"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 8137942 | Method of preparing a modified surface Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including si... | 03/20/2012 |
| 7998716 | Method to bind enzyme to carrier using cationic copolymers and product produced thereby Disclosed are a method of adhering active enzymes to an inert support, the product produced thereby, and a method of using the enzyme-coated support in enzyme-catalyzed reactions such as the glucose isomerase-catalyzed conversion of glucose to fructose. The method i... | 08/16/2011 |
| 7993892 | Production of organic/inorganic composite hydrogel The present invention provides a production process of an organic/inorganic composite hydrogel, which demonstrates superior mechanical properties, by uniformly dispersing a clay mineral in an organic polymer over a wide range of clay mineral content, and a dried for... | 08/09/2011 |
| 7892801 | Process for enhancing the activity of glucose oxidase Effective activation of a biological material such as an enzyme has been demanded. The present invention provides a process for activating a biological material which includes providing a porous material having mesopores; immobilizing a biological material on the po... | 02/22/2011 |
| 7838273 | Biomolecular hybrid material and process for preparing same and uses for same Disclosed is a composition and method for fabricating novel hybrid materials comprised of, e.g., carbon nanotubes (CNTs) and crosslinked enzyme clusters (CECs). In one method, enzyme-CNT hybrids are prepared by precipitation of enzymes which are subsequently crossli... | 11/23/2010 |
| 7642077 | Biocomposite comprising co-precipitate of enzyme, silicate and polyamine This invention relates to a method of immobilizing biocatalysts including protein and cells by co-precipitation with silicate or organosilicate matrices through the action of an organic template molecule. The organic template molecule is in general a polyamine such ... | 01/05/2010 |
| 7563608 | Method for manufacturing a sintered compact for use as a cell culture base A method for manufacturing a sintered compact having high density, and a sintered compact manufactured by the manufacturing method are provided. The manufacturing method comprises the steps of preparing hydroxyapatite powder, molding a green compact, shaping the gre... | 07/21/2009 |
| 7541167 | Porous glass composite material A porous glass composite material comprising at least one alkoxodisilane (precursor) having the general formula (or1)3Si-spacer-Si(OR2)3,wherein R1 and R2 are the same or different and may be hydrogen... | 06/02/2009 |
| 7429472 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 09/30/2008 |
| 7427497 | In vitro metabolic engineering on microscale devices Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a means for sequentially directing a starting material and each ensuing reac... | 09/23/2008 |
| 7423010 | Nonporous microparticle-prodrug conjugates for treatment of infection This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such biologically active compounds by phagocytic cells and delivery of such c... | 09/09/2008 |
| 7419679 | Medical implant having a layer of titanium or titanium alloy fibers It is intended to provide a scaffold whereby a bone and a metallic material can three dimensionally form together a stereoscopic binding layer. Thus, a geometric space sufficient for cell actions is provided. As a result, the time required for the formation of a ste... | 09/02/2008 |
| 7413883 | Enantioselective immobilized lipase Immobilization of Candida rugosa lipase on a carrier selected from the group consisting of macroporous adsorbent resin of the acrylic type, synthetic epoxy activated resin and Mg—Al-hydrotalcite enhances its enantioselectivity by six to seven folds. The imm... | 08/19/2008 |
| 7402381 | Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption of a number of molecules. The immobilization method can include the st... | 07/22/2008 |
| 7399644 | Immunoassay, reagent for immunoassay, and production method of the same An assay method for determining presence of a target antibody or antigen in a specimen qualitatively or quantitatively by mixing the specimen with an antigen or antibody immunologically reactive with the target antibody or antigen, and assaying the level of the immu... | 07/15/2008 |
| 7398161 | Sampling method and sampling device, and logD measuring method and logD measuring system A sampling method sampling a lower-layer liquid from a liquid body comprised of two layers of liquids, an upper-layer liquid (octanol) and the lower-layer liquid (buffer solution), without mixing the layers. An extracting device is provided with a tubular apical end... | 07/08/2008 |
| 7390498 | Method of forming bone with porous βtricalcium phosphate granules A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-... | 06/24/2008 |
| 7371830 | Method for separating biological material from a fluid using magnetic particles Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles are used for separating biological material such as nucleic acids. A... | 05/13/2008 |
| 7371471 | Electromagnetic noise suppressing thin film An electromagnetic noise suppressing thin film has a structure including an inorganic insulating matrix made of oxie, nitride, fluoride, or a mixture thereof and columnar-structured particles made of a pure metal of Fe, Co, or Ni or an alloy containing at least 20 w... | 05/13/2008 |
| 7371457 | Nanoparticle comprising nanoshell of thickness less than the bulk electron mean free path of the shell material The present invention is for particulate compositions and methods for producing them that can absorb or scatter electromagnetic radiation. The particles are homogeneous in size and are comprised of a nonconducting inner layer that is surrounded by an electrically co... | 05/13/2008 |
| 7361369 | Implant with structure allowing injection of polymer for attaching implant to tissue Methods and apparatus for bone implants that allow for the directed application of an osteogenic compound. The implant is preferably constructed of a biodegradable polymer formed into a structure having micro-architectural features and includes features that allow f... | 04/22/2008 |
| 7357941 | Method of delivering a bioactive agent with porous β-tricalcium phosphate granules A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-... | 04/15/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7354750 | Methods for separating molecules The present invention provides compositions and methods for the separation of metals or molecules such as polypeptides, nucleic acids, or endotoxins using a metal-modified solid support. The metals or molecules are isolated from a starting material using the modifie... | 04/08/2008 |
| 7351798 | Stabilized protein crystals, formulations comprising them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and composition... | 04/01/2008 |
| 7341863 | Method for the degradation of MTBE and TBA A method for the degradation of methyl-tertiary-butyl-ether (MTBE) and tertiary-butanol (TBA) using a mixture of Pseudomonas putida is described. The method enables almost complete remediation of MTBE and TBA in situ in contaminated water and/or soil. ... | 03/11/2008 |
| 7335383 | Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The reactive agent has nitrite reductase activity, nitrate reductase activity, a... | 02/26/2008 |
| 7319003 | Arrays of probes for positional sequencing by hybridization This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods whereby sequence information is obtained rapidly and efficiently in discret... | 01/15/2008 |
| 7314845 | Supported catalyst systems The present invention relates to a supported catalyst system. The supported catalyst of the present invention comprises an inorganic support having attached to at least one surface thereof non-acidic, hydrophilic, hydroxyl-containing organic R10 groups ha... | 01/01/2008 |
| 7311839 | Removal of biological pathogens using surfactant-modified zeolite Systems and methods are described for removing biological pathogens using surfactant-modified zeolite (SMZ). A method for removing biological pathogens from a fluid or a fluid-based gel includes filtering the fluid or fluid-based gel using SMZs. A method for removin... | 12/25/2007 |
| 7312056 | Enhancement of enzyme activity through purification and immobilization An improved method of making an immobilized enzyme comprising (a) treating an immobilization support with an aqueous solution comprising a cross-linking agent and polymeric aldehyde species and active centre species to produce a modified support; (b) isolating the m... | 12/25/2007 |
| 7304015 | Compositions for separating molecules The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports. ... | 12/04/2007 |
| 7304016 | Compositions for separating molecules The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports. ... | 12/04/2007 |
| 7297510 | Compositions containing enzymes bound to cationic copolymers Disclosed are a method of adhering active enzymes to an inert support, the product produced thereby, and a method of using the enzyme-coated support in enzyme-catalyzed reactions such as the glucose isomerase-catalyzed conversion of glucose to fructose. The method i... | 11/20/2007 |
| 7292336 | Method and instrument for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An instrument system for detecting a biochemical interaction on a biosensor. The system includes an array of... | 11/06/2007 |
| 7285422 | Systems and methods for preparing and analyzing low volume analyte array elements The invention provides methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. The tool can dis... | 10/23/2007 |
| 7276283 | Plasma-enhanced functionalization of carbon-containing substrates Methods for producing plasma-treated, functionalized carbon-containing surfaces are provided. The methods include the steps of subjecting a carbon-containing substrate to a plasma to create surface active sites on the surface of the substrate and reacting the surfac... | 10/02/2007 |
| 7270829 | Industrial production of meat using cell culture methods A meat product containing in vitro produced animal cells in a three dimensional form and a method for producing the meat product. ... | 09/18/2007 |
| 7267971 | Process for preparation of thermostable enzyme A process for the preparation of thermostable enzyme glucose oxidase of high Transition temperature (Tm) useful for biological processes of high temperature, said process comprising steps of silanizaton of the activated glass beads by evaporative depositi... | 09/11/2007 |
| 7267938 | Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to... | 09/11/2007 |