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| Number | Title | Issue Date |
| 8114646 | Method for ultrasonic cell removal The present invention provides a method for treating cell culture vessels including multi-layer cell culture vessels with ultrasonic energy to dissociate cells growing on surfaces of cell culture vessels. ... | 02/14/2012 |
| 7923229 | Method of classifying and counting leukocytes A method for classifying and counting leukocytes, which comprises steps of: staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent, with a fluorescent dye; introducing the sample containing the stained cells into a flow c... | 04/12/2011 |
| 7625730 | Method for classifying and counting leukocytes There is provided a method for classifying and counting leukocytes with abnormal DNA amount, which comprises: (1) a step of staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent to lyse... | 12/01/2009 |
| 7569373 | Method for counting megakaryocytes A method for counting megakaryocytes in a specimen is described. In the method, first, erythrocytes in the specimen are lysed and nucleic acid in the megakaryocytes is stained with a fluorescent dye, and thereby, a measurement sample is prepared. Next, the cells in ... | 08/04/2009 |
| 7439048 | Apparatus for acoustic ejection of circumscribed volumes from a fluid This invention is directed to the use of focused energy, particularly focused acoustic energy, in the spatially directed ejection of circumscribed volumes of a fluid which differ in acoustic impedance from the surrounding fluid. ... | 10/21/2008 |
| 7419808 | Methods and compositions for the production of adenoviral vectors The present invention addresses the need to improve the yield of adenovirus when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of infection temperatures lower than 37° C. in a cell culture system results in impr... | 09/02/2008 |
| 7399609 | /patents/7399609/description.html The invention relates to methods of detecting staphylococcus. ... | 07/15/2008 |
| 7384559 | Device and method for treating magnetic particles A device for treating magnetizable or magnetically attractable particles which are present in a liquid, comprising a holder for one ore more reaction vessel(s) with the liquid containing the particles, at least two movably arranged permanent magnets, a drive unit fo... | 06/10/2008 |
| 7371830 | Method for separating biological material from a fluid using magnetic particles Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles are used for separating biological material such as nucleic acids. A... | 05/13/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7351558 | Solventless extraction process The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing wa... | 04/01/2008 |
| 7332352 | Separation particles A composition comprising colloidal Fe3O4 particles coated with streptavidin is disclosed. These particles can be used in a method for separating biotinylated compounds from a solution in which the biotinylated compounds bind to the streptavidin... | 02/19/2008 |
| 7306924 | Biosensor and related method A method for collecting a microbiological substance utilizes a micro fabricated biochip having a collection chamber. A fluid sample containing a microbiological entity of interest is delivered to the collection chamber in the biochip. Then a non-uniform electric fie... | 12/11/2007 |
| 7270986 | Ejection of localized volumes from fluids A method is provided for acoustically ejecting from a channel or other container a plurality of fluid droplets, each of which contains one or more particles or other localized volumes. The localized volumes, which can be living cells, are ejected towards sites on a ... | 09/18/2007 |
| 7270990 | Virus production An improved process for recovery of virus from allantoic fluid of virus-infected chick embryos. Virus associated with granular and fibrous debris in the allantoic fluid can be disassociated from the debris and recovered, thereby increasing viral yield. Dissociation ... | 09/18/2007 |
| 7169282 | Dielectrophoresis apparatus Devices for filtering fluids using dielectrophoresis are disclosed. ... | 01/30/2007 |
| 7157257 | Method of treating biological cells and/or their cell components with electrical fields A method is described for treating biological cells and/or their cell components with electrical fields in a reaction medium, in which an inhibitor is added to the reaction medium to counteract the action of enzymes that break down protein. ... | 01/02/2007 |
| 7151000 | Method of concentrating proteins from serum A sample is prepared from blood in a manner which makes it possible to further analyze proteins in the sample, e.g. to detect prions in the sample. Blood is extracted, allowed to clot and subjected to separation processing (e.g. centrifugation) to obtain serum. The ... | 12/19/2006 |
| 7135144 | Method for the manipulation of a fluid sample The invention provides a device and method for the manipulation of materials (e.g., particles, cells, macromolecules, such as proteins, nucleic acids or other moieties) in a fluid sample. The device comprises a substrate having a plurality of microstructures and an ... | 11/14/2006 |
| 7125696 | Method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent A invention concerns a novel method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent, and polypeptides obtainable by said method. The invention also concerns the use of said polypeptides, in particular for preparing medicines or ... | 10/24/2006 |
| 7105081 | Methods and apparatus for electrosmear analysis Methods and apparatus for preparing a smear for cytopathology or other analysis. In a representative embodiment, cells of a sample are subjected to a dielectrophoretic force to segregate the cells into two or more zones of a surface. The particles are attached to th... | 09/12/2006 |
| 7033473 | Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures Methods and apparatuses for discriminating matter utilizing dielectrophoresis combined with magnetophoresis. A sample having one or more constituents is injected into an inlet port of a chamber. A carrier medium flow is initiated at the inlet port to establish a flo... | 04/25/2006 |
| 7014744 | Method of purification and concentration using AC fields with a transfer tip Embodiments of methods and devices are disclosed for the manipulation (e.g., concentration, purification, capture, trapping, location, transfer, etc.) of analytes, e.g., biomolecules, with respect to analyte-containing solutions using one or more electric fields. | 03/21/2006 |
| 6989086 | Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis The present invention comprises devices and methods for performing channel-less separation of cell particles by dielectrophoresis, DC high voltage-pulsed electronic lysis of separated cells, separation of desired components from crude mixtures such as cell lysates, ... | 01/24/2006 |
| 6969449 | Multi-well plate and electrode assemblies for ion channel assays Plate and electrode assemblies include configurations allowing for relatively uniform electric field production. The electrodes may comprise strips of conductive material plated onto the bottom surface of sample wells or they may comprise plate electrodes extending ... | 11/29/2005 |
| 6955924 | Laminin chains: diagnostic uses The instant invention provides for the identification, diagnosis, monitoring, and treatment of invasive cells using the laminin 5 gamma-2 chain protein or nucleic acid sequence, or antibodies thereto. ... | 10/18/2005 |
| 6930314 | Light detection device Apparatus and methods for optical illumination and/or detection with improved flexibility and/or read speed. The apparatus and methods may include mechanisms for selecting and switching between multiple excitation wavelengths and/or simultaneously reading from a plu... | 08/16/2005 |
| 6908766 | Device and method for capturing biological tissues A device and method for capturing a biological tissue, comprises cutting a minute biological cellular tissue using a contactless cutting apparatus, wherein, by inverting a biological tissue slide provided with a sample thereon, and after cutting a cellular tissue pr... | 06/21/2005 |
| 6900029 | Method of selection of a population or subpopulation of a sample utilizing particles and gravity sedimentation A separation procedure for separating a selected desired or undesired population from a biological sample utilizing relatively heavy, dense particles and gravity sedimentation. The particles have one or more reactants bound thereto which are specific to and will bin... | 05/31/2005 |
| 6887362 | Dielectrophoretic separation and immunoassay methods on active electronic matrix devices This invention relates to devices and methods for performing active, multi-step molecular and biological sample preparation and diagnostic analyses employing immunochemical techniques. It relates generally to bioparticle separation, bioparticle enrichment, and elect... | 05/03/2005 |
| 6870047 | Magnetic pigment Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free class surface or having pores with a diameter offices than 10 nm. The particles are used for separating biological material such as nucleic acids. A... | 03/22/2005 |
| 6849423 | Focused acoustics for detection and sorting of fluid volumes A method is provided for acoustically ejecting from a channel or other container a plurality of fluid droplets, each of which contains one or more particles or other localized volumes. The localized volumes, which can be living cells, are ejected towards sites on a ... | 02/01/2005 |
| 6777214 | Method for controlling organisms and material therefor, method for selective adsorption of proteins and material therefor, cement material and biomaterial A method for controlling organisms which comprises growing, decreasing, activating or inactivating cells, bacteria, viruses or fungi at an N-surface or a P-surface of a ceramic which is formed by treating the ceramic by polarization; and a material for controlling o... | 08/17/2004 |
| 6773903 | Laser cell purification system A process and apparatus for cell purification and ablation is disclosed. The present invention comprises a laser system which directs radiant energy at computer or manually selected individual cells thereby disrupting DNA, RNA and protein structure in those cells. T... | 08/10/2004 |
| 6767699 | Method for the quantitation of alphavirus replicon particles Methods of production and purification for viruses and virus-derived vectors, including those related to alphaviruses, are disclosed. In one aspect, methods of purification that subject alphavirus replicon particle preparations to one or more steps of chromatographi... | 07/27/2004 |
| 6750048 | Solventless extraction process The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing wa... | 06/15/2004 |
| 6660493 | Hydrodynamic enhanced dielectrophoretic particle trapping Hydrodynamic enhanced dielectrophoretic particle trapping carried out by introducing a side stream into the main stream to squeeze the fluid containing particles close to the electrodes producing the dielelectrophoretic forces. The region of most effectiv... | 12/09/2003 |
| 6635181 | Continuous, hybrid field-gradient device for magnetic colloid based separations A continuous, hybrid magnetic field gradient device for colloidal magnetic affinity separation having an axially-rotating horizontal glass tube, and a plurality of axially located repeating magnetic units. Each magnetic units consists of an alternating cu... | 10/21/2003 |
| 6630299 | Fluorescence detection The present invention provides methods of detecting and/or characterizing the viral vector particle content of a medium. A medium is provided and contacted with an excitation energy such that, if a viral vector particle is in the medium, an electron assoc... | 10/07/2003 |
| 6602422 | Micro column system A separation and release process for purifying biological material on a micro separation column includes release of the biological material from magnetic carriers and elution from the micro separation column while the magnetic carriers are still magnetica... | 08/05/2003 |
