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| Number | Title | Issue Date |
| 7363726 | Powder formation by atmospheric spray-freeze drying A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrog... | 04/29/2008 |
| 7354190 | Two-stage mixing system, apparatus, and method A two-stage mixing system, apparatus, and method produces a solution including a first substance and a second substance in a predetermined ratio by first mixing the first substance with a first liquid to produce a first solution and then mixing the first solution wi... | 04/08/2008 |
| 7282358 | Monochromatic fluid treatment systems Methods, systems and apparatus for photo-processing of fluids, particularly complex fluids, such as blood products, pharmaceuticals, injectables and vaccines, are provided. The disclosed methods and systems employ non-laser light source(s) to generate monochromatic ... | 10/16/2007 |
| 7252799 | Methods for sterilizing preparations containing albumin Methods are disclosed for sterilizing preparations containing albumin to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, na... | 08/07/2007 |
| 7220747 | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer This invention provides methods for treating cellular blood components and other cells containing mitochondria to improve vital qualities of the cells by contacting the cells with a mitochondrial enhancer to the cells. Mitochondrial enhancers prevent damage to and r... | 05/22/2007 |
| 7132277 | Helper dependent vector system for gene therapy The present invention features helper-dependent adenoviral vector elements, and helper adenoviral elements, that enhance the production and isolation of helper-dependent adenoviral vectors. Such elements include a modified packaging signal having low homology to, an... | 11/07/2006 |
| 7122518 | Method for preventing or reducing collateral phototoxic damage to neighboring tissues during photodynamic therapy of a target tissue A method is provided for preventing or reducing the adverse effects of photodynamic therapy such as collateral damage by regulating the localized phototoxicity of an effector photosensitizer molecule. During photodynamic therapy, the activity of the effector photose... | 10/17/2006 |
| 7094378 | Method and apparatus for inactivation of biological contaminants using photosensitizers Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein, blood and blood constituents are provided. The methods comprise adjusti... | 08/22/2006 |
| 7087376 | Detection and identification of bacterial strains The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the support coupled with the bacteriophages and/or bacteriophage proteins w... | 08/08/2006 |
| 7049110 | Inactivation of West Nile virus and malaria using photosensitizers Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic a... | 05/23/2006 |
| 7045344 | Adenoviral vector and methods for making and using the same In vitro methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In the subject methods, the subject genomes are prepared from first and second vectors. The fi... | 05/16/2006 |
| 7041441 | Phage display of intact domains at high copy number Disclosed is a phage display system in which the molecules to be displayed (i.e., molecules of interest) are bound to dispensable capsid polypeptides such as SOC (small outer capsid) and HOC (highly antigenic outer capsid) polypeptides that are, in turn, bound to a ... | 05/09/2006 |
| 7037642 | Removing compounds from blood products with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly po... | 05/02/2006 |
| 7018826 | Particles for gene therapy The present invention relates to particles, comprising: a protein envelope with a fusion protein, which comprises a virus protein, a cell permeability-mediating peptide and a heterologous cell-specific binding site; and a nucleic acid present in the protein envelope... | 03/28/2006 |
| 6979829 | Devices and methods for determining the amount of energy absorbed during irradiation Devices and methods are disclosed for determining the amount of energy absorbed during irradiation. Such devices comprise a material that absorbs radiation in a quantifiable manner and a cooling agent to maintain the temperature of that material within a predetermin... | 12/27/2005 |
| 6967076 | Method for producing recombinant cells for detecting HIV Recombinant expression vectors and methods are provided for detecting HIV and monitoring HIV drug resistance. The method comprises: taking a culture of cells; adding a recombinant viral vector into the culture to transduce the cells, the recombinant viral vector com... | 11/22/2005 |
| 6951713 | Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent p... | 10/04/2005 |
| 6951754 | DNA transfection system for the generation of infectious influenza virus The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably ... | 10/04/2005 |
| 6913916 | Elongase genes and uses thereof The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In p... | 07/05/2005 |
| 6884422 | Freeze-dried hepatitis A attenuated live vaccine and its stabilizer The present invention relates to hepatitis A vaccine, especially to a lyophilized attenuated hepatitis A vaccine which can be stored at ambient temperature for extended periods of time, and to a method for producing the same. The present invention further relates to... | 04/26/2005 |
| 6872576 | Antigens embedded in thermoplastic The invention relates to an immunoassays, binding assays, solid phase substrates (12) and other devices with an antigen or antibody or ligand or receptor (11) embedded into a solid phase substrate (12). The antigen or antibody is mixed with a mo... | 03/29/2005 |
| 6849446 | Modified bovine adenovirus having altered tropism The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is associated with altered tropism. The present invention provides aden... | 02/01/2005 |
| 6803041 | Equine herpesvirus vaccine A vaccine for protecting a horse against diseases associated with EHV-1 and/or EHV-4 is provided. The vaccine commonly includes inactivated EHV-1 (e.g., chemically inactivated EHV-1 KyA virus) and an adjuvant. The adjuvant can include a cross-linked olefinically uns... | 10/12/2004 |
| 6794404 | Viral polymerase inhibitors A compound of the formula I: wherein: X is CH or N; Y is O or S; Z is OH, NH2, NMeR3, NHR3; OR3 or 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N an... | 09/21/2004 |
| 6740511 | Modified adenoviral fibre and uses thereof The present invention relates to a modified fiber of an adenovirus, comprising at least one mutation at one or more residues within the region of said fiber stretching from pleated sheet A to pleated sheet B, and including loop AB. ... | 05/25/2004 |
| 6733757 | Adeno-associated virus capsid immunologic determinants Polypeptides of adeno-associated virus (AAV) that bind to AAV antibodies or block binding of AAV to mammalian cells are described. Derivatives of peptides can be less immunogenic, enhance binding to cells, render a virus tissue specific and so on. The nucleic acid s... | 05/11/2004 |
| 6730923 | Transmissive conveyor for use in pulsed light sterilization An apparatus for carrying a target object having a plurality of surfaces, within a pulsed light sterilization chamber including a treatment zone within which pulsed sterilizing light is emitted, comprises: a transmissive carrier within the treatment zone detachably ... | 05/04/2004 |
| 6730305 | Nucleotide sequences encoding bovine respiratory syncytial virus immunogenic proteins The present invention relates to recombinant DNA molecules which encode bovine respiratory syncytial (BRS) virus proteins, to BRS virus proteins, and peptides and to recombinant BRS virus vaccines produced therefrom. It is based, in part, on the cloning of substanti... | 05/04/2004 |
| 6719981 | Stable, attenuated rabies virus mutants and live vaccines thereof The present invention relates to recombinant rabies virus mutants comprising a mutation in the viral genome, whereby said mutation comprises at least a substitution of the Arg333 codon in the gene encoding the G protein with a codon that differs by three ... | 04/13/2004 |
| 6682883 | Diagnosis of flavivirus infection The invention provides methods and kits for use in diagnosing flavivirus infection.... | 01/27/2004 |
| 6569422 | Genetically engineered cell culture adapted infectious bursal diseases virus (IBDV) mutants The present invention relates to a method for the adaptation of infectious bursal disease viruses (IBDV) to growth in CEF cell culture. Changing the codons for amino acid residues 253 (Gln) and 284 (Ala) to 253 (His) and 284 (Thr) allowed bursa adapted Cl... | 05/27/2003 |
| 6562350 | Combined vaccine against both HAV and measles virus and method of producing it A combined hepatitis A-measles live vaccine, its lyophilized formulations with enhanced storage stability and methods of preparing the same by mixing the viral stocks of hepatitis A virus and measles virus or by propagating the two viruses on same diploid... | 05/13/2003 |
| 6562599 | Single-stranded antibody against hepatitis B virus core protein, gene thereof, and therapeutic agent for hepatitis B containing these A DNA characterized by coding for a single-stranded antibody capable of binding to a hepatitis B virus core protein: a single-stranded antibody coding for the DNA: a therapeutic agent for hepatitis B comprising the single-stranded antibody as the active i... | 05/13/2003 |
| 6548242 | Process for the sterilization of biological compositions and the product thereby The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile protei... | 04/15/2003 |
| 6509020 | Replication-competent herpes simplex virus A promising approach for the therapeutic treatment of brain tumors utilizes replication-competent, neuroattenuated herpes simplex virus-1 (HSV-1) mutants. This approach requires mutation of HSV-1 to eliminate killing of normal, non-dividing cells of the b... | 01/21/2003 |
| 6492148 | Genetically engineered cell culture adapted infectious bursal disease virus (IBDV) mutants The present invention relates to a method for the adaptation of infectious bursal disease viruses (IBDV) to growth in CEF cell culture. Changing the codons for amino acid residues 253 (Gln) and 284 (Ala) to 253 (His) and 284 (Thr) allowed bursa adapted Cl... | 12/10/2002 |
| 6479280 | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor The invention relates to a genetically modified bacteriophage, pseudovirion or phagemid capable of entering a host cell by binding of its artificial ligand to an artificial receptor present on said host cell. The invention relates also to the use of the g... | 11/12/2002 |
| 6455286 | Psoralens for pathogen inactivation Psoralen compound compositions are synthesized which have primaryamino substitutions on the 3-, 4-, 5-, and 8-positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these psoralens re... | 09/24/2002 |
| 6448281 | Viral polymerase inhibitors A compound of the formula I: ##STR1## wherein: X is CH or N; Y is O or S; Z is OH, NH2, NMeR3, NHR3 ; OR3 or 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S, said heterocycle bei... | 09/10/2002 |
| 6413714 | Process for the sterilization of biological compositions and the product produced thereby The present invention concerns a process for inactivating extracellular and intracellular virus in a biological composition without incurring substantial disruption or inactivation thereof, said process comprising subjecting said composition to a virucida... | 07/02/2002 |
