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| Number | Title | Issue Date |
| 5382516 | Method and devices for delivery of substrate for the detection of enzyme-linked, membrane-based binding assays The invention provides a method for supplying an enzyme substrate to a membrane-based, enzyme-linked reaction, comprising providing an open pore, high liquid retention capacity material impregnated with a predetermined amount of a substrate for the enzyme... | 01/17/1995 |
| 5378609 | Lipase single reagent system A single system reagent for the determination of lipase, formulated as an emulsion comprising a lipase-active fatty acid source; a first lipase activator comprising colipase; a second lipase activator; a lipoprotein lipase inhibitor; an emulsion stabilize... | 01/03/1995 |
| 5369013 | Method, reagent mixture and kit for determining the presence of bacterial or somatic cells in urine A method, reagent mixture and test kit are provided for testing a urine sample for the presence of bacterial or somatic cells, by reacting a urine sample with a catalase-free alkaline protease enzyme and a detergent compatible therewith, so as to disrupt ... | 11/29/1994 |
| 5364767 | Chromogenic compounds and methods of using same The present invention relates to chromogenic compounds which are represented by the general Formula (I): ##STR1## wherein R1 is a sugar group, ester group, hydrocarbyl group, phosphate group, sulfate group or a salt thereof, with the provi... | 11/15/1994 |
| 5362627 | Stabilization and reduction of background fluorescence of hydroxy coumarin ester enzyme substrates Hydroxy coumarin ester enzyme substrates can be stored in a strong base at pH above 11 to stabilize the substrate against premature hydrolysis of the ester bond and to reduce the revel of contaminating hydroxy coumarin. When diluted in buffer at pH below ... | 11/08/1994 |
| 5362628 | Fluorescent haloalkyl derivatives of reporter molecules well retained in cells The subject invention provides a method for analyzing the metabolic activity in cells by improving the retention of a detectable reporter molecule only in intact cells where a particular enzyme is present. In particular, improved retention results from a ... | 11/08/1994 |
| 5338663 | Method of identifying inhibitors of ଲ-protein esterase activity Disclosed is a method for identifying a compound which inhibits the esterase activity of ଲ-protein. More specifically, in the method disclosed, ଲ-protein is combined with an appropriate substrate and a compound to be tested for its ability to ... | 08/16/1994 |
| 5334507 | Composition for measurement of potassium ion concentration and composition for elimination of ammonium ions There is disclosed a composition for measurement of potassium ion concentration, which contains a) pyruvate kinase, b) glycerol kinase, c) glycerol-3-phosphate oxidase, d) peroxidase, e) a chromogen of reduced type, f) adenosine diphosphate or a salt ther... | 08/02/1994 |
| 5332662 | Methods for determining peroxidatively active substances Methods and compositions are disclosed for determining a peroxidatively active substance (PAS). The methods comprise the step of detecting a fluorescent signal produced upon cleavage of a compound of the formula F-L-Q, wherein F is a fluorester capable of... | 07/26/1994 |
| 5328832 | Method of determining lipase activity using a transparent stable aqueous solution of triglyceride substrate A transparent and stable aqueous solution of a substrate for a determination of lipase, comprising triglyceride uniformly solubilized therein, a method for determination of lipase activity in a sample, employing the aqueous solution, and a process for the... | 07/12/1994 |
| 5320968 | Method for detecting lipoprotein (a) and associated cholesterol A method for assaying lipoprotein (a) in a liquid sample containing other lipoproteins, and a assay device for use in the method are disclosed. In the method, the liquid is contacted with a solid-support reagent containing lectin attached to a solid suppo... | 06/14/1994 |
| 5316907 | Enzymatic fluorometric assay for adenylate cyclase A method of measuring adenylate cyclase (AC) in a sample of physiological material which does not employ radioactive reagents is provided, comprising: (a) providing a physiological sample of physiological material comprising cAMP produced by endogenous AC... | 05/31/1994 |
| 5312743 | Cholesterol esterases with variable substrate specificity For the preparation of cholesterol esterases with variable substrate specificity by cloning of a cholesterol esterase gene, the active center of which has the sequence -Gly-His-Ser-X-Gly-, wherein X signifies an amino acid, into a vector, transformation o... | 05/17/1994 |
| 5292669 | Agents for the detection of substrates with hydrolase activity A method of detecting hydrolase activity using as substrates the compounds of the formula ##STR1## wherein each of R1, R2 and R3 is C1 -C4 alkyl, or phenyl optionally substituted in the meta- or ... | 03/08/1994 |
| 5286626 | Process and apparatus for direct determination of low density lipoprotein Low density lipoprotein are directly determined in body fluids by selectively precipitating very low density lipoprotein, forming clusters with low density lipoproteins, selectively consuming the high density lipoproteins, and resolubilizing the low densi... | 02/15/1994 |
| 5270173 | Method of monitoring cell culture A method of monitoring cell culture which comprises digitizing an image of cultured cells inputted to an image processing equipment through a TV camera connected with an observing means and measuring the number and cell proliferation of cultured cells by ... | 12/14/1993 |
| 5268273 | Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same The present invention discloses the Pichia pastoris acid phospbatase gene, which includes the 5' regulatory region, signal sequence, structural gene, and 3' transcription termination sequence. Also disclosed are methods of using these fragments, which inc... | 12/07/1993 |
| 5268269 | Scleroprotein and scleroprotein hydrolysate containing agent for detection of cholesterol The present invention provides a diagnostic agent for the enzymatic determination of cholesterol, wherein, besides the necessary enzymes, it contains a scleroprotein or a scleroprotein hydrolysate; said invention also provides a process for the production... | 12/07/1993 |
| 5250429 | Glassified restriction enzymes A room temperature stable restriction enzyme in a glassified carbohydrate stabilizer is disclosed. A restriction enzyme reaction buffer containing Mg+2 is dispersed in the stabilizer. One cleaves DNA merely by adding water and DNA to the compos... | 10/05/1993 |
| 5248618 | Methods for generating light with chemiluminescent dioxetanes activated by anchimeric assisted cleavage Novel assay methods employing compounds which are chemically or enzymatically cleavable and which give rise to an intermediate which further decomposes by an intramolecular anchimeric displacement reaction which releases a signal producing species are dis... | 09/28/1993 |
| 5248598 | Lipase single reagent system A single system reagent for the determination of lipase, formulated as an emulsion comprising a lipase-active fatty acid source; a first lipase activator comprising colipase; a second lipase activator; a lipoprotein lipase inhibitor; a first emulsion stab... | 09/28/1993 |
| 5244789 | Process for the determination of phospholipase A in body fluids The present invention provides a process for the determination of phospholipase A in body fluids, wherein the body fluid is incubated with a mixture containing a substrate having a fatty acid residue for the phospholipase and at least two emulsifiers of d... | 09/14/1993 |
| 5227291 | Method for determination of acid phosphatase activity using 4-acyl-2, 6-dihalophenyl phosphoric acid derivatives Phosphoric acid derivatives represented by formula (I): ##STR1## wherein X is a halogen and R is --(CH2)n CH3 (n=0 to 3), or salts thereof are stable to non-enzymatic hydrolysis and are capable of specifically reactin... | 07/13/1993 |
| 5225328 | Stable alkaline phosphatase compositions with color enhancement and their use in assays Methods and compositions for membrane flow-through assays using substrate and enzyme conjugate is described. A preferred method of the present invention comprises providing E. coli alkaline phosphatase (ECAP) conjugate, with additional color enhancement p... | 07/06/1993 |
| 5223402 | Method of detecting microbes utilizing chemiluminescent compound A method of detecting, identifying, and enumerating microbes in biological and non-biological samples includes the steps of combining the sample with a triggerable chemiluminescent compound specifically susceptible to the initiation of chemiluminescent de... | 06/29/1993 |
| 5223401 | Rapid read-out sterility indicator A unitary sterility indicator and a method for its use, the indicator comprising an outer container having liquid impermeable and gas non-absorptive walls, and having a gas-transmissive, bacteria impermeable opening therein; contained within the outer con... | 06/29/1993 |
| 5221615 | Liquid stable triglyceride reagent system A stable triglyceride assay solution for use with a chromogen system is comprised of a solution buffered with a Zwitterionic buffering agent and/or TRIS and stabilized with sortibol, gelatin, and ammonium sulfate. Solution pH is in the range of from 6.8 t... | 06/22/1993 |
| 5208148 | Lipophilic fluorescent glycosidase substrates The claimed invention relates to a substrate for evaluating glycosidic enzymes comprising a fluorescein derivative of the general formula: ##STR1## wherein GlyX is a carbohydrate bonded to fluorescein by a glycosidic linkage; Y, which may be the same... | 05/04/1993 |
| 5200338 | Bacterial extracellular lignin peroxidase A newly discovered lignin peroxidase enzyme is provided. The enzyme is obtained from a bacterial source and is capable of degrading the lignin portion of lignocellulose in the presence of hydrogen peroxide. The enzyme is extracellular, oxidative, inducibl... | 04/06/1993 |
| 5190862 | Chromogenic compounds and the use thereof as enzyme substrates The present invention provides compounds of the general formula: ##STR1## wherein R1 is an amino acid residue or a residue of an oligopeptide in which the amino groups are optionally substituted by protective groups, R2 and R | 03/02/1993 |
| 5191073 | Chromogenic merocyanine enzyme substrates Chromogenic merocyanine enzyme substrate compounds of the general formula: ##STR1## where Y is an enzymatically-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid; A and B represent r... | 03/02/1993 |
| 5188941 | Enzymatic determination of theophylline The present invention provides a new methodology and test composition for determining the presence of theophylline in test samples. The methodology employs enzymes that utilize or recognize theophylline as a substrate to measure the concentration thereof ... | 02/23/1993 |
| 5188937 | Layered sandwich assay method for chlamydia and materials therefor An assay for Chlamydia includes contacting Chlamydia organisms in a liquid with a solid support having an antispecies Fe antibody immobilized thereon and an anti-Chlamydia capture antibody. After binding of Chlamydia antigen to the capture antibody and bi... | 02/23/1993 |
| 5180662 | Cytotoxic T lymphocyte activation assay A method is provided for the quantitative study of cytotoxic T-lymphocyte activation by measuring secreted granule-associated BLT esterase activity after incubating the cytotoxic T-lymphocytes with activating stimuli. This method can be used to screen inh... | 01/19/1993 |
| 5173417 | Thermostable lipoprotein lipase, process for producing the same, and triglyceride determining reagent using the same The present invention is directed toward a thermostable lipoprotein lipase capable of hydrolyzing triglycerides in lipoproteins to glycerol and fatty acids, a process for producing the thermostable lipoprotein lipase, and a blood triglyceride determining ... | 12/22/1992 |
| 5166049 | Measurement of diaphorase activity and reagent therefor A method for measuring diaphorase activity comprising mixing a sample comprising diaphorase with nitro blue tetrazolium, EDTA or a salt thereof, at least one of nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate, and a surfa... | 11/24/1992 |
| 5162201 | Analytical method making use of monoglyceride lipase Disclosed herein is a novel monoglygeride lipase at least capable of catalyzing an enzymatic reaction of the following equation (a) and as substrate specificity, capable of acting on monoglyceride but incapable of acting on diglyceride and triglyceride: M... | 11/10/1992 |
| 5126246 | Reagent for analysis of triglycerides and analysis using the same Reagent for analysis of triglycerides contained in blood serum is provided, which comprises lipases and monoglyceride lipases capable of acting on monoglycerides having substrate specificity and capable of catalyzing the following enzymatic reaction: mono... | 06/30/1992 |
| 5122454 | Assay method for lecithin-cholesterol acyltransferase An assay with high sensitivity for activity of lecithin-cholesterol acyltransferase in blood for functional analysis of liver, by bringing the blood into contact with lecithin and free cholesterol until lysolecithin and cholesterol ester are produced, all... | 06/16/1992 |
| 5122602 | Chromogenic merocyanine enzyme substrates Chromogenic merocyanine enzyme substrate compounds of the general formula: ##STR1## where Y is an enzymatically-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid; A and B represent r... | 06/16/1992 |
