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| Number | Title | Issue Date |
| 6495527 | Complex of DNA and microparticle of defatted lipid-binding protein for gene therapy Removal of lipid from lipid-bound protein such as human serum albumin to produce defatted protein enhances ability of the protein to bind therapeutic agents for use as a carrier for the therapeutic agent. The defatted protein may be reloaded with cationic... | 12/17/2002 |
| 6495136 | Proteases having modified amino acid sequences conjugated to addition moieties Protease conjugates such as subtilisin conjugates are provided comprising a protease moiety and one or more addition moieties wherein the protease moiety has a modified amino acid sequence of a parent amino acid sequence. The parent amino acid sequence co... | 12/17/2002 |
| 6492162 | Apparatus for the recovery of nucleic acids Methods and apparatus are provided for the recovery of nucleic acids from a nucleic acid-containing material by which nucleic acids can be rapidly and easily recovered at a high purity without deteriorating the yield. The methods are composed of step 1 fo... | 12/10/2002 |
| 6485928 | Use of granulysin as an antimicrobial agent The T cell activation marker, granulysin, is demonstrated to be an effective antimicrobial agent. It is used in vitro and in vivo to reduce the population of viable cells in a microbial population. Of particular interest is the use of the active fragment ... | 11/26/2002 |
| 6479066 | Device having a microporous membrane lined deformable wall for implanting cell cultures A device and method of using the device are provided for implanting cell cultures in a host. The device is formed of a deformable body, a microporous membrane and a sealable port. The shape of the body which is preferably rounded can be altered by applyin... | 11/12/2002 |
| 6479064 | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction artificial organs are reconstructed using a three-dimensional scaffold produced by decellularizing biostructures from a donor organ. The three-dimensional scaffold is perfused with isolated endothelial cells that develop to produce an endothelial tissue l... | 11/12/2002 |
| 6468811 | Light-controlled electrokinetic assembly of particles near surfaces A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces ... | 10/22/2002 |
| 6465227 | Spherical particles containing microorganism cells having enzyme activity A process is presented for producing spherical particles containing microorganism cells having desired enzyme activity. The process comprises the steps of mixing the cells directly with a primary or secondary amine-containing polymer, combining the result... | 10/15/2002 |
| 6465226 | Preparing small microcapsules containing high concentration of cells or tissue Biologically active substances such as cells or tissue are microencapsulated by methods that provide a high proportion of microcapsules containing a core of the biologically active substance as compared to microcapsules not containing the biologically act... | 10/15/2002 |
| 6465205 | In vitro cell culture device including cartilage and methods of using the same The present invention relates to an in vitro cell culture device which includes a vessel comprising an inner surface, a layer of cartilage disposed on at least a portion of said inner surface, the layer of cartilage including a plurality of chondrocytes i... | 10/15/2002 |
| 6458601 | Test piece and system for reading out image information from the test piece A test piece for use in biological analyses includes a plurality of different known specific binding substances disposed in predetermined positions on a substrate. The specific binding substances are disposed on a plurality of surfaces provided by the sub... | 10/01/2002 |
| 6451585 | Product for pre-emptive potential in remediation of oil spills A process for pre-emptive potential in bioremediation of oil spills comprising the steps of fabricating cells of micro-organisms capable of degrading hydrocarbons, encapsulating the cells into pods dissolvable in a non-hydrocarbon environment such as wate... | 09/17/2002 |
| 6444261 | Storage-stable particle, in particular carrier for carrier-bound reactions, and methods of producing said particle A particle resistant to storage of at least one first and at least one second component, wherein said second component of at least one crosslinkable polymer as a shell at least partially envelops and/or encloses said first component as a core and said fir... | 09/03/2002 |
| 6440296 | Microstructured biosensor, use of the biosensor and process for the immobilization of biocatalysts A biosensor is used for measuring principal metabolites in blood and other substances. The biosensor has a special structure formed of a two-layer enzymatic membrane with a considerably increased functionality compared with enzymatic membranes of the prio... | 08/27/2002 |
| 6436722 | Device and method for integrated diagnostics with multiple independent flow paths Invention performs an assay to determine presence or quantity of specific analyte in fluid sample. Representative device has two separate flow paths established sequentially in device with a single user activation step. First flow path delivers sample, an... | 08/20/2002 |
| 6433078 | Reversibly soluble enzyme-polymer conjugates The present invention is directed to a method for producing reversibly soluble, catalytically active enzyme-polymer conjugates and the products thereof. In particular, the invention is directed to reversibly soluble catalytically active enzyme-polymer con... | 08/13/2002 |
| 6426214 | Cell encapsulating device containing a cell displacing core for maintaining cell viability Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds th... | 07/30/2002 |
| 6423522 | Microorganism lactamase enzyme obtained therefrom and their use A lactamase enzyme having good stability, capable of hydrolysing an enantiomer of the bicyclic lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one, to give (-) lactam and (+) amino acid, has been found in a strain of Comamonas acidivorans. The enzyme has been isol... | 07/23/2002 |
| 6420171 | Leukemic cell-adsorbing material containing lectin protein from Agrocybe cylindracea or jequirity plant seed An efficient method for therapeutic treatment of leukemia is provided in which a patient's body fluid during external circulation is brought into direct contact with an adsorbent material capable of specifically and selectively adsorbing leukemic cells in... | 07/16/2002 |
| 6420146 | Process for the preparation of stable yeast crystals for enhanced production of ethanol The invention provides a process for the preparation of stable yeast crystals for enhanced production of ethanol, said process comprising the steps of culturing yeast Sacchromyces spp. in a growth medium, obtaining immobilized yeast heads, separating and ... | 07/16/2002 |
| 6416756 | Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care Modified enzymes are prepared for use in skin care products by covalently coupling to the enzymes from 4 to 70 polymeric molecules with or without a linker such as a triazine ring. Molecular weight of the polymeric molecules may be from 1 to 35 kDa and of... | 07/09/2002 |
| 6416717 | Evacuated blood collection tube for rapid blood coagulation Providing an evacuated blood collection tube for blood collection rapidly, whereby serum of high purity can be isolated in a rapid and simple manner with no occurrence of fibrin deposition. Beads each coated with a blood coagulation-promoting enzyme compr... | 07/09/2002 |
| 6413749 | Granule containing protein and corn starch layered on an inert particle Granules are prepared containing an admixture of protein and starch layered over an inert particle. Proteins include pharmaceutically important proteins such as hormones, or industrially important proteins such as enzymes including proteases, amylases, li... | 07/02/2002 |
| 6406851 | Method for coating a substrate quickly and uniformly with a small volume of fluid A method is provided for applying a small volume of fluid such as fluids used in DNA array fabrication quickly and uniformly onto a surface of a solid substrate. The method employs a distribution member having an upper surface and a lower surface, and inc... | 06/18/2002 |
| 6399355 | Non-naturally occurring targeted lipolytic compounds and related compositions and methods This invention provides a non-naturally occurring targeted lipolytic compound comprising a lipolytic agent linked to a targeting agent. In an embodiment, the lipolytic agent is covalently attached to the targeting agent. In an embodiment, the lipolytic ag... | 06/04/2002 |
| 6399341 | Artificial pancreas An artificial pancreas is described herein which comprises one or more viable and physiologically active pancreatic islet cells capable of producing insulin, encapsulated within a semipermeable spheroidal membrane comprising agar gel. Further disclosed ar... | 06/04/2002 |
| 6395522 | Biologically active support containing bound adsorbent particles and microorganisms for waste stream purification A biologically active support is provided for removal of pollutants such as aliphatics, aromatics, heteroaromatics and halogenated derivatives from waste streams. The support contains a particulate adsorbent such as activated carbon bound by a polymer bin... | 05/28/2002 |
| 6391280 | J chain polypeptide targeting molecule linked to an imaging agent Polypeptide targeting molecules are provided for use in delivering imaging agents to epithelial tissue. Upon delivery, the imaging agent(s) may remain within an epithelial cell or may undergo transepithelial transport via transcytosis. The targeting molec... | 05/21/2002 |
| 6383819 | Method for determining cholesterol and sensor applicable to the same The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low den... | 05/07/2002 |
| 6379599 | Process for the preparation of molecularly imprinted polymers useful for separation of enzymes The invention relates to a process for the preparation of molecularly imprinted polymers useful for separation of enzymes, which comprises the steps of reacting a complex of enzyme and affinity monomer, a comonomer and a crosslinker, with a polymerization... | 04/30/2002 |
| 6379699 | Liposome having attached target-binding moiety and artherosclerotic plaque interacting moiety Complexes are prepared containing two or more different effector molecules joined to each other by a joining component. One effector molecule is a binding molecule such as an antibody or Fc receptor that binds to a molecular target such as a virus or anti... | 04/30/2002 |
| 6379909 | Method of detecting an antibody in a liquid sample The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of ... | 04/30/2002 |
| 6380140 | Enzyme granules containing phosphated starch Enzyme granules suitable for incorporating into detergents or cleaners are provided containing an enzyme, a carrier material and a granulation auxiliary containing phosphated starch. The phosphated starch preferably has a mean degree of phosphation rangin... | 04/30/2002 |
| 6379956 | Method for populating substrates with biological cells and populating devices that can be used therefor The populating method for populating a substrate with living cells provides a population with at least one populating phase and at least one perfusion phase. During the populating phase the substrate can be held in contact with the cell suspension by cont... | 04/30/2002 |
| 6379937 | Process for the preparation of a mixture of 19 hydroxyelcosatetraenoic acid and 20 hydroxyeicosatetracnoic acid (10 hete and 20 hete) The present invention relates to a novel process for the preparation of mixture of 19 hydroxyeicosatetraenoic acid and 20 hydroxyeicosatetraenoic acid (19 HETE and 20 HETE) by biotransformation of Arachidonic acid or Poly Unsaturated Fatty Acids (PUFA) wi... | 04/30/2002 |
| 6379922 | Membrane enzyme reactor containing a plurality of biocatalyst-immobilized sheets An enzyme membrane reactor is designed to enhance the production efficiency of foods, pharmaceutical products, and other bioproducts. The reactor is formed of a cap and a container in which a plurality of the biocatalyst-immobilized sheets are located at ... | 04/30/2002 |
| 6372813 | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays The present invention provides solid supports (e.g., glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprisin... | 04/16/2002 |
| 6372712 | Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. The molecular weight of the bifunctional molecule is p... | 04/16/2002 |
| 6372472 | Filter media containing powered cellulose and immobilized lipase for swimming pool and spa water filteration A composition is provided containing powdered cellulose and at least one water insoluble, immobilized water treatment additive. Preferably, a filter media composition is provided containing powdered cellulose and at least one water insoluble, immobilized ... | 04/16/2002 |
| 6372447 | Method of distributing cells as single layer on a substrate from a suspension An apparatus and method are provided for preparing specimens of biological cells uniformly distributed over a substrate surface. The method comprises providing a suspension of biological cells in fluid, and then extracting biological target cells from the... | 04/16/2002 |
