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| Number | Title | Issue Date |
| 8168406 | Dry analytical element for lipase measurement The present invention provides a method for producing a dry analytical element for measurement of pancreatic lipase contained in a body fluid which contains triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glyceri... | 05/01/2012 |
| 8101376 | Swatch for testing the washing performance of an enzyme The present invention relates to a swatch comprising a pH-indicator substance and a substrate for an enzyme for testing the washing performance of the enzyme, e.g. an enzyme for use in detergent compositions. ... | 01/24/2012 |
| 8053207 | Cancer diagnosis by measuring polyisoprenylated methylated protein methyl esterase activity Methods for cancer diagnosis and treatment; in particular, methods for diagnosis and treatment of triple negative breast cancer by measuring the activity of PMPMEase. ... | 11/08/2011 |
| 8017350 | Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation The present invention relates to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC wherein a] a mammalian cell is incubated with glimepiride; b] hcDIGs of the cells of a] are prepared; c] the hc... | 09/13/2011 |
| 7858334 | Degradation of hydrophobic ester pesticides and toxins The present invention relates to methods for degrading hydrophobic ester pesticides and toxins. In particular, the present invention relates to the use of insect esterases, and mutants thereof, in the bioremediation of hydrophobic ester pesticides and toxins residue... | 12/28/2010 |
| 7704705 | Esterases and their use for processes for kinetic resolution of butinolesters New enzymes having esterase activity and their use for processes for kinetic resolution of butinolesters. ... | 04/27/2010 |
| 7598053 | Plant gene and uses thereof A novel gene isolated from Deschampsia antarctica coding for a lipase like protein is disclosed. A system for production of recombinant enzyme is also disclosed as well as uses for the enzyme. ... | 10/06/2009 |
| 7572598 | Preparation comprising albumin esterified with a labeled substance for diagnosis of pancreatic exocrine function A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into the blood and/or is excreted out of the body, wherein the substance ... | 08/11/2009 |
| 7550272 | Method for diagnosis of pancreatic exocrine function A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into the blood and/or is excreted out of the body, wherein the substance ... | 06/23/2009 |
| 7537912 | Methods of measuring luminogenic activity with a protected coelenterazine A method of measuring the enzymatic activity of a luciferase includes contacting a luminogenic protein, such as a luciferase, with a protected luminophore to form a composition; and detecting light produced from the composition. The protected luminophore provides in... | 05/26/2009 |
| 7514234 | Rapid diagnostic method for distinguishing allergies and infections and nasal secretion collection unit A method and device for rapidly, non-invasively and inexpensively differentiating between allergic rhinitis, upper respiratory tract viral infection and bacterial sinusitis, comprising a support strip upon which is fixed discrete indicators of pH, protein content, n... | 04/07/2009 |
| 7504235 | Enzyme detection technique A diagnostic test kit for detecting the presence or absence of an enzyme (e.g., leukocyte esterase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the enzyme to release a nucleophilic aromatic... | 03/17/2009 |
| 7459285 | Compounds and methods of use thereof for assaying lysophospholipase D activity Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such... | 12/02/2008 |
| 7442535 | Fusion protein incorporating a cysteinized ribonuclease A fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1. ... | 10/28/2008 |
| 7442536 | Cysteinized ribonuclease and targeting moiety conjugated thereto A cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1 is disclosed. A targeting moiety can be conjugated to the cysteine residue. ... | 10/28/2008 |
| 7432097 | Phytases, nucleic acids encoding them and methods of making and using them In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved pro... | 10/07/2008 |
| 7416875 | Cytotoxic ribonuclease variants This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the ribonuclease inhibitor while still retaining catalytic properties. Whi... | 08/26/2008 |
| 7416703 | Polymer based lanthanide luminescent sensors for the detection of organophosphorus compounds A device for measuring and detecting the organophosphonis compounds, such as a pesticides or a nerve agents is provided. The devices function by selectively binding an organophosphorous compound to a luminescent functionality-imprinted copolymer. The copolymers poss... | 08/26/2008 |
| 7416856 | High sensitivity assay for detection of nucleoside diphosphate production The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bin... | 08/26/2008 |
| 7407785 | Human DNase I hyperactive variants The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive variants, thereby enabling the production of these variants in quantit... | 08/05/2008 |
| 7402310 | Deoxyribonuclease, gene encoding same and use thereof This invention provides a novel acid DNase (DLAD) which is an endonuclease capable of cleaving DNA independently from divalent cations, under acidic conditions, which retains its activity in acidic to even neutral pH range, and which is not inhibited by G-actin. Thi... | 07/22/2008 |
| 7396669 | Mammalian endonucleases and methods of use Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular response to DNA damage comprises contacting a chemical compound to be test... | 07/08/2008 |
| 7378254 | Compositions and assays utilizing ADP or phosphate for detecting protein modulators Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high th... | 05/27/2008 |
| 7374898 | Peptide inhibitors against seprase The invention generally relates compositions and methods for the treatment of patients with melanoma and other malignant cancers. The compositions of the present invention are novel peptide sequences that inhibit seprase-mediated cell migration. Said sequences may a... | 05/20/2008 |
| 7368237 | Cell death-related nucleases and their uses An assay uses apoptotic nucleases to screen for apoptosis modulators, in a method of modulating apoptosis, and in a method of aiding in a diagnosis of a disease, among other methods. materials for use in the assay include isolated or recombinant polypeptides and pol... | 05/06/2008 |
| 7364918 | Colorimetric sensors constructed of diacetylene materials Colorimetric sensors comprising a receptor incorporated within polydiacetylene assemblies to form a transducer capable of indicating a color change when contacted with an analyte are disclosed. Methods of using the colorimetric sensor and a kit for the colorimetric ... | 04/29/2008 |
| 7351542 | Methods of modulating tubulin deacetylase activity The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubulin deacetylase activity in a... | 04/01/2008 |
| 7344703 | Mycobacterial sulfation pathway proteins and methods of use thereof Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, di... | 03/18/2008 |
| 7335483 | Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins with an enzyme, the substrate of which is free cholesterol, optionally ... | 02/26/2008 |
| 7323317 | Analytical method for detecting alkaline sphingomyelinase and kit for use in such method An analytical fluorometric method and a kit for use in such method are disclosed for assessing the presence of alkaline sphingomyelinase (SMase) in the stool of a patient in need of such an assessment since alkaline SMase is a marker of serious pathological states, ... | 01/29/2008 |
| 7319029 | Lipase from sp. strain T1 A biologically pure culture of Geobacillus Strain T1 bacteria isolated from Palm Oil Mill Effluent capable of producing thermostable lipase T1 gene. The production of thermostable lipase T1 gene from a novel Geobacillus bacterium having a designated as... | 01/15/2008 |
| 7309596 | Isolated monomers of a type II serine proteinase inhibitor The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to isolated monomers of a type II serine proteinase inhibitor. ... | 12/18/2007 |
| 7291478 | Rapid screening and analysis of present and potential nerve agents and their degradation products Methods are described for detecting organophosphorus compounds in a sample. ... | 11/06/2007 |
| 7285385 | Methods for analyzing animal products The present invention provides methods for analysing animal products. In particular methods for differentiating animal products on the basis of breed origin or validating an animal product are provided. ... | 10/23/2007 |
| 7282347 | Method for extracting quantitative information relating to interactions between cellular components A method is described to assay for protein interactions in living cells, e.g. by the introduction of two heterologous conjugates into the cell. The method uses the measurement of cellular distribution of a detectable component (e.g. a GFP-labeledĖfluorescent probe)... | 10/16/2007 |
| 7279277 | Methods for clinical diagnosis A method for the identification of human foetal cell nuclei is provided wherein the method involves subjecting chromosomes of cell nuclei to exonucleolytic digestion by an enzyme so as to remove end regions of each chromosome; and detecting the presence of a DNA seq... | 10/09/2007 |
| 7273739 | Nucleic acid molecules encoding endonucleases and methods of use thereof We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective ... | 09/25/2007 |
| 7270975 | Methods for regulating bud-hypha transitions and cAMP levels in The infection of a mammalian host by a microorganism can be prevented or treated through the alteration of the C. albicans homologue of the high affinity phosphodiesterase, PDE2, gene and/or the adenylate cyclase-associated protein gene. These methods may be ... | 09/18/2007 |
| 7271198 | Method of treating autoimmune diseases A method of treating an autoimmune disease comprising administering to the subject a treatment effective amount of a histone hyperacetylating agent, or a pharmaceutically acceptable salt thereof. ... | 09/18/2007 |
| 7270974 | Rapid diagnostic method for detecting bacterial sinusitis A method and device for rapidly, non-invasively and inexpensively differentiating between allergic rhinitis, upper respiratory tract viral infection and bacterial sinusitis, comprising a support strip upon which is fixed discrete indicators of pH, protein content, n... | 09/18/2007 |
