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| Number | Title | Issue Date |
| 8173407 | Nanoengineered biophotonic hybrid device An improved method for the design and development of high performance hybrid devices having biological and nonbiological components. The biological component is used in hybrid constructs that may be nanostructures, given the small size of the biological parts. In on... | 05/08/2012 |
| 8163527 | Subsystems and methods for use in patch clamp systems Subsystems and methods for use in patch clamp systems are provided. For example, in certain embodiments, compensation circuitry is used to compensate for non-idealities present in the patch clamp system. The accuracy of this compensation may be verified by employing... | 04/24/2012 |
| 8101388 | Method and structure for extracting molecular species The present invention in one embodiment provides a method for extracting molecular material including providing a probe comprising a penetration portion having a nanoscale surface for penetrating a biological compartment, a receptor present on the penetrating portio... | 01/24/2012 |
| 7803588 | Method and device to probe a membrane by applying an in-plane electric field The present invention disposes a membrane between two electrical conductive walls having a height at least as great as the thickness of the membrane. The conductive walls are fabricated on an electrically insulative chip base. The chip base has one or more through h... | 09/28/2010 |
| 7674610 | Method and device for probing changes in a membrane by applying an in-plane electric field The present invention is directed to disposing a membrane, for example, a biological cell membrane including amphiphilic lipids and proteins, or a liquid crystal membrane, between two electrical conductive walls having a height that is at least as great as the thick... | 03/09/2010 |
| 7442550 | Method for detecting the expression of an envelope protein of a human endogenous retrovirus and uses of a gene coding for said protein A method for detecting the expression of a polypeptide in cells and for detecting the interaction between a polypeptide and cells, ex vivo or in vitro, wherein the polypeptide is selected from the group consisting of: a peptide comprising the cyt domain of the envel... | 10/28/2008 |
| 7435578 | Device and methods for monitoring the status of at least one cell A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate... | 10/14/2008 |
| 7425426 | Methods for purification of cells based on product secretion The invention provides methods for purifying one or more cells based on the level of one or more products secreted by the cells. In one embodiment, the method involves (a) contacting a plurality of cells immobilized in proximity to a capture matrix, the capture matr... | 09/16/2008 |
| 7407781 | Oocyte recording chamber An oocyte recording chamber for electrophysiological measurements. The recording chamber includes a base and a cover attached to the base. The cover and the base define a chamber having a size sufficient to accommodate an oocyte. The recording chamber includes a fir... | 08/05/2008 |
| 7371565 | Apparatus and method for measuring intracellular reactions An intracellular-reaction measuring apparatus for measuring intracellular reactions by the use of a specimen in which a plurality of cell colonies are contained in a non-contact state, the apparatus includes a device that specifies the intensity of first light emitt... | 05/13/2008 |
| 7361478 | High-throughput screen for identifying selective persistent sodium channels channel blockers A method for identifying a selective persistent Na+ channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na+ current to a greater degree than a transient Na+ current. Aspects of the present method... | 04/22/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7332313 | Electrical wounding assay for cells in vitro A method and system for electrically wounding and/or monitoring cell activity in vitro. The invention comprises methods and systems for wounding and/or monitoring cells that place a cell culture on a well that has an exposed electrode. The cell culture can then be w... | 02/19/2008 |
| 7332349 | Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be oriented with what was the outer surface of the cell membrane facing ... | 02/19/2008 |
| 7317216 | Ultrasensitive biochemical sensing platform An electronic sensor is provided for detecting the presence of one or more targets of interest in a sample. The sensor preferably comprises a special type of field effect transistor in which conductance is enhanced by target binding to recognition elements in the ac... | 01/08/2008 |
| 7291711 | Fluorescent proteins from aquatic species Provided are four new fluorescent proteins. The proteins were derived from two wild-type fluorescent proteins: a red fluorescent protein (RFP) that was isolated from Actinodiscus or Discosoma sp. 1 and a green fluorescent protein (GFP) isolated from | 11/06/2007 |
| 7266457 | High throughput functional genomics This invention focuses on the marriage of solid-state electronics and neuronal function to create a new high-throughput electrophysiological assay to determine a compound's acute and chronic effect on cellular function. Electronics, surface chemistry, biotechnology,... | 09/04/2007 |
| 7240497 | Cryostat having a heating plate A cryostat (1) having a sealable housing (2) is described, the housing (2) enclosing a coolable cryostat chamber (3). For cooling the cryostat chamber (3), a refrigeration device (4), a control system (5) and a power ... | 07/10/2007 |
| 7201836 | Multiaperture sample positioning and analysis system Systems for positioning and/or analyzing samples such as cells, vesicles, cellular organelles, and fragments, derivatives, and mixtures thereof, for electrical and/or optical analysis, especially relating to the presence and/or activity of ion channels. ... | 04/10/2007 |
| 7192752 | Real time electronic cell sensing systems and applications for cell-based assays The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, ... | 03/20/2007 |
| 7193706 | Computer interfaced scanning fluorescence lifetime microscope applied to directed evolution This invention provides a method for screening large numbers of individual cells or colonies of cells using scanning microscopy coupled with fluorescence lifetime measurement and analysis, using time-correlated single photon counting. This invention further provides... | 03/20/2007 |
| 7190990 | Cellular surgery utilizing confocal microscopy An improved system for cellular surgery which includes a laser for producing a laser beam, and confocal optics for scanning and focusing the laser beam in tissue and generating confocal images of the tissue in accordance with returned light from the tissue. The conf... | 03/13/2007 |
| 7179587 | Method and apparatus for high frequency interfacing to biochemical membranes High frequency interfacing to biochemical membranes, such as supported bilayers and cell membranes, is carried out by supporting a biochemical membrane on a support surface while allowing access to the surface of the membrane through an opening in the support. A sha... | 02/20/2007 |
| 7166444 | Nucleic acids encoding chromophores/fluorophores and methods for using the same Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the encoded proteins, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of tw... | 01/23/2007 |
| 7157257 | Method of treating biological cells and/or their cell components with electrical fields A method is described for treating biological cells and/or their cell components with electrical fields in a reaction medium, in which an inhibitor is added to the reaction medium to counteract the action of enzymes that break down protein. ... | 01/02/2007 |
| 7157565 | Far red shifted fluorescent proteins Nucleic acid compositions encoding Stichodactylidaen chromoproteins and fluorescent mutants thereof. The proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. Als... | 01/02/2007 |
| 7153648 | Dielectrophoretic separation of stained cells This invention relates generally to the field of cell separation or isolation. In particular, the invention provides a method for separating cells, which method comprises: a) selectively staining cells to be separated with a dye so that there is a sufficient differe... | 12/26/2006 |
| 7129070 | Targeted system for removing tumor cells from cell populations A method is presented for killing a first population of cells within a mixture of viable cells by providing the mixture of viable cells, contacting the cells with a label, illuminating a portion of the mixture, capturing an image of multiple cells in the illuminated... | 10/31/2006 |
| 7115401 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face of the membrane ... | 10/03/2006 |
| 7112433 | Electrical analysis of biological membranes A biochip device for electrical analysis of biological membranes. The device may include a substrate assembly defining an array of apertures and including thin-film devices configured to sense an electrical property of biological membranes that seal the apertures. T... | 09/26/2006 |
| 7075045 | Automatic, microwave assisted tissue histoprocessor A system and for automatic histoprocessing of organic tissue specimens using microwaves, two cavities and automatic fluid and specimen transfer between the two cavities. ... | 07/11/2006 |
| 7070968 | DNA damaging agents in combination with tyrosine kinase inhibitors The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases. ... | 07/04/2006 |
| 7067293 | Nanoengineered biophotonic hybrid device An improved method for the design and development of high performance hybrid devices having biological and nonbiological components. A figure of merit is developed for the biological component or components. The component is subjected to various environmental variab... | 06/27/2006 |
| 6998850 | Systems and methods for measuring picoampere current levels In one embodiment, a circuit measures picoampere current levels. The circuit comprises: an operational-amplifier that has differential inputs and differential outputs; a switching structure that switchably couples an input line to one of the differential inputs in r... | 02/14/2006 |
| 6991910 | High-throughput screen for identifying channel blockers that selectively distinguish transient from persistent sodium channels A method for identifying a Na+ channel blocker, including providing a cell containing a Na+ channel, demonstrating both a transient and a persistent current. The cell includes a potassium (K+) channel and a Na/K ATPase (Na+ | 01/31/2006 |
| 6979553 | Use of Nernstein voltage sensitive dyes in measuring transmembrane voltage Transmembrane potential measurement methods using cationic dyes, and anionic dyes are provided. Compositions of the cationic and anionic dyes and microfluidic systems which include the dyes and membranes are provided in conjunction with processing elements for trans... | 12/27/2005 |
| 6969597 | Nucleic acids encoding non aggregating fluorescent proteins and methods for using the same Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the encoded proteins, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the non-aggrega... | 11/29/2005 |
| 6939687 | Method of testing adequacy of cells in a specimen The present invention provides a device and method for determining the adequacy of squamous (ectocervical) cells, columnar (endocervical) cells, neutrophils, and noncellular material in a liquid based cytology specimen. The invention first analyzes a liquid based cy... | 09/06/2005 |
| 6932893 | System for electrophysiological measurements The present invention relates to a high through-put system for determining and/or monitoring electrophysiological properties of ion channels of ion channel-containing membranes, typically lipid membrane-containing structures such as cells. In particular, the inventi... | 08/23/2005 |
| 6933106 | Platelet immunoglobulin bead suspension and flow cytometry Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and fluorochrome labeled antibodies, to simultaneously detect the presence and amount of one or more analytes in a sample. By combining FALS and fluorescence, it ... | 08/23/2005 |
