Class 435/175 - Multi-enzyme system

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter wherein two or more functionally different
No. of patents: 139
Last issue date: 02/14/2012

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Number	Title	Issue Date
8114647	Blood brain barrier device Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects. ...	02/14/2012
7855062	Bone cell delivery device Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects. ...	12/21/2010
7427497	In vitro metabolic engineering on microscale devices Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a means for sequentially directing a starting material and each ensuing reac...	09/23/2008
7402381	Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption of a number of molecules. The immobilization method can include the st...	07/22/2008
7364884	Method for producing a hydroxylation catalyst and the use thereof A process for preparing a hydroxylation catalyst by i) embedding a cystochrome P450 monooxygenase in a sol-gel matrix, ii) embedding an enzymatic NADPH-regenerating system in a sol-gel matrix, and combini...	04/29/2008
7354752	Acid-stable alpha amylases having granular starch hydrolyzing activity and enzyme compositions The present invention relates to an acid-stable alpha amylase (asAA) derived from a strain of Aspergillus kawachi, which has granular starch hydrolyzing (GSH) activity, the heterologous expression of the asAA having GSH activity in filamentous fungal host cel...	04/08/2008
7348169	Method of making bioactive catalytic material A bioactive catalytic material is disclosed for providing protection from chemical exposure. The material is composed of enzymes immobilized within polyelectrolyte multilayers and a polymerizable end-capping layer to render stability to enzymes. Also disclosed is th...	03/25/2008
7332319	Heterologous alpha amylase expression in The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same. ...	02/19/2008
7323305	Methods of amplifying and sequencing nucleic acids An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing, amplifying the prepared DNA in a representative manner, and performing multip...	01/29/2008
7300022	Modified membranes A porous polymeric membrane formed from a blend of a polymeric membrane forming material, such as polyvinylidene fluoride or polysulfone and a polymeric reactivity modifying agent adapted to modify the surface active properties of the porous polymeric membrane. The ...	11/27/2007
7273736	Method for preparing an enzyme containing granule The invention relates processes for producing enzyme containing granules having an enzyme containing core and a shell coating the core wherein the preparation of the core and application of the shell are independent and are physically separated by time and/or locati...	09/25/2007
7208287	Reagent set and method for detecting cholesterol in a high-density lipoprotein or low density lipoprotein A method for quantitating a specific component in lipoproteins contained in a biological sample, for example, HDL (high-density lipoprotein), LDL (low-density lipoprotein) or VLDL (very low-density lipoprotein) by using a commonly employed automatic analyzer without...	04/24/2007
7198785	Systems and methods related to degradation of uremic toxins The present invention generally relates to the treatment of uremic toxins in vivo using uremic toxin-treating enzymes, and/or cells capable of producing uremic toxin-treating enzymes or otherwise reacting with uremic toxins. Non-limiting examples of cases where the ...	04/03/2007
7172682	Enzyme immobilization for electroosmotic flow Disclosed herein is a method and apparatus of immobilizing a biocatalyst on a microfluidic biochip for conducting reactions in the presence of electroosmotic flow. The biochip includes a polymer on its microfluidic flow surfaces, wherein the polymer includes a first...	02/06/2007
7112453	Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d...	09/26/2006
7109007	Polyhydroxybutyrate polymerase A method for controlling and modifying biopolymer synthesis by manipulation of the genetics and enzymology of synthesis of polyhydroxybutyrate (PHB) and polyhydroxyalkanoate (PHA) polyesters at the molecular level in procaryotic and eukaryotic cells, especially plan...	09/19/2006
7105339	Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d...	09/12/2006
7045365	Supported aldehydic silanes and method of manufacture A method for producing a derivatized aldehydic support matrix material includes activating surface hydroxyl groups on the support matrix material and reacting the activated hydroxyl groups with an aldehydic alkoxy silane. The derivatized aldehydic support matrix mat...	05/16/2006
7018794	Methods for monitoring multiple gene expression The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus ...	03/28/2006
6979543	Method for detecting biological agents A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate combination of a recognition element, a tethering element and a property-alteri...	12/27/2005
6939681	Method of detecting an antibody in a liquid sample The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of the sample ...	09/06/2005
6884597	Method for detecting acetyltransferase and deacetylase activities and method for screening inhibitors or enhancers of these enzymes A method for simply and conveniently detecting acetyltransferase and deacetylase activities of proteins by executing an acetylation reaction of a peptide substrate with an acetyltransferase, or a deacetylation reaction of an acetylated peptide substrate with a deace...	04/26/2005
6867002	Sample treating kit and sample treating method using the same for analysis with a biosensor A sample solution treating instrument is provided for facilitating rapid and simplified adjustment of the condition of a sample solution proper for analysis with a biosensor before supplying the solution to the biosensor. The sample solution treating instrument incl...	03/15/2005
6861232	Creatinine biosensor The present invention generally relates to a method for producing biosensors and a biosensor for determination of creatinine. The biosensor comprises at least two enzymes, for the amperometric determination of enzymatically degradable substances in biological liquid...	03/01/2005
6858403	Polymer matrix containing catalase co-immobilized with analytic enzyme that generates hydrogen peroxide Hydrogels containing catalase co-immobilized with an analyte-sensitive enzyme such as glucose oxidase are disclosed. The hydrogels may be pH-sensitive, and preferably are thin and lightly crosslinked. The catalase is present in concentrations ranging generally from ...	02/22/2005
6825000	Immunoassay reagent and immunoassay method An immunoassay reagent is obtained whereby a microscale substance such as an antigen or antibody can be assayed at a high sensitivity, and whereby a need to separate a reacted substance, e.g., an immunoreacted substance, from an unreacted substance can be eliminated...	11/30/2004
6812000	Product removal process for use in a biofermentation system This invention relates to a bioprocess engineering solution for a product removal process for use in a biofermentation. The invention discloses a process for withdrawing an aliquot of broth from a biofermentation vessel during at least a portion of the biofermentati...	11/02/2004
6780607	Method for cell-free protein complete post-translational modification The present invention relates to methods of production of the completely post-translationally modified protein by combination of cell-free protein synthesis and cell-free co- and post-translational modification. Previous cell-free protein synthesis system has only b...	08/24/2004
6759220	Enzyme-containing polyurethanes A method of increasing loading of active enzyme immobilized in a polyurethane polymer including the steps of: synthesizing the polyurethane polymer in a reaction mixture containing water and enzyme; and including a sufficient amount of a surfactant in the reaction m...	07/06/2004
6667066	Multi-enzyme product with glucoamylase, proteolytic and xylanase activities and method for producing same by solid state fermentation of wheat bran with Aspergillus niger The invention concerns a multi-enzyme product with glucoamylase, proteolytic and xylanase activities, characterized in that it consists of wheat bran fermented with an Aspergillus niger strain, said enzymatic glucoamylase, proteolytic and xylanase activit...	12/23/2003
6613582	Methods for rapid and efficient protein cross-linking The present application describes novel uses of ruthenium bipyridyls or palladium porphyrins as photo-activatable crosslinking agents. Crosslinking can be between any two molecules including peptides, proteins, or compounds. Crosslinking occurs in the pre...	09/02/2003
6602716	Method and device for referencing fluorescence intensity signals A method and device for fluorimetric determination of a biological, chemical or physical parameter of a sample utilize at least two different luminescent materials, the first of which is sensitive to the parameter, at least with respect to luminescence in...	08/05/2003
6596516	Process for the fermentative preparation of L-amino acids using coryneform bacteria A process for the preparation of L-amino acids, in which the following steps are carried out, a) fermenting the desired L-amino acid-producing bacteria in which at least the glyA gene is attenuated, in particular by removal of the natural promoter, and op...	07/22/2003
6541230	Detoxification with sponges or foams containing plurality of enzymes and encapsulated indicator A reusable sponge or foam made of a polymer such as polyurethane is prepared containing a plurality of different enzymes or a cross-linked complex of the plurality of enzymes for detoxification of a diverse array of hazardous chemicals such as organophosp...	04/01/2003
6534282	Detection of hypertension using immunoreactive metabolic products A method to assess hypertension by measuring the amount of free and conjugated hydroxyeicosatrienoic acids (DHETs) and metabolites of DHETs, which are metabolites of arachidonic acid (AA) epoxygenases and epoxide hydrolases, in a biological sample which c...	03/18/2003
6448029	Method and reagent for quantitative determination of 1,5-anhydroglucitol The present invention provides a simple method for the determination of a specific component, e.g. 1,5-anhydroglucitol (1,5-AG) in a sample containing glucose, and a reagent and a reagent kit useful in the method. In one embodiment, a method for the deter...	09/10/2002
6440682	Detection of hypertension using immunoreactive metabolic products A method to assess hypertension by measuring the amount of free and conjugated hydroxyeicosatrienoic acids (DHETS) and metabolites of DHETs, which are metabolites of arachidonic acid (AA) epoxygenases and epoxide hydrolases, in a biological sample which c...	08/27/2002
6379909	Method of detecting an antibody in a liquid sample The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of ...	04/30/2002
6309852	Method and reagent for quantitative determination of 1,5-anhydroglucitol The present invention provides a simple method for the determination of a specific component, e.g. 1,5-anhydroglucitol (1,5-AG) in a sample containing glucose, and a reagent and a reagent kit useful in the method. In one embodiment, a method for the deter...	10/30/2001
6248234	Water-dissolvable bioremediation device and method of use A bioremediation device including a water dissolvable material that may be held in a netting capable of suspension. The material preferably comprises surfactants that contain hydrophilic and/or hydrophobic tails that can easily form emulsions with the sew...	06/19/2001

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Class 435/175 - Multi-enzyme system