Class 435/195 - Hydrolase (3. )

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter wherein the enzyme catalyzes the followingreaction;
No. of patents: 721
Last issue date: 04/10/2012

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Number	Title	Issue Date
6387673	Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds In accordance with the present invention, it has been discovered that histone deacetylase associates with hormone receptor complexes and contributes to the repression thereof. It has further been discovered that exposure of a repressed system to histone d...	05/14/2002
6383792	RAQ genes and their uses The invention features polynucleotides encoding novel GTP-binding polypeptides, hereinafter referred to as RAQ polypeptides; expression vectors comprising a RAQ polynucleotide of the invention; isolated cells comprising a RAQ-encoding vector; a transgenic...	05/07/2002
6379938	Epoxide hydrolase The present invention is related to an isolated and purified nucleotide sequence from microbial origin, encoding an epoxide hydrolase, the vector comprising said nucleotide sequence, the recombinant host cell transformed by said nucleotide sequence and th...	04/30/2002
6376210	Methods and compositions for assaying analytes Compositions and methods for assaying analytes, preferably, small molecule analytes. Assay methods that employ, in place of antibodies or molecules that bind to target analytes or substrates, modified enzymes, called substrate trapping enzymes. These modi...	04/23/2002
6376222	Riboflavin production The present invention provides a transformed yeast strain containing a DNA sequence transcriptionally linked to a promoter functional in such yeast cells, which when expressed in a suitable host cell, encodes at least one polypeptide having riboflavin bio...	04/23/2002
6372247	Phytase having a low Michaelis constant for phytic acid from monascus Provided is an isolated phytase derived from a microorganism. The microorganism is preferably from the genus Monascus. The phytase has a Michaelis constant of 10 to 110 μM when phytic acid is used as a substrate. A process for producing the phytase is al...	04/16/2002
6372469	CDNA encoding plant-derived epoxide hydrolase, gene encoding same and transformant Isolation of a cDNA encoding a plant-derived epoxide hydrolase and an expression system of the enzyme in Escherichia coli are established, so as to permit the mass-scale production of the plant-derived epoxide hydrolase. The invention provides a cDNA enco...	04/16/2002
6368844	Glycosidase enzymes A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry, pharmaceutical...	04/09/2002
6361987	Gene encoding a protein having asymmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives and its expression product This invention provides DNA fragments for efficiently preparing a protein having asymmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives, transformants obtained by using such a DNA fragment, and a process for preparing the aforesai...	03/26/2002
6355228	Oral care product comprising a mutan binding domain Disclosed is a polypeptide hybrid containing an amino acid sequence with binding affinity for mutan, the amino acid sequence being bound to an active component useful for oral care purposes; an oral care composition comprising a mutan binding domain; an o...	03/12/2002
6355457	Genes for the biosynthesis of epothilones Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. I...	03/12/2002
6352848	Recombinant L-N-carbamoylase from Arthrobacter aurescens and method of producing L-amino acids therewith A novel rec-L-N-carbamoylase from Arthrobacter aurescens and its method of use for producing L-amino acids. The recombinantly produced L-carbamoylase is unexpectedly stable, so that an industrial method of producing L-amino acids can be established with i...	03/05/2002
6350447	Methods and compositions relating to CD39-like polypeptides and nucleic acids The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides and polynucleotides of the...	02/26/2002
6350604	Alkaline lipolytic enzyme Lipolytic enzymes with high activity at alkaline pH in the absence of Ca++ can be obtained from filamentous fungi of the genera Gliocladium, Verticillium and Trichophaea and that the lipolytic enzymes are effective for improving the effect of d...	02/26/2002
6348337	Process for the preparation of C-4 deacetyltaxanes A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme derived therefrom t...	02/19/2002
6348344	Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active hepar...	02/19/2002
6337187	18891, a novel human lipase The present invention relates to a newly identified human lipase belonging to the family of mammalian lipases. The invention also relates to polynucleotides encoding the lipase. The invention further relates to methods using the lipase polypeptides and po...	01/08/2002
6337197	Coenzymes useful for the synthesis of L-carnitine The invention described herein relates to coenzymes useful for the synthesis of L-carnitine, particularly a compound of coenzyme A, and more particularly gamma-butyrobetainyl-coenzyme A and crotonobetainyl-coenzyme A, to procedures for their preparation a...	01/08/2002
6337085	Phytase having a low michaelis constant for phytic acid from monascus The phytase is preferably isolated from Monascus anka IFO 30873. The phytase has a Km of 20 μm when phytic acid is used as a substrate, the optimum pH is 6.0, the optimum temperature is 50° C., the molecular weight of the phytase is 120 kDa when measure...	01/08/2002
6337202	Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function i...	01/08/2002
6331425	Recombinant protein having bacteriophage endosialidase enzymatic activity A recombinant protein having bacteriophage endosialidase enzymatic activity obtainable by expression from a recombinant vector comprising a DNA sequence encoding a bacteriophage endosialidase linked to a DNA sequence of an expression vector which express ...	12/18/2001
6329184	Crystalline form of activated tartrate-resistant and purple acid phosphatase A crystalline form of mammalian TRAP (tartrate-resistant and purple acid phosphatase) is described. The enzyme is activated by cleavage prior to crystallization with a protease and the crystalline form of the mammalian TRAP is capable of being used for X-...	12/11/2001
6326470	Enhancement of accessibility of cellulose by expansins Plant cell expansion is regulated by wall relaxation and yielding, which is thought to be catalyzed by elusive "wall loosening" enzymes. By employing a reconstitution approach, we initially found that a crude protein extract from the cell walls of growing...	12/04/2001
6323017	Platelet activating factor acetylhydrolase, and gene thereof The present invention relates to an isolated human protein having platelet activating factor acetylhydrolase activity....	11/27/2001
6319680	Method for analyzing monosaccharide in a sugar composition A method for the determination of monosaccharides in a sugar composition by simultaneous quantitative analysis of monosaccharides constituting the sugar composition, comprising the steps of: (1) liberating sialic acid from the sugar composition with siali...	11/20/2001
6312931	Protecting molecules in biologically derived compositions while treating with high intensity broad-spectrum pulsed light A method of protecting a biomolecule from substantial degradation while reducing the content of a pathogen or chemical toxin contained by a biologically derived composition is described. The method involves first providing a biologically derived compositi...	11/06/2001
6309868	Cloning of the prolyl-dipeptidyl-peptidase from Aspergillus oryzae The invention has for object the new recombinant prolyl-dipeptidyl-peptidase enzyme (DPP IV) from Aspergillus oryzae comprising the amino-acid sequence from amino acid 1 to amino acid 755 of SEQ ID NO:2 or functional derivatives thereof, and providing a h...	10/30/2001
6309869	Polypeptides having acid phosphatase activity and nucleic acids encoding same The present invention relates to isolated polypeptides having acid phosphatase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic ac...	10/30/2001
6309874	Selection marker The present invention relates to a new selection marker, namely a mutated (Na,K)-ATPase comprising the amino acid sequence: IFIIANIPXPXGTVTIXXID wherein X is chosen from the group of cysteine, leucine, glycine, alanine, valine, isoleucine, and where at least o...	10/30/2001
6306631	PPGPP synthetase and expression systems for improved production of protein of interest The present invention relates to a novel ppGpp synthetase and expression systems for improved production of proteins of interest in Gram-positive bacteria, involving use of the novel ppGpp synthetase....	10/23/2001
6303340	Method for producing a peptide with a pI above 8 or below 5 A method is described for producing a peptide having a pI above 8 or below 5 wherein the peptide is expressed as a fusion protein in which it is linked to a fusion partner through an acid cleavage site. The peptide is released from the fusion partner by a...	10/16/2001
6303354	Microbial production of indigo There is provided an improved process for the biosynthetic production of indigo, the improvement comprising removing unwanted by-products such as isatin or indirubin from the broth in which such indigo is produced. Isatin can be removed by enzymatic activ...	10/16/2001
6300112	ଲ-xylosidase, nucleotide sequence encoding it, and use thereof A nucleotide sequence is provided which encodes a peptide having ଲ-xylosidase activity and exhibits at least 30% amino acid identity with the amino acid sequence shown in SEQ ID NO. 1 and described in SEQ ID NO. 3 or hybridises under stringent condi...	10/09/2001
6294345	Genes encoding proteins essential for plant growth and methods of use The present invention provides plant ENR-A, CBL, UROD, PBGD, and CPPO genes. Also disclosed are the recombinant production of ENR-A, CBL, UROD, PBGD, and CPPO enzymes in heterologous hosts, screening chemicals for herbicidal activity using these recombina...	09/25/2001
6291229	Gram-positive alkaliphilic microorganisms The present invention provides novel aerobic, Gram-positive alkaliphilic bacteria which have been isolated from in and around alkaline soda lakes. These alkaliphiles have been analyzed according to the principles of numerical taxonomy with respect to each...	09/18/2001
6287837	Mammalian ATP-diphosphohydrolases and process of purification thereof The present invention relates to two ATP-diphosphohydrolases (ATPDase enzymes) isolated from bovine aorta and pig pancreas, which enzymes have a molecular weight for their catalytic unit of about 78 and 54 Kilodaltons, respectively. A first process for ob...	09/11/2001
6281345	Parasite astacin metalloendopeptidase nucleic acid molecules and uses thereof The present invention relates to parasite astacin metalloendopeptidase proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and compounds that can inhibit the activities of parasite astacin m...	08/28/2001
6280976	Nucleic acids encoding polypeptides having cellobiose dehydrogenase activity The present invention relates to isolated nucleic acid sequences encoding polypeptides having cellobiose dehydrogenase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well a...	08/28/2001
6274362	RGS-containing molecules and uses thereof Novel RGS polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length RGS proteins, the invention further provides isolated RGS fusion proteins, antigenic peptides, and anti-RGS antibodies. The invention also pro...	08/14/2001
6274360	Conversion of compactin to pravastatin by Actinomadura A method for converting compactin to pravastatin is described. Compactin is provided and contacted with an agent derived from Actinomadura under conditions in which the agent converts compactin to pravastatin. Also described are an Actinomadura strain, an...	08/14/2001

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Class 435/195 - Hydrolase (3. )