad members of the protein kinase gene family and are useful in the detection and evaluation of kinase inhibitors. ... | 03/25/2008 |
| 7341845 | Method for identifying kinesin inhibitors The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bio... | 03/11/2008 |
| 7332333 | Host cells containing multiple integrating vectors The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vec... | 02/19/2008 |
| 7329523 | Phosphoserine phosphatase of coryneform bacteria and variants thereof The present invention provides a DNA coding for a protein defined in the following (A) or (B) is obtained from Brevibacterium flavum chromosomal DNA library by cloning a DNA fragment that complicates serB deficiency of Escherichia coli as a open readin... | 02/12/2008 |
| 7321829 | Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips The present invention is related to a method for the identification and/or the quantification of a target compound obtained from a sample, preferably a biological sample, comprising the steps of putting into contact the target compound with a capture molecule in ord... | 01/22/2008 |
