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| Number | Title | Issue Date |
| 7427680 | Fluorogenic substrates for BETA-lactamase gene expression Fluorescent substrates for beta-lactamases having the general formula shown above are provided. Z includes a fluorophore or chromophore and includes a group that may link to the lactam-containing group; R1 and R2 are independently selected from... | 09/23/2008 |
| 7396926 | Beta-lactamase substrates having phenolic ethers Provided are fluorescent substrates for β-lactamases having the general formula I: in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R′ is selected from the group consisting of H, physiologically acceptable ... | 07/08/2008 |
| 7359116 | Microscope turret mounted laser EPI-illumination port An optical injection system for use in conjunction with a microscope having a turret supporting an objective having an optical path is provided. The optical injection system includes a dichroic mirror disposed between the turret and the objective, along the optical ... | 04/15/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7351590 | Methods and compositions for directed microwave chemistry The present invention concerns a novel means by which specific chosen reactions can be accelerated through the use of a new type of artificial enzyme. The invention allows specific reactions to occur at an accelerated rate, even in the presence of other non-chosen m... | 04/01/2008 |
| 7348182 | Directed microwave chemistry The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special chips using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increas... | 03/25/2008 |
| 7267818 | Method for killing spores A method for killing or inactivating spores, by contacting the spores with a haloperoxidase, a source of hydrogen peroxide and a source of iodide ions. The spores may additionally be contacted with a haloperoxidase enhancing agent. ... | 09/11/2007 |
| 7235164 | Electrokinetic pump having capacitive electrodes An electrokinetic pump achieves high and low flow rates without producing significant gaseous byproducts and without significant evolution of the pump fluid. A first feature of the pump is that the electrodes in the pump are capacitive with a capacitance of at least... | 06/26/2007 |
| 7172864 | Methods for electronically-controlled enzymatic reactions A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridizations, antibody/anti... | 02/06/2007 |
| 7094528 | Magnetic enzyme detection techniques A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined... | 08/22/2006 |
| 7037642 | Removing compounds from blood products with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly po... | 05/02/2006 |
| 6991926 | Method comprising the indirect electrochemical regeneration of NAD(P)H A method comprising the indirect electrochemical regeneration of NAD(P)H in enzymatic substrate conversions which are catalyzed by monooxygenases, for example, is described. In particular, a method for the electroenzymatic preparation of 2,3-dihydroxyphenyl derivati... | 01/31/2006 |
| 6952656 | Wafer fabrication data acquisition and management systems The present invention provides a semiconductor processing device (800) including a tool (802) having one or more sensors, a primary data communication port (804) and a secondary data communication port (806). A sensor data acquisition sub... | 10/04/2005 |
| 6951713 | Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent p... | 10/04/2005 |
| 6949753 | Device and method for photoactivation Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfusion. Inact... | 09/27/2005 |
| 6946098 | Methods for sterilizing biological materials Methods are disclosed for sterilizing biological materials to reduce the level therein of one or more biological contaminants or pathogens, such as prions, responsible for the disease states known as transmissible spongiform encephalopathies (TSEs) in mammals. These... | 09/20/2005 |
| 6783968 | Methods for sterilizing preparations of glycosidases Methods are disclosed for sterilizing preparations of glycosidases to reduce the level therein of one or more active biological contaminants or pathogens, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanob... | 08/31/2004 |
| 6541228 | Electrodialysis methods for purification and recovery of gluconic acid derivatives A process for purifying and concentrating a gluconic acid derivative, such as 2-keto-L-gulonic acid, comprising introducing a non-viable and/or acidified fermentation medium or an in-vitro reactor medium comprising at least the gluconic acid derivative an... | 04/01/2003 |
| 6379956 | Method for populating substrates with biological cells and populating devices that can be used therefor The populating method for populating a substrate with living cells provides a population with at least one populating phase and at least one perfusion phase. During the populating phase the substrate can be held in contact with the cell suspension by cont... | 04/30/2002 |
| 6333181 | Ethanol production from lignocellulose This invention presents a method of improving enzymatic degradation of lignocellulose, as in the production of ethanol from lignocellulosic material, through the use of ultrasonic treatment. The invention shows that ultrasonic treatment reduces cellulase ... | 12/25/2001 |
| 6238899 | Method and apparatus for altering ionic interactions with magnetic fields A method for altering or affecting ionic interactions in systems containing an unhydrated ion in a chemical or biological system comprising controlling the orientation and varying the intensity and fluctuation frequency of perpendicular or perpendicular a... | 05/29/2001 |
| 6010573 | Apparatus and method for endothelial cell seeding/transfection of intravascular stents An apparatus for modifying an intravascular stent with endothelial cells and/or engineered endothelial cells which may have genetically altered DNA to minimize failure rates includes an external conductor sleeve, an insulating tube held therein, and a pai... | 01/04/2000 |
| 5985593 | Compositions and methods for enzymatic decontamination The present invention is related to a method for the enzymatic decontamination of specimens as a means to control microbiological contamination. The compositions and methods of the invention are especially useful to eliminate non-gram negative contaminant... | 11/16/1999 |
| 5972177 | Process for producing protein hydrolysates The invention relates to a method for producing protein hydrolyzates from animal and/or vegetable starting materials by comminuting the starting materials, mashing the comminuted starting materials into a pumpable mass, decomposing the mashed starting mat... | 10/26/1999 |
| 5972667 | Method and apparatus for activating a thermo-enzyme reaction with electromagnetic energy A method and apparatus for activating a thermo-enzyme reaction, such as a polymerase chain reaction or other temperature-sensitive transformation of biological systems are provided. Electromagnetic energy is applied to a target to produce a rapid elevatio... | 10/26/1999 |
| 5919679 | Method and apparatus for altering ionic interactions with magnetic fields A method is presented for altering or affecting ionic interactions in systems containing an unhydrated ion, including cells and organisms, using magnetic fields. The method involves controlling the orientation and varying the intensity and fluctuation fre... | 07/06/1999 |
| 5905032 | Electrosynthetic method of modifying biomolecules in particular enzymes Pendant groups in the alpha-amino acid monomer residues comprising a polypeptide molecule are selectively modified by applying an electric potential across an electrochemical cell containing the polypeptide.... | 05/18/1999 |
| 5597457 | System and method for forming synthetic protein crystals to determine the conformational structure by crystallography A method for forming synthetic crystals of proteins in a carrier fluid by use of the dipole moments of protein macromolecules that self-align in the Helmholtz layer adjacent to an electrode. The voltage gradients of such layers easily exceed 106 | 01/28/1997 |
| 5525198 | Electrorheological crystallization of proteins and other molecules An electrorheological crystalline mass of a molecule is formed by dispersing the molecule in a dispersion fluid and subjecting the molecule dispersion to a uniform electrical field for a period of time during which time an electrorheological crystalline m... | 06/11/1996 |
| 5403730 | Process for the selective deactivation of esterases and catalases in trigonopsis variabilis cells by microwave heating while retaining D-amino acid oxidase activity Microwave heating of intact Trigonopsis variabilis cells to 60°-68° C. for 20-40 seconds selectively deactivates esterases and catalases while retaining the activity of D-amino acid oxidase. The heating is effected with a microwave frequency of 0.4-24 G... | 04/04/1995 |
| 5358614 | Method and apparatus for the removal of bioconversion of constituents of organic liquids A method and apparatus for the removal or conversion of constituents from bulk organic liquids. A countercurrent biphasic bioreactor system is utilized to disperse and recoalesce a biocatalyst contained in the aqueous liquid phase into the organic liquid ... | 10/25/1994 |
| 5350686 | Microwave acceleration of enzyme-catalyzed modification of macromolecules A method of enhancing the enzyme-catalyzed modification of macromolecules comprising exposure of the enzyme and its macromolecule substrate to microwaves is disclosed. A frequency of from 1800 to 3000 MHz and a power of from 50 to 100 watts is preferred. ... | 09/27/1994 |
| 5332484 | Apparatus and process for the large scale separation and retrieval of proteins from cellular extracts A protein purification system employs a pretreatment device which operates in concert with an electrophoretic purification device to separate and retrieve a large volume of highly purified proteins or other products from a mass of crude cellular extract. ... | 07/26/1994 |
| 5218137 | Light activated acyl-enzymes Light activated acyl-enzymes of the formula: ##STR1## are disclosed. In the compounds of Formula (III), ENZ is an enzyme, X is O or S, Y is --NR3 R4, --OR5, or --SR5, and Z is a nucleophile. m is 0 to 3 and... | 06/08/1993 |
| 5166063 | Immobolization of biomolecules by enhanced electrophoretic precipitation The present invention provides a method for immobilizing biomolecules on a conductive substrate to produce a biosensor.... | 11/24/1992 |
| 5120648 | Chemical analyzer using RF radiation attenuation measurements A chemical analyzer in which the measurement of the change in attenuation of RF radiation propagated through a sample is used as the basis for calculating the change in concentration of a given chemical in the sample. Also disclosed are various probe and ... | 06/09/1992 |
| 5120640 | Placental isoferritins for the prognosis and diagnosis of immunosuppression Methods for diagnosis and prognosis of immunosuppressive conditions are disclosed, involving the detection of a particular isoform of ferritin, placental ferritin (PLF), in patient samples such as sera or on peripheral blood lymphocytes. PLF is elevated i... | 06/09/1992 |
| 5114851 | Light activated acyl-enzymes Light activated acyl-enzymes of the formula: ##STR1## are disclosed. In the compounds of Formula (III), ENZ is an enzyme, X is O or S, Y is --NR3 R4, --OR5, or --SR5, and Z is a nucleophile. m is 0 to 3 and... | 05/19/1992 |
| 5087338 | Process and device for separating electrically charged macromolecular compounds by forced-flow membrane electrophoresis A process and apparatus for the continuous separation of electrically charged macromolecular compounds, such as proteins, by forced-flow membrane electrophoresis is provided. Said process is conducted in an electrophoretic cell comprising a membrane compa... | 02/11/1992 |
| 4849346 | Method for determining thioredoxin reductase activity The present invention provides a method for measuring the activity of thioredoxin reductase in mammalian cells by contacting the cells in vivo or in vitro with a quaternary ammonium salt spin-labelled with a stable nitroxide free radical, and measuring th... | 07/18/1989 |
