Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 8058043 | Non invasive method of electroporation mediated by carbon nanotubes and device for putting the method into practice A non-invasive method for the electroporation of cells contained in a substrate wherein the cells are placed in contact with carbon nanotubes and then said substrate is subjected to the action of two orthogonal pulsed electric fields generated by means of two pairs ... | 11/15/2011 |
| 7910343 | Device and method for rapidly lysing cells or viruses A cell lysis device for lysing cells or viruses, comprising a cell lysis tube having a sample inlet; a pump connected to the cell lysis tube for transferring a sample into the tube; a sealing unit for reversibly sealing a specific region of the tube; and a laser sou... | 03/22/2011 |
| 7608440 | Apparatus for ultrasonic microbial disruption Apparatus for microbial disruption, comprises a cylindrical transducer having a beat conducting, solid transmission layer disposed along at least a part of the inner longitudinal surface thereof, said transmission layer or said transducer and transmission layer defi... | 10/27/2009 |
| 7553647 | Microfluidic differential extraction cartridge A differential extraction system is directed to a microfluidic-based integrated cartridge to automate differential extraction of specific cell types within a mixed sample. The integrated cartridge includes a sonication module for selective cell lysis, separating mea... | 06/30/2009 |
| 7541166 | Sonication to selectively lyse different cell types A sonication apparatus is directed to a microfluidic-based system to automate differential extraction of specific cell types within a mixed sample. The microfluidic-based system includes a sonication module for selective cell lysis, separating means to eliminate cen... | 06/02/2009 |
| 7435578 | Device and methods for monitoring the status of at least one cell A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate... | 10/14/2008 |
| 7419575 | Microfluidic systems and methods for transport and lysis of cells and analysis of cell lysate Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rap... | 09/02/2008 |
| 7358077 | Method and device for electroporation of biological cells Described are methods for electrical treatment of biological cells, in particular using electrical field pulses, involving the steps: arrangement of the cells (1) on apertures (2) of a solid planar carrier element (3) which divides a measuring c... | 04/15/2008 |
| 7351380 | Microfluidic structures and methods for integrating a functional component into a microfluidic device Injection molding is used to form microfluidic devices with integrated functional components. One or more functional components are placed in a mold cavity which is then closed. Molten thermoplastic resin is injected into the mold and then cooled, thereby forming a ... | 04/01/2008 |
| 7320885 | Method of perforating membrane and apparatus therefor A method of perforating a membrane 10 is presented. The method comprises: bringing a membrane-denaturing substance into contact with or close proximity to at least a site of said membrane 10, said substance inducing a membrane-denaturing reaction by a ... | 01/22/2008 |
| 7270786 | Methods and systems for processing microfluidic samples of particle containing fluids The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a microfabricated substrate having an enrichment channel to prepare an enriched cell sample from the cell-containing liquid. A flow through member is ... | 09/18/2007 |
| 7267676 | Method for hair removal by electroporation The present invention provides method for removal of body hair using electroporation using an apparatus having a pulse generator capable of generating electrical pulses of the desired amplitude and duration to kill hair follicles and an applicator having a first ele... | 09/11/2007 |
| 7261824 | Method of fabrication of a microfluidic device The present invention relates to a method of fabricating a microfluidic device including at least two substrates provided with a fluid channel, comprising the steps of: a) etching at least a channel and one or more fluid ports in a... | 08/28/2007 |
| 7250270 | Methods and compositions for preparing tissue samples for RNA extraction The present invention concerns the methods and compositions for preparing a tissue section or biological sample, particularly to preserve RNA in the section or sample, by not exposing or contacting the sample or section to a solution that is composed of mostly water... | 07/31/2007 |
| 7230217 | Hybrid rectangular heating applicators A rectangular microwave applicator operating at a predetermined frequency and comprising a microwave enclosure forming a cavity having first and second transverse dimensions and a longitudinal dimension n the direction of propagation of microwave energy, wherein sai... | 06/12/2007 |
| 7211083 | Apparatus and method for hair removal by electroporation The present invention provides apparatus and method for removal of body hair using electroporation. The apparatus has a pulse generator capable of generator electrical pulses of the desired amplitude and duration to kill hair follicles and an applicator having a fir... | 05/01/2007 |
| 7192557 | Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a lysing zone to receive the cell-containing sample and a positioning element to position the cell-containing sample in a lysing position in the vicin... | 03/20/2007 |
| 7176018 | Cell lysis device A micromachined cell lysis device with electrodes that are spaced by less than 10 μm from one another. The cells are attracted to the space between the electrodes and then lysed. ... | 02/13/2007 |
| 7132285 | Apoptotic entities for use in treatment of neurodegenerative and other neurological disorders Treatment and/or prophylaxis, in mammalian patients, of neurodegenerative and other neurological medical disorders is effected by administering to the patient effective amounts of apoptotic bodies and/or apoptotic cells, preferably those derived from the patient's o... | 11/07/2006 |
| 7129070 | Targeted system for removing tumor cells from cell populations A method is presented for killing a first population of cells within a mixture of viable cells by providing the mixture of viable cells, contacting the cells with a label, illuminating a portion of the mixture, capturing an image of multiple cells in the illuminated... | 10/31/2006 |
| 7096061 | Apparatus for monitoring CHF patients using bio-impedance technique A method is described for generating an impedance image of the chest, in which electrical data of the chest is acquired, and a finite volume method is used to calculate an impedance image from the electrical data, using an analytical expression for the Jacobian.... | 08/22/2006 |
| 7090974 | Ultrasound-mediated high-speed biological reaction and tissue processing Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1–50 MHz is used and the sample or tissue receives 0.1–200 W/cm2 of ultr... | 08/15/2006 |
| 7056430 | Detachable cell-delivery system for patch-clamp unit The cell-delivery unit of a high-throughput electrophysiological testing system is implemented as a reusable movable unit suitable for repetitive delivery of cells to a disposable, multi-aperture patch-clamp tray. An electric field emanating from the patch aperture ... | 06/06/2006 |
| 7053063 | Controlled electroporation and mass transfer across cell membranes in tissue Electroporation is performed in a controlled manner in individual and multiple biological cells present in biological tissue by monitoring the electrical impedance, defined herein as the ratio of current to voltage in the electroporation cell. The impedance detects ... | 05/30/2006 |
| 7016725 | Method and apparatus for destroying dividing cells The present invention provides a method and apparatus for selectively destroying dividing cells in living tissue formed of dividing cells and non-dividing cells. The dividing cells contain polarizable intracellular members and during late anaphase or telophase, the ... | 03/21/2006 |
| 6989086 | Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis The present invention comprises devices and methods for performing channel-less separation of cell particles by dielectrophoresis, DC high voltage-pulsed electronic lysis of separated cells, separation of desired components from crude mixtures such as cell lysates, ... | 01/24/2006 |
| 6977156 | Flow cytometry reagent and system An improved reagent system for preparation of cells for flow cytometry having a physiologically compatible salt solution composition including a lysing agent, an agent for minimizing white blood cell lysis, and optionally a preservative. ... | 12/20/2005 |
| 6951746 | Method of manufacturing polyamine composition After yeast somatic components are digested with nuclease or hydrolyzed with alkali, polyamine is recovered to obtain a polyamine composition in volume efficiently at a high recovery rate from yeast somatic components. ... | 10/04/2005 |
| 6939696 | Cell disruption method using sonication The present invention relates to a method for disrupting cells by subjecting the cells to ultrasonic energy in the absence of beads. The present invention also relates to the enhancement of cell disruption methods using ultrasonic energy by reducing the surface tens... | 09/06/2005 |
| 6927049 | Cell viability detection using electrical measurements A method of determining information about cell viability and other characteristics relating to cell membrane permeability is disclosed. The method involves determining the effect of a cell on current flow and relating that effect to a known standard which standard m... | 08/09/2005 |
| 6887693 | Device and method for lysing cells, spores, or microorganisms A device for lysing components (e.g., cells, spores, or microorganisms) of a fluid sample comprises a cartridge having a lysing chamber for receiving the sample and having at least one solid phase in the lysing chamber for capturing the sample components to be lysed... | 05/03/2005 |
| 6887362 | Dielectrophoretic separation and immunoassay methods on active electronic matrix devices This invention relates to devices and methods for performing active, multi-step molecular and biological sample preparation and diagnostic analyses employing immunochemical techniques. It relates generally to bioparticle separation, bioparticle enrichment, and elect... | 05/03/2005 |
| 6812204 | Delivery of an agent The invention relates to a method for selectively releasing an agent loaded into a red blood cell, comprising electrosensitizing the red blood cell by application of an electric field and subsequently disrupting the cell selectively using ultrasound. ... | 11/02/2004 |
| 6811981 | Release of intracellular material Intracellular material is released from bacterial, yeast, plant, animal, insect or human cells by the application of a low voltage such as 1 to 10 V to a suspension containing the cells. The conditions may be selected such that DNA released from the cells is electro... | 11/02/2004 |
| 6787339 | Microfluidic devices having embedded metal conductors and methods of fabricating said devices The present invention provides low cost microfluidic devices having embedded metal conductors. The devices of the invention comprise a electronic component comprising a substrate having a first surface, a layer of electrically-conductive material deposited on a port... | 09/07/2004 |
| 6777214 | Method for controlling organisms and material therefor, method for selective adsorption of proteins and material therefor, cement material and biomaterial A method for controlling organisms which comprises growing, decreasing, activating or inactivating cells, bacteria, viruses or fungi at an N-surface or a P-surface of a ceramic which is formed by treating the ceramic by polarization; and a material for controlling o... | 08/17/2004 |
| 6773903 | Laser cell purification system A process and apparatus for cell purification and ablation is disclosed. The present invention comprises a laser system which directs radiant energy at computer or manually selected individual cells thereby disrupting DNA, RNA and protein structure in those cells. T... | 08/10/2004 |
| 6743591 | Method for counting leukocytes and leukocyte counter A method for counting leukocytes which comprises liberating elastase from granulocytes contained in a specimen, adding an anti-granulocyte elastase antibody to the thus liberated elastase, measuring the antibody bonded to the elastase to thereby determine the concen... | 06/01/2004 |
| 6706498 | Method for isolating DNA The invention describes a method for the isolation of components from samples, particularly large molecular weight DNA from biological samples. The method involves the application of controlled oscillatory mechanical energy to the sample for short periods of time of... | 03/16/2004 |
| 6686195 | Method and apparatus for ultrasonic lysis of biological cells An apparatus including at least one sonotrode (2) designed to generate ultrasound of variable power in at least one biological sample (5) containing cells to be lysed, the sample (5) being contained in at least one receptacle (4 or 10) such that the sonot... | 02/03/2004 |
