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| Number | Title | Issue Date |
| 8067216 | Method for macerating biological material and apparatus for carrying out said method In order to ensure consistently good maceration of biological material in an electroporation reactor, it is proposed to monitor the conductivity of the mixture therein and to detect any arcing which occurs therein. The results of such monitoring are used to modify t... | 11/29/2011 |
| 8058042 | Method and circuit arrangement for treating biomaterial Disclosed is a circuit arrangement comprising at least one storage device for electrical charges to generate at least one voltage pulse by selectively discharging the storage device, and at least one control unit for controlling the discharge. A controller for monit... | 11/15/2011 |
| 8043838 | Electroporation cuvette with spatially variable electric field An electroporation cuvette is constructed with electroporation electrodes arranged in non-parallel relation to form a gap whose width varies with the location within the cuvette, plus a pair of positioning electrodes that are arranged to cause electrophoretic migrat... | 10/25/2011 |
| 8017368 | Molecular delivery to cells using aspirin-related compounds The present invention provides for a system and method whereby aspirin and acetic acid help to permeabilize cell membranes to allow exogenous molecules to gain access to the cell interior. As such, the present invention provides a low cost drug and gene delivery too... | 09/13/2011 |
| 8017367 | Biochip electroporator and its use in multi-site, single-cell electroporation The introduction of genetic material or molecules of biological interest into cells is a procedure with an increasing interest both for experimental and application purposes, so that electroporation is a widely used technique, but the electroporation of single adher... | 09/13/2011 |
| 7955827 | Controlled electroporation and mass transfer across cell membranes Electroporation is performed in a controlled manner in either individual or multiple biological cells or biological tissue by monitoring the electrical impedance, defined herein as the ratio of current to voltage in the electroporation cell. The impedance detects th... | 06/07/2011 |
| 7790427 | Method of treating biocells A method of treating biocells includes the steps of: a. providing biocells; b. applying at least one stressor to the biocells sufficient to cause nonlethal and reparable cell wall damage to the biocells, thereby putting the biocells in a catabolic state during which... | 09/07/2010 |
| 7781195 | Electroporation device A device for manipulating a molecule in vivo relative to a target tissue includes at least one elongated member having at least two discrete and separately activatable electrodes separated by an insulating material interposed therebetween. The electrodes are configu... | 08/24/2010 |
| 7732175 | Method and circuit arrangement for treating biomaterial The invention relates to a method for treating biomaterial using at least one electrical field generated by a first voltage pulse which is terminated once the value for an electrical parameter has exceeded or dropped below a preset limit. After the first voltage pul... | 06/08/2010 |
| 7718409 | Controlled electroporation and mass transfer across cell membranes Electroporation is performed in a controlled manner in either individual or multiple biological cells or biological tissue by monitoring the electrical impedance, defined herein as the ratio of current to voltage in the electroporation cell. The impedance detects th... | 05/18/2010 |
| 7625729 | Electroporation device Electro-poration device for the permeabilization of cells contained in a substrate comprising a signal generator for generating a stimulating signal applied by means of electrodes to the substrate wherein an electric field permeabilizing the cells membranes is induc... | 12/01/2009 |
| 7412284 | Apparatus for electroporation mediated delivery for drugs and genes A device for in vivo electroporation therapy comprising an electrode applicator with at least two pairs of electrodes arranged relative to one another to form an array and a power supply. The device is used to generate an electric field in a biological sample and ef... | 08/12/2008 |
| 7390308 | Apparatus and process for optimized electro-hydraulic pressure pulse generation The invention relates to an apparatus and a process for optimized electro-hydraulic pressure pulse generation that records characteristic parameters which can be measured insusceptible to error and compared with set values. The object of the invention is achieved by... | 06/24/2008 |
| 7371561 | In vitro, multiple electrode pair array and multiple treatment cell apparatus for use in electroporation A multiple electrode pair array apparatus is provided for use with a multiple well plate which has multiple wells distributed in a two-dimensional matrix array which has R rows and C columns. The multiple electrode pair array apparatus includes a non-conductive base... | 05/13/2008 |
| 7361335 | Methods for using an elastase The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzy... | 04/22/2008 |
| 7358077 | Method and device for electroporation of biological cells Described are methods for electrical treatment of biological cells, in particular using electrical field pulses, involving the steps: arrangement of the cells (1) on apertures (2) of a solid planar carrier element (3) which divides a measuring c... | 04/15/2008 |
| 7341864 | Molecule transferring device, auxiliary for molecule transferring device, and molecule transferring method A molecule introducing apparatus is provided with a power supply circuit 20 for supplying power, a step-up transformer 30 which is supplied with power from the power supply circuit 20 and which outputs a high voltage, a switching transistor 2... | 03/11/2008 |
| 7338796 | Vesicle-based method and apparatus for collecting, manipulating, and chemically processing trace macromolecular species Disclosed is an apparatus and method for inserting one or several chemical or biological species into phospholipid containers that are controlled within a microfluidic network, wherein individual containers are tracked and manipulated by electric fields and wherein ... | 03/04/2008 |
| 7332313 | Electrical wounding assay for cells in vitro A method and system for electrically wounding and/or monitoring cell activity in vitro. The invention comprises methods and systems for wounding and/or monitoring cells that place a cell culture on a well that has an exposed electrode. The cell culture can then be w... | 02/19/2008 |
| 7306940 | Electroporation device and method, delivering a modulated signal under continuous control of cell electropermeabilization An electroporation device having a signal generating circuit (3) connectable at the output to electrodes (5) fittable to a substrate (35) having cells. The electrodes (5) produce an electric field which induces permeabilization of the cel... | 12/11/2007 |
| 7294511 | Methods for delivering nucleic acid molecules into cells and assessment thereof Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial ... | 11/13/2007 |
| 7262158 | Cleansing compositions comprising a liquid silicone and ester mixture Cleansing compositions suitable for use in personal cleansing applications, and in particular make-up removal applications, which not only impart superior cleansing properties, but also which are relatively non-irritating and thus suitable for use by people having s... | 08/28/2007 |
| 7255839 | Device and method for treating a substance containing undesirable organisms using a pulsed electrical field A device for treating a substance containing at least one undesirable organism, using a pulsed electrical field. The device includes at least one treatment zone of the substance located within a passage zone associated with the substance. Each treatment zone is only... | 08/14/2007 |
| 7244349 | Multiaperture sample positioning and analysis system Systems for positioning and/or analyzing samples such as cells, vesicles, cellular organelles, and fragments, derivatives, and mixtures thereof, for electrical and/or optical analysis, especially relating to the presence and/or activity of ion channels. ... | 07/17/2007 |
| 7195738 | Sensor and detecting method A sensor is provided for detecting a target substance in a sample by detecting a product formed in the presence of an enzyme and an enzyme substrate. The sensor comprises two or more working electrodes, a first capturing molecule immobilized on the working electrode... | 03/27/2007 |
| 7186559 | Apparatus and method for electroporation of biological samples The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substa... | 03/06/2007 |
| 7157257 | Method of treating biological cells and/or their cell components with electrical fields A method is described for treating biological cells and/or their cell components with electrical fields in a reaction medium, in which an inhibitor is added to the reaction medium to counteract the action of enzymes that break down protein. ... | 01/02/2007 |
| 7153505 | Methods for enlarging the diameter of an artery or vein in a human subject The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzy... | 12/26/2006 |
| 7147846 | Prosthetic grafts An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The a... | 12/12/2006 |
| 7141425 | Apparatus and method for electroporation of biological samples The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substa... | 11/28/2006 |
| 7132404 | Compositions for receptor/liposome mediated transfection and methods of using same The present invention provides a composition of matter for introducing an exogenous nucleic acid molecule into a target cell, comprising a liposome, a ligand polymeric scaffold, wherein the ligand can bind to a cell surface receptor or molecule. The invention also p... | 11/07/2006 |
| 7118899 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems. In one aspect, the method comprises; a) providing a living cell with a first reagent comprising a charged hydrophobi... | 10/10/2006 |
| 7115401 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face of the membrane ... | 10/03/2006 |
| 7087416 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems. In one aspect, the method comprises; a) providing a living cell with a first reagent comprising a charged hydrophobi... | 08/08/2006 |
| 7078227 | Ready-to-use electroporation cuvette including frozen electrocompetent cells A ready-to-use electroporation cuvette is provided that includes a cuvette, first and second electrodes positioned within the cuvette and electroporation competent cells frozen in a suspension solution within the cuvette, wherein the electroporation cuvette is confi... | 07/18/2006 |
| 7074747 | Cleansing compositions Cleansing compositions suitable for use in personal cleansing applications, and in particular make-up removal applications, which not only impart superior cleansing properties, but also which are relatively non-irritating and thus suitable for use by people having s... | 07/11/2006 |
| 7063838 | Methods for treating an artery or vein in a human subject The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzy... | 06/20/2006 |
| 7053063 | Controlled electroporation and mass transfer across cell membranes in tissue Electroporation is performed in a controlled manner in individual and multiple biological cells present in biological tissue by monitoring the electrical impedance, defined herein as the ratio of current to voltage in the electroporation cell. The impedance detects ... | 05/30/2006 |
| 7029916 | Apparatus and method for flow electroporation of biological samples The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substa... | 04/18/2006 |
| 7018819 | Method and apparatus for manipulation of cells and cell-like structures focused electric fields in microfludic systems and use thereof An apparatus and method are disclosed for electromanipulation of at least one cell or cell-like structure having cell-like membranes, the method comprising the steps: (a) at least one cell or cell-like structure is transported from one or more sample containers loca... | 03/28/2006 |
