Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 8080399 | Photoporation of cells An opening is formed in a cell using laser radiation. A Bessel beam is formed using the laser radiation and the Bessel beam is directed onto the cell to form an opening. The guiding of material towards the opening may be involved using optical trapping/manipulation.... | 12/20/2011 |
| 7981649 | Device and methods for monitoring the status of at least one cell A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate... | 07/19/2011 |
| 7449314 | Rapid thermal cycle processing methods and apparatus A system and method for processing a lipid membrane bound structure, the method comprising the steps of providing the structure to be processed in a liquid medium; and heating the liquid medium containing the structure at a rate and through a range sufficient to cau... | 11/11/2008 |
| 7435578 | Device and methods for monitoring the status of at least one cell A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate... | 10/14/2008 |
| 7341864 | Molecule transferring device, auxiliary for molecule transferring device, and molecule transferring method A molecule introducing apparatus is provided with a power supply circuit 20 for supplying power, a step-up transformer 30 which is supplied with power from the power supply circuit 20 and which outputs a high voltage, a switching transistor 2... | 03/11/2008 |
| 7332313 | Electrical wounding assay for cells in vitro A method and system for electrically wounding and/or monitoring cell activity in vitro. The invention comprises methods and systems for wounding and/or monitoring cells that place a cell culture on a well that has an exposed electrode. The cell culture can then be w... | 02/19/2008 |
| 7320885 | Method of perforating membrane and apparatus therefor A method of perforating a membrane 10 is presented. The method comprises: bringing a membrane-denaturing substance into contact with or close proximity to at least a site of said membrane 10, said substance inducing a membrane-denaturing reaction by a ... | 01/22/2008 |
| 7306940 | Electroporation device and method, delivering a modulated signal under continuous control of cell electropermeabilization An electroporation device having a signal generating circuit (3) connectable at the output to electrodes (5) fittable to a substrate (35) having cells. The electrodes (5) produce an electric field which induces permeabilization of the cel... | 12/11/2007 |
| 7300795 | Optoinjection methods Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irrad... | 11/27/2007 |
| 7294511 | Methods for delivering nucleic acid molecules into cells and assessment thereof Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial ... | 11/13/2007 |
| 7223600 | Photochemical internalization for delivery of molecules into the cytosol The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosentistising agent, the cell is irradiated with light of a wavelength effective to activate the photosentisitising agent and, sub... | 05/29/2007 |
| 7159407 | Atomized liquid jet refrigeration system A system for controlling temperature includes an atomizer that forms micron-sized hydrogen-bonded refrigerant droplets within a chamber. A vacuum pump is coupled to the chamber to lower its interior pressure. Under these conditions, the refrigerant droplets evaporat... | 01/09/2007 |
| 7157257 | Method of treating biological cells and/or their cell components with electrical fields A method is described for treating biological cells and/or their cell components with electrical fields in a reaction medium, in which an inhibitor is added to the reaction medium to counteract the action of enzymes that break down protein. ... | 01/02/2007 |
| 7153648 | Dielectrophoretic separation of stained cells This invention relates generally to the field of cell separation or isolation. In particular, the invention provides a method for separating cells, which method comprises: a) selectively staining cells to be separated with a dye so that there is a sufficient differe... | 12/26/2006 |
| 7118899 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems. In one aspect, the method comprises; a) providing a living cell with a first reagent comprising a charged hydrophobi... | 10/10/2006 |
| 7115401 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face of the membrane ... | 10/03/2006 |
| 7094378 | Method and apparatus for inactivation of biological contaminants using photosensitizers Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein, blood and blood constituents are provided. The methods comprise adjusti... | 08/22/2006 |
| 7092557 | Method and device for selectively targeting cells within a three-dimensional specimen The invention provides an apparatus for electromagnetically affecting a particle of interest in a specimen. The apparatus includes (a) a stage capable of supporting the specimen; (b) a detector including at least one camera, wherein the detector is capable of resolv... | 08/15/2006 |
| 7087416 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems. In one aspect, the method comprises; a) providing a living cell with a first reagent comprising a charged hydrophobi... | 08/08/2006 |
| 7078227 | Ready-to-use electroporation cuvette including frozen electrocompetent cells A ready-to-use electroporation cuvette is provided that includes a cuvette, first and second electrodes positioned within the cuvette and electroporation competent cells frozen in a suspension solution within the cuvette, wherein the electroporation cuvette is confi... | 07/18/2006 |
| 7025120 | Rapid thermal cycling device A lid for a well plate is provided. Pins penetrate the lid and project downwardly into the wells of the well plate. Thermal energy is applied to the upper end of the pin to regulate the temperature of liquid samples in the well plate. Ultrasonic energy is applied to... | 04/11/2006 |
| 7008369 | Apparatus and method for electromagnetic therapy A device for applying an electromagnetic field, an electric field, or both, to at least a part of a body, comprises at least a transducer and a generator for applying an ac signal to the transducer. The transducer is adapted for applying to at least part of the body... | 03/07/2006 |
| H2119 | Acoustic fusion of aquatic animal tissue cells with biological agents Biological agents in solution within an underwater treatment zone are transferred by infusion to living cells under an acoustic energy field of limited duration and certain accompanying water flow and temperature conditions to maximize processing efficiency. ... | 06/07/2005 |
| 6828131 | Biological fertilizer based on yeasts The present invention provides biological fertilizer compositions that comprise yeast cells that have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals and compounds, decompose complex carbon c... | 12/07/2004 |
| 6828132 | Biological fertilizer compositions comprising garbage The present invention provides biological fertilizer compositions that comprise yeast cells and garbage. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen, decompose phosphorus minerals and compounds, decompose potassium minerals ... | 12/07/2004 |
| 6811981 | Release of intracellular material Intracellular material is released from bacterial, yeast, plant, animal, insect or human cells by the application of a low voltage such as 1 to 10 V to a suspension containing the cells. The conditions may be selected such that DNA released from the cells is electro... | 11/02/2004 |
| 6812204 | Delivery of an agent The invention relates to a method for selectively releasing an agent loaded into a red blood cell, comprising electrosensitizing the red blood cell by application of an electric field and subsequently disrupting the cell selectively using ultrasound. ... | 11/02/2004 |
| 6753171 | Site-specific cell perforation technique A technique for controlling membrane denaturation reactions other than physical shear force was developed. For example, the present invention provides, a method for causing membrane disruption at a specific site by reacting a stimulus such as light with a compound t... | 06/22/2004 |
| 6743591 | Method for counting leukocytes and leukocyte counter A method for counting leukocytes which comprises liberating elastase from granulocytes contained in a specimen, adding an anti-granulocyte elastase antibody to the thus liberated elastase, measuring the antibody bonded to the elastase to thereby determine the concen... | 06/01/2004 |
| 6699697 | Planar patch clamp electrodes The present invention relates to ionic electrodes, particularly microelectrodes and electrode arrays, and also relates to fabrication methods for such electrodes. In particular, the present invention relates to planar polymer electrodes for making patch c... | 03/02/2004 |
| 6653114 | Method and apparatus for treating materials with electrical fields having varying orientations The object of the invention is to provide a method and apparatus for treating membrane-containing material with electrical fields, in vitro, and with an added treating substance. With the method, a plurality of electrodes are arrayed around the material t... | 11/25/2003 |
| 6645464 | Loading metal particles into cell membrane vesicles and metal particular use for imaging and therapy Delivery of metal particles to living tissue, then applying external energy that interacts with the metal particles, is found to selectively increase the energy deposition and interaction surrounding the metal particles. The method is useful to improve tr... | 11/11/2003 |
| 6627421 | Methods and systems for applying multi-mode energy to biological samples A system for applying energy to cells so as to elicit the formation of pores, to enhance transfection, and/or cell transformation, includes a computer, a plurality of acoustic probes for controllably applying acoustic energy to batches of cells, and a rob... | 09/30/2003 |
| 6617153 | Portable magneto-mechanical delivery device and method for delivery of reactive substances A method of delivery of reactive substances that are attached to magnetizable needle-like particles using a magneto-mechanical delivery device. The subject method and device can be utilized for the delivery of reactive or other substances, such as DNA via... | 09/09/2003 |
| 6593130 | Method and apparatus for ex vivo and in vivo cellular electroporation of gene protein or drug therapy An array is placed in contact with or close proximity with an organ or tissue surface to cause electroporation for gene, protein, drug delivery in both ex vivo and in vivo applications. A low DC voltage with a short pulse duration, and long burst pulse is... | 07/15/2003 |
| 6589786 | Cell separation using electric fields The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. ... | 07/08/2003 |
| 6579706 | Rapid thermal cycle processing methods and apparatus A system and method for processing a cells, the method comprising the steps of providing the cells to be processed in a liquid medium; and heating the liquid medium containing the cells at a rate and through a range sufficient to cause an instability in a... | 06/17/2003 |
| 6562623 | Method for introducing a substance into a cell Provided is a method for introducing a substance into a cell, which method comprises: (a) generating one or more bubbles of a gas in a liquid medium comprising the cell, the bubbles being capable of forming a hole in the surface of the cell when one or mo... | 05/13/2003 |
| 6534308 | Method and apparatus for selectively targeting specific cells within a mixed cell population This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a mixed cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every ... | 03/18/2003 |
| 6379956 | Method for populating substrates with biological cells and populating devices that can be used therefor The populating method for populating a substrate with living cells provides a population with at least one populating phase and at least one perfusion phase. During the populating phase the substrate can be held in contact with the cell suspension by cont... | 04/30/2002 |
